Version: 8.0.0Date: Tue Jan 28 2025
Category
Cited2
(Rattus norvegicus)Gene
Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Synonyms: cbp/p300-interacting transactivator 2, MGC93288, Mrg1
Source: RGD:620112
Biotype: protein coding gene
Symbol: Cited2 (Rno)
Symbol: Cited2
Gene Synopsis: Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain
Automated Gene Synopsis: Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain
Strict Orthology Symbols: cited2
cited2
(Danio rerio)Gene
Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Synonyms: zgc:103418
Source: ZFIN:ZDB-GENE-041010-141
Biotype: protein coding gene
Symbol: cited2 (Dre)
Symbol: cited2
Automated Gene Synopsis: Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain
Strict Orthology Symbols: cited2
Cited2
(Mus musculus)Gene
Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Synonyms: Msg2, expressed sequence AI835299, melanocyte specific gene 2, AI835299, Mrg1, p35srj
Source: MGI:1306784
Biotype: protein coding gene
Symbol: Cited2 (Mmu)
Symbol: Cited2
Automated Gene Synopsis: Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain
Strict Orthology Symbols: cited2
Alleles: Cited2
CITED2
(Homo sapiens)Gene
Name: Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Synonyms: MSG-related protein 1, cbp/p300-interacting transactivator 2, P35SRJ, VSD2, Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, MRG-1, MSG1-related gene 1, ASD8, melanocyte-specific gene 1-related gene 1, MRG1, Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2
Source: HGNC:1987
Biotype: protein coding gene
Symbol: CITED2 (Hsa)
Symbol: CITED2
Strict Orthology Symbols: cited2
cited2
(Xenopus tropicalis)Gene
Name: Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2
Synonyms: cited2, MGC75612, Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2
Source: Xenbase:XB-GENE-495035
Biotype: gene
Symbol: cited2
Symbol: cited2 (Xtr)
Automated Gene Synopsis: Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain
Synonyms: cited2...cited2...cited2
Strict Orthology Symbols: cited2
cited2.L
(Xenopus laevis)Gene
Name: Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2
Synonyms: cited2.L, MGC75612, Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2
Source: Xenbase:XB-GENE-866410
Biotype: gene
Symbol: cited2.L (Xla)
Automated Gene Synopsis: Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain
Strict Orthology Symbols: cited2
Symbol: cited2.L
Cited2m1H
(Mus musculus)Allele/Variant
Source: MGI:5646605
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2m1H
Cited2tm2Bha
(Mus musculus)Allele/Variant
Source: MGI:3803778
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm2Bha
Cited2em24Gpt
(Mus musculus)Allele/Variant
Source: MGI:7297017
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2em24Gpt
Cited2tm1Dunw
(Mus musculus)Allele/Variant
Source: MGI:3696061
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm1Dunw
Cited2tm4Bha
(Mus musculus)Allele/Variant
Source: MGI:5472020
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm4Bha
Cited2tm1Bha
(Mus musculus)Allele/Variant
Source: MGI:2179740
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm1Bha
Cited2tm1.2Dunw
(Mus musculus)Allele/Variant
Source: MGI:3696063
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm1.2Dunw
Cited2em1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7750509
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2em1Smoc
Cited2tm5Bha
(Mus musculus)Allele/Variant
Source: MGI:5472021
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm5Bha
Cited2tm3.1Bha
(Mus musculus)Allele/Variant
Source: MGI:5472019
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm3.1Bha
Cited2tm1.1Dunw
(Mus musculus)Allele/Variant
Source: MGI:3696062
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm1.1Dunw
Cited2tm6Bha
(Mus musculus)Allele/Variant
Source: MGI:5472022
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm6Bha
Cited2tm1Jpmb
(Mus musculus)Allele/Variant
Source: MGI:2176158
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm1Jpmb
Cited2tm1Ycy
(Mus musculus)Allele/Variant
Source: MGI:2385355
Genes: Cited2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: tetralogy of Fallot
Variant Name: Not Available
Symbol: Cited2
Genes: Cited2 (Mmu)
Symbol: Cited2tm1Ycy
Cited2tm1Bha/Cited2tm2Bha Mesp1tm2(cre)Ysa/Mesp1+ [background:] involves: 129 * C57BL/6 * CBA * SJL
(Mus musculus)Model
Id: MGI:3804087
Synonyms: Not Available
Symbol: Cited2/Cited2 Mesp1/Mesp1<+> [background:] involves: 129 * C57BL/6 * CBA
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 Mesp1/Mesp1<+> [background:] involves: 129 * C57BL/6 * CBA
Cited2tm1Bha/Cited2tm2Bha Edil3Tg(Sox2-cre)1Amc/Edil3+ [background:] involves: 129 * C57BL/6 * CBA * SJL
(Mus musculus)Model
Id: MGI:3804085
Synonyms: Not Available
Symbol: Cited2/Cited2 Edil3/Edil3<+> [background:] involves: 129 * C57BL/6
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 Edil3/Edil3<+> [background:] involves: 129 * C57BL/6
Id: MGI:5472105
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129S4/SvJaeSor * C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129S4/SvJaeSor * C57BL/6J
Cited2tm1Bha/Cited2tm2Bha H2az2Tg(Wnt1-cre)11Rth/H2az2+ [background:] involves: 129 * C57BL/6 * CBA * SJL
(Mus musculus)Model
Id: MGI:3804086
Synonyms: Not Available
Symbol: Cited2/Cited2 H2az2/H2az2<+> [background:] involves: 129 * C57BL/
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 H2az2/H2az2<+> [background:] involves: 129 * C57BL/
Model
Id: MGI:4887356
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] B6.Cg-Cited2 (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] B6.Cg-Cited2
Model
Id: MGI:5472115
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Model
Id: MGI:3696401
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129S1/Sv * C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129S1/Sv * C57BL/6J
Model
Id: MGI:3696403
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129S1/Sv * C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129S1/Sv * C57BL/6J
Model
Id: MGI:3804089
Synonyms: Not Available
Symbol: Cited2/Cited2<+> [background:] involves: 129P2/OlaHsd (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2<+> [background:] involves: 129P2/OlaHsd
Cited2tm1Bha/Cited2tm3.1Bha [background:] involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
(Mus musculus)Model
Id: MGI:5472108
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J (Mmu
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Model
Id: MGI:3771393
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129P2/OlaHsd (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129P2/OlaHsd
Model
Id: MGI:2176280
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6 (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6
Model
Id: MGI:3054743
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129 * C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129 * C57BL/6J
Model
Id: MGI:2179746
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6J
Model
Id: MGI:5472111
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Model
Id: MGI:5472116
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: C57BL/6J * C57BL/6N (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: C57BL/6J * C57BL/6N
Model
Id: MGI:5472114
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: C57BL/6J * C57BL/6N (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: C57BL/6J * C57BL/6N
Model
Id: MGI:3696402
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129S1/Sv * C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129S1/Sv * C57BL/6J
Model
Id: MGI:5472117
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Model
Id: MGI:3054742
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] B6.129P2-Cited2 (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] B6.129P2-Cited2
CITED2 is a conserved regulator of deep placentation (Rat I)
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE202337
Tags: unclassified
Summary: Establishment of the hemochorial placentation site requires the exodus of trophoblast cells from the placenta and their transformative actions on the uterine vasculature, which is a critical but poorly understood developmental process. CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl terminal domain 2 (CITED2) is a member of the CITED protein family of co-regulators and has been shown to possess roles in embryogenesis, including placenta development. We examined the involvement of CITED2 in the rat, which exhibits deep hemochorial placentation, a feature it shares with the human. CITED2 is distinctively expressed in the junctional zone compartment of the rat placentation site and in intrauterine invasive trophoblast cells. Homozygous disruption of the rat Cited2 locus resulted in placental and fetal growth restriction and abnormalities in heart and lung development, which are also characteristic of the CITED deficient mouse model. However, other features of the mouse Cited2 null phenotype, including exencephaly, adrenal gland agenesis, and prenatal lethality were not associated with CITED2 deficiency in the rat. Trophoblast-specific lentiviral CITED2 knockdown in the rat yielded a growth arrested placental phenotype. Smaller Cited2 null placentas were associated with a growth restricted junctional zone and coincided with a delay in intrauterine trophoblast cell invasion. Invasive trophoblast cells arise from the junctional zone. Transcriptomes of the junctional zone, the invasive trophoblast cell lineage, and differentiating trophoblast stem cells were affected by CITED2 disruption, as were placental adaptations to hypoxia and exposure to viral mimetics. Evidence for the conservation of CITED2 expression in human placental tissue and conserved actions in invasive/extravillous trophoblast cell development were demonstrated. We conclude that CITED2 is a conserved regulator of deep hemochorial placentation.
Symbol: CITED2 is a conserved regulator of deep placentation (Rat I)
Name: CITED2 is a conserved regulator of deep placentation (Rat I)
Model
Id: MGI:3718980
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: 129P2/OlaHsd (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: 129P2/OlaHsd
CITED2 is a conserved regulator of deep placentation (Rat II)
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE202338
Tags: unclassified
Summary: Establishment of the hemochorial placentation site requires the exodus of trophoblast cells from the placenta and their transformative actions on the uterine vasculature, which is a critical but poorly understood developmental process. CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl terminal domain 2 (CITED2) is a member of the CITED protein family of co-regulators and has been shown to possess roles in embryogenesis, including placenta development. We examined the involvement of CITED2 in the rat, which exhibits deep hemochorial placentation, a feature it shares with the human. CITED2 is distinctively expressed in the junctional zone compartment of the rat placentation site and in intrauterine invasive trophoblast cells. Homozygous disruption of the rat Cited2 locus resulted in placental and fetal growth restriction and abnormalities in heart and lung development, which are also characteristic of the CITED deficient mouse model. However, other features of the mouse Cited2 null phenotype, including exencephaly, adrenal gland agenesis, and prenatal lethality were not associated with CITED2 deficiency in the rat. Trophoblast-specific lentiviral CITED2 knockdown in the rat yielded a growth arrested placental phenotype. Smaller Cited2 null placentas were associated with a growth restricted junctional zone and coincided with a delay in intrauterine trophoblast cell invasion. Invasive trophoblast cells arise from the junctional zone. Transcriptomes of the junctional zone, the invasive trophoblast cell lineage, and differentiating trophoblast stem cells were affected by CITED2 disruption, as were placental adaptations to hypoxia and exposure to viral mimetics. Evidence for the conservation of CITED2 expression in human placental tissue and conserved actions in invasive/extravillous trophoblast cell development were demonstrated. We conclude that CITED2 is a conserved regulator of deep hemochorial placentation.
Symbol: CITED2 is a conserved regulator of deep placentation (Rat II)
Name: CITED2 is a conserved regulator of deep placentation (Rat II)
Model
Id: MGI:2667200
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: C57BL/6J
Cited2tm1Ycy/Cited2+ [background:] involves: C57BL/6J
(Mus musculus)Model
Id: MGI:2667201
Synonyms: Not Available
Symbol: Cited2/Cited2<+> [background:] involves: C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2<+> [background:] involves: C57BL/6J
Cited2tm1Bha/Cited2tm2Bha Tg(T-cre)1Lwd/0 [background:] involves: 129 * C3H * C57BL/6 * SJL
(Mus musculus)Model
Id: MGI:3804088
Synonyms: Not Available
Symbol: Cited2/Cited2 Tg(T-cre)1Lwd/0 [background:] involves: 129 * C3H * C57BL/6 * SJL (Mmu
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 Tg(T-cre)1Lwd/0 [background:] involves: 129 * C3H * C57BL/6 * SJL
Model
Id: MGI:5646606
Synonyms: Not Available
Symbol: Cited2/Cited2 [background:] involves: BALB/c * C57BL/6J (Mmu)
Genes: Cited2 (Mmu)
Alleles: Cited2
Name: Cited2/Cited2 [background:] involves: BALB/c * C57BL/6J
Disease
Source: DOID:0110113
Definition: An atrial heart septal defect that has_material_basis_in heterozygous mutation in the CITED2 gene on chromosome 6q23.3.
Genes: Cited2 (Mmu)...cited2.L (Xla)...Cited2 (Rno)...CITED2 (Hsa)...cited2 (Xtr)
Gene Ontology
Source: GO:0003156
Synonyms: Not Available
Branch: biological process
Genes: Cited2 (Mmu)...Cited2 (Rno)...CITED2 (Hsa)
Source: GO:0061308
Synonyms: Not Available
Branch: biological process
Genes: Cited2 (Mmu)...Cited2 (Rno)...CITED2 (Hsa)