Version: 8.0.0Date: Tue Jan 28 2025
Disease Genes: Il6 (Mmu)
Disease
Source: DOID:10652
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Genes: Il6 (Mmu)
Disease
Source: DOID:0080600
Definition: A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2.
Genes: Il6 (Mmu)
Disease
Source: DOID:2841
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.
Genes: Il6 (Mmu)
Disease
Source: DOID:9352
Definition: A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
Genes: Il6 (Mmu)
Disease
Source: DOID:1612
Definition: An organ system cancer that originates in the mammary gland.
Genes: Il6 (Mmu)
Disease
Source: DOID:6000
Definition: A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.
Genes: Il6 (Mmu)
Disease
Source: DOID:1826
Definition: A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.
Genes: Il6 (Mmu)
Disease
Source: DOID:9351
Definition: A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
Genes: Il6 (Mmu)
Disease
Source: DOID:9744
Definition: A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.
Genes: Il6 (Mmu)
Disease
Source: DOID:1793
Definition: An endocrine gland cancer located_in the pancreas.
Genes: Il6 (Mmu)
Disease
Source: DOID:552
Definition: A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.
Genes: Il6 (Mmu)
Source: DOID:331
Definition: A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.
Genes: Il6 (Mmu)
Disease
Source: DOID:2377
Definition: A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Genes: Il6 (Mmu)
Disease
Source: DOID:9970
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Genes: Il6 (Mmu)
Disease
Source: DOID:12858
Definition: A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.
Genes: Il6 (Mmu)
Disease
Source: DOID:9452
Definition: A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes.
Genes: Il6 (Mmu)
Disease
Source: DOID:10763
Definition: An artery disease characterized by chronic elevated blood pressure in the arteries.
Genes: Il6 (Mmu)
Source: DOID:0080208
Definition: A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.
Genes: Il6 (Mmu)
Disease
Source: DOID:8778
Definition: An intestinal disease that involves inflammation located_in intestine.
Genes: Il6 (Mmu)
Source: DOID:2945
Definition: A Coronavirus infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.
Genes: Il6 (Mmu)
Disease
Source: DOID:850
Definition: A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide.
Genes: Il6 (Mmu)
Disease
Source: DOID:9119
Definition: A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
Genes: Il6 (Mmu)
Disease
Source: DOID:12849
Definition: An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.
Genes: Il6 (Mmu)
Disease
Source: DOID:3393
Definition: An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.
Genes: Il6 (Mmu)
Disease
Source: DOID:1485
Definition: A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs.
Genes: Il6 (Mmu)
Disease
Source: DOID:13241
Definition: A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.
Genes: Il6 (Mmu)
Disease
Source: DOID:10534
Definition: A gastrointestinal system cancer that is located_in the stomach.
Genes: Il6 (Mmu)
Disease
Source: DOID:684
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Genes: Il6 (Mmu)
Disease
Source: DOID:4947
Definition: A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.
Genes: Il6 (Mmu)
Disease
Source: DOID:9256
Definition: A large intestine cancer that is located_in the colon and/or located_in the rectum.
Genes: Il6 (Mmu)
Source: DOID:676
Definition: A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.
Genes: Il6 (Mmu)
Disease
Source: DOID:11758
Definition: A microcytic anemia that is characterized by pallor, fatigue, lightheadedness, and weakness and has_material_basis_in low total body iron causing impaired synthesis of red blood cells.
Genes: Il6 (Mmu)
Disease
Source: DOID:12704
Definition: An autosomal recessive cerebellar ataxia that is characterized by cerebellar ataxia, telangiectases, immune defects, and a predisposition to malignancy and that has_material_basis_in homozygous or compound heterozygous mutation in the ATM gene on chromosome 11q22.
Genes: Il6 (Mmu)
Disease
Source: DOID:10591
Definition: A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.
Genes: Il6 (Mmu)
Disease
Source: DOID:7147
Definition: An arthritis that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.
Genes: Il6 (Mmu)
Disease
Source: DOID:418
Definition: A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.
Genes: Il6 (Mmu)
Disease
Source: DOID:0060901
Definition: A B-cell lymphoma characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein.
Genes: Il6 (Mmu)
Disease
Source: DOID:5844
Definition: A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.
Genes: Il6 (Mmu)
Source: DOID:0050625
Definition: A hepatobiliary benign neoplasm located_in the biliary tract.
Genes: Il6 (Mmu)
Disease
Source: DOID:13141
Definition: An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid.
Genes: Il6 (Mmu)
Disease
Source: DOID:2987
Definition: An autoinflammatory disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has_material_basis_in mutations in the MEFV gene, which encodes the protein pyrin.
Genes: Il6 (Mmu)
Source: DOID:526
Definition: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.
Genes: Il6 (Mmu)
Disease
Source: DOID:1470
Definition: A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
Genes: Il6 (Mmu)
Disease
Source: DOID:4251
Definition: An eye disease affecting the conjunctiva, which is the mucous membrane surrounding the eye and interior of the eyelids.
Genes: Il6 (Mmu)
Disease
Source: DOID:1924
Definition: A gonadal disease that is characterized by diminished functional activity of the gonads.
Genes: Il6 (Mmu)