Version: 8.0.0Date: Tue Jan 28 2025
Disease Genes: Bdnf (Mmu)
Disease
Source: DOID:10652
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Genes: Bdnf (Mmu)
Disease
Source: DOID:2841
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.
Genes: Bdnf (Mmu)
Disease
Source: DOID:9352
Definition: A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
Genes: Bdnf (Mmu)
Disease
Source: DOID:14330
Definition: A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
Genes: Bdnf (Mmu)
Disease
Source: DOID:8466
Definition: A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina.
Genes: Bdnf (Mmu)
Disease
Source: DOID:0060041
Definition: A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior.
Genes: Bdnf (Mmu)
Disease
Source: DOID:1686
Definition: An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function.
Genes: Bdnf (Mmu)
Disease
Source: DOID:3310
Definition: An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.
Genes: Bdnf (Mmu)
Disease
Source: DOID:2377
Definition: A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Genes: Bdnf (Mmu)
Disease
Source: DOID:9970
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Genes: Bdnf (Mmu)
Disease
Source: DOID:12858
Definition: A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.
Genes: Bdnf (Mmu)
Disease
Source: DOID:10126
Definition: A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape.
Genes: Bdnf (Mmu)
Disease
Source: DOID:1070
Definition: An open-angle glaucoma that is characterized by the absence of any apparent obstruction of aqueous outflow through the trabecular meshwork with gonioscopy, but often with elevated intraocular pressure.
Genes: Bdnf (Mmu)
Disease
Source: DOID:2030
Definition: A cognitive disorder that involves an excessive, irrational dread of everyday situations.
Genes: Bdnf (Mmu)
Disease
Source: DOID:1561
Definition: A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.
Genes: Bdnf (Mmu)
Source: DOID:1094
Definition: A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age.
Genes: Bdnf (Mmu)
Disease
Source: DOID:9778
Definition: An intestinal disease that is characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.
Genes: Bdnf (Mmu)
Disease
Source: DOID:1459
Definition: A thyroid gland disease which involves an underproduction of thyroid hormone.
Genes: Bdnf (Mmu)
Disease
Source: DOID:3082
Definition: A lung disease that is characterized by inflammation and altered lung interstitium compromising pulmonary function and often has_symptom shortness of breath, dyspnea, and/or cough.
Genes: Bdnf (Mmu)
Disease
Source: DOID:418
Definition: A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.
Genes: Bdnf (Mmu)
Source: DOID:10933
Definition: An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).
Genes: Bdnf (Mmu)
Disease
Source: DOID:3324
Definition: A cognitive disorder that involves a disturbance in mood as the predominant underlying feature.
Genes: Bdnf (Mmu)
Disease
Source: DOID:1470
Definition: A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
Genes: Bdnf (Mmu)
Disease
Source: DOID:3770
Definition: An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.
Genes: Bdnf (Mmu)
Source: DOID:2055
Definition: An anxiety disorder which results from a traumatic experience that results in psychological trauma.
Genes: Bdnf (Mmu)
Disease
Source: DOID:13399
Definition: A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions.
Genes: Bdnf (Mmu)
Disease
Source: DOID:4483
Definition: A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.
Genes: Bdnf (Mmu)
Disease
Source: DOID:13544
Definition: An open-angle glaucoma characterized by increased intrinsic resistance to aqueous outflow without known secondary causes, an anatomically narrow anterior chamber angle, or elevated intraocular pressure compared to the average population. Normal tension glaucoma has_symptom progressive decreased vision and progressive loss of peripheral vision.
Genes: Bdnf (Mmu)
Disease
Source: DOID:0050741
Definition: A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol.
Genes: Bdnf (Mmu)
Disease
Source: DOID:12894
Definition: An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.
Genes: Bdnf (Mmu)
Source: DOID:0060731
Definition: An autonomic nervous system disease characterized by reduced responsiveness of the respiratory center to carbon dioxide, diminished pupillary light responses, and other symptoms related to defects in the autonomic nervous system and that has_material_basis_in most commonly heterozygous mutation in the PHOX2B gene on chromosome 4p13 and less frequently mutations in the RET, GDNF, EDN3, BDNF, or ASCL1 genes.
Genes: Bdnf (Mmu)
Disease
Source: DOID:1574
Definition: A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.
Genes: Bdnf (Mmu)
Disease
Source: DOID:1596
Definition: A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function.
Genes: Bdnf (Mmu)
Disease
Source: DOID:9975
Definition: A drug dependence that is a psychological dependency on the regular use of cocaine.
Genes: Bdnf (Mmu)
Source: DOID:9719
Definition: A retinal and vitreous disease characterized by ocular inflammation, vascular dropout, large spots of hyperpigmentation, neovascularization of the peripheral and posterior retina, vitreous hemorrhage, and retinal detachment that has_material_basis_in heterozygous mutation in the CAPN5 gene on chromosome 11q13.5.
Genes: Bdnf (Mmu)
Disease
Source: DOID:670
Definition: A substance abuse that involves the recurring use of amphetamines despite negative consequences.
Genes: Bdnf (Mmu)
Disease
Source: DOID:13406
Definition: A sarcoidosis that is characterized by noncaseating granulomatous infiltration of the lungs and supporting lymph nodes, bilateral hilar adenopathy, and pulmonary issues, has_symptom shortness of breath, fatigue, wheezing, and chronic cough, and develops_from a type IV hypersensitivity reaction.
Genes: Bdnf (Mmu)
Disease
Source: DOID:8725
Definition: A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.
Genes: Bdnf (Mmu)
Disease
Source: DOID:0050742
Definition: A substance dependence that is characterized by a physical dependence on nicotine.
Genes: Bdnf (Mmu)
Disease
Source: DOID:0050848
Definition: A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.
Genes: Bdnf (Mmu)
Disease
Source: DOID:1679
Definition: A bladder disease that is characterized by inflammation of the bladder.
Genes: Bdnf (Mmu)
Source: DOID:3525
Definition: Not Available
Genes: Bdnf (Mmu)
Disease
Source: DOID:5154
Definition: A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.
Genes: Bdnf (Mmu)
Disease
Source: DOID:2559
Definition: A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.
Genes: Bdnf (Mmu)