Version: 8.0.0
Date: Tue Jan 28 2025
tomt
Danio rerioZFIN:ZDB-GENE-160629-1
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

tomt

Species
Danio rerio
Symbol
tomt
Name
transmembrane O-methyltransferase
Synonyms
  • mercury
  • mrc
Biotype
protein coding gene
Automated Description
Predicted to enable catechol O-methyltransferase activity. Involved in auditory behavior. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception; neuromast development; and neuron differentiation. Located in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in anterior macula; inner ear; neuromast hair cell; and posterior macula. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to human LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing) and TOMT (transmembrane O-methyltransferase).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          No data available

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          tomt molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            tomt role
            tomt genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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