Version: 8.1.0Date: Fri Apr 18 2025
Category
ARID5B
(Homo sapiens)Gene
Name: AT-rich interaction domain 5B
Synonyms: MRF1-like protein, modulator recognition factor 2 (MRF2), FLJ41888, FLJ21150, AT-rich interactive domain 5B (MRF1-like), MRF-2, ARID domain-containing protein 5B, MRF2, AT-rich interactive domain-containing protein 5B, DESRT, RP11-341A19.1, AT rich interactive domain 5B (MRF1-like)
Source: HGNC:17362
Biotype: protein coding gene
Symbol: ARID5B (Hsa)
Symbol: ARID5B
Strict Orthology Symbols: arid5b
Arid5b
(Rattus norvegicus)Gene
Name: AT-rich interaction domain 5B
Synonyms: LOC309728, AT-rich interactive domain-containing protein 5B, AT rich interactive domain 5B (Mrf1 like)
Source: RGD:1311735
Biotype: protein coding gene
Symbol: Arid5b (Rno)
Symbol: Arid5b
Gene Synopsis: Orthologous to human ARID5B (AT-rich interaction domain 5B); INTERACTS WITH 17beta-estradiol; 2,2',5,5
Automated Gene Synopsis: Orthologous to human ARID5B (AT-rich interaction domain 5B).
Strict Orthology Symbols: arid5b
arid5b
(Danio rerio)Gene
Name: AT-rich interaction domain 5B
Synonyms: si:dkey-247f17.3
Source: ZFIN:ZDB-GENE-121214-272
Biotype: protein coding gene
Symbol: arid5b (Dre)
Symbol: arid5b
Automated Gene Synopsis: Orthologous to human ARID5B (AT-rich interaction domain 5B).
Strict Orthology Symbols: arid5b
Arid5b
(Mus musculus)Gene
Name: AT-rich interaction domain 5B
Synonyms: developmentally and sexually retarded with transient immune abnormalities, RIKEN cDNA 5430435G07 gene, Mrf2, expressed sequence AI467247, Desrt, AI467247, Mrf2beta, 5430435G07Rik, Mrf2alpha
Source: MGI:2175912
Biotype: protein coding gene
Symbol: Arid5b (Mmu)
Symbol: Arid5b
Automated Gene Synopsis: Orthologous to human ARID5B (AT-rich interaction domain 5B).
Strict Orthology Symbols: arid5b
Alleles: Arid5b
arid5b
(Xenopus tropicalis)Gene
Name: AT-rich interaction domain 5B
Synonyms: arid5b, AT-rich interaction domain 5B, LOC108696083
Source: Xenbase:XB-GENE-1007579
Biotype: gene
Symbol: arid5b
Symbol: arid5b (Xtr)
Automated Gene Synopsis: Orthologous to human ARID5B (AT-rich interaction domain 5B).
Synonyms: arid5b...arid5b...arid5b
Strict Orthology Symbols: arid5b
arid5b.S
(Xenopus laevis)Gene
Name: AT-rich interaction domain 5B
Synonyms: arid5b.S, AT-rich interaction domain 5B, LOC108696083
Source: Xenbase:XB-GENE-1007582
Biotype: gene
Symbol: arid5b.S (Xla)
Automated Gene Synopsis: Orthologous to human ARID5B (AT-rich interaction domain 5B).
Strict Orthology Symbols: arid5b
Symbol: arid5b.S
Arid5btm1Pjh
(Mus musculus)Allele/Variant
Source: MGI:2445941
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5btm1Pjh
Arid5bem1Cya
(Mus musculus)Allele/Variant
Source: MGI:7792143
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5bem1Cya
Arid5bem1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7288342
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5bem1Smoc
Arid5btm1c(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:7506548
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5btm1c(KOMP)Wtsi
Arid5btm1a(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5008750
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5btm1a(KOMP)Wtsi
Arid5btm1Whit
(Mus musculus)Allele/Variant
Source: MGI:3771593
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5btm1Whit
Arid5bem2Cya
(Mus musculus)Allele/Variant
Source: MGI:7792144
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5bem2Cya
Arid5bem2Smoc
(Mus musculus)Allele/Variant
Source: MGI:7750358
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5bem2Smoc
Arid5bGt(ROSA)75Sor
(Mus musculus)Allele/Variant
Source: MGI:3526852
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5bGt(ROSA)75Sor
Arid5bem1Tcp
(Mus musculus)Allele/Variant
Source: MGI:7574121
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5bem1Tcp
Arid5btm1d(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:7628241
Genes: Arid5b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Arid5b
Genes: Arid5b (Mmu)
Symbol: Arid5btm1d(KOMP)Wtsi
Model
Id: MGI:3698629
Synonyms: Not Available
Symbol: Arid5b/Arid5b [background:] involves: 129S4/SvJae * BALB/c (Mmu)
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b [background:] involves: 129S4/SvJae * BALB/c
Id: MGI:3717110
Synonyms: Not Available
Symbol: Arid5b/Arid5b [background:] involves: 129S4/SvJaeSor (Mmu)
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b [background:] involves: 129S4/SvJaeSor
Model
Id: MGI:3771617
Synonyms: Not Available
Symbol: Arid5b/Arid5b [background:] involves: 129S1/Sv * C57BL/6J (Mmu)
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b [background:] involves: 129S1/Sv * C57BL/6J
Model
Id: MGI:3771616
Synonyms: Not Available
Symbol: Arid5b/Arid5b<+> [background:] 129S1/Sv-Arid5b (Mmu)
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b<+> [background:] 129S1/Sv-Arid5b
Model
Id: MGI:5696783
Synonyms: Not Available
Symbol: Arid5b/Arid5b [background:] B6.129S1-Arid5b (Mmu)
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b [background:] B6.129S1-Arid5b
Model
Id: MGI:3771618
Synonyms: Not Available
Symbol: Arid5b/Arid5b<+> [background:] involves: 129S1/Sv * C57BL/6J (Mmu)
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b<+> [background:] involves: 129S1/Sv * C57BL/6J
Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor Pdgfratm2Sor/Pdgfra+ [background:] involves: 129S4/SvJaeSor
(Mus musculus)Model
Id: MGI:3717132
Synonyms: Not Available
Symbol: Arid5b/Arid5b Pdgfra/Pdgfra<+> [background:] involves: 129S4/SvJaeSor
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b Pdgfra/Pdgfra<+> [background:] involves: 129S4/SvJaeSor
Model
Id: MGI:3771619
Synonyms: Not Available
Symbol: Arid5b/Arid5b [background:] involves: 129S1/Sv (Mmu)
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b [background:] involves: 129S1/Sv
Model
Id: MGI:3771615
Synonyms: Not Available
Symbol: Arid5b/Arid5b [background:] 129S1/Sv-Arid5b (Mmu)
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Arid5b/Arid5b [background:] 129S1/Sv-Arid5b
arid6
(Danio rerio)Gene
Name: AT-rich interaction domain 6
Synonyms: arid5b, zgc:158706
Source: ZFIN:ZDB-GENE-070112-1882
Biotype: protein coding gene
Synonyms: arid5b...arid5b...arid5b
SWI1
(Saccharomyces cerevisiae)Gene
Name: SWItching deficient
Synonyms: GAM3, YPL016W, LPA1, ADR6, [SWI(+)], [SWI+]
Source: SGD:S000005937
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human ARID5B (AT-rich interaction domain 5B).
Strict Orthology Symbols: arid5b
Gene Ontology
Source: GO:0060613
Synonyms: Not Available
Branch: biological process
Genes: Arid5b (Mmu)...ARID5B (Hsa)...Arid5b (Rno)
Zfp950Gt(ROSA)76Sor/Zfp950Gt(ROSA)76Sor Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor [background:] involves: 129S4/SvJaeSor
(Mus musculus)Model
Id: MGI:3717128
Synonyms: Not Available
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Zfp950/Zfp950 Arid5b/Arid5b [background:
Symbol: Zfp950/Zfp950 Arid5b/Arid5b [background:
Zfp950Gt(ROSA)76Sor/Zfp950+ Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor [background:] involves: 129S4/SvJaeSor
(Mus musculus)Model
Id: MGI:3717130
Synonyms: Not Available
Genes: Arid5b (Mmu)
Alleles: Arid5b
Name: Zfp950/Zfp950<+> Arid5b/Arid5b [background:] involves:
Symbol: Zfp950/Zfp950<+> Arid5b/Arid5b [background:] involves:
Gene Ontology
Source: GO:0048644
Synonyms: Not Available
Branch: biological process
Genes: Arid5b (Mmu)...ARID5B (Hsa)...Arid5b (Rno)
Gene Ontology
Source: GO:0007588
Synonyms: Not Available
Branch: biological process
Genes: Arid5b (Mmu)
Gene Ontology
Source: GO:0010761
Synonyms:
- fibroblast cell migration
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0008585
Synonyms:
- ovarian development
- ovary development
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0030325
Synonyms:
- interrenal gland
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Source: GO:0048008
Synonyms:
- PDGF receptor signaling pathway
- PDGF receptor signalling pathway
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0060325
Synonyms: Not Available
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0060612
Synonyms:
- adipogenesis
Branch: biological process
Genes: arid5b (Dre)...ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0048468
Synonyms:
- terminal differentiation
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0048705
Synonyms:
- skeletal morphogenesis
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Source: GO:0051091
Synonyms:
- activation of transcription factor activity
- positive regulation of DNA binding transcription factor activity
Branch: biological process
Genes: arid5b (Dre)...ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0060021
Synonyms:
- palatum development
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0045444
Synonyms:
- adipocyte cell differentiation
- adipocyte differentiation
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0009791
Synonyms: Not Available
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Giant island mice exhibit widespread gene regulatory evolution in key metabolic organs
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE135007
Tags: strain study, anatomical structure, baseline, age, developmental stage
Summary: Background: Island populations repeatedly evolve extreme body sizes, but the genomic basis of this morphological pattern remains largely unknown. To understand how organisms on islands evolve gigantism, we compared genome-wide patterns of gene expression in Gough Island mice, the largest wild house mice in the world, and mice from the WSB/EiJ wild-derived inbred strain. In a highly replicated experiment, we used RNASeq to quantify differences in gene expression in three key metabolic organs: gonadal adipose depot, hypothalamus, and liver. Results: We discovered pervasive evidence of transcriptional evolution, with 20% or more of differentially regulated transcripts in each organ exhibiting expression fold changes of at least 2X. By considering differential expression jointly with the genomic positions of quantitative trait loci for body size and single nucleotide differences located within established tissue-specific regulatory elements, we nominated 66 candidate genes for extreme size evolution, including Irs1 and Lrp1. Patterns of differential expression across three developmental time points in the liver revealed that Arid5b potentially regulates tens of co-regulated gene groups. Functional enrichment analyses on thousands of differentially expressed genes pointed to cell cycling, mitochondrial function, signaling pathways, immune reactivity, and nutrient metabolism as potential causes of weight accumulation in Gough Island mice. Conclusion: Collectively, our results suggest that extensive regulatory evolution in metabolic organs contributed to the rapid evolution of gigantism during the short time house mice have inhabited Gough Island. mRNA profiles were generated for 5 females and 5 males for two mouse strains in each of 5 conditions: 28-day-old gonadal adipose depot, 28-day-old hypothalamus, Theiler stage 24-25 (E16.5) liver, 14-day-old liver, and 28-day-old liver.
Gene Ontology
Source: GO:0008584
Synonyms:
- testicular development
- testis development
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0035264
Synonyms:
- body growth
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0001822
Synonyms:
- nephrogenesis
Branch: biological process
Genes: ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)
Gene Ontology
Source: GO:0003713
Synonyms:
- RNA polymerase II transcription co-activator activity
- RNA polymerase II transcription coactivator activity
Branch: molecular function
Genes: arid5b (Dre)...ARID5B (Hsa)...Arid5b (Rno)...Arid5b (Mmu)