[object Object]

Category

864 results for CTSH

Page 1 of 18

Ctsh

(Mus musculus)

Gene

Name: cathepsin H

Synonyms: Cat H, expressed sequence AL022844, AL022844

Source: MGI:107285

Biotype: protein coding gene

Symbol: Ctsh (Mmu)

Symbol: Ctsh

Automated Gene Synopsis: Orthologous to human CTSH (cathepsin H).

Strict Orthology Symbols: CTSH

Alleles: Ctsh (Mmu)...Ctsh (Mmu)...Ctsh (Mmu)...Ctsh (Mmu)...Ctsh (Mmu)

Ctsh

(Rattus norvegicus)

Gene

Name: cathepsin H

Synonyms: cathepsin B3, cathepsin BA, pro-cathepsin H

Source: RGD:2447

Biotype: protein coding gene

Symbol: Ctsh (Rno)

Symbol: Ctsh

Gene Synopsis: Orthologous to human CTSH (cathepsin H); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol

Automated Gene Synopsis: Orthologous to human CTSH (cathepsin H).

Strict Orthology Symbols: CTSH

CTSH

(Homo sapiens)

Gene

Name: cathepsin H

Synonyms: cathepsin B3, CPSB, pro-cathepsin H, ACC5, ACC4, DKFZp686B24257, cathepsin BA, minichain, N-benzoylarginine-beta-naphthylamide hydrolase, ACC-5, MGC1519, ACC-4, aleurain

Source: HGNC:2535

Biotype: protein coding gene

Symbol: CTSH (Hsa)

Symbol: CTSH

Strict Orthology Symbols: Ctsh...ctsh...ctsh.L

ctsh

(Danio rerio)

Gene

Name: cathepsin H

Synonyms: wu:fc44c02, zgc:85774, fc44c02

Source: ZFIN:ZDB-GENE-030131-3539

Biotype: protein coding gene

Symbol: ctsh (Dre)

Symbol: ctsh

Automated Gene Synopsis: Orthologous to human CTSH (cathepsin H).

Strict Orthology Symbols: CTSH

ctsh

(Xenopus tropicalis)

Gene

Name: cathepsin H

Synonyms: cathepsin H, ctsh, LOC496748

Source: Xenbase:XB-GENE-5820392

Biotype: gene

Symbol: ctsh (Xtr)

Symbol: ctsh

Synonyms: ctsh...ctsh

Strict Orthology Symbols: ctsh.L

ctsh.L

(Xenopus laevis)

Gene

Name: cathepsin H

Synonyms: cathepsin H, ctsh.L, LOC496748

Source: Xenbase:XB-GENE-5820439

Biotype: gene

Symbol: ctsh.L (Xla)

Automated Gene Synopsis: Orthologous to human CTSH (cathepsin H).

Strict Orthology Symbols: CTSH

Symbol: ctsh.L

Disease (3)

Ctsh^em2Cya

(Mus musculus)

Allele/Variant

Source: MGI:7583212

Genes: Ctsh (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Ctsh (Mmu)

Genes: Ctsh (Mmu)

Symbol: Ctsh^em2Cya

Gene (1)

Ctsh^tm1Thre

(Mus musculus)

Allele/Variant

Source: MGI:4840055

Genes: Ctsh (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Ctsh (Mmu)

Genes: Ctsh (Mmu)

Symbol: Ctsh^tm1Thre

Ctsh^em1Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7297562

Genes: Ctsh (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Ctsh (Mmu)

Genes: Ctsh (Mmu)

Symbol: Ctsh^em1Gpt

Gene (1)

Ctsh^em3Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7297563

Genes: Ctsh (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Ctsh (Mmu)

Genes: Ctsh (Mmu)

Symbol: Ctsh^em3Gpt

Gene (1)

Ctsh^{tm1b(KOMP)Wtsi}

(Mus musculus)

Allele/Variant

Source: MGI:5616353

Genes: Ctsh (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Ctsh (Mmu)

Genes: Ctsh (Mmu)

Symbol: Ctsh^{tm1b(KOMP)Wtsi}

Ctsh^em1Cya

(Mus musculus)

Allele/Variant

Source: MGI:7583211

Genes: Ctsh (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Ctsh (Mmu)

Genes: Ctsh (Mmu)

Symbol: Ctsh^em1Cya

Gene (1)

Ctsh^{tm1a(KOMP)Wtsi}

(Mus musculus)

Allele/Variant

Source: MGI:4363323

Genes: Ctsh (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Ctsh (Mmu)

Genes: Ctsh (Mmu)

Symbol: Ctsh^{tm1a(KOMP)Wtsi}

Gene (1)

Ctsh^{tm1b(KOMP)Wtsi}/Ctsh^{tm1b(KOMP)Wtsi} [background:] C57BL/6N-Ctsh^{tm1b(KOMP)Wtsi}/Bay

(Mus musculus)

Model

Id: MGI:6288409

Synonyms: Not Available

Symbol: Ctsh/Ctsh [background:] C57BL/6N-Ctsh/Bay (Mmu)

Genes: Ctsh (Mmu)

Alleles: Ctsh (Mmu)

Name: Ctsh/Ctsh [background:] C57BL/6N-Ctsh/Bay

Gene (1)

Ctsh-ps

(Mus musculus)

Gene

Name: cathepsin H, pseudogene

Synonyms: Ctsh-rs1, cathepsin, related sequence 1

Source: MGI:1346994

Biotype: pseudogene

Symbol: Ctsh-ps (Mmu)

Symbol: Ctsh-ps

Ctsh^tm1Thre/Ctsh^tm1Thre [background:] B6N.129P2-Ctsh^tm1Thre

(Mus musculus)

Model

Id: MGI:4840057

Synonyms: Not Available

Symbol: Ctsh/Ctsh [background:] B6N.129P2-Ctsh (Mmu)

Genes: Ctsh (Mmu)

Alleles: Ctsh (Mmu)

Name: Ctsh/Ctsh [background:] B6N.129P2-Ctsh

Gene (1)

Ctsh^tm1Thre/Ctsh^tm1Thre [background:] involves: 129P2/OlaHsd

(Mus musculus)

Model

Id: MGI:5552740

Synonyms: Not Available

Symbol: Ctsh/Ctsh [background:] involves: 129P2/OlaHsd (Mmu)

Genes: Ctsh (Mmu)

Alleles: Ctsh (Mmu)

Name: Ctsh/Ctsh [background:] involves: 129P2/OlaHsd

Gene (1)

CtsL3

(Drosophila melanogaster)

Gene

Name: Cathepsin L3

Synonyms: Cts5, CG11459, CTS L

Source: FB:FBgn0037396

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human CTSH (cathepsin H).

Strict Orthology Symbols: CTSH

K02E7.10

(Caenorhabditis elegans)

Gene

Name: Peptidase C1A papain C-terminal domain-containing protein

Synonyms: CELE_K02E7.10

Source: WB:WBGene00019314

Biotype: protein coding gene

Gene Synopsis: Is an ortholog of human CTSH (cathepsin H); CTSK (cathepsin K); and CTSS (cathepsin S).

Automated Gene Synopsis: Orthologous to human CTSH (cathepsin H); CTSK (cathepsin K); and CTSS (cathepsin S).

Strict Orthology Symbols: CTSH

ctsl

(Xenopus tropicalis)

Gene

Name: cathepsin L

Synonyms: ctsl, cpl-1, catl, mep, cathepsin L

Source: Xenbase:XB-GENE-5907229

Biotype: gene

Automated Gene Synopsis: Orthologous to human CTSH (cathepsin H).

Strict Orthology Symbols: CTSH

Disease (4)

Y51A2D.8

(Caenorhabditis elegans)

Gene

Name: Cysteine proteinase

Synonyms: CELE_Y51A2D.8

Source: WB:WBGene00013076

Biotype: protein coding gene

Strict Orthology Symbols: ctsh

Allele/Variant (87)

Y51A2D.1

(Caenorhabditis elegans)

Gene

Name: Pept_C1 domain-containing protein

Synonyms: CELE_Y51A2D.1

Source: WB:WBGene00013072

Biotype: protein coding gene

Strict Orthology Symbols: ctsh

Allele/Variant (100)

neuropeptide catabolic process

Gene Ontology

Source: GO:0010813

Synonyms: Not Available

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (14)

HLA-A specific activating MHC class I receptor activity

Gene Ontology

Source: GO:0030108

Synonyms: Not Available

Branch: molecular function

Genes: CTSH (Hsa)...Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (3)

positive regulation of peptidase activity

Gene Ontology

Source: GO:0010952

Synonyms: Not Available

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (412)

dichotomous subdivision of terminal units involved in lung branching

Gene Ontology

Source: GO:0060448

Synonyms:

bud bifurcation involved in lung branching

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (9)

peptidase activator activity involved in apoptotic process

Gene Ontology

Source: GO:0016505

Synonyms:

apoptotic protease activator activity

Branch: molecular function

Genes: CTSH (Hsa)...Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (63)

bradykinin catabolic process

Gene Ontology

Source: GO:0010815

Synonyms: Not Available

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (21)

thyroid hormone binding

Gene Ontology

Source: GO:0070324

Synonyms:

thyroxine binding
triiodothyronine binding

Branch: molecular function

Genes: CTSH (Hsa)...Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (24)

kininogen binding

Gene Ontology

Source: GO:0030984

Synonyms: Not Available

Branch: molecular function

Genes: Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (9)

cysteine-type endopeptidase activator activity involved in apoptotic process

Gene Ontology

Source: GO:0008656

Synonyms:

caspase activator activity

Branch: molecular function

Genes: CTSH (Hsa)...Ctsh (Mmu)...ctsh (Dre)...Ctsh (Rno)

Genes Annotated with this GO Term (57)

cellular response to thyroid hormone stimulus

Gene Ontology

Source: GO:0097067

Synonyms: Not Available

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Mmu)...Ctsh (Rno)

Genes Annotated with this GO Term (45)

Ctsc^tm1Ley/Ctsc^tm1Ley Ctsh^tm1Thre/Ctsh^tm1Thre [background:] involves: 129P2/OlaHsd * 129X1/SvJ

(Mus musculus)

Model

Id: MGI:4840058

Synonyms: Not Available

Genes: Ctsh (Mmu)

Alleles: Ctsh (Mmu)

Name: Ctsc/Ctsc Ctsh/Ctsh [background:] involves: 129P2/OlaHsd * 129X1/SvJ

Symbol: Ctsc/Ctsc Ctsh/Ctsh [background:] involves: 129P2/OlaHsd * 129X1/SvJ

Gene (2)

alveolar lamellar body

Gene Ontology

Source: GO:0097208

Synonyms: Not Available

Branch: cellular component

Genes: CTSH (Hsa)...Ctsh (Rno)...Ctsh (Mmu)

Genes Annotated with this GO Term (28)

outer dense fiber

Gene Ontology

Source: GO:0001520

Synonyms:

outer dense fibre

Branch: cellular component

Genes: Ctsh (Mmu)...Ctsh (Rno)

Genes Annotated with this GO Term (32)

membrane protein proteolysis

Gene Ontology

Source: GO:0033619

Synonyms: Not Available

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Mmu)...Ctsh (Rno)

Genes Annotated with this GO Term (163)

la020359Tg

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-120806-10458

Genes: ctsh (Dre)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Genes: ctsh (Dre)

Gene (1)

surfactant homeostasis

Gene Ontology

Source: GO:0043129

Synonyms:

regulation of liquid surface tension
regulation of surface tension of a liquid

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Mmu)...Ctsh (Rno)

Genes Annotated with this GO Term (84)

immune response-regulating signaling pathway

Gene Ontology

Source: GO:0002764

Synonyms:

immune response-regulating signalling pathway

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Mmu)...Ctsh (Rno)

Genes Annotated with this GO Term (1186)

multivesicular body lumen

Gene Ontology

Source: GO:0097486

Synonyms: Not Available

Branch: cellular component

Genes: CTSH (Hsa)

Genes Annotated with this GO Term (7)

zymogen activation

Gene Ontology

Source: GO:0031638

Synonyms:

zymogen activation by proteolytic cleavage

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Mmu)...Ctsh (Rno)

Genes Annotated with this GO Term (191)

T cell mediated cytotoxicity

Gene Ontology

Source: GO:0001913

Synonyms:

T cell mediated apoptosis
T cell mediated cell death

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Mmu)...Ctsh (Rno)

Genes Annotated with this GO Term (78)

positive regulation of apoptotic signaling pathway

Gene Ontology

Source: GO:2001235

Synonyms:

positive regulation of apoptotic signalling pathway

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Mmu)...ctsh (Dre)...Ctsh (Rno)

Genes Annotated with this GO Term (574)

The Rac2 GTPase contributes to Cathepsin H-mediated protection against cytokine-induced β-cell apoptosis

(Rattus norvegicus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by RGD

ID: GEO:GSE136643

Tags: unclassified

Summary: Microarray analysis identified a total of 63 annotated genes differentially expressed between stable CTSH-overexpressing insulin-secreting INS-1 cells and control cells transfected with an empty vector after treatment with IL-1β and IFNγ for 0, 6 and 16 hours. Permutation test taking all time-points into consideration identified 10 genes differentially expressed between the CTSH-overexpressing cells and the control cells: Elmod1, Fam49a, Gas7, Gna15, Msrb3, Nox1, Ptgs1, Rac2, Scn7a and Ttn. Pathway analysis identified one significant pathway “Inflammation mediated by chemokine and cytokine signaling pathway” with the genes Gna15, Ptgs1 and Rac2. Since Gna15 and Rac2 were upregulated by CTSH overexpression, their expression was knocked down using small interfering RNAs (siRNAs) to evaluate their potential as mediators of the protective effect of CTSH. Knockdown of Rac2 abolished the protective effect of CTSH overexpression on cytokine-induced apoptosis.

positive regulation of epithelial cell migration

Gene Ontology

Source: GO:0010634

Synonyms: Not Available

Branch: biological process

Genes: CTSH (Hsa)...Ctsh (Mmu)...Ctsh (Rno)

Genes Annotated with this GO Term (212)

polycystic kidney disease

Disease

Source: DOID:0080322

Definition: A cystic kidney disease that is characterized by the growth of fluid-filled cysts in the kidneys that reduces kidney function and may lead to kidney failure.

Genes: Ctsh (Mmu)...CTSH (Hsa)...ctsh (Dre)...Ctsh (Rno)