Predicted to enable histone H3K36 methyltransferase activity; histone H3K4 methyltransferase activity; and transcription coactivator activity. Predicted to be involved in chromatin remodeling; positive regulation of inflammatory response; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within peptidyl-lysine trimethylation. Is expressed in telencephalon. Orthologous to human SETD4 (SET domain containing 4).