Gene

dot1l

Species
Danio rerio
Symbol
dot1l
Name
DOT1-like histone H3K79 methyltransferase
Synonyms
  • si:dkey-211f22.1
Biotype
protein coding gene
Automated Description
Predicted to enable histone H3K79 trimethyltransferase activity. Acts upstream of or within canonical Wnt signaling pathway and intestinal epithelial structure maintenance. Predicted to be located in nucleus. Is expressed in hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21451
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
apchu745/hu745 + MO1-dot1l + MO4-tp53
has condition:
standard conditions
  • intestine moderately well differentiated, abnormal
ZFIN
apchu745/hu745 + MO2-dot1l + MO4-tp53
has condition:
standard conditions
  • intestine moderately well differentiated, abnormal
ZFIN
dot1lsa1413/sa1413 (TL)
has condition:
standard conditions
  • whole organism quality, normal
ZFIN
w25Tg + MO1-dot1l + MO4-tp53
has condition:
standard conditions
  • canonical Wnt signaling pathway decreased process quality, abnormal
ZFIN
w25Tg + MO2-dot1l + MO4-tp53
has condition:
standard conditions
  • canonical Wnt signaling pathway decreased process quality, abnormal
ZFIN
WT + MO1-dot1l + MO4-tp53
has condition:
standard conditions
  • canonical Wnt signaling pathway decreased process quality, abnormal
  • intestinal epithelial structure maintenance decreased process quality, abnormal
ZFIN
WT + MO2-dot1l + MO4-tp53
has condition:
standard conditions
  • canonical Wnt signaling pathway decreased process quality, abnormal
  • intestinal epithelial structure maintenance decreased process quality, abnormal
ZFIN
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Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
20.790M20.795M20.800M20.805M20.810M20.815M20.820M20.825M

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
dot1l molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
lmnaDanio rerio
protein
  • affinity chromatography technology
PMID:34332124
Showing 1 - 1 of 1 rows
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Genetic Interactions

No data available