Version: 8.0.0Date: Tue Jan 28 2025
Category
BRDT
(Homo sapiens)Gene
Name: bromodomain testis associated
Synonyms: SPGF21, cancer/testis antigen 9, bromodomain, testis-specific, CT9, BRD6, RING3-like protein, bromodomain testis-specific protein
Source: HGNC:1105
Biotype: protein coding gene
Symbol: BRDT (Hsa)
Symbol: BRDT
Gene Synopsis: BRDT is similar to the RING3 protein family.
Strict Orthology Symbols: brdt
brdt
(Danio rerio)Gene
Name: bromodomain, testis-specific
Synonyms: si:dkeyp-85h7.3, fi25h02, wu:fi25h02
Source: ZFIN:ZDB-GENE-030131-5928
Biotype: protein coding gene
Symbol: brdt (Dre)
Symbol: brdt
Automated Gene Synopsis: Orthologous to human BRDT (bromodomain testis associated).
Strict Orthology Symbols: brdt
Brdt
(Rattus norvegicus)Gene
Name: bromodomain testis associated
Synonyms: bromodomain, testis-specific, LOC305123, bromodomain testis-specific protein
Source: RGD:1306678
Biotype: protein coding gene
Symbol: Brdt (Rno)
Symbol: Brdt
Gene Synopsis: Orthologous to human BRDT (bromodomain testis associated); PARTICIPATES IN histone modification pathway
Automated Gene Synopsis: Orthologous to human BRDT (bromodomain testis associated).
Strict Orthology Symbols: brdt
Brdt
(Mus musculus)Gene
Name: bromodomain, testis-specific
Synonyms: Fsrg3, female sterile homeotic-related gene 3, RIKEN cDNA 7420412D09 gene, 7420412D09Rik, Brd6
Source: MGI:1891374
Biotype: protein coding gene
Symbol: Brdt (Mmu)
Symbol: Brdt
Automated Gene Synopsis: Orthologous to human BRDT (bromodomain testis associated).
Strict Orthology Symbols: brdt
Alleles: Brdt
brdt
(Xenopus tropicalis)Gene
Name: bromodomain, testis-specific
Synonyms: bromodomain, testis-specific, ct9, brd6, brdt
Source: Xenbase:XB-GENE-983868
Biotype: gene
Symbol: brdt
Symbol: brdt (Xtr)
Automated Gene Synopsis: Orthologous to human BRDT (bromodomain testis associated).
Synonyms: brdt...brdt...brdt
Strict Orthology Symbols: brdt
brdt.S
(Xenopus laevis)Gene
Name: bromodomain, testis-specific
Synonyms: brdt.S, bromodomain, testis-specific, ct9, brd6
Source: Xenbase:XB-GENE-983871
Biotype: gene
Symbol: brdt.S (Xla)
Automated Gene Synopsis: Orthologous to human BRDT (bromodomain testis associated).
Strict Orthology Symbols: brdt
Symbol: brdt.S
brdt.L
(Xenopus laevis)Gene
Name: bromodomain, testis-specific
Synonyms: bromodomain, testis-specific, ct9, brd6, brdt.L
Source: Xenbase:XB-GENE-17346476
Biotype: gene
Symbol: brdt.L (Xla)
Automated Gene Synopsis: Orthologous to human BRDT (bromodomain testis associated).
Strict Orthology Symbols: brdt
Symbol: brdt.L
Brdtem1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7376275
Genes: Brdt (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Brdt
Genes: Brdt (Mmu)
Symbol: Brdtem1Gpt
Brdttm1a(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4455954
Genes: Brdt (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Brdt
Genes: Brdt (Mmu)
Symbol: Brdttm1a(EUCOMM)Wtsi
Brdttm1Djw
(Mus musculus)Allele/Variant
Source: MGI:3765973
Genes: Brdt (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Brdt
Genes: Brdt (Mmu)
Symbol: Brdttm1Djw
Brdtem5Gpt
(Mus musculus)Allele/Variant
Source: MGI:7296005
Genes: Brdt (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Brdt
Genes: Brdt (Mmu)
Symbol: Brdtem5Gpt
BRDTP1
(Homo sapiens)Gene
Name: bromodomain testis associated pseudogene 1
Synonyms: Not Available
Source: HGNC:51447
Biotype: pseudogene
Symbol: BRDTP1 (Hsa)
Symbol: BRDTP1
Model
Id: MGI:5448640
Synonyms: Not Available
Symbol: Brdt/Brdt [background:] involves: C57BL/6N (Mmu)
Genes: Brdt (Mmu)
Alleles: Brdt
Name: Brdt/Brdt [background:] involves: C57BL/6N
Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi [background:] B6JTyr;B6N-Brdttm1a(EUCOMM)Wtsi/Wtsi
(Mus musculus)Model
Id: MGI:5782037
Synonyms: Not Available
Symbol: Brdt/Brdt [background:] B6JTyr;B6N-Brdt/Wtsi (
Genes: Brdt (Mmu)
Alleles: Brdt
Name: Brdt/Brdt [background:] B6JTyr;B6N-Brdt/Wtsi
Model
Id: MGI:5790374
Synonyms: Not Available
Symbol: Brdt/Brdt [background:] C57BL/6-Brdt (Mmu)
Genes: Brdt (Mmu)
Alleles: Brdt
Name: Brdt/Brdt [background:] C57BL/6-Brdt
Model
Id: MGI:3765974
Synonyms: Not Available
Symbol: Brdt/Brdt [background:] involves: 129S/SvEv * C57BL/6J (Mmu)
Genes: Brdt (Mmu)
Alleles: Brdt
Name: Brdt/Brdt [background:] involves: 129S/SvEv * C57BL/6J
Brdt KO mice: Wild-type vs. Mutant
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE72786
Tags: WT vs. mutant, genotype
Summary: Transcriptional profiling of mouse pituitary tissue comparing WT with Brdt KO mice. Goal was to determine the effects of Brdt absence on pituitary gene expression. Four pools each of total RNA (three mice per pool) extracted from Brdt-/- and wild-type mice. Biological replicates: 2 WT replicates, 2 Brdt KO replicates.
Symbol: Brdt KO mice: Wild-type vs. Mutant
Name: Brdt KO mice: Wild-type vs. Mutant
bet-2
(Caenorhabditis elegans)Gene
Name: BET (two bromodomains) family protein 2
Synonyms: F57C7.1, CELE_F57C7.1
Source: WB:WBGene00010199
Biotype: protein coding gene
Gene Synopsis: Is an ortholog of human BRDT (bromodomain testis associated).
Automated Gene Synopsis: Orthologous to human BRDT (bromodomain testis associated).
Strict Orthology Symbols: BRDT...Brdt
BDF1
(Saccharomyces cerevisiae)Gene
Name: BromoDomain Factor
Synonyms: YLR399C
Source: SGD:S000004391
Biotype: protein coding gene
Automated Gene Synopsis: several human genes including BRD2 (bromodomain containing 2); BRD3 (bromodomain containing 3); and BRDT
Strict Orthology Symbols: brdt
BDF2
(Saccharomyces cerevisiae)Gene
Name: BromoDomain Factor
Synonyms: YDL070W
Source: SGD:S000002228
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including BRDT (bromodomain testis associated).
Strict Orthology Symbols: brdt
bet-1
(Caenorhabditis elegans)Gene
Name: BET (two bromodomains) family protein 1
Synonyms: CELE_Y119C1B.8, tag-332, Y119C1B.d, Y119C1B.8
Source: WB:WBGene00022473
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including BRD2 (bromodomain containing 2) and BRDT (bromodomain testis
Strict Orthology Symbols: brdt
tbrd-1
(Drosophila melanogaster)Gene
Name: testis-specifically expressed bromodomain containing protein-1
Synonyms: CG13597, tBrd-1, tBRD-1
Source: FB:FBgn0039124
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human BRD2 (bromodomain containing 2); BRD3 (bromodomain containing 3); and BRDT (bromodomain
Strict Orthology Symbols: BRDT
fs(1)h
(Drosophila melanogaster)Gene
Name: female sterile (1) homeotic
Synonyms: fst(1)h, dBrd4, dBRD4, anon-EST:fe1G2, l(1)G0495, Fs1hL, Female sterile 1 homeotic, fs(1)1456, Fs(1)h, anon-EST:Liang-1.81, fs(1)M16, Fs(1)h-L, fs1h, CG2252, rancor, fs(1)R10.4, ORE-1, l(1)G0093, FSH, Fsh, Brd4, female sterile homeotic, FSH-S, fs[1]h, Fs(1)hS, female sterile 1 homeotic, anon-fast-evolving-1G2, Fs(1)h/Brd4, rnc, l(1)7Da, N72, female sterile (1) homoeotic, Fs(1)hL, fs(1)26/26A, clone 1.81, fsh
Source: FB:FBgn0004656
Biotype: protein coding gene
Strict Orthology Symbols: brdt
Disease
Source: DOID:0070163
Definition: A male infertility due to acephalic spermatozoa that is characterized by acephalic spermatozoa, reduced sperm number and impaired sperm motility that has_material_basis_in homozygous mutation in the BRDT gene on chromosome 1p22.
Genes: brdt (Xtr)...brdt.L (Xla)...brdt (Dre)...Brdt (Rno)...Brdt (Mmu)
Disease
Source: DOID:14228
Definition: A male fertility issue defined as a low sperm concentration in the ejaculate.
Genes: brdt.L (Xla)...brdt.S (Xla)...Brdt (Rno)...BRDT (Hsa)...brdt (Xtr)
Gene Ontology
Source: GO:0035092
Synonyms:
- sperm chromatin condensation
- spermatogenesis, exchange of chromosomal proteins
Branch: biological process
Genes: BRDT (Hsa)...brdt (Dre)...Brdt (Mmu)...Brdt (Rno)
Gene Ontology
Source: GO:0140566
Synonyms:
- epigenetic reader
- histone reader
Branch: molecular function
Genes: BRDT (Hsa)...brdt (Dre)...Brdt (Mmu)...Brdt (Rno)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE136752
Tags: WT vs. mutant, genotype
Summary: Spermatogenesis is a complex process of sperm generation, including mitosis, meiosis, and spermiogenesis. During spermiogenesis, histones in post-meiotic spermatids are removed from chromatin and replaced by protamines. Although histone-to-protamine exchange is important for sperm nuclear condensation, the underlying regulatory mechanism is still poorly understood. Here, we identify PHD finger protein 7 (PHF7) as an E3 ubiquitin ligase for histone H3K14 in post-meiotic spermatids. Generation of Phf7-deficient mice and Phf7 C160A knockin mice with impaired E3 ubiquitin ligase activity reveals defects in histone-to-protamine exchange caused by dysregulation of histone removal factor Bromodomain, testis-specific (BRDT) in early condensing spermatids. Surprisingly, E3 ubiquitin ligase activity of PHF7 on histone ubiquitination leads to stabilization of BRDT by attenuating ubiquitination of BRDT. Collectively, our findings identify PHF7 as a critical factor for sperm chromatin condensation and contribute to mechanistic understanding of fundamental phenomenon of histone-to-protamine exchange and potential for drug development for the male reproduction system. single cell RNA sequencing performed with testicular cells from Phf7 f/f and Phf7 tKO mice.
Symbol: PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis
Name: PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis
Disease
Source: DOID:14227
Definition: A male infertility disease characterized by the absence of any measurable level of sperm in semen.
Genes: BRDT (Hsa)...brdt.S (Xla)...brdt (Xtr)...Brdt (Rno)...brdt (Dre)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-33132, GEO:GSE33132
Tags: WT vs. mutant, genotype
Summary: Brdt is a testis specific member of a family of chromatin interacting proteins. All of the family members have been shown to regulate transcription. Brdt is highly expressed in round spermatids, and may play a role in transcriptional regulation in these cells. We investigated transcriptional changes in mutant round spermatids that were homozygous for a mutation in which the first bromodomain of Brdt was removed. Round spermatids were purified from seven adult animals of each genotype for each Affymetrix microarray. Purity of round spermatids was assessed by propidium iodide staining.
Symbol: Expression data from purified control and Brdt-delta-BD1 round spermatids
Gene Ontology
Source: GO:0070577
Synonyms:
- acetylated histone residue binding
Branch: molecular function
Genes: BRDT (Hsa)...Brdt (Rno)...brdt (Dre)...Brdt (Mmu)
Gene Ontology
Source: GO:0007141
Synonyms:
- male meiosis I nuclear division
Branch: biological process
Genes: BRDT (Hsa)...Brdt (Rno)...brdt (Dre)...Brdt (Mmu)
Bromodomain-dependent stage-specific male genome programming by Brdt [Illumina BeadArray]
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-39909, GEO:GSE39909
Tags: WT vs. mutant, genotype
Summary: Male germ cell differentiation is a highly regulated multistep process initiated by the commitment of progenitor cells into meiosis and characterized by major chromatin reorganizations in haploid spermatids. We report here that a single member of the double bromodomain BET factors, Brdt, is a master regulator of both meiotic divisions and post-meiotic genome repackaging. Upon its activation at the onset of meiosis, Brdt drives and determines the developmental timing of a testis-specific gene expression program. In meiotic cells, Brdt initiates a genuine histone acetylation-guided programming of the genome by activating essential meiotic genes and repressing a "progenitor cells" gene expression program, while "priming" a post-meiotic gene group for further activation. At post-meiotic stages, a global chromatin hyperacetylation gives the signal for Brdt's first bromodomain to direct the genome-wide replacement of histones by transition proteins. Brdt is therefore a unique and essential regulator of male germ cell differentiation, which, by using various domains in a developmentally controlled manner, first drives a specific spermatogenic gene expression program, and later controls the tight packaging of the male genome. Total RNA obtained from testes from prepuberal mice at 17dpp and at 20dpp were compared between Brdt-/- and Brdt+/- (17dpp), between Brdt-/- and Brdt +/+ (20dpp) and between BrdtBD1del and Brdt wt mice (20dpp). In each experiments, 6 replicates of each genotype and condition were used.
Symbol: Bromodomain-dependent stage-specific male genome programming by Brdt [Illumina BeadArray]
Name: Bromodomain-dependent stage-specific male genome programming by Brdt [Illumina BeadArray]
Gene Ontology
Source: GO:0007140
Synonyms:
- male meiosis
- male nuclear division
Branch: biological process
Genes: BRDT (Hsa)...Brdt (Rno)...brdt (Dre)...Brdt (Mmu)
Gene Ontology
Source: GO:0043484
Synonyms: Not Available
Branch: biological process
Genes: BRDT (Hsa)...Brdt (Rno)...brdt (Dre)...Brdt (Mmu)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE212116
Tags: baseline, cell type
Summary: During meiotic prophase I, germ cells must balance transcriptional activation with meiotic recombination and chromosome synapsis, biological processes requiring extensive changes to chromatin state and structure. Here we explored the interplay between chromatin accessibility and transcription across a detailed time-course of murine male meiosis by measuring genome-wide patterns of chromatin accessibility, transcription, and processed mRNA. To understand the relationship between these parameters of gene regulation and recombination, we integrated these data with maps of double-strand break formation. Maps of nascent transcription showed that Pol II is loaded on chromatin and maintained in a paused state early during meiosis. In pachynema, paused Pol II is released in a coordinated transcriptional burst resulting in ~3-fold increase in transcription. Release from pause is mediated by the transcription factor A-MYB and the testis-specific bromodomain protein, BRDT. The burst of transcriptional activity is both temporally and spatially segregated from key steps of meiotic recombination: double strand breaks show evidence of chromatin accessibility earlier during prophase I and at distinct loci from those undergoing transcriptional activation, despite shared chromatin marks. Our findings uncover the mechanisms of transcriptional activation and how cells compartmentalize transcription and recombination during meiosis.
Symbol: Meiotic gene transcription programs are mediated by A-MYB and BRDT-dependent RNA Pol II pause release
Gene Ontology
Source: GO:0042393
Synonyms:
- histone-specific chaperone activity
Branch: molecular function
Genes: BRDT (Hsa)...Brdt (Rno)...Brdt (Mmu)
Gene Ontology
Source: GO:0008380
Synonyms:
- pre-mRNA splicing factor activity
Branch: biological process
Genes: BRDT (Hsa)...Brdt (Rno)...Brdt (Mmu)
Gene Ontology
Source: GO:0010628
Synonyms: Not Available
Branch: biological process
Genes: brdt (Dre)...Brdt (Mmu)...BRDT (Hsa)...Brdt (Rno)
Gene Ontology
Source: GO:0006397
Synonyms:
- mRNA maturation
Branch: biological process
Genes: BRDT (Hsa)...Brdt (Rno)...Brdt (Mmu)
Gene Ontology
Source: GO:0051321
Synonyms:
- meiosis
Branch: biological process
Genes: BRDT (Hsa)
Gene Ontology
Source: GO:0000785
Synonyms:
- chromosome scaffold
- cytoplasmic chromatin
Branch: cellular component
Genes: brdt (Dre)...Brdt (Mmu)...BRDT (Hsa)...Brdt (Rno)
Gene Ontology
Source: GO:0006338
Synonyms:
- ATP-dependent chromatin remodeling
- ATP-dependent chromatin remodelling
Branch: biological process
Genes: Brdt (Mmu)...BRDT (Hsa)...Brdt (Rno)...brdt (Dre)
Gene Ontology
Source: GO:0007283
Synonyms:
- generation of spermatozoa
Branch: biological process
Genes: Brdt (Mmu)...BRDT (Hsa)...Brdt (Rno)
sa20686
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-131217-15467
Genes: brdt (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: brdt (Dre)
sa33848
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-160601-2692
Genes: brdt (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: brdt (Dre)
Gene Ontology
Source: GO:0003713
Synonyms:
- RNA polymerase II transcription co-activator activity
- RNA polymerase II transcription coactivator activity
Branch: molecular function
Genes: BRDT (Hsa)
Gene Ontology
Source: GO:0005515
Synonyms:
- glycoprotein binding
- protein amino acid binding
Branch: molecular function
Genes: Brdt (Mmu)...Brdt (Rno)
(GRCh38)1:91977379C>A
(Homo sapiens)Allele/Variant
Source: NC_000001.11:g.91977379C>A
Genes: BRDT (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:91977379C>A
(GRCh38)1:91968164C>T
(Homo sapiens)Allele/Variant
Source: rs371270716
Genes: BRDT (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (GRCh38)1:91968164C>T