Version: 8.0.0Date: Tue Jan 28 2025
Disease Genes: InR (Dme)
Disease
Source: DOID:10652
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Genes: InR (Dme)
Disease
Source: DOID:9352
Definition: A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
Genes: InR (Dme)
Disease
Source: DOID:1612
Definition: An organ system cancer that originates in the mammary gland.
Genes: InR (Dme)
Disease
Source: DOID:162
Definition: A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
Genes: InR (Dme)
Disease
Source: DOID:14330
Definition: A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
Genes: InR (Dme)
Disease
Source: DOID:9351
Definition: A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
Genes: InR (Dme)
Disease
Source: DOID:1793
Definition: An endocrine gland cancer located_in the pancreas.
Genes: InR (Dme)
Source: DOID:332
Definition: A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.
Genes: InR (Dme)
Disease
Source: DOID:0050700
Definition: A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.
Genes: InR (Dme)
Disease
Source: DOID:9970
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Genes: InR (Dme)
Disease
Source: DOID:9452
Definition: A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes.
Genes: InR (Dme)
Disease
Source: DOID:10283
Definition: A male reproductive organ cancer that is located_in the prostate.
Genes: InR (Dme)
Disease
Source: DOID:10763
Definition: An artery disease characterized by chronic elevated blood pressure in the arteries.
Genes: InR (Dme)
Disease
Source: DOID:784
Definition: A kidney failure that is characterized by the gradual loss of kidney function.
Genes: InR (Dme)
Source: DOID:0080208
Definition: A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.
Genes: InR (Dme)
Disease
Source: DOID:535
Definition: A disease of mental health that involves disruption of sleep patterns.
Genes: InR (Dme)
Disease
Source: DOID:8398
Definition: An arthritis that has_material_basis_in worn out cartilage located_in joint.
Genes: InR (Dme)
Disease
Source: DOID:8577
Definition: A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.
Genes: InR (Dme)
Disease
Source: DOID:684
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Genes: InR (Dme)
Disease
Source: DOID:11984
Definition: An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.
Genes: InR (Dme)
Disease
Source: DOID:3070
Definition: A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine.
Genes: InR (Dme)
Disease
Source: DOID:5844
Definition: A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.
Genes: InR (Dme)
Disease
Source: DOID:3594
Definition: A placenta cancer that has_material_basis_in trophoblastic cells.
Genes: InR (Dme)
Disease
Source: DOID:1307
Definition: A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.
Genes: InR (Dme)
Disease
Source: DOID:11476
Definition: A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.
Genes: InR (Dme)
Disease
Source: DOID:7998
Definition: A thyroid gland disease that involves an over production of thyroid hormone.
Genes: InR (Dme)
Disease
Source: DOID:0050782
Definition: A syndrome that is characterized by the development of a one or more tumors (gastrinoma) in the pancreas, duodenum, or both that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach.
Genes: InR (Dme)
Disease
Source: DOID:769
Definition: An autonomic nervous system neoplasm that derives_from immature nerve cells.
Genes: InR (Dme)
Disease
Source: DOID:0050741
Definition: A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol.
Genes: InR (Dme)
Disease
Source: DOID:10605
Definition: An intestinal disease that is characterized by a reduced ability to absorb nutrients due to the physical loss or the loss of function of a portion of the small and/or large intestine.
Genes: InR (Dme)
Disease
Source: DOID:12217
Definition: A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies.
Genes: InR (Dme)
Source: DOID:0050696
Definition: A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.
Genes: InR (Dme)
Disease
Source: DOID:4450
Definition: A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.
Genes: InR (Dme)
Disease
Source: DOID:3587
Definition: A pancreatic carcinoma located_in the pancreatic duct.
Genes: InR (Dme)
Disease
Source: DOID:10286
Definition: A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Genes: InR (Dme)
Disease
Source: DOID:2526
Definition: A prostate carcinoma that derives_from epithelial cells of glandular origin.
Genes: InR (Dme)
Disease
Source: DOID:13413
Definition: A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood.
Genes: InR (Dme)
Disease
Source: DOID:2986
Definition: A glomerulonephritis characterized by build up of IgA antibody in the glomerulus.
Genes: InR (Dme)
Disease
Source: DOID:0060071
Definition: A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.
Genes: InR (Dme)
Disease
Source: DOID:8725
Definition: A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.
Genes: InR (Dme)
Disease
Source: DOID:4194
Definition: A carbohydrate metabolic disorder that is characterized by blood glucose levels which cannot be maintained within the normal range.
Genes: InR (Dme)
Disease
Source: DOID:9620
Definition: A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter.
Genes: InR (Dme)
Disease
Source: DOID:4440
Definition: A germinoma that has_material_basis_in cells that make sperm and eggs.
Genes: InR (Dme)
Disease
Source: DOID:2154
Definition: A kidney cancer that affects the kidneys and typically occuring in children.
Genes: InR (Dme)
Disease
Source: DOID:3602
Definition: A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems.
Genes: InR (Dme)