Version: 8.1.0Date: Fri Apr 18 2025
Category
REP2
(Saccharomyces cerevisiae)Gene
Name: REPlication
Synonyms: R0040C
Source: SGD:S000029676
Biotype: protein coding gene
Symbol: REP2 (Sce)
Symbol: REP2
Alleles: rep2- L185A,L186A (Sce)...rep2-1-231 (Sce)
Rep2
(Mus musculus)Gene
Name: repair of chromatin damage 2
Synonyms: Rep-2
Source: MGI:97901
Biotype: heritable phenotypic marker
Symbol: Rep2 (Mmu)
Symbol: Rep2
Gene Synopsis: PHENOTYPE: Analysis of congenic strains located genes Rep1 and Rep2 controlling chromatin damage repair
rep2-1-231
(Saccharomyces cerevisiae)Allele/Variant
Source: SGD:S000340167
Genes: REP2 (Sce)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: rep2-1-231 (Sce)
Genes: REP2 (Sce)
Symbol: rep2-1-231
rep2- L185A,L186A
(Saccharomyces cerevisiae)Allele/Variant
Source: SGD:S000340166
Genes: REP2 (Sce)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: rep2- L185A,L186A (Sce)
Genes: REP2 (Sce)
Symbol: rep2- L185A,L186A
Drep2
(Drosophila melanogaster)Gene
Name: DNA fragmentation factor-related protein 2
Synonyms: rep2, Drep-2, anon-WO0118547.168, Rep2, DREP-2, anon-WO0118547.162, Drep2, DREP2, CG1975, drep2
Source: FB:FBgn0028408
Biotype: protein coding gene
Synonyms: rep2...Rep2...rep2...Rep2...Rep2
Chml
(Mus musculus)Gene
Name: choroideremia-like
Synonyms: Rep2, AI450814, E030003F13Rik, RIKEN cDNA E030003F13 gene, expressed sequence AI450814
Source: MGI:101913
Biotype: protein coding gene
Synonyms: Rep2...Rep2...Rep2
CHML
(Homo sapiens)Gene
Name: CHM like Rab escort protein
Synonyms: rab escort protein 2, choroideremia-like protein, REP2, REP-2, Rab escort protein 2, FLJ13361, choroideremia-like (Rab escort protein 2), choroideraemia-like protein, CHM like Rab escort protein 2, FLJ10071, rab proteins geranylgeranyltransferase component A 2, CHM like, Rab escort protein 2
Source: HGNC:1941
Biotype: protein coding gene
Synonyms: REP2...REP2
Gene Ontology
Source: GO:0030543
Synonyms: Not Available
Branch: biological process
Genes: REP2 (Sce)
Gene Ontology
Source: GO:0030541
Synonyms: Not Available
Branch: biological process
Genes: REP2 (Sce)
Drep2c05007
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0181985
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: rep2...Rep2
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE10669
Tags: unclassified
Summary: Keywords: comparative genomic hybridization
Cell/ Tissues: LIVER_ Drug REP2...LIVER_ Model REP2...LIVER_CONTROL REP2
Chronic Gene Expression after Traumatic Brain Injury
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE111452
Tags: unclassified
Summary: This project continues our acute TBI studies and initiates chronic studies -- characterizing the temporal genomic profile of the injured brain up to 12 months post-TBI. Thus, the primary objective of this proposal is to determine the long-term effects of traumatic brain injury on gene expression in the hippocampus and cortex, two brain regions known to be particularly vulnerable to TBI.
Cell/ Tissues: Hippocampus Naive 6mo, rep2...Cortex Naive 2wk, rep2...Cortex Naive 24hr, rep2...Cortex Naive 6mo, rep2...Cortex Naive 1yr, rep2
Evidence for a rheostat that determines neuronal survival after traumatic brain injury
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE16735
Tags: unclassified
Summary: To investigate the determinants of neuronal survival after traumatic brain injury, we compared the transcriptional profiles of dying (Fluoro-Jade-positive) and immediately adjacent surviving (Fluoro-Jade-negative) neurons from the CA3 subfield of the rat hippocampus 24 hours after experimental TBI. We found that hippocampal neurons that survive TBI invariably express high levels of genes that have cellular functions involved in survival, regeneration, development, proliferation, neuronal plasticity such as cAMP response element binding protein (CREB), brain-derived-neurotrophic factor (BDNF) and mitogen-activated protein kinase 1 (MAPK1). Dying neurons express high levels of genes involved in aberrant cell cycle progression, immune response, inflammation, oxidative stress and apoptosis such as Interleukin-1ß (IL-1ß), caspase 3 and B-cell linker (BLNK). We conclude that shifting the balance between the global levels of these proteins with pharmacotherapeutic drugs that induce expression of cell survival associated genes, is expected to alter the cellular rheostat that determines cell survival or cell death.
Cell/ Tissues: Hippocampal neuron, Sham injury, rep2...Hippocampal neuron, fluid percussion injury, Fluoro-Jade-positive, rep2...Hippocampal neuron, no treatment, rep2...Hippocampal neuron, fluid percussion injury, Fluoro-Jade-negative, rep2
Expression data from NRK-52E cells treated with chlorothalonil for 6h, 24h and 72h.
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE46852
Tags: unclassified
Summary: We used microarrays to detail the mechanism of toxicity and possibly carcinogenicity.
Cell/ Tissues: Chlorothalonil-treated NRK-52E cells at 6h, biological rep2...DMSO-treated NRK-52E cells at 24h, biological rep2...DMSO-treated NRK-52E cells at 72h, biological rep2...DMSO-treated NRK-52E cells at 6h, biological rep2...Chlorothalonil-treated NRK-52E cells at 24h, biological rep2
Expression data of rat insulinoma cells induced with ER stress +/- IRE1 inhibitor treatment
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE58866
Tags: unclassified
Summary: We used microarray gene expression arrays to analyze the IRE1-dependent activation of genes in response to misfolded proinsulin expression in an inducible mutant proinsulin (C96Y) insulinoma cell line by inhibiting the IRE1 endoribonucleas activity with a specific inhibitor, 4u8c.
Cell/ Tissues: (C96Y-Ins2) INS1 insulinoma cell line, doxycycline and 4u8c treated, rep2...(C96Y-Ins2) INS1 insulinoma cell line, doxycycline treated, rep2...(C96Y-Ins2) INS1 insulinoma cell line, untreated, rep2
Blood transcriptional signatures for disease progression in a rat model of osteoarthritis
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE99021
Tags: unclassified
Summary: Biomarkers of osteoarthritis (OA) that can accurately diagnose the disease at the earliest stage would significantly support efforts to develop treatments for prevention and early intervention. The different stages of disease progression are described by the complex pattern of transcriptional regulations. The dynamics in pattern alterations were monitored in each individual animal during the time-course of OA progression.
Cell/ Tissues: rat nai day14 rep2...rat nai day28 rep2...rat nai day0 rep2...rat mia day2 rep2...rat mia day0 rep2
Rep1
(Mus musculus)Gene
Name: repair of chromatin damage 1
Synonyms: Rep-1
Source: MGI:97900
Biotype: heritable phenotypic marker
Gene Synopsis: PHENOTYPE: Analysis of congenic strains located genes Rep1 and Rep2 controlling chromatin damage repair
Expression data from embryonic rat kidney timepoints and a budded WD-MM recombination tissue
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE9570
Tags: unclassified
Summary: Keywords: time course
Cell/ Tissues: non-branched in vitro-formed UBs and MM, rep2...rat kidney at week 4 post birth, rep2...rat kidney at embryonic day 13, rep2...rat kidney at embryonic day 18, rep2
Transcript changes in primary Leydig cells treated with Sertoli cell released exosomes
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE158251
Tags: unclassified
Summary: In this study, we aim to figure out if Sertoli cells released exosomes can regulate the survival and steroidogenesis of Leydig cells. We found Sertoli cells released exosomes can cross the blood-testis barrier, deliver their contents into the Leydig cells, and promote the survival of Leydig cells through CCL20.
Cell/ Tissues: Leydig cells reference rep2...Leydig cells treated with exosomes (5ug/ml) for 24h rep2
Identification of a Serum Induced Transcriptional Signature Associated with Type 1 Diabetes in the BioBreeding Rat
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE19537
Tags: unclassified
Summary: Here we report that sera of both spontaneously diabetic BB DRlyp/lyp and diabetes inducible BB DR+/+ rats induce inflammatory signatures in healthy PBMC of non-diabetic Brown Norway (BN) rats, while allogeneic BN sera does not. Consistent with their common T1D susceptibility, transcriptional signatures of both BB sub-strains share identity, including cytokines, immune receptors and signaling molecules. However, like the human T1D signature, the DRlyp/lyp signature, which is associated with progression to diabetes, is differentiated from that of the DR+/+ by induction of many IL-1 regulated genes. Addition of IL-1RA to cultures significantly ablates the DRlyp/lyp signature. Daily treatment of DRlyp/lyp rats with human recombinant IL-1RA significantly delays onset and sera of treated animals do not induce the characteristic IL-1 signature. Consistent with the presence of immune regulation in DR+/+ rats is induction of a signature showing negative regulation of the NF¿B pathway. This study supports prior human investigations of serum that reflect disease processes associated with progression to T1D and add to a growing body of evidence implicating the balance of IL-1 and IL-1RA as key factors influencing the severity and outcome of inflammatory responses.
Cell/ Tissues: d60 DRlyp/lyp serum, rep2...DRlyp/lyp rats treated with PBS, rep2...d60 DR++ serum, rep2...allogeneic BN serum, rep2...autologous BN serum, rep2
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE100203
Tags: unclassified
Summary: Compared to the uninfected BN rat, the uninfected LEW rat has inherently higher transcript levels of cytochrome enzymes [Cyp2d3, Cyp2d5 and Cybrd1 that catalyze generation of reactive oxygen species (ROS)], with concomitant higher levels of ROS.
Cell/ Tissues: Brown Norway rat infected by T. gondii for 24 hours rep2...Lewis rat PBS control rep2...Lewis rat infected by T. gondii for 24 hours rep2...Brown Norway rat PBS control rep2
Molecular responses in skeletal muscles following spinal cord injury and the effect of locomotor training
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE45550
Tags: unclassified
Summary: The overall objective of this study is to implement genome wide expression profiling of skeletal muscle to define the molecular pathways associated with muscle remodeling after SCI and during locomotor training (TM).
Cell/ Tissues: rat soleus, 14 days after SCI, with locomotor treadmill training, rep2...rat soleus, 14 days after SCI, rep2...rat soleus, 8 days after SCI, rep2...rat soleus, 3 days after SCI, rep2...rat soleus, control, rep2
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE80517
Tags: unclassified
Summary: Sequencing of the bacterial 16S rRNA gene revealed that these treatments significantly altered the ileal and cecal microbiota, resulting in increases in the Firmicutes:Bacteriodetes ratio, and abundances of lactobacilli and butyrate producing genera. Both treatments partially normalized the peripheral inflammatory state, reducing plasma cytokine, chemokine and TLR-4 activity levels. The proinflammatory islet transcriptome was more extensively normalized by HCD and immune-fluorescent staining revealed reductions in β-cell chemokine expression. HCD and antibiotic treatment did not normalize BB rat PBMC hyper-responsiveness to ex vivo mitogen stimulation. Combined, these studies link islet-level T1D susceptibility in BB rats to a genetically controlled innate inflammatory state that is influenced by environmental determinants encompassing the diet and the intestinal microbiota.
Cell/ Tissues: Autologous BN (Brown Rorway) Rat, rep2
Age alters the gene expression profiles of rat oculomotor nucleus and spinal cord
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE3305
Tags: unclassified
Summary: Keywords: time course, aging
Cell/ Tissues: 6 month oculomotor nucleus rep2
Gene expression in follicle-stimulating hormone-treated rat Sertoli cells
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE509
Tags: unclassified
Summary: Keywords: other
Cell/ Tissues: Twenty day old rat Sertoli cells FSH treated 8 hr rep2
Gene Ontology
Source: GO:0050821
Synonyms:
- lysosomal protein stabilization
- positive regulation of protein stability
Branch: biological process
Genes: REP2 (Sce)
(R6)2R:9293077G>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9293077G>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9293077G>A
Gene Synonyms: rep2...Rep2
(R6)2R:9293966G>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9293966G>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9293966G>A
Gene Synonyms: rep2...Rep2
(R6)2R:9294079T>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9294079T>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9294079T>A
Gene Synonyms: rep2...Rep2
(R6)2R:9302171A>G
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9302171A>G
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:9302171A>G
Gene Synonyms: rep2...Rep2
(R6)2R:9294002A>C
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9294002A>C
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9294002A>C
Gene Synonyms: rep2...Rep2
(R6)2R:9292143T>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9292143T>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:9292143T>A
Gene Synonyms: rep2...Rep2
(R6)2R:9301952T>C
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9301952T>C
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:9301952T>C
Gene Synonyms: rep2...Rep2
(R6)2R:9302645A>C
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9302645A>C
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:9302645A>C
Gene Synonyms: rep2...Rep2
(R6)2R:9297592A>T
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9297592A>T
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9297592A>T
Gene Synonyms: rep2...Rep2
(R6)2R:9299555C>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9299555C>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:9299555C>A
Gene Synonyms: rep2...Rep2
(R6)2R:9292661C>T
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9292661C>T
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:9292661C>T
Gene Synonyms: rep2...Rep2
(R6)2R:9293174C>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9293174C>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9293174C>A
Gene Synonyms: rep2...Rep2
(R6)2R:9293547A>T
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9293547A>T
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9293547A>T
Gene Synonyms: rep2...Rep2
(R6)2R:9292276T>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9292276T>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:9292276T>A
Gene Synonyms: rep2...Rep2
(R6)2R:9292430C>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9292430C>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:9292430C>A
Gene Synonyms: rep2...Rep2
(R6)2R:9294215G>T
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9294215G>T
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9294215G>T
Gene Synonyms: rep2...Rep2
(R6)2R:9294463G>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9294463G>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9294463G>A
Gene Synonyms: rep2...Rep2
(R6)2R:9294589A>G
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9294589A>G
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9294589A>G
Gene Synonyms: rep2...Rep2
(R6)2R:9296180C>T
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9296180C>T
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9296180C>T
Gene Synonyms: rep2...Rep2
(R6)2R:9296224C>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9296224C>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9296224C>A
Gene Synonyms: rep2...Rep2
(R6)2R:9297624T>A
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9297624T>A
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9297624T>A
Gene Synonyms: rep2...Rep2
(R6)2R:9293234A>T
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9293234A>T
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9293234A>T
Gene Synonyms: rep2...Rep2
(R6)2R:9294225A>C
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9294225A>C
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9294225A>C
Gene Synonyms: rep2...Rep2
(R6)2R:9294489G>T
(Drosophila melanogaster)Allele/Variant
Source: NT_033778.4:g.9294489G>T
Genes: Drep2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:9294489G>T
Gene Synonyms: rep2...Rep2