Version: 8.0.0Date: Tue Jan 28 2025
Gene
hck
- Species
- Danio rerio
- Symbol
- hck
- Name
- HCK proto-oncogene, Src family tyrosine kinase
- Synonyms
- si:ch211-200e2.4
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in plasma membrane. Orthologous to human HCK (HCK proto-oncogene, Src family tyrosine kinase).
- ZFIN Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24418
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | HCK | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Mus musculus | Hck | 9 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☐ |
| Rattus norvegicus | Hck | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Drosophila melanogaster | Src64B | 3 of 10 | Yes | Yes | ☐ ☑☐☐☑☐☑☐☐ ☐ |
| Caenorhabditis elegans | src-1 | 8 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☐ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| blk | 1 | 503 | 78 | 63 | 6 of 8 | ☑ ☑☐☑☑☑☑☐ |
| yes1 | 2 | 542 | 71 | 56 | 6 of 8 | ☑ ☑☐☑☑☑☑☐ |
| fynb | 3 | 545 | 70 | 55 | 6 of 8 | ☑ ☑☐☑☑☑☑☐ |
| fyna | 4 | 538 | 70 | 56 | 6 of 8 | ☑ ☑☐☑☑☑☑☐ |
| yrk | 5 | 526 | 71 | 57 | 6 of 8 | ☑ ☑☐☑☑☑☑☐ |
| src | 6 | 552 | 70 | 53 | 6 of 8 | ☑ ☑☐☑☑☑☑☐ |
| lck | 7 | 455 | 82 | 64 | 6 of 8 | ☑ ☑☐☑☑☑☑☐ |
| frk | 8 | 465 | 68 | 53 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| abl1 | 9 | 506 | 59 | 41 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| srms | 10 | 475 | 63 | 42 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| ptk6b | 11 | 496 | 59 | 40 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| abl2 | 12 | 469 | 62 | 41 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| ptk6a | 13 | 475 | 60 | 41 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| itk | 14 | 462 | 57 | 38 | 5 of 8 | ☑ ☑☐☑☐☑☑☐ |
| csk | 15 | 464 | 56 | 38 | 5 of 8 | ☑ ☑☐☑☐☑☑☐ |
| si:ch73-340m8.2 | 16 | 473 | 55 | 37 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| btk | 17 | 442 | 56 | 36 | 5 of 8 | ☑ ☑☐☑☐☑☑☐ |
| matk | 18 | 462 | 53 | 34 | 5 of 8 | ☑ ☑☐☑☐☑☑☐ |
| tec | 19 | 462 | 55 | 35 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| syk | 20 | 572 | 45 | 30 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| txk | 21 | 458 | 56 | 37 | 3 of 8 | ☐ ☐☐☑☐☑☑☐ |
| zap70 | 22 | 557 | 45 | 28 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| fer | 23 | 434 | 53 | 36 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| jak2a | 24 | 548 | 43 | 28 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
| fes | 25 | 390 | 55 | 36 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| ptk2ab | 26 | 457 | 48 | 30 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| jak3 | 27 | 565 | 41 | 25 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
| ptk2ba | 28 | 363 | 52 | 34 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| jak2b | 29 | 434 | 47 | 28 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
| tyk2 | 30 | 451 | 45 | 27 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
| tnk2b | 31 | 344 | 52 | 35 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| jak1 | 32 | 389 | 49 | 30 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
| ptk2bb | 33 | 311 | 54 | 35 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| tnk2a | 34 | 294 | 56 | 37 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| tnk1 | 35 | 265 | 55 | 38 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| si:ch73-206d17.1 | 36 | 299 | 47 | 30 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| sla1a | 37 | 272 | 49 | 36 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| styk1b | 38 | 318 | 45 | 24 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| sla2a | 39 | 213 | 51 | 36 | 2 of 8 | ☐ ☐☐☑☐☐☑☐ |
| grb2b | 40 | 193 | 54 | 33 | 2 of 8 | ☐ ☐☐☑☐☐☑☐ |
| grb2a | 41 | 179 | 54 | 32 | 2 of 8 | ☐ ☐☐☑☐☐☑☐ |
| grap2b | 42 | 179 | 53 | 32 | 2 of 8 | ☐ ☐☐☑☐☐☑☐ |
| grapb | 43 | 148 | 56 | 33 | 2 of 8 | ☐ ☐☐☑☐☐☑☐ |
| grapa | 43 | 148 | 55 | 34 | 2 of 8 | ☐ ☐☐☑☐☐☑☐ |
| grap2a | 44 | 142 | 56 | 37 | 2 of 8 | ☐ ☐☐☑☐☐☑☐ |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
- Genome location
- Chr23:7505943...7545960 (40.02 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction
Sequence Feature Viewer
- Genome location
- Chr23:7505943...7545960 (40.02 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction