Version: 8.1.0
Date: Fri Apr 18 2025
2 results for Cbr-nipi-3

nipi-3

(Caenorhabditis elegans)
Gene
Name: No Induction of Peptide after Drechmeria Infection 3
Synonyms: K09A9.1, CELE_K09A9.1
Source: WB:WBGene00010700
Biotype: protein coding gene
Symbol: nipi-3 (Cel)

NIPI-3 regulates the expression of C. elegans immune genes

(Caenorhabditis elegans)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by WB
ID: WB:Microarray_Study.WBPaper00050515.ce.mr,
Tags: innate immune response
Summary: Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis which triggers the induction of a subset of P. aeruginosa-response genes in the nematode Caenorhabditis elegans. We found that losing one ToxA-induced C. elegans gene, the Tribbles pseudokinase ortholog nipi-3, results in hypersusceptibility to both P. aeruginosa and ToxA. We determined that NIPI-3 mediates the post-developmental expression of intestinal immune genes and proteins and primarily functions in parallel to known immune pathways, including p38 PMK-1 MAPK signaling. Here we present the microarray data that was used to determine that (1) nipi-3 regulates immune gene expression and that (2) nipi-3 and pmk-1 regulate non-overlapping gene sets consistent with them functioning in parallel. We used microarray analysis to identify the genes regulated by nipi-3 and pmk-1 at the L4 stage.
Symbol: NIPI-3 regulates the expression of C. elegans immune genes
Name: NIPI-3 regulates the expression of C. elegans immune genes