Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Acts upstream of or within androgen metabolic process and estrogen biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in brain and gonad. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1).