Version: 8.2.0Date: Wed Aug 27 2025
Category
asp-4
(Caenorhabditis elegans)Gene
Name: ASpartyl Protease 4
Synonyms: CELE_R12H7.2, R12H7.2
Source: WB:WBGene00000217
Biotype: protein coding gene
Symbol: asp-4 (Cel)
Symbol: asp-4
Gene Synopsis: asp-4 encodes an aspartyl protease homolog that is required, in parallel with ASP-3 but downstream of
Cross References: WB:asp-4...asp-4...asp-4
REN
(Homo sapiens)Gene
Name: renin
Synonyms: RTD, renin precursor, renal, HNFJ2, FLJ10761, angiotensinogenase, angiotensin-forming enzyme, ADTKD4, renin 1
Source: HGNC:9958
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
CTSD
(Homo sapiens)Gene
Name: cathepsin D
Synonyms: lysosomal aspartyl peptidase, CPSD, ceroid-lipofuscinosis, neuronal 10, HEL-S-130P, MGC2311, CLN10, lysosomal aspartyl protease, cathepsin d (lysosomal aspartyl protease), epididymis secretory sperm binding protein Li 130P
Source: HGNC:2529
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
PEP4
(Saccharomyces cerevisiae)Gene
Name: carboxyPEPtidase Y-deficient
Synonyms: yscA, PHO9, PRA1, YPL154C
Source: SGD:S000006075
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
Ren1
(Mus musculus)Gene
Name: renin 1 structural
Synonyms: expressed sequence D19352, RATRENAA, Rn-1, Ren-1, renin 1, D19352, renin, Rnr, Ren, Ren-A, Ren1d, renin A, Ren1c, RENAA
Source: MGI:97898
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
Ren
(Rattus norvegicus)Gene
Name: renin
Synonyms: Ren1, angiotensinogenase, RATRENAA, renin 1 structural, renin 1, RENAA
Source: RGD:3554
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
ctsd
(Danio rerio)Gene
Name: cathepsin D
Synonyms: wu:fb93e11, etID16901.18, LAP, wu:fj17b09
Source: ZFIN:ZDB-GENE-010131-8
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
ren
(Danio rerio)Gene
Name: renin
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-040630-3
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
Ctsd
(Mus musculus)Gene
Name: cathepsin D
Synonyms: CatD, CD
Source: MGI:88562
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
CG10104
(Drosophila melanogaster)Gene
Name: Not Available
Synonyms: Not Available
Source: FB:FBgn0033933
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
napsa
(Danio rerio)Gene
Name: napsin A aspartic peptidase
Synonyms: fa94d12, zgc:63831, wu:fa94d12
Source: ZFIN:ZDB-GENE-030131-8690
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
Ctsd
(Rattus norvegicus)Gene
Name: cathepsin D
Synonyms: Not Available
Source: RGD:621511
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
cathD
(Drosophila melanogaster)Gene
Name: cathepsin D
Synonyms: cathD, cathepsin D, Cathepsin-D, CT3996, CG1548, CathepsinD, Cathepsin D, T17, CTSD, CATH, CathD
Source: FB:FBgn0029093
Biotype: protein coding gene
Strict Orthology Symbols: asp-4
NAPSA
(Homo sapiens)Gene
Name: napsin A aspartic peptidase
Synonyms: NAPA, SNAPA, ASP4, Kdap, kidney-derived aspartic protease-like protein, napsin-A, NAP1, CTB-191K22.6, TA01/TA02, NR1H2-AS1, pronapsin A, KAP, napsin-1, aspartyl protease 4, asp 4, NR1H2 antisense RNA 1
Source: HGNC:13395
Biotype: protein coding gene
Synonyms: asp 4
RB2035
(Caenorhabditis elegans)Model
Id: WB:WBStrain00032719
Synonyms: Not Available
Genes: asp-4 (Cel)
LOC116410386
(Xenopus tropicalis)Gene
Name: cathepsin D-like
Synonyms: LOC116410386, cathepsin D-like
Source: Xenbase:XB-GENE-29096095
Biotype: gene
Strict Orthology Symbols: asp-4
LOC101735147
(Xenopus tropicalis)Gene
Name: cathepsin D
Synonyms: LOC101735147, cathepsin D
Source: Xenbase:XB-GENE-29088319
Biotype: gene
Strict Orthology Symbols: asp-4
ctsd
(Xenopus tropicalis)Gene
Name: cathepsin D
Synonyms: cathepsin D, ctsd
Source: Xenbase:XB-GENE-5906945
Biotype: gene
Strict Orthology Symbols: asp-4
LOC613063
(Xenopus tropicalis)Gene
Name: cathepsin D-like
Synonyms: LOC613063, cathepsin D-like
Source: Xenbase:XB-GENE-29099015
Biotype: gene
Strict Orthology Symbols: asp-4
LOC101733630
(Xenopus tropicalis)Gene
Name: cathepsin D
Synonyms: LOC101733630, cathepsin D
Source: Xenbase:XB-GENE-29087091
Biotype: gene
Strict Orthology Symbols: asp-4
napsa
(Xenopus tropicalis)Gene
Name: napsin A aspartic peptidase
Synonyms: napsa, napa, napsin A aspartic peptidase, nap1, kdap, kap, snapa
Source: Xenbase:XB-GENE-947098
Biotype: gene
Strict Orthology Symbols: asp-4
asp-3
(Caenorhabditis elegans)Gene
Name: ASpartyl Protease 3
Synonyms: H22K11.1, CELE_H22K11.1
Source: WB:WBGene00000216
Biotype: protein coding gene
Gene Synopsis: asp-3 encodes an aspartyl protease homolog that is required, in parallel with ASP-4 but downstream of
Source: DOID:0110725
Definition: A neuronal ceroid lipofuscinosis that has_material_basis_in homozygous or compound heterozygous mutation in the CTSD gene on chromosome 11p15.
Genes: asp-4 (Cel)
Source: DOID:0061119
Definition: An autosomal dominant tubulointerstitial kidney disease characterized by early-onset anemia and increased serum uric acid with a bland urinalysis and without proteinuria that has_material_basis_in heterozygous mutation in the renin gene on chromosome 1q32.
Genes: asp-4 (Cel)
Gene Ontology
Source: GO:0097300
Synonyms:
- programmed cell death by necrosis
- regulated necrosis
Branch: biological process
Genes: asp-4 (Cel)
Source: DOID:0080827
Definition: A viral infectious disease that has_material_basis_in Human betaherpesvirus 5 (Cytomegalovirus humanbeta5).
Genes: asp-4 (Cel)
Disease
Source: DOID:10881
Definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Enterovirus A (Enterovirus alphacoxsackie), which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.
Genes: asp-4 (Cel)
Source: DOID:0050811
Definition: A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgyny manifestations resulting from steroidogenic enzyme deficiency.
Genes: asp-4 (Cel)
Disease
Source: DOID:8544
Definition: A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.
Genes: asp-4 (Cel)
Disease
Source: DOID:446
Definition: An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.
Genes: asp-4 (Cel)
Gene Ontology
Source: GO:0012501
Synonyms:
- PCD
- RCD
Branch: biological process
Genes: asp-4 (Cel)
Gene Ontology
Source: GO:0004190
Synonyms:
- aspartate protease activity
- aspartic endopeptidase activity
Branch: molecular function
Genes: asp-4 (Cel)
Source: DOID:0070508
Definition: A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and elevated alcohol consumption. This disease is distinguished from MASLD by increased alcohol consumption and from ALD by the evidence of one or more of the specified cardiometabolic risk factors. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.
Genes: asp-4 (Cel)
Disease
Source: DOID:14115
Definition: A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus, which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.
Genes: asp-4 (Cel)
Disease
Source: DOID:0060224
Definition: A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain.
Genes: asp-4 (Cel)
Disease
Source: DOID:10825
Definition: A hypertension with no known cause. It is the most common type of hypertension.
Genes: asp-4 (Cel)
Disease
Source: DOID:12236
Definition: A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.
Genes: asp-4 (Cel)
Disease
Source: DOID:1596
Definition: A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function.
Genes: asp-4 (Cel)
Disease
Source: DOID:5844
Definition: A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.
Genes: asp-4 (Cel)
Disease
Source: DOID:1612
Definition: An organ system cancer that originates in the mammary gland.
Genes: asp-4 (Cel)
(WBcel235)X:13221265A>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13221265A>G
Genes: asp-4 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13221265A>G
Gene Cross References: asp-4
(WBcel235)X:13219393T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13219393T>A
Genes: asp-4 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13219393T>A
Gene Cross References: asp-4
(WBcel235)X:13219641C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13219641C>T
Genes: asp-4 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: (WBcel235)X:13219641C>T
Gene Cross References: asp-4
(WBcel235)X:13219698G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13219698G>A
Genes: asp-4 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13219698G>A
Gene Cross References: asp-4
(WBcel235)X:13220790C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13220790C>T
Genes: asp-4 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13220790C>T
Gene Cross References: asp-4
(WBcel235)X:13221288C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13221288C>T
Genes: asp-4 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13221288C>T
Gene Cross References: asp-4