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8,462 results for camk4

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camk4

(Danio rerio)

Gene

Name: calcium/calmodulin-dependent protein kinase IV

Synonyms: zCaMKIV, wu:fj42a03, zgc:110275

Source: ZFIN:ZDB-GENE-050417-76

Biotype: protein coding gene

Symbol: camk4 (Dre)

Symbol: camk4

Automated Gene Synopsis: Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV).

Strict Orthology Symbols: camk4

Camk4

(Rattus norvegicus)

Gene

Name: calcium/calmodulin-dependent protein kinase IV

Synonyms: Ccdpk, Calmodulin-dependent protein kinase IV, RATCCDPK, calspermin, calcium/calmodulin-dependent protein kinase type IV, CAM kinase-GR, caMK IV

Source: RGD:2264

Biotype: protein coding gene

Symbol: Camk4 (Rno)

Symbol: Camk4

Gene Synopsis: Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV); PARTICIPATES IN calcium/

Automated Gene Synopsis: Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV).

Strict Orthology Symbols: camk4

Camk4

(Mus musculus)

Gene

Name: calcium/calmodulin-dependent protein kinase IV

Synonyms: Ccdpk, AI666733, RIKEN cDNA A430110E23 gene, CaMKIV/Gr, RATCCDPK, D18Bwg0362e, CaMKIV, DNA segment, Chr 18, Brigham & Women's Genetics 0362 expressed, Ca2+/calmodulin-dependent protein kinase type IV/Gr, A430110E23Rik, expressed sequence AI666733

Source: MGI:88258

Biotype: protein coding gene

Symbol: Camk4 (Mmu)

Symbol: Camk4

Automated Gene Synopsis: Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV).

Strict Orthology Symbols: camk4

Alleles: Camk4 (Mmu)...Camk4 (Mmu)...Camk4 (Mmu)...Camk4 (Mmu)...Camk4 (Mmu)

CAMK4

(Homo sapiens)

Gene

Name: calcium/calmodulin dependent protein kinase IV

Synonyms: CaMKIV, CAM kinase- GR, calcium/calmodulin-dependent protein kinase type IV, brain Ca++-calmodulin-dependent protein kinase type IV, IV, CAM kinase IV, caMK, calcium/calmodulin-dependent protein kinase IV, MGC36771, CaMK IV, brain Ca(2+)-calmodulin-dependent protein kinase type IV, CaMK-GR, caM kinase-GR, calcium/calmodulin-dependent protein kinase type IV catalytic chain

Source: HGNC:1464

Biotype: protein coding gene

Symbol: CAMK4 (Hsa)

Symbol: CAMK4

Strict Orthology Symbols: camk4

camk4

(Xenopus tropicalis)

Gene

Name: calcium/calmodulin-dependent protein kinase IV

Synonyms: xCaM, calcium/calmodulin-dependent protein kinase IV, camk4

Source: Xenbase:XB-GENE-5911781

Biotype: gene

Symbol: camk4

Symbol: camk4 (Xtr)

Automated Gene Synopsis: Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV).

Synonyms: camk4...camk4...camk4

Strict Orthology Symbols: camk4

Disease (3)

camk4.S

(Xenopus laevis)

Gene

Name: calcium/calmodulin-dependent protein kinase IV

Synonyms: xCaM, calcium/calmodulin-dependent protein kinase IV, camk4.S

Source: Xenbase:XB-GENE-17337568

Biotype: gene

Symbol: camk4.S (Xla)

Automated Gene Synopsis: Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV).

Strict Orthology Symbols: camk4

Symbol: camk4.S

Disease (1)

camk4.L

(Xenopus laevis)

Gene

Name: calcium/calmodulin-dependent protein kinase IV

Synonyms: xCaM, calcium/calmodulin-dependent protein kinase IV, camk4.L

Source: Xenbase:XB-GENE-5911786

Biotype: gene

Symbol: camk4.L (Xla)

Automated Gene Synopsis: Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV).

Strict Orthology Symbols: camk4

Symbol: camk4.L

Disease (1)

Camk4^tm1Gsc

(Mus musculus)

Allele/Variant

Source: MGI:2181436

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^tm1Gsc

Camk4^em1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7288624

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^em1Smoc

Gene (1)

Camk4^tm2Arm

(Mus musculus)

Allele/Variant

Source: MGI:2388343

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^tm2Arm

Camk4^tm1Tch

(Mus musculus)

Allele/Variant

Source: MGI:1888972

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^tm1Tch

Camk4^tm1Arm

(Mus musculus)

Allele/Variant

Source: MGI:2158694

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^tm1Arm

Camk4^{em1(IMPC)Ccpcz}

(Mus musculus)

Allele/Variant

Source: MGI:6358082

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^{em1(IMPC)Ccpcz}

Camk4^tm1Tsmi

(Mus musculus)

Allele/Variant

Source: MGI:4442999

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^tm1Tsmi

Camk4^em2Cya

(Mus musculus)

Allele/Variant

Source: MGI:7582695

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^em2Cya

Gene (1)

Camk4^em2Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7296192

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^em2Gpt

Gene (1)

Camk4^em1Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7296191

Genes: Camk4 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Camk4 (Mmu)

Genes: Camk4 (Mmu)

Symbol: Camk4^em1Gpt

Gene (1)

Camk4^{em1(IMPC)Ccpcz}/Camk4^{em1(IMPC)Ccpcz} [background:] C57BL/6N-Camk4^{em1(IMPC)Ccpcz}/Ccpcz

(Mus musculus)

Model

Id: MGI:6731264

Synonyms: Not Available

Symbol: Camk4/Camk4 [background:] C57BL/6N-Camk4/Ccpcz (Mmu)

Genes: Camk4 (Mmu)

Alleles: Camk4 (Mmu)

Name: Camk4/Camk4 [background:] C57BL/6N-Camk4/Ccpcz

Gene (1)

Camk4^tm1Tch/Camk4^tm1Tch [background:] involves: 129X1/SvJ * C57BL/6

(Mus musculus)

Model

Id: MGI:3794860

Synonyms: Not Available

Symbol: Camk4/Camk4 [background:] involves: 129X1/SvJ * C57BL/6 (Mmu)

Genes: Camk4 (Mmu)

Alleles: Camk4 (Mmu)

Name: Camk4/Camk4 [background:] involves: 129X1/SvJ * C57BL/6

Gene (1)

Camk4^tm1Tsmi/Camk4^tm1Tsmi [background:] B6N.129S-Camk4^tm1Tsmi

(Mus musculus)

Model

Id: MGI:4443001

Synonyms: Not Available

Symbol: Camk4/Camk4 [background:] B6N.129S-Camk4 (Mmu)

Genes: Camk4 (Mmu)

Alleles: Camk4 (Mmu)

Name: Camk4/Camk4 [background:] B6N.129S-Camk4

Gene (1)

Camk4^tm1Tch/Camk4^tm1Tch [background:] B6.129X1-Camk4^tm1Tch

(Mus musculus)

Model

Id: MGI:3794864

Synonyms: Not Available

Symbol: Camk4/Camk4 [background:] B6.129X1-Camk4 (Mmu)

Genes: Camk4 (Mmu)

Alleles: Camk4 (Mmu)

Name: Camk4/Camk4 [background:] B6.129X1-Camk4

Gene (1)

Camk4^tm2Arm/Camk4^tm2Arm [background:] involves: 129 * C57BL/6J

(Mus musculus)

Model

Id: MGI:3034061

Synonyms: Not Available

Symbol: Camk4/Camk4 [background:] involves: 129 * C57BL/6J (Mmu)

Genes: Camk4 (Mmu)

Alleles: Camk4 (Mmu)

Name: Camk4/Camk4 [background:] involves: 129 * C57BL/6J

Gene (1)

Camk4^tm1Arm/Camk4^tm1Arm [background:] involves: 129 * C57BL/6J

(Mus musculus)

Model

Id: MGI:2451150

Synonyms: Not Available

Symbol: Camk4/Camk4 [background:] involves: 129 * C57BL/6J (Mmu)

Genes: Camk4 (Mmu)

Alleles: Camk4 (Mmu)

Name: Camk4/Camk4 [background:] involves: 129 * C57BL/6J

Gene (1)

Camk4^tm1Gsc/Camk4^tm1Gsc Tg(Drd1a-cre)1Gsc/0 [background:] involves: 129 * FVB/N

(Mus musculus)

Model

Id: MGI:4843914

Synonyms: Not Available

Symbol: Camk4/Camk4 Tg(Drd1a-cre)1Gsc/0 [background:] involves: 129 * FVB/N (Mmu)

Genes: Camk4 (Mmu)

Alleles: Camk4 (Mmu)

Name: Camk4/Camk4 Tg(Drd1a-cre)1Gsc/0 [background:] involves: 129 * FVB/N

Gene (1)

CMK1

(Saccharomyces cerevisiae)

Gene

Name: CalModulin dependent protein Kinase

Synonyms: YFR014C

Source: SGD:S000001910

Biotype: protein coding gene

Strict Orthology Symbols: camk4

CMK2

(Saccharomyces cerevisiae)

Gene

Name: CalModulin dependent protein Kinase

Synonyms: YOL016C

Source: SGD:S000005376

Biotype: protein coding gene

Strict Orthology Symbols: camk4

calcium-dependent protein serine/threonine kinase activity

Gene Ontology

Source: GO:0009931

Synonyms: Not Available

Branch: molecular function

Genes: CAMK4 (Hsa)...Camk4 (Mmu)...camk4 (Dre)...Camk4 (Rno)

Genes Annotated with this GO Term (108)

la011571Tg

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-130129-2060

Genes: camk4 (Dre)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Genes: camk4 (Dre)

Gene (1)

la025178Tg

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-120806-9464

Genes: camk4 (Dre)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Genes: camk4 (Dre)

Gene (1)

positive regulation of myeloid dendritic cell cytokine production

Gene Ontology

Source: GO:0002735

Synonyms:

activation of myeloid dendritic cell cytokine production
stimulation of myeloid dendritic cell cytokine production

Branch: biological process

Genes: CAMK4 (Hsa)...Camk4 (Rno)

Genes Annotated with this GO Term (20)

zf169Tg + MO1-camk4

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-160212-1

Synonyms: Not Available

Genes: camk4 (Dre)

Name: zf169Tg + MO1-camk4

Gene (1)

postsynapse to nucleus signaling pathway

Gene Ontology

Source: GO:0099527

Synonyms:

postsynaptic signaling to nucleus

Branch: biological process

Genes: CAMK4 (Hsa)...Camk4 (Mmu)...Camk4 (Rno)

Genes Annotated with this GO Term (44)

neuron-neuron synaptic transmission

Gene Ontology

Source: GO:0007270

Synonyms:

nerve-nerve synaptic transmission

Branch: biological process

Genes: Camk4 (Mmu)...Camk4 (Rno)...CAMK4 (Hsa)

Genes Annotated with this GO Term (53)

WT + MO1-camk4

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-160212-2

Synonyms: Not Available

Genes: camk4 (Dre)

Name: WT + MO1-camk4

Gene (1)

positive regulation of protein export from nucleus

Gene Ontology

Source: GO:0046827

Synonyms:

activation of protein export from nucleus
positive regulation of protein export from cell nucleus

Branch: biological process

Genes: Camk4 (Mmu)...Camk4 (Rno)...CAMK4 (Hsa)

Genes Annotated with this GO Term (68)

calcium/calmodulin-dependent protein kinase activity

Gene Ontology

Source: GO:0004683

Synonyms:

ATP:caldesmon O-phosphotransferase activity
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity

Branch: molecular function

Genes: CAMK4 (Hsa)...Camk4 (Mmu)...Camk4 (Rno)...camk4 (Dre)

Genes Annotated with this GO Term (126)

myeloid dendritic cell differentiation

Gene Ontology

Source: GO:0043011

Synonyms: Not Available

Branch: biological process

Genes: Camk4 (Mmu)...Camk4 (Rno)...CAMK4 (Hsa)

Genes Annotated with this GO Term (74)

postsynaptic modulation of chemical synaptic transmission

Gene Ontology

Source: GO:0099170

Synonyms: Not Available

Branch: biological process

Genes: CAMK4 (Hsa)...Camk4 (Mmu)...Camk4 (Rno)

Genes Annotated with this GO Term (133)

cocaine dependence

Disease

Source: DOID:9975

Definition: A drug dependence that is a psychological dependency on the regular use of cocaine.

Genes: camk4.L (Xla)...CAMK4 (Hsa)...camk4.S (Xla)...Camk4 (Mmu)...camk4 (Dre)

Gene (289)

withdrawal disorder

Disease

Source: DOID:0060001

Definition: A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol.

Genes: CAMK4 (Hsa)...Camk4 (Mmu)...camk4 (Dre)...camk4 (Xtr)...Camk4 (Rno)

regulation of T cell differentiation in thymus

Gene Ontology

Source: GO:0033081

Synonyms:

regulation of T cell development in thymus
regulation of thymic T cell differentiation

Branch: biological process

Genes: CAMK4 (Hsa)

Genes Annotated with this GO Term (94)

regulation of osteoclast differentiation

Gene Ontology

Source: GO:0045670

Synonyms: Not Available

Branch: biological process

Genes: CAMK4 (Hsa)

Genes Annotated with this GO Term (267)

nucleocytoplasmic transport

Gene Ontology

Source: GO:0006913

Synonyms:

nucleocytoplasmic shuttling

Branch: biological process

Genes: CAMK4 (Hsa)...Camk4 (Mmu)...Camk4 (Rno)

Genes Annotated with this GO Term (1274)

long-term memory

Gene Ontology

Source: GO:0007616

Synonyms: Not Available

Branch: biological process

Genes: CAMK4 (Hsa)...Camk4 (Mmu)...Camk4 (Rno)

Genes Annotated with this GO Term (223)

definitive hemopoiesis

Gene Ontology

Source: GO:0060216

Synonyms:

definitive haematopoiesis
definitive haemopoiesis

Branch: biological process

Genes: camk4 (Dre)

Genes Annotated with this GO Term (132)

calmodulin binding

Gene Ontology

Source: GO:0005516

Synonyms: Not Available

Branch: molecular function

Genes: Camk4 (Mmu)...CAMK4 (Hsa)...camk4 (Dre)...Camk4 (Rno)

Genes Annotated with this GO Term (823)

Gene expression data from mouse HDAC4 KO pups, postnatal day 3

(Mus musculus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by MGI

ID: ArrayExpress:E-GEOD-49383, GEO:GSE49383

Tags: WT vs. mutant, genotype

Summary: Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). HDAC4, like its class IIa counterparts, is a potent transcriptional repressor through interactions with tissue-specific transcription factors via its N-terminal domain. Whilst the lysine deacetylase activity of the class IIa HDACs is much less potent than that of the class I enzymes, HDAC4 has been reported to influence protein deacetylation through its interaction with HDAC3. To investigate the influence of HDAC4 on protein acetylation, we employed the unbiased AcetylScan proteomic screen. We identified many proteins known to be modified by acetylation, but found that the absence of HDAC4 had no effect on the acetylation profile of the murine neonate brain. This is consistent with the biochemical data suggesting that HDAC4 may not function as a lysine deacetylase, but these in vivo data do not support the previous report showing that the enzymatic activity of HDAC3 might be modified by its interaction with HDAC4. To complement this work, we used Affymetrix arrays to investigate the effect of HDAC4 knock-out on the transcriptional profile of the postnatal murine brain. There was no effect on global transcription, consistent with the absence of a differential histone acetylation profile. Validation of the array data by Taq-man qPCR indicated that only protamine 1 and Igfbp6 mRNA levels were increased by more than one-fold and only CamK4 was decreased. The lack of a major effect on the transcriptional profile is consistent with the cytoplasmic location of HDAC4 in the P3 murine brain. mRNA expression analysis was performed by microarray in 3-day-old HDAC4 KO pups and WT littermates. Ten samples were analysed for each genotype. Microarray quality control was performed using the software package provided on RACE (http://race.unil.ch).