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Category

488 results for TDP2

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TDP2

(Homo sapiens)

Gene

Name: tyrosyl-DNA phosphodiesterase 2

Synonyms: TRAF and TNF receptor associated protein, TTRAP, tyrosyl-RNA phosphodiesterase, RP1-30M3.3, ETS1-associated protein II, ETS1-associated protein 2, 5'-Tyr-DNA phosphodiesterase, MGC9099, tyr-DNA phosphodiesterase 2, MGC111021, TRAF and TNF receptor-associated protein, 5'-tyrosyl-DNA phosphodiesterase, hTDP2, VPg unlinkase, AD022, EAP2, EAPII, dJ30M3.3

Source: HGNC:17768

Biotype: protein coding gene

Symbol: TDP2 (Hsa)

Symbol: TDP2

Strict Orthology Symbols: tdp2.S...tdp2b...tdp2...Tdp2

Tdp2

(Mus musculus)

Gene

Name: tyrosyl-DNA phosphodiesterase 2

Synonyms: TRAF and TNF receptor associated protein, D13Ertd656e, Ttrap, DNA segment, Chr 13, ERATO Doi 656, expressed

Source: MGI:1860486

Biotype: protein coding gene

Symbol: Tdp2 (Mmu)

Symbol: Tdp2

Automated Gene Synopsis: Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).

Strict Orthology Symbols: TDP2

Alleles: Tdp2 (Mmu)...Tdp2 (Mmu)...Tdp2 (Mmu)...Tdp2 (Mmu)...Tdp2 (Mmu)

Tdp2

(Rattus norvegicus)

Gene

Name: tyrosyl-DNA phosphodiesterase 2

Synonyms: 5'-Tyr-DNA phosphodiesterase, LOC498749, Traf and Tnf receptor associated protein, tyr-DNA phosphodiesterase 2, Ttrap, 5'-tyrosyl-DNA phosphodiesterase, similar to putative TRAF and TNF receptor associated protein, TRAF and TNF receptor-associated protein, MGC124734

Source: RGD:1560342

Biotype: protein coding gene

Symbol: Tdp2 (Rno)

Symbol: Tdp2

Gene Synopsis: Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2); INTERACTS WITH azoxystrobin; bisphenol A

Automated Gene Synopsis: Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).

Strict Orthology Symbols: TDP2

tdp2

(Xenopus tropicalis)

Gene

Name: tyrosyl-DNA phosphodiesterase 2

Synonyms: eap2, tyrosyl-DNA phosphodiesterase 2, tdp2, ad022, ttrap

Source: Xenbase:XB-GENE-967013

Biotype: gene

Symbol: tdp2 (Xtr)

Symbol: tdp2

Automated Gene Synopsis: Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).

Synonyms: tdp2...tdp2

Strict Orthology Symbols: TDP2

Disease (1)

tdp2b

(Danio rerio)

Gene

Name: tyrosyl-DNA phosphodiesterase 2b

Synonyms: ttrapl, tdp2, ttrap

Source: ZFIN:ZDB-GENE-050816-1

Biotype: protein coding gene

Symbol: tdp2b (Dre)

Automated Gene Synopsis: Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).

Synonyms: tdp2...tdp2

Strict Orthology Symbols: TDP2

Symbol: tdp2b

tdp2.S

(Xenopus laevis)

Gene

Name: tyrosyl-DNA phosphodiesterase 2

Synonyms: tdp2.S, eap2, tyrosyl-DNA phosphodiesterase 2, ad022, ttrap

Source: Xenbase:XB-GENE-967018

Biotype: gene

Symbol: tdp2.S (Xla)

Automated Gene Synopsis: Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).

Strict Orthology Symbols: TDP2

Symbol: tdp2.S

Disease (1)

tdp2a

(Danio rerio)

Gene

Name: tyrosyl-DNA phosphodiesterase 2a

Synonyms: Not Available

Source: ZFIN:ZDB-GENE-110218-1

Biotype: protein coding gene

Symbol: tdp2a (Dre)

Symbol: tdp2a

Allele/Variant (1)

Tdp2^tm1.1Huy

(Mus musculus)

Allele/Variant

Source: MGI:5503302

Genes: Tdp2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Tdp2 (Mmu)

Genes: Tdp2 (Mmu)

Symbol: Tdp2^tm1.1Huy

tdp253

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-050216-12

Genes: musk (Dre)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: tdp253 (Dre)

Symbol: tdp253

Tdp2^em1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7292717

Genes: Tdp2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Tdp2 (Mmu)

Genes: Tdp2 (Mmu)

Symbol: Tdp2^em1Smoc

Gene (1)

Tdp2^tm1Huy

(Mus musculus)

Allele/Variant

Source: MGI:5503301

Genes: Tdp2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Tdp2 (Mmu)

Genes: Tdp2 (Mmu)

Symbol: Tdp2^tm1Huy

Tdp2^{Gt(RRS512)Byg}

(Mus musculus)

Allele/Variant

Source: MGI:4332298

Genes: Tdp2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Tdp2 (Mmu)

Genes: Tdp2 (Mmu)

Symbol: Tdp2^{Gt(RRS512)Byg}

Tdp2^em1Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7307263

Genes: Tdp2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Tdp2 (Mmu)

Genes: Tdp2 (Mmu)

Symbol: Tdp2^em1Gpt

Gene (1)

Tdp2^tm1Huy/Tdp2^tm1Huy [background:] involves: 129P2/OlaHsd * CD-1

(Mus musculus)

Model

Id: MGI:5503306

Synonyms: Not Available

Symbol: Tdp2/Tdp2 [background:] involves: 129P2/OlaHsd * CD-1 (Mmu)

Genes: Tdp2 (Mmu)

Alleles: Tdp2 (Mmu)

Name: Tdp2/Tdp2 [background:] involves: 129P2/OlaHsd * CD-1

Gene (1)

Tdp2^tm1.1Huy/Tdp2^tm1.1Huy [background:] involves: 129P2/OlaHsd * CD-1

(Mus musculus)

Model

Id: MGI:5503307

Synonyms: Not Available

Symbol: Tdp2/Tdp2 [background:] involves: 129P2/OlaHsd * CD-1 (Mmu)

Genes: Tdp2 (Mmu)

Alleles: Tdp2 (Mmu)

Name: Tdp2/Tdp2 [background:] involves: 129P2/OlaHsd * CD-1

Gene (1)

Tdp2^{Gt(RRS512)Byg}/Tdp2^{Gt(RRS512)Byg} [background:] involves: 129P2/OlaHsd * CD-1

(Mus musculus)

Model

Id: MGI:4365565

Synonyms: Not Available

Symbol: Tdp2/Tdp2 [background:] involves: 129P2/OlaHsd * CD-1 (Mmu)

Genes: Tdp2 (Mmu)

Alleles: Tdp2 (Mmu)

Name: Tdp2/Tdp2 [background:] involves: 129P2/OlaHsd * CD-1

Gene (1)

tdpt-1

(Caenorhabditis elegans)

Gene

Name: Tyrosyl-DNA Phosphodiesterase Two homolog 1

Synonyms: Y63D3A.4, TDP2, CELE_Y63D3A.4

Source: WB:WBGene00013405

Biotype: protein coding gene

Gene Synopsis: Is an ortholog of human TDP2 (tyrosyl-DNA phosphodiesterase 2).

Automated Gene Synopsis: Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).

Synonyms: TDP2...TDP2...TDP2

Strict Orthology Symbols: TDP2

ZNF451

(Homo sapiens)

Gene

Name: zinc finger protein 451

Synonyms: dJ417I1.1, FLJ23421, FLJ53246, MGC26701, COASTER, ZATT, E3 SUMO-protein transferase ZNF451, zinc finger protein associated with TDP2 and TOP2, KIAA1702, coactivator for steroid receptors, KIAA0576, FLJ90693, E3 SUMO-protein ligase ZNF451

Source: HGNC:21091

Biotype: protein coding gene

Synonyms: zinc finger protein associated with TDP2 and TOP2

Allele/Variant (43)

5'-tyrosyl-DNA phosphodiesterase activity

Gene Ontology

Source: GO:0070260

Synonyms: Not Available

Branch: molecular function

Genes: TDP2 (Hsa)...tdp2a (Dre)...tdp2b (Dre)...Tdp2 (Rno)...Tdp2 (Mmu)

Genes Annotated with this GO Term (7)

autosomal recessive spinocerebellar ataxia 23

Disease

Source: DOID:0111613

Definition: An autosomal recessive cerebellar ataxia characterized by epilepsy, intellectual disability, and gait ataxia that has_material_basis_in homozygous or compound heterozygous mutation in the TDP2 gene on chromosome 6p22.3.

Genes: TDP2 (Hsa)...tdp2b (Dre)...Tdp2 (Rno)...tdp2 (Xtr)...Tdp2 (Mmu)

Gene (7)

tyrosyl-RNA phosphodiesterase activity

Gene Ontology

Source: GO:0036317

Synonyms:

VPg unlinkase activity
Y-pUpN PDE activity

Branch: molecular function

Genes: TDP2 (Hsa)...Tdp2 (Rno)...Tdp2 (Mmu)

Genes Annotated with this GO Term (3)

musk

(Danio rerio)

Gene

Name: muscle, skeletal, receptor tyrosine kinase

Synonyms: unplugged, si:dz57f23.3, unp, fj98e12, si:busm1-57f23.3, si:dz46m7.2, zgc:63467, wu:fj98e12

Source: ZFIN:ZDB-GENE-030131-6458

Biotype: protein coding gene

Alleles: tdp253 (Dre)

musk^{tdp253/tdp253}

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-11606

Synonyms: Not Available

Alleles: tdp253 (Dre)

Gene (1)

la010924Tg

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-120130-481

Genes: tdp2b (Dre)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Gene Synonyms: tdp2

Genes: tdp2b (Dre)

Gene (1)

WT + MO2-tdp2b

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-27311

Synonyms: Not Available

Genes: tdp2b (Dre)

Gene (1)

WT + MO1-tdp2b + MO2-tdp2b

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-10052

Synonyms: Not Available

Genes: tdp2b (Dre)

Gene (1)

tyrosyl-DNA phosphodiesterase activity

Gene Ontology

Source: GO:0070259

Synonyms: Not Available

Branch: molecular function

Genes: tdp2b (Dre)

Genes Annotated with this GO Term (15)

WT + MO1-tdp2b

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-60

Synonyms: Not Available

Genes: tdp2b (Dre)

Gene (1)

WT + MO1-smad2 + MO1-tdp2b + MO2-tdp2b

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-26372

Synonyms: Not Available

Genes: tdp2b (Dre)

Gene (2)

WT + MO3-tdp2b

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-61

Synonyms: Not Available

Genes: tdp2b (Dre)

Gene (1)

WT + MO1-snai1a + MO1-tdp2b

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-12801

Synonyms: Not Available

Genes: tdp2b (Dre)

Gene (2)

WT + MO1-smad3b + MO1-tdp2b + MO2-tdp2b

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-1891

Synonyms: Not Available

Genes: tdp2b (Dre)

Gene (2)

aggresome

Gene Ontology

Source: GO:0016235

Synonyms: Not Available

Branch: cellular component

Genes: Tdp2 (Rno)...TDP2 (Hsa)...Tdp2 (Mmu)

Genes Annotated with this GO Term (118)

PML body

Gene Ontology

Source: GO:0016605

Synonyms:

ND10
PML NB

Branch: cellular component

Genes: Tdp2 (Rno)...tdp2a (Dre)...tdp2b (Dre)...TDP2 (Hsa)...Tdp2 (Mmu)

Genes Annotated with this GO Term (362)

double-strand break repair

Gene Ontology

Source: GO:0006302

Synonyms: Not Available

Branch: biological process

Genes: Tdp2 (Rno)...tdp2a (Dre)...tdp2b (Dre)...TDP2 (Hsa)...Tdp2 (Mmu)

Genes Annotated with this GO Term (1103)

Expression data from E16.5 mouse embryonic brain wild-type and knock-out conditions

(Mus musculus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by MGI

ID: ArrayExpress:E-GEOD-54628, GEO:GSE54628

Tags: WT vs. mutant, genotype

Summary: In this dataset, we include the expression data obtained from dissected mouse 16.5 embryonic brains using 3 wild type and 3 Tdp2Delta1-3 individuals. These data are used to obtain 165 genes that are differentially expressed as a consequence of Tdp2 absence. The data (obtained from three independent pairs of wild type and TDP2D1-3 brains) was normalised using RMA (Robust Multi-Array Average) and genes changing 1.5 fold (corrected p-value cut-off:0.05) between Tdp2+/+ and Tdp2Delta1-3