Version: 8.0.0Date: Tue Jan 28 2025
Disease Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:10652
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:2841
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:1612
Definition: An organ system cancer that originates in the mammary gland.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:14330
Definition: A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:7148
Definition: An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:9849
Definition: A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:9074
Definition: A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:9744
Definition: A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:1686
Definition: An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:2377
Definition: A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:289
Definition: A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:10283
Definition: A male reproductive organ cancer that is located_in the prostate.
Genes: H2-Eb1 (Mmu)
Source: DOID:2945
Definition: A Coronavirus infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:12849
Definition: An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:13241
Definition: A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:3459
Definition: A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:417
Definition: An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:13774
Definition: An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:9415
Definition: An extrinsic asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:1459
Definition: A thyroid gland disease which involves an underproduction of thyroid hormone.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:399
Definition: A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.
Genes: H2-Eb1 (Mmu)
Source: DOID:676
Definition: A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:437
Definition: An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:104
Definition: A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:7147
Definition: An arthritis that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:13141
Definition: An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:3526
Definition: A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:2048
Definition: An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells.
Genes: H2-Eb1 (Mmu)
Source: DOID:0050156
Definition: A pulmonary fibrosis that is characterized by scarring of the lung characterized by stiffness in the lungs and makes it difficult to breathe.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:1205
Definition: An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:0050827
Definition: A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:8986
Definition: A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:0080162
Definition: A glomerulonephritis that is characterized by inflammation of the kidneys resulting from systemic lupus erythematosus.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:2988
Definition: An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:7188
Definition: An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:14115
Definition: A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus, which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:10003
Definition: An inner ear disease that is characterized by hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:12859
Definition: A movement disease characterized by brief, semi-directed, irregular movements that not repetitive or rhythmic, but appear to flow from one muscle to the next.
Genes: H2-Eb1 (Mmu)
Source: DOID:526
Definition: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:7693
Definition: An aortic aneurysm that is located_in the abdominal aorta.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:12306
Definition: An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.
Genes: H2-Eb1 (Mmu)
Source: DOID:0050784
Definition: A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:2508
Definition: A vasculitis that involves inflammation of the aorta that carries blood from the heart to the rest of the body.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:10608
Definition: An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:11335
Definition: A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:12894
Definition: An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.
Genes: H2-Eb1 (Mmu)
Disease
Source: DOID:4450
Definition: A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.
Genes: H2-Eb1 (Mmu)
Source: DOID:11266
Definition: A viral infectious disease that is a hemorrhagic fever, located in kidney, has_material_basis_in Orthohantavirus dobravaense, has_material_basis_in Orthohantavirus hantanense, has_material_basis_in Orthohantavirus puumalaense, has_material_basis_in Orthohantavirus seoulense, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom proteinuria, and has symptom renal failure.
Genes: H2-Eb1 (Mmu)