Version: 8.0.0Date: Tue Jan 28 2025
Category
AGO4
(Homo sapiens)Gene
Name: argonaute RISC component 4
Synonyms: eIF-2C 4, EIF2C4, eukaryotic translation initiation factor 2C, 4, argonaute4, protein argonaute-4, hAgo4, argonaute 4, RISC catalytic component, argonaute RISC catalytic component 4, eIF2C 4, argonaute 4
Source: HGNC:18424
Biotype: protein coding gene
Symbol: AGO4 (Hsa)
Symbol: AGO4
Strict Orthology Symbols: ago4
Ago4
(Mus musculus)Gene
Name: argonaute RISC catalytic subunit 4
Synonyms: AI481660, expressed sequence AI481660, eukaryotic translation initiation factor 2C, 4, Eif2c4, 5730550L01Rik, RIKEN cDNA 5730550L01 gene, argonaute 4
Source: MGI:1924100
Biotype: protein coding gene
Symbol: Ago4 (Mmu)
Symbol: Ago4
Automated Gene Synopsis: Orthologous to human AGO4 (argonaute RISC component 4).
Strict Orthology Symbols: ago4
Alleles: Ago4
ago4
(Danio rerio)Gene
Name: argonaute RISC component 4
Synonyms: eif2c4, fd14f04, Ago4, wu:fd14f04
Source: ZFIN:ZDB-GENE-030131-5357
Biotype: protein coding gene
Symbol: ago4 (Dre)
Symbol: ago4
Automated Gene Synopsis: Orthologous to human AGO4 (argonaute RISC component 4).
Synonyms: Ago4...Ago4
Strict Orthology Symbols: ago4
Ago4
(Rattus norvegicus)Gene
Name: argonaute RISC component 4
Synonyms: eukaryotic translation initiation factor 2C, 4, Eif2c4, protein argonaute-4-like, LOC102554576, protein argonaute-4, LOC298533, argonaute RISC catalytic component 4, argonaute 4, RISC catalytic component
Source: RGD:1304583
Biotype: protein coding gene
Symbol: Ago4 (Rno)
Symbol: Ago4
Gene Synopsis: Orthologous to human AGO4 (argonaute RISC component 4); PARTICIPATES IN microRNA pathway; INTERACTS WITH
Automated Gene Synopsis: Orthologous to human AGO4 (argonaute RISC component 4).
Strict Orthology Symbols: ago4
ago4
(Xenopus tropicalis)Gene
Name: argonaute 4, RISC catalytic component
Synonyms: argonaute-4, eif2c4, Argonaute4, ago4, argonaute 4, RISC catalytic component
Source: Xenbase:XB-GENE-1006882
Biotype: gene
Symbol: ago4
Symbol: ago4 (Xtr)
Automated Gene Synopsis: Orthologous to human AGO4 (argonaute RISC component 4).
Synonyms: ago4...ago4...ago4
Strict Orthology Symbols: ago4
ago4.S
(Xenopus laevis)Gene
Name: argonaute 4, RISC catalytic component
Synonyms: argonaute-4, eif2c4, ago4.S, Argonaute4, argonaute 4, RISC catalytic component
Source: Xenbase:XB-GENE-17331923
Biotype: gene
Symbol: ago4.S (Xla)
Automated Gene Synopsis: Orthologous to human AGO4 (argonaute RISC component 4).
Strict Orthology Symbols: ago4
Symbol: ago4.S
ago4.L
(Xenopus laevis)Gene
Name: argonaute 4, RISC catalytic component
Synonyms: argonaute-4, eif2c4, Argonaute4, ago4.L, argonaute 4, RISC catalytic component
Source: Xenbase:XB-GENE-1006885
Biotype: gene
Symbol: ago4.L (Xla)
Automated Gene Synopsis: Orthologous to human AGO4 (argonaute RISC component 4).
Strict Orthology Symbols: ago4
Symbol: ago4.L
Ago4em1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7288184
Genes: Ago4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ago4
Genes: Ago4 (Mmu)
Symbol: Ago4em1Smoc
Ago4tm1.1Peco
(Mus musculus)Allele/Variant
Source: MGI:5438526
Genes: Ago4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ago4
Genes: Ago4 (Mmu)
Symbol: Ago4tm1.1Peco
Ago4em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7309591
Genes: Ago4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ago4
Genes: Ago4 (Mmu)
Symbol: Ago4em1Gpt
Model
Id: MGI:5438527
Synonyms: Not Available
Symbol: Ago4/Ago4 [background:] B6.129P2(FVB)-Ago4 (Mmu)
Genes: Ago4 (Mmu)
Alleles: Ago4
Name: Ago4/Ago4 [background:] B6.129P2(FVB)-Ago4
AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-39652, GEO:GSE39652
Tags: WT vs. mutant, anatomical structure, developmental stage, genotype
Summary: The four mammalian Argonaute family members are thought to share redundant functions in the microRNA pathway, yet only AGO2 possesses the catalytic "slicer" function required for RNA interference. Whether AGO1, AGO3, or AGO4 possess specialized functions remains unclear. Here, we Series_summary = show that AGO4 localizes to spermatocyte nuclei during meiotic prophase I, specifically at sites of asynapsis and in the transcriptionally silenced XY sub-domain, the sex body. We generated Ago4 knockout mice and show that Ago4-/- spermatogonia initiate meiosis early, resulting from premature induction of retinoic acid-response genes. During prophase I, the sex body assembles incorrectly in Ago4-/- mice, leading to disrupted meiotic sex chromosome inactivation (MSCI). This is associated with a dramatic loss of microRNAs, >20% of which arise from the X chromosome. Loss of AGO4 results in increased AGO3 in spermatocytes, indicating some degree of redundancy. Thus, AGO4 regulates meiotic entry and MSCI in mammalian germ cells, implicating small RNA pathways in these processes. mRNA transcripts were isolated and prepared using pachytene spermatocytes, pre-meiotic testes and other tissues from Ago4+/+ and Ago4-/- littermates and sequenced using Illumina HiSeq2000. small RNA transcripts were isolated and prepared using pachytene spermatocytes from adult Ago4+/+ and Ago4-/- littermates and sequenced using Illumina GAII.
Symbol: AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline
Name: AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline
alg-2
(Caenorhabditis elegans)Gene
Name: Argonaute (plant)-Like Gene 2
Synonyms: CELE_T07D3.7, T07D3.7, T07D3
Source: WB:WBGene00000106
Biotype: protein coding gene
Strict Orthology Symbols: ago4
alg-1
(Caenorhabditis elegans)Gene
Name: Argonaute (plant)-Like Gene 1
Synonyms: F48F7.1, CELE_F48F7.1
Source: WB:WBGene00000105
Biotype: protein coding gene
Strict Orthology Symbols: ago4
AGO1
(Drosophila melanogaster)Gene
Name: Argonaute-1
Synonyms: Argonaute 1, Argonaute protein 1, ago1-1, Ago-1, argonaute 1, mRNA-like ncRNA in embryogenesis 20, l(2)k08121, anon-WO0257455.29, dAGO1, Argonaute, Agp1, l(2)04845, l(2)4845, MRE20, argonaute-1, ago1, Ago, CG6671, ago-1, ARGONAUTE-1, argonaute1, dAgo1, dmAgo1, Dm Ago1, Ago1, AGO-1, DmAgo1, Argonaute1, l(2)k00208
Source: FB:FBgn0262739
Biotype: protein coding gene
Strict Orthology Symbols: ago4
Ago3
(Rattus norvegicus)Gene
Name: argonaute RISC catalytic component 3
Synonyms: eukaryotic translation initiation factor 2C, 3, Eif2c3, LOC313593, argonaute 3, RISC catalytic component, protein argonaute-3
Source: RGD:1309163
Biotype: protein coding gene
Strict Orthology Symbols: ago4
Ago1
(Rattus norvegicus)Gene
Name: argonaute RISC component 1
Synonyms: eukaryotic translation initiation factor 2C, 1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, Eif2c1, LOC313594, protein argonaute-1
Source: RGD:1304619
Biotype: protein coding gene
Strict Orthology Symbols: ago4
Source: GO:0090625
Synonyms:
- gene silencing by mRNA cleavage
- mRNA cleavage involved in gene silencing by siRNA
Branch: biological process
Genes: Ago4 (Rno)...AGO4 (Hsa)
Gene Ontology
Source: GO:0010501
Synonyms:
- RNA duplex unwinding
Branch: biological process
Genes: Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0010586
Synonyms:
- microRNA metabolic process
Branch: biological process
Genes: Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0031054
Synonyms:
- pre-microRNA processing
Branch: biological process
Genes: ago4 (Dre)...Ago4 (Rno)...Ago4 (Mmu)...AGO4 (Hsa)
Gene Ontology
Source: GO:0070578
Synonyms:
- RLC
- miRLC
Branch: cellular component
Genes: Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0070922
Synonyms:
- RISC assembly
- gene silencing by RNA, small RNA loading onto RISC
Branch: biological process
Genes: Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0061980
Synonyms: Not Available
Branch: molecular function
Genes: AGO4 (Hsa)
Gene Ontology
Source: GO:0035196
Synonyms:
- gene silencing by miRNA, production of miRNAs
- miRNA biogenesis
Branch: biological process
Genes: Ago4 (Rno)...Ago4 (Mmu)...AGO4 (Hsa)
Source: GO:0035194
Synonyms:
- PTGS
- RNA interference
Branch: biological process
Genes: ago4 (Dre)...AGO4 (Hsa)...Ago4 (Rno)...Ago4 (Mmu)
Gene Ontology
Source: GO:0007130
Synonyms:
- synaptonemal complex formation
Branch: biological process
Genes: AGO4 (Hsa)...Ago4 (Rno)...Ago4 (Mmu)
Gene Ontology
Source: GO:0022604
Synonyms:
- negative regulation of cell shape and cell size
- positive regulation of cell shape and cell size
Branch: biological process
Genes: AGO4 (Hsa)...Ago4 (Rno)...Ago4 (Mmu)
Gene Ontology
Source: GO:0035198
Synonyms:
- microRNA binding
Branch: molecular function
Genes: ago4 (Dre)...AGO4 (Hsa)...Ago4 (Rno)...Ago4 (Mmu)
Gene Ontology
Source: GO:0007140
Synonyms:
- male meiosis
- male nuclear division
Branch: biological process
Genes: AGO4 (Hsa)...Ago4 (Rno)...Ago4 (Mmu)
Gene Ontology
Source: GO:0004521
Synonyms:
- endonuclease G activity
- endoribonuclease activity
Branch: molecular function
Genes: ago4 (Dre)...Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0003727
Synonyms:
- ssRNA binding
Branch: molecular function
Genes: ago4 (Dre)...Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0006402
Synonyms:
- mRNA breakdown
- mRNA catabolism
Branch: biological process
Genes: AGO4 (Hsa)...Ago4 (Rno)...Ago4 (Mmu)
Source: GO:0035278
Synonyms:
- down regulation of translation involved in gene silencing by miRNA
- down-regulation of translation involved in gene silencing by miRNA
Branch: biological process
Genes: ago4 (Dre)...Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0036464
Synonyms:
- Staufen granule
Branch: cellular component
Genes: ago4 (Dre)...Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0000932
Synonyms:
- P body
- cytoplasmic foci
Branch: cellular component
Genes: ago4 (Dre)...Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0003725
Synonyms:
- dsRNA binding
Branch: molecular function
Genes: Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Source: GO:0035279
Synonyms:
- deadenylation involved in gene silencing by miRNA
- gene silencing by mRNA cleavage
Branch: biological process
Genes: AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0008584
Synonyms:
- testicular development
- testis development
Branch: biological process
Genes: Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)
Gene Ontology
Source: GO:0031047
Synonyms:
- RNA-dependent gene silencing
- RNA-mediated gene silencing
Branch: biological process
Genes: ago4 (Dre)...AGO4 (Hsa)
Gene Ontology
Source: GO:0043232
Synonyms:
- intracellular non-membrane-bounded organelle
- intracellular non-membrane-enclosed organelle
Branch: cellular component
Genes: AGO4 (Hsa)
Gene Ontology
Source: GO:0016442
Synonyms:
- RNA-induced silencing complex
- miRNP complex
Branch: cellular component
Genes: Ago4 (Mmu)...AGO4 (Hsa)...Ago4 (Rno)...ago4 (Dre)
Gene Ontology
Source: GO:0006417
Synonyms:
- regulation of protein anabolism
- regulation of protein biosynthesis
Branch: biological process
Genes: ago4 (Dre)...AGO4 (Hsa)
Gene Ontology
Source: GO:0003723
Synonyms:
- base pairing with RNA
- poly(A) RNA binding
Branch: molecular function
Genes: Ago4 (Rno)...AGO4 (Hsa)...Ago4 (Mmu)...ago4 (Dre)
Gene Ontology
Source: GO:0043066
Synonyms:
- anti-apoptosis
- apoptosis inhibitor activity
Branch: biological process
Genes: AGO4 (Hsa)...Ago4 (Rno)...Ago4 (Mmu)
sa23604
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-160601-349
Genes: ago4 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Ago4
Genes: ago4 (Dre)
sa13019
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-130411-2689
Genes: ago4 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Ago4
Genes: ago4 (Dre)
Gene Ontology
Source: GO:1990904
Synonyms:
- RNA-protein complex
- RNP
Branch: cellular component
Genes: AGO4 (Hsa)...ago4 (Dre)
ago4
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0126455
Genes: ago (Dme)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: ago4
Name: ago4
(GRCh38)1:35834009C>T
(Homo sapiens)Allele/Variant
Source: rs765652702
Genes: AGO4 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (GRCh38)1:35834009C>T