X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms
im:7137560
Ku80
Biotype
protein coding gene
Automated Description
Predicted to enable telomeric DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of apoptotic process; and response to ionizing radiation. Predicted to be located in chromosome and nucleus. Predicted to be part of Ku70:Ku80 complex. Is expressed in several structures, including blastomere; central nervous system; cloaca; presumptive neural retina; and pronephric duct. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple myeloma; and rectum cancer. Orthologous to human XRCC5 (X-ray repair cross complementing 5).