Version: 8.2.0
Date: Wed Aug 27 2025
725 results for Kcnc3

Kcnc3

(Mus musculus)
Gene
Name: potassium voltage gated channel, Shaw-related subfamily, member 3
Synonyms: K<+> channel, delayed rectifier, subtype 2, gene 3 [Drosophila Shal homolog], KShIIID, Kv3.3, Kcr2-3
Source: MGI:96669
Biotype: protein coding gene
Symbol: Kcnc3 (Mmu)
Symbol: Kcnc3
Automated Gene Synopsis: Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3).
Strict Orthology Symbols: Kcnc3
Alleles: Kcnc3 (Mmu)...Kcnc3 (Mmu)...Kcnc3 (Mmu)...Kcnc3 (Mmu)...Kcnc3 (Mmu)

KCNC3

(Homo sapiens)
Gene
Name: potassium voltage-gated channel subfamily C member 3
Synonyms: potassium voltage-gated channel, Shaw-related subfamily, member 3, SCA13, potassium channel, voltage gated Shaw related subfamily C, member 3, voltage-gated potassium channel KCNC3, KSHIIID, KV3.3, voltage-gated potassium channel protein KV3.3, voltage-gated potassium channel subunit Kv3.3, spinocerebellar ataxia 13, Shaw-related voltage-gated potassium channel protein 3
Source: HGNC:6235
Biotype: protein coding gene
Symbol: KCNC3 (Hsa)
Symbol: KCNC3
Synonyms: voltage-gated potassium channel KCNC3
Strict Orthology Symbols: Kcnc3

Kcnc3

(Rattus norvegicus)
Gene
Name: potassium voltage-gated channel subfamily C member 3
Synonyms: potassium channel, voltage gated Shaw-related subfamily C, member 3, voltage-gated potassium channel KCNC3, voltage-gated potassium channel subunit Kv3.3, Kv3.3, KShIIID, potassium voltage gated channel, Shaw-related subfamily, member 3
Source: RGD:621358
Biotype: protein coding gene
Symbol: Kcnc3 (Rno)
Symbol: Kcnc3
Gene Synopsis: Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3); INTERACTS WITH 2,2
Automated Gene Synopsis: Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3).
Synonyms: voltage-gated potassium channel KCNC3
Strict Orthology Symbols: Kcnc3

kcnc3a

(Danio rerio)
Gene
Name: potassium voltage-gated channel, Shaw-related subfamily, member 3a
Synonyms: kv3.3
Source: ZFIN:ZDB-GENE-100901-1
Biotype: protein coding gene
Symbol: kcnc3a (Dre)
Automated Gene Synopsis: Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3).
Strict Orthology Symbols: Kcnc3
Symbol: kcnc3a

kcnc3b

(Danio rerio)
Gene
Name: potassium voltage-gated channel, Shaw-related subfamily, member 3b
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-100901-2
Biotype: protein coding gene
Symbol: kcnc3b (Dre)
Automated Gene Synopsis: Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3).
Strict Orthology Symbols: Kcnc3
Symbol: kcnc3b

kcnc3.L

(Xenopus laevis)
Gene
Name: potassium channel, voltage gated Shaw related subfamily C, member 3
Synonyms: sca13, kv3.1, kcnc3.L, potassium channel, voltage gated Shaw related subfamily C, member 3, kv3.3, kshiiid
Source: Xenbase:XB-GENE-958409
Biotype: gene
Symbol: kcnc3.L (Xla)
Symbol: kcnc3.L

Kcnc3em1Smoc

(Mus musculus)
Allele/Variant
Source: MGI:7290652
Genes: Kcnc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Kcnc3 (Mmu)
Genes: Kcnc3 (Mmu)
Symbol: Kcnc3em1Smoc

Kcnc3em1(IMPC)Bay

(Mus musculus)
Allele/Variant
Source: MGI:6257805
Genes: Kcnc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Kcnc3 (Mmu)
Genes: Kcnc3 (Mmu)
Symbol: Kcnc3em1(IMPC)Bay

Kcnc3em1(IMPC)J

(Mus musculus)
Allele/Variant
Source: MGI:5697086
Genes: Kcnc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Kcnc3 (Mmu)
Genes: Kcnc3 (Mmu)
Symbol: Kcnc3em1(IMPC)J

Kcnc3tm1Echa

(Mus musculus)
Allele/Variant
Source: MGI:2675309
Genes: Kcnc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Kcnc3 (Mmu)
Genes: Kcnc3 (Mmu)
Symbol: Kcnc3tm1Echa

Kcnc3Clue

(Mus musculus)
Allele/Variant
Source: MGI:5904166
Genes: Kcnc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Kcnc3 (Mmu)
Genes: Kcnc3 (Mmu)
Symbol: Kcnc3Clue

Kcnc3em1(IMPC)J/Kcnc3em1(IMPC)J [background:] C57BL/6NJ-Kcnc3em1(IMPC)J/J

(Mus musculus)
Model
Id: MGI:6262733
Synonyms: Not Available
Symbol: Kcnc3/Kcnc3 [background:] C57BL/6NJ-Kcnc3/J (Mmu)
Genes: Kcnc3 (Mmu)
Alleles: Kcnc3 (Mmu)
Name: Kcnc3/Kcnc3 [background:] C57BL/6NJ-Kcnc3/J

Kcnc3tm1Echa/Kcnc3tm1Echa [background:] Not Specified

(Mus musculus)
Model
Id: MGI:2675344
Synonyms: Not Available
Symbol: Kcnc3/Kcnc3 [background:] Not Specified (Mmu)
Genes: Kcnc3 (Mmu)
Alleles: Kcnc3 (Mmu)
Name: Kcnc3/Kcnc3 [background:] Not Specified

Kcnc3em1(IMPC)Bay/Kcnc3em1(IMPC)Bay [background:] C57BL/6N-Kcnc3em1(IMPC)Bay/Bay

(Mus musculus)
Model
Id: MGI:6288538
Synonyms: Not Available
Symbol: Kcnc3/Kcnc3 [background:] C57BL/6N-Kcnc3/Bay (Mmu)
Genes: Kcnc3 (Mmu)
Alleles: Kcnc3 (Mmu)
Name: Kcnc3/Kcnc3 [background:] C57BL/6N-Kcnc3/Bay

Kcnc3em1Jt

(Mus musculus)
Allele/Variant
Source: MGI:7341848
Genes: Kcnc3 (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Kcnc3 (Mmu)
Genes: Kcnc3 (Mmu)
Symbol: Kcnc3em1Jt

LOC100497714

(Xenopus tropicalis)
Gene
Name: potassium voltage-gated channel subfamily C member 1
Synonyms: LOC100497714, potassium voltage-gated channel subfamily C member 1
Source: Xenbase:XB-GENE-29083803
Biotype: gene
Automated Gene Synopsis: Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3).
Strict Orthology Symbols: Kcnc3

shw-1

(Caenorhabditis elegans)
Gene
Name: SHaW family of potassium channels 1
Synonyms: F14F11.1, CELE_F14F11.1
Source: WB:WBGene00008819
Biotype: protein coding gene
Strict Orthology Symbols: Kcnc3

Shaw

(Drosophila melanogaster)
Gene
Name: Shaker cognate w
Synonyms: CG15419, Shaw2, dShaw2, dShaw, Kv3, Kv3.1, Shaw, K[[v]]3, CG2822, shaw
Source: FB:FBgn0003386
Biotype: protein coding gene
Strict Orthology Symbols: Kcnc3

Shawl

(Drosophila melanogaster)
Gene
Name: Shaw-like
Synonyms: Shawl, shawl, Kv3, CG4450, Kv3.2, CG34366, CG13111
Source: FB:FBgn0085395
Biotype: protein coding gene
Strict Orthology Symbols: Kcnc3

egl-36

(Caenorhabditis elegans)
Gene
Name: EGg Laying defective 36
Synonyms: shw-2, R07A4.1, CELE_R07A4.1
Source: WB:WBGene00001202
Biotype: protein coding gene
Strict Orthology Symbols: kcnc3b...kcnc3a

shw-3

(Caenorhabditis elegans)
Gene
Name: SHaW family of potassium channels 3
Synonyms: CELE_R186.5, R186.5, kht-1
Source: WB:WBGene00004793
Biotype: protein coding gene
Strict Orthology Symbols: kcnc3b...kcnc3a

spinocerebellar ataxia type 13

Disease
Source: DOID:0050963
Definition: An autosomal dominant cerebellar ataxia that is characterized by developmental delay, ataxia, myoclinic jerks, dysarthria, dysphagia and seizure, and has_material_basis_in mutation in the KCNC3 gene.
Genes: KCNC3 (Hsa)...kcnc3b (Dre)...Kcnc3 (Rno)...Kcnc3 (Mmu)...kcnc3a (Dre)

Kcnc1tm1Joho/Kcnc1tm1Joho Kcnc3tm1Echa/Kcnc3tm1Echa [background:] involves: 129/Sv * C57BL/6

(Mus musculus)
Model
Id: MGI:2675347
Synonyms: Not Available
Genes: Kcnc3 (Mmu)
Alleles: Kcnc3 (Mmu)
Name: Kcnc1/Kcnc1 Kcnc3/Kcnc3 [background:] involves: 129/Sv * C57BL/6
Symbol: Kcnc1/Kcnc1 Kcnc3/Kcnc3 [background:] involves: 129/Sv * C57BL/6

delayed rectifier potassium channel activity

Gene Ontology
Source: GO:0005251
Synonyms: Not Available
Branch: molecular function
Genes: kcnc3a (Dre)...kcnc3b (Dre)...KCNC3 (Hsa)...Kcnc3 (Rno)...Kcnc3 (Mmu)

la024109Tg

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-120806-10807
Genes: kcnc3a (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: kcnc3a (Dre)

axolemma

Gene Ontology
Source: GO:0030673
Synonyms:
  • axonal membrane
Branch: cellular component
Genes: Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

dendritic spine membrane

Gene Ontology
Source: GO:0032591
Synonyms: Not Available
Branch: cellular component
Genes: Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

Kcnc1tm1Joho/Kcnc1+ Kcnc3tm1Echa/Kcnc3+ [background:] involves: 129/Sv * C57BL/6

(Mus musculus)
Model
Id: MGI:4415253
Synonyms: Not Available
Genes: Kcnc3 (Mmu)
Alleles: Kcnc3 (Mmu)
Name: Kcnc1/Kcnc1<+> Kcnc3/Kcnc3<+> [background:] involves: 129/Sv * C57BL/6
Symbol: Kcnc1/Kcnc1<+> Kcnc3/Kcnc3<+> [background:] involves: 129/Sv * C57BL/6 (Mmu)

A Missense Mutation in Kcnc3 Causes Hippocampal Learning Deficits in Mice

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE202094
Tags: WT vs. mutant, anatomical structure, genotype
Summary: Although a wide variety of genetic tools have been developed to study learning and memory, the molecular basis of memory encoding remains incompletely understood. Here, we undertook an unbiased approach to identify novel genes critical for memory encoding. From a large-scale in vivo mutagenesis screen using contextual fear conditioning, we isolated a mutant, named Clueless, with spatial learning deficits. A causative missense mutation (G434V) was found in the voltage gated potassium channel, subfamily C member 3 (Kcnc3) gene in a region that encodes a transmembrane voltage sensor. Generation of a Kcnc3G434V CRISPR mutant mouse confirmed this mutation as the cause of the learning defects. While G434V had no effect on transcription, translation, or trafficking of the channel, electrophysiological analysis of the G434V Kcnc3 mutant channel revealed a complete loss of voltage-gated conductance, a broadening of the action potential, and decreased neuronal firing. Together, our findings have revealed a previously unrecognized role for Kcnc3 in learning and memory.
Symbol: A Missense Mutation in Kcnc3 Causes Hippocampal Learning Deficits in Mice
Name: A Missense Mutation in Kcnc3 Causes Hippocampal Learning Deficits in Mice

Hsap\KCNC3UAS.cGa

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0305161
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hsap\KCNC3
Construct Expressed Component: KCNC3 (Hsa)
Constructs: KCNC3[WT]...KCNC3WT

regulation of synaptic vesicle endocytosis

Gene Ontology
Source: GO:1900242
Synonyms:
  • regulation of synaptic vesicle retrieval
Branch: biological process
Genes: KCNC3 (Hsa)...Kcnc3 (Rno)...Kcnc3 (Mmu)

Hsap\KCNC3R420H.UAS

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0305162
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: autosomal dominant cerebellar ataxia
Variant Name: Not Available
Symbol: Hsap\KCNC3
Construct Expressed Component: KCNC3 (Hsa)
Constructs: KCNC3R420H...KCNC3[R420H]

regulation of neurotransmitter secretion

Gene Ontology
Source: GO:0046928
Synonyms: Not Available
Branch: biological process
Genes: KCNC3 (Hsa)...Kcnc3 (Rno)...Kcnc3 (Mmu)

la024108Tg

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-120806-9354
Genes: kcnc3a (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: kcnc3a (Dre)

neuronal cell body membrane

Gene Ontology
Source: GO:0032809
Synonyms:
  • neuron cell body membrane
  • neuronal cell soma membrane
Branch: cellular component
Genes: kcnc3a (Dre)...kcnc3b (Dre)...KCNC3 (Hsa)...Kcnc3 (Rno)...Kcnc3 (Mmu)

calyx of Held

Gene Ontology
Source: GO:0044305
Synonyms: Not Available
Branch: cellular component
Genes: KCNC3 (Hsa)...Kcnc3 (Rno)...Kcnc3 (Mmu)

dendrite membrane

Gene Ontology
Source: GO:0032590
Synonyms: Not Available
Branch: cellular component
Genes: kcnc3a (Dre)...kcnc3b (Dre)...Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

action potential

Gene Ontology
Source: GO:0001508
Synonyms: Not Available
Branch: biological process
Genes: kcnc3a (Dre)...kcnc3b (Dre)...Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

protein tetramerization

Gene Ontology
Source: GO:0051262
Synonyms:
  • protein tetramer assembly
  • protein tetramer biosynthesis
Branch: biological process
Genes: KCNC3 (Hsa)...Kcnc3 (Rno)...Kcnc3 (Mmu)

axon terminus

Gene Ontology
Source: GO:0043679
Synonyms:
  • axon terminal
  • axon terminal specialization
Branch: cellular component
Genes: kcnc3a (Dre)...kcnc3b (Dre)...Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

voltage-gated potassium channel complex

Gene Ontology
Source: GO:0008076
Synonyms:
  • voltage gated potassium channel complex
  • voltage-dependent potassium channel complex
Branch: cellular component
Genes: kcnc3a (Dre)...kcnc3b (Dre)...Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

cortical actin cytoskeleton organization

Gene Ontology
Source: GO:0030866
Synonyms:
  • actin cortex stabilization
  • cortical actin cytoskeleton organisation
Branch: biological process
Genes: KCNC3 (Hsa)...Kcnc3 (Rno)...Kcnc3 (Mmu)

voltage-gated potassium channel activity

Gene Ontology
Source: GO:0005249
Synonyms:
  • voltage gated potassium channel activity
  • voltage-dependent potassium channel activity
Branch: molecular function
Genes: kcnc3a (Dre)...kcnc3b (Dre)...Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

Hsap\KCNC3R423H.UAS

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0342186
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: spinocerebellar ataxia type 13
Variant Name: Not Available
Symbol: Hsap\KCNC3
Construct Expressed Component: KCNC3 (Hsa)

Hsap\KCNC3WT.UAS

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0342185
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hsap\KCNC3
Construct Expressed Component: KCNC3 (Hsa)

corpus callosum development

Gene Ontology
Source: GO:0022038
Synonyms: Not Available
Branch: biological process
Genes: Kcnc3 (Rno)

potassium channel activity

Gene Ontology
Source: GO:0005267
Synonyms: Not Available
Branch: molecular function
Genes: kcnc3b (Dre)...kcnc3a (Dre)...Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

optic nerve development

Gene Ontology
Source: GO:0021554
Synonyms:
  • CN II development
  • cranial nerve 2 development
Branch: biological process
Genes: Kcnc3 (Rno)

protein homooligomerization

Gene Ontology
Source: GO:0051260
Synonyms:
  • protein homooligomer assembly
  • protein homooligomer biosynthesis
Branch: biological process
Genes: kcnc3b (Dre)...kcnc3a (Dre)...Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)

potassium ion transmembrane transport

Gene Ontology
Source: GO:0071805
Synonyms:
  • high affinity potassium ion import
  • high affinity potassium ion uptake
Branch: biological process
Genes: kcnc3b (Dre)...kcnc3a (Dre)...Kcnc3 (Rno)...KCNC3 (Hsa)...Kcnc3 (Mmu)