Predicted to enable DNA endonuclease activity and single-stranded DNA binding activity. Predicted to act upstream of or within nucleotide-excision repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease).