Version: 8.0.0Date: Tue Jan 28 2025
Gene
prkaa2
- Species
- Danio rerio
- Symbol
- prkaa2
- Name
- protein kinase, AMP-activated, alpha 2 catalytic subunit
- Synonyms
- ampka2
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of TORC1 signaling; and protein localization to lipid droplet. Predicted to act upstream of or within several processes, including Wnt signaling pathway; cholesterol biosynthetic process; and protein phosphorylation. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2).
- ZFIN Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- Not Available
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | PRKAA2 | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Mus musculus | Prkaa2 | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Rattus norvegicus | Prkaa2 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | prkaa2 | 4 of 9 | Yes | Yes | ☑ ☐☐☑☑☐☑☐☐ |
| Drosophila melanogaster | AMPKα | 9 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☐ |
| Caenorhabditis elegans | aak-2 | 8 of 9 | Yes | Yes | ☐ ☑☑☑☑☑☑☑☑ |
| Saccharomyces cerevisiae | SNF1 | 8 of 9 | Yes | Yes | ☐ ☑☑☑☑☑☑☑☑ |
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| prkaa1 | 1 | 575 | 83 | 73 | 8 of 8 | ☑ ☑☑☑☑☑☑☑ |
| brsk2a | 2 | 628 | 48 | 32 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| sik2b | 3 | 612 | 47 | 33 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| sik2a | 4 | 665 | 44 | 30 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| sik1 | 5 | 584 | 49 | 33 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| brsk1b | 6 | 558 | 51 | 35 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| brsk1a | 7 | 549 | 50 | 34 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| brsk2b | 8 | 545 | 50 | 34 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| nuak2 | 9 | 601 | 45 | 30 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| snrka | 10 | 626 | 43 | 28 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| hunk | 11 | 632 | 42 | 28 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| nuak1a | 12 | 554 | 46 | 31 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| nuak1b | 13 | 577 | 44 | 31 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| melk | 14 | 517 | 47 | 34 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| snrkb | 15 | 410 | 51 | 33 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| nim1ka | 16 | 356 | 52 | 35 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| nim1kb | 17 | 331 | 56 | 35 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| chek1 | 18 | 362 | 51 | 31 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| stk11 | 19 | 362 | 49 | 31 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| tssk6 | 20 | 260 | 54 | 33 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
|---|---|---|---|---|---|
| prkaa1nei011/nei011; prkaa2nei012/nei012 (AB) |
|
| ZFIN |
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