Gene

cd28

Species
Danio rerio
Symbol
cd28
Name
CD28 molecule
Synonyms
  • ctla4
  • si:ch211-160b7.1
Biotype
protein coding gene
Automated Description
Predicted to be involved in T cell receptor signaling pathway. Predicted to act upstream of or within regulation of T cell proliferation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in head kidney; kidney; spleen; and testis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); graft-versus-host disease; hematologic cancer (multiple); kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to several human genes including CTLA4 (cytotoxic T-lymphocyte associated protein 4).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
13.9865M13.9870M13.9875M13.9880M13.9885M13.9890M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions