Version: 8.0.0Date: Tue Jan 28 2025
Disease Genes: App (Rno)
Disease
Source: DOID:10652
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Genes: App (Rno)
Disease
Source: DOID:9970
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Genes: App (Rno)
Disease
Source: DOID:0080348
Definition: An Alzheimer's disease that has_material_basis_in mutation heterozygous mutation in the APP gene, which encodes the amyloid precursor protein, on chromosome 21q21.
Genes: App (Rno)
Disease
Source: DOID:10763
Definition: An artery disease characterized by chronic elevated blood pressure in the arteries.
Genes: App (Rno)
Disease
Source: DOID:1561
Definition: A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.
Genes: App (Rno)
Disease
Source: DOID:11758
Definition: A microcytic anemia that is characterized by pallor, fatigue, lightheadedness, and weakness and has_material_basis_in low total body iron causing impaired synthesis of red blood cells.
Genes: App (Rno)
Source: DOID:0070028
Definition: A cerebral amyloid angiopathy that has_material_basis_in an autosomal dominant mutation of APP on chromosome 21q21.3.
Genes: App (Rno)
Disease
Source: DOID:0050850
Definition: A brain disease that is characterized by functional impairment of cognition, cerebral signal conduction, neurotransmission and synaptic plasticity, and underlying structural pathology associated with diabetes.
Genes: App (Rno)
Disease
Source: DOID:0081292
Definition: A brain disease that is characterized by brain dysfunction caused by an outside force, usually a violent blow to the head.
Genes: App (Rno)