Version: 8.0.0Date: Tue Jan 28 2025
Disease Genes: Ttr (Mmu)
Disease
Source: DOID:10652
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Genes: Ttr (Mmu)
Disease
Source: DOID:1324
Definition: A respiratory system cancer that is located_in the lung.
Genes: Ttr (Mmu)
Disease
Source: DOID:10534
Definition: A gastrointestinal system cancer that is located_in the stomach.
Genes: Ttr (Mmu)
Disease
Source: DOID:684
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Genes: Ttr (Mmu)
Disease
Source: DOID:4947
Definition: A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.
Genes: Ttr (Mmu)
Disease
Source: DOID:9256
Definition: A large intestine cancer that is located_in the colon and/or located_in the rectum.
Genes: Ttr (Mmu)
Disease
Source: DOID:0050638
Definition: An amyloidosis that is characterized by a loss of sensation in the extremities, cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis resulting from abnormal deposits of amyloid protein in the body's organs and tissues and has_material_basis_in autosomal dominant inheritance of mutations in the TTR gene.
Genes: Ttr (Mmu)
Source: DOID:3908
Definition: A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.
Genes: Ttr (Mmu)
Disease
Source: DOID:9120
Definition: A disease of metabolism that is characterized by extracellular tissue deposition of mis-folded amyloid fibrils built up by twisted protofilaments, deposited in the spaces between the cells of vital organs, causing disruption of organ tissue structure and function. These deposits may result in a wide range of clinical manifestations depending upon their type, location, and the amount of deposition.
Genes: Ttr (Mmu)
Disease
Source: DOID:0050860
Definition: An intestinal benign neoplasm that has_material_basis_in epithelial tissue of glandular origin and is located_in colon and located_in rectum.
Genes: Ttr (Mmu)
Source: DOID:0080219
Definition: A hyperthyroxinemia that is characterized by an increased affinity for thyroxine (T4) by transthyretin in clinically euthyroid individuals and that has_material_basis_in heterozygous mutation in the TTR gene on chromosome 18q12.
Genes: Ttr (Mmu)
Disease
Source: DOID:0050866
Definition: An oral cavity cancer that has_material_basis_in squamous cells.
Genes: Ttr (Mmu)
Disease
Source: DOID:2316
Definition: An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.
Genes: Ttr (Mmu)
Disease
Source: DOID:0070466
Definition: A carpal tunnel syndrome that has_material_basis_in heterozygous mutation in the TTR gene on chromosome 18q12.1.
Genes: Ttr (Mmu)