Version: 8.2.0
Date: Wed Aug 27 2025
3 results for Cbr-yap-1

yap-1

(Caenorhabditis elegans)
Gene
Name: Yes-Associated Protein homolog 1
Synonyms: CELE_F13E6.4, F13E6.4
Source: WB:WBGene00008748
Biotype: protein coding gene
Symbol: yap-1 (Cel)

Microarray based gene expression comparison between wild type and yap-1(ys38) C. elegans embyos

(Caenorhabditis elegans)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by WB
ID: WB:Microarray_Study.WBPaper00057136.ce.mr,
Tags: WT vs. mutant
Summary: Although multiple determinants for establishing polarity in membranes of epithelial cells have been identified, the mechanism for maintaining the apicobasal polarity is not fully understood. Here, we show that the conserved Hippo kinase pathway plays a role in the maintenance of apicobasal polarity in the developing intestine of Caenorhabditis elegans. We screened suppressors of the mutation in wts-1, the gene encoding the LATS kinase homolog, whose deficiency leads to the disturbance of the apicobasal polarity of the intestinal cells and the eventual death of organisms. Multiple alleles of yap-1 and egl-44, each encoding the worm homologs of YAP/Yki and TEAD/Sd, respectively, were identified as suppressors. WTS-1 directly bound to YAP-1 and inhibited its nuclear accumulation in intestinal cells. We also found that NFM-1, the worm homolog of NF2/Merlin, functioned in the same genetic pathway as WTS-1 to regulate YAP-1 for maintaining cellular polarity. The transcriptome analysis using microarray identified several target candidates of the YAP-1-EGL-44 complex including TAT-2, encoding a putative P-type ATPase. In summary, we have delineated the conserved Hippo pathway in worms consisting of NFM-1-WTS-1-YAP-1-EGL-44 and prove that the proper regulation of YAP-1 by upstream NFM-1 and WTS-1 is esssential for the maintenance of apicobasal membrane identities of the growing intestine
Symbol: Microarray based gene expression comparison between wild type and yap-1(ys38) C. elegans embyos
Name: Microarray based gene expression comparison between wild type and yap-1(ys38) C. elegans embyos

YAP1

(Homo sapiens)
Gene
Name: Yes1 associated transcriptional regulator
Synonyms: yes-associated protein YAP65 homolog, yes-associated protein beta, YAP2, YAP65, COB1, Yes-associated protein 1, yorkie homolog, Yes-associated protein 1, 65kDa, YAP-1, YAP, Yes associated protein 1, YKI, yes-associated protein delta, yes-associated protein 2, transcriptional coactivator YAP1, 65 kDa Yes-associated protein
Source: HGNC:16262
Biotype: protein coding gene
Synonyms: YAP-1