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Category

422 results for cmtr2

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CMTR2

(Homo sapiens)

Gene

Name: cap methyltransferase 2

Synonyms: adrift homolog, MTr2, HMTr2, ftsJ methyltransferase domain-containing protein 1, FtsJ methyltransferase domain containing 1, cap2 2'O-ribose methyltransferase 2, FTSJD1, FLJ11171, cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2, AFT

Source: HGNC:25635

Biotype: protein coding gene

Symbol: CMTR2 (Hsa)

Symbol: CMTR2

Strict Orthology Symbols: cmtr2

Allele/Variant (34)

Cmtr2

(Rattus norvegicus)

Gene

Name: cap methyltransferase 2

Synonyms: similar to adrift CG5032-PA, LOC292016, ftsJ methyltransferase domain-containing protein 1, Ftsjd1, FtsJ methyltransferase domain containing 1, RGD1309394, cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Source: RGD:1309394

Biotype: protein coding gene

Symbol: Cmtr2 (Rno)

Symbol: Cmtr2

Gene Synopsis: Orthologous to human CMTR2 (cap methyltransferase 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine

Automated Gene Synopsis: Orthologous to human CMTR2 (cap methyltransferase 2).

Strict Orthology Symbols: cmtr2

Allele/Variant (22)

cmtr2

(Danio rerio)

Gene

Name: cap methyltransferase 2

Synonyms: ftsjd1, wu:fj48c05, zgc:55686

Source: ZFIN:ZDB-GENE-040426-2775

Biotype: protein coding gene

Symbol: cmtr2 (Dre)

Symbol: cmtr2

Automated Gene Synopsis: Orthologous to human CMTR2 (cap methyltransferase 2).

Strict Orthology Symbols: cmtr2

Allele/Variant (2)

Cmtr2

(Mus musculus)

Gene

Name: cap methyltransferase 2

Synonyms: AU022703, expressed sequence AU022703, cDNA sequence BC025546, BC025546, MGC:38131, FtsJ methyltransferase domain containing 1, Ftsjd1, RIKEN cDNA C730036L12 gene, RGD1309394, C730036L12Rik

Source: MGI:2384580

Biotype: protein coding gene

Symbol: Cmtr2 (Mmu)

Symbol: Cmtr2

Automated Gene Synopsis: Orthologous to human CMTR2 (cap methyltransferase 2).

Strict Orthology Symbols: cmtr2

Alleles: Cmtr2 (Mmu)...Cmtr2 (Mmu)...Cmtr2 (Mmu)...Cmtr2 (Mmu)...Cmtr2 (Mmu)

cmtr2

(Xenopus tropicalis)

Gene

Name: cap methyltransferase 2

Synonyms: cap methyltransferase 2, cmtr2

Source: Xenbase:XB-GENE-6035233

Biotype: gene

Symbol: cmtr2

Symbol: cmtr2 (Xtr)

Automated Gene Synopsis: Orthologous to human CMTR2 (cap methyltransferase 2).

Synonyms: cmtr2...cmtr2...cmtr2

Strict Orthology Symbols: cmtr2

cmtr2.L

(Xenopus laevis)

Gene

Name: cap methyltransferase 2

Synonyms: cap methyltransferase 2, cmtr2.L

Source: Xenbase:XB-GENE-17344821

Biotype: gene

Symbol: cmtr2.L (Xla)

Automated Gene Synopsis: Orthologous to human CMTR2 (cap methyltransferase 2).

Strict Orthology Symbols: cmtr2

Symbol: cmtr2.L

Cmtr2^{tm1(KOMP)Vlcg}

(Mus musculus)

Allele/Variant

Source: MGI:4887777

Genes: Cmtr2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Cmtr2 (Mmu)

Genes: Cmtr2 (Mmu)

Symbol: Cmtr2^{tm1(KOMP)Vlcg}

Gene (1)

Cmtr2^{tm1.1(KOMP)Vlcg}

(Mus musculus)

Allele/Variant

Source: MGI:5708242

Genes: Cmtr2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Cmtr2 (Mmu)

Genes: Cmtr2 (Mmu)

Symbol: Cmtr2^{tm1.1(KOMP)Vlcg}

Cmtr2^em2Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7783584

Genes: Cmtr2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Cmtr2 (Mmu)

Genes: Cmtr2 (Mmu)

Symbol: Cmtr2^em2Smoc

Gene (1)

Cmtr2^em1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7289048

Genes: Cmtr2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Cmtr2 (Mmu)

Genes: Cmtr2 (Mmu)

Symbol: Cmtr2^em1Smoc

Gene (1)

Cmtr2^em1Cya

(Mus musculus)

Allele/Variant

Source: MGI:7583073

Genes: Cmtr2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Cmtr2 (Mmu)

Genes: Cmtr2 (Mmu)

Symbol: Cmtr2^em1Cya

Gene (1)

Cmtr2^em2Cya

(Mus musculus)

Allele/Variant

Source: MGI:7583074

Genes: Cmtr2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Cmtr2 (Mmu)

Genes: Cmtr2 (Mmu)

Symbol: Cmtr2^em2Cya

Gene (1)

Cmtr2^{tm1.1(KOMP)Vlcg}/Cmtr2⁺ [background:] B6N(Cg)-Cmtr2^{tm1.1(KOMP)Vlcg}/2J

(Mus musculus)

Model

Id: MGI:6461161

Synonyms: Not Available

Symbol: Cmtr2/Cmtr2<+> [background:] B6N(Cg)-Cmtr2/2J (Mmu)

Genes: Cmtr2 (Mmu)

Alleles: Cmtr2 (Mmu)

Name: Cmtr2/Cmtr2<+> [background:] B6N(Cg)-Cmtr2/2J

Gene (1)

Cmtr2^{tm1.1(KOMP)Vlcg}/Cmtr2^{tm1.1(KOMP)Vlcg} [background:] B6N(Cg)-Cmtr2^{tm1.1(KOMP)Vlcg}/2J

(Mus musculus)

Model

Id: MGI:6262168

Synonyms: Not Available

Symbol: Cmtr2/Cmtr2 [background:] B6N(Cg)-Cmtr2/2J (Mmu)

Genes: Cmtr2 (Mmu)

Alleles: Cmtr2 (Mmu)

Name: Cmtr2/Cmtr2 [background:] B6N(Cg)-Cmtr2/2J

Gene (1)

aft

(Drosophila melanogaster)

Gene

Name: adrift

Synonyms: CG5032, EG:52C10.7, CMTr2

Source: FB:FBgn0026309

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human CMTR2 (cap methyltransferase 2).

Synonyms: CMTr2...CMTr2

Strict Orthology Symbols: cmtr2

Allele/Variant (84)

cmtr-2

(Caenorhabditis elegans)

Gene

Name: Cap MethylTRansferase homolog 2

Synonyms: Y40D12A.1, CELE_Y40D12A.1

Source: WB:WBGene00021502

Biotype: protein coding gene

Gene Synopsis: Is an ortholog of human CMTR2 (cap methyltransferase 2).

Automated Gene Synopsis: Orthologous to human CMTR2 (cap methyltransferase 2).

Strict Orthology Symbols: cmtr2

Allele/Variant (39)

mRNA (nucleoside-2'-O-)-methyltransferase activity

Gene Ontology

Source: GO:0004483

Synonyms:

S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity
mRNA (adenosine-2'-O-)-methyltransferase activity

Branch: molecular function

Genes: cmtr2 (Dre)...Cmtr2 (Mmu)...CMTR2 (Hsa)...Cmtr2 (Rno)

Genes Annotated with this GO Term (12)

7-methylguanosine mRNA capping

Gene Ontology

Source: GO:0006370

Synonyms:

5' end capping
5' mRNA capping

Branch: biological process

Genes: cmtr2 (Dre)...CMTR2 (Hsa)...Cmtr2 (Mmu)...Cmtr2 (Rno)

Genes Annotated with this GO Term (43)

aft²

(Drosophila melanogaster)

Allele/Variant

Source: FB:FBal0097081

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Gene Synonyms: CMTr2

Gene (1)

la029305Tg

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-130129-3088

Genes: cmtr2 (Dre)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Genes: cmtr2 (Dre)

Gene (1)

An essential role for Cmtr2 in mammalian embryonic development [RNA-Seq]

(Mus musculus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by MGI

ID: ArrayExpress:GSE271281

Tags: WT vs. mutant, anatomical structure, developmental stage, genotype

Summary: CMTR2 is an mRNA cap methyltransferase with poorly understood physiological functions. It catalyzes 2'-O-ribose methylation of the second transcribed nucleotide of mRNAs, potentially serving to mark RNAs as self to evade the cellular innate immune response. Here we analyze the consequences of Cmtr2 deficiency in mice. We discover that constitutive deletion of Cmtr2 results in mouse embryos that die during mid-gestation, exhibiting defects in embryo size, placental malformation and yolk sac vascularization. Endothelial cell deletion of Cmtr2 in mice results in vascular and hematopoietic defects, and perinatal lethality. Detailed characterization of the constitutive Cmtr2 KO phenotype shows an activation of the p53 pathway and decreased proliferation, but no evidence of interferon pathway activation. In summary, our study reveals the essential roles of Cmtr2 in mammalian cells beyond its immunoregulatory function. To examine the impact on gene expression in the Cmtr2 constitutive knockout embryos, we analyzed RNA sequences from E8.5 embryos that appeared morphologically similar to the wild-type littermate controls. We also sequenced embryos and yolk sacs isolated 1 day later at E9.5 where the Cmtr2-/- embryos are smaller than the littermate controls. E8.5 group contains samples from two different litters; E9.5 embryo and yolk sac groups contain samples from four different litters.

Symbol: An essential role for Cmtr2 in mammalian embryonic development [RNA-Seq]

Name: An essential role for Cmtr2 in mammalian embryonic development [RNA-Seq]

aft^M32

(Drosophila melanogaster)

Allele/Variant

Source: FB:FBal0373466

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Gene Synonyms: CMTr2

Gene (1)

aft¹

(Drosophila melanogaster)

Allele/Variant

Source: FB:FBal0097082

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Gene Synonyms: CMTr2

Gene (1)

An essential role for Cmtr2 in mammalian embryonic development [scRNA-Seq]

(Mus musculus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by MGI

ID: ArrayExpress:GSE270969

Tags: WT vs. mutant, genotype

Summary: CMTR2 is an mRNA cap methyltransferase with poorly understood physiological functions. It catalyzes 2'-O-ribose methylation of the second transcribed nucleotide of mRNAs, potentially serving to mark RNAs as self to evade the cellular innate immune response. Here we analyze the consequences of Cmtr2 deficiency in mice. We discover that constitutive deletion of Cmtr2 results in mouse embryos that die during mid-gestation, exhibiting defects in embryo size, placental malformation and yolk sac vascularization. Endothelial cell deletion of Cmtr2 in mice results in vascular and hematopoietic defects, and perinatal lethality. Detailed characterization of the constitutive Cmtr2 KO phenotype shows an activation of the p53 pathway and decreased proliferation, but no evidence of interferon pathway activation. In summary, our study reveals the essential roles of Cmtr2 in mammalian cells beyond its immunoregulatory function. To identify potential targets of Cmtr2, we performed and analyzed single-nucleus RNA sequencing (snRNA-seq) from four Cmtr2+/+ and five Cmtr2-/- E9.5 embryos from 5 different litters.

Symbol: An essential role for Cmtr2 in mammalian embryonic development [scRNA-Seq]

Name: An essential role for Cmtr2 in mammalian embryonic development [scRNA-Seq]

aft^UAS.Tag:FLAG

(Drosophila melanogaster)

Allele/Variant

Source: FB:FBal0373468

Genes: Not Available

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Constructs: UAS CMTr2:FLAG

RNA methyltransferase activity

Gene Ontology

Source: GO:0008173

Synonyms: Not Available

Branch: molecular function

Genes: CMTR2 (Hsa)

Genes Annotated with this GO Term (381)

S-adenosylmethionine-dependent methyltransferase activity

Gene Ontology

Source: GO:0008757

Synonyms:

S-adenosyl methionine-dependent methyltransferase activity
SAM-dependent methyltransferase activity

Branch: molecular function

Genes: CMTR2 (Hsa)

Genes Annotated with this GO Term (962)

methylation

Gene Ontology

Source: GO:0032259

Synonyms: Not Available

Branch: biological process

Genes: cmtr2 (Dre)...Cmtr2 (Rno)...Cmtr2 (Mmu)...CMTR2 (Hsa)

Genes Annotated with this GO Term (1256)

methyltransferase activity

Gene Ontology

Source: GO:0008168

Synonyms:

methylase

Branch: molecular function

Genes: cmtr2 (Dre)...CMTR2 (Hsa)

Genes Annotated with this GO Term (1256)

(R6)2R:17786233C>T

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786233C>T

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant

Diseases: Not Available

Variant Name: (R6)2R:17786233C>T

Gene Synonyms: CMTr2

(R6)2R:17786653T>G

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786653T>G

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: synonymous_variant

Diseases: Not Available

Variant Name: (R6)2R:17786653T>G

Gene Synonyms: CMTr2

(R6)2R:17787174T>C

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17787174T>C

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: synonymous_variant

Diseases: Not Available

Variant Name: (R6)2R:17787174T>C

Gene Synonyms: CMTr2

(R6)2R:17788018A>G

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17788018A>G

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant

Diseases: Not Available

Variant Name: (R6)2R:17788018A>G

Gene Synonyms: CMTr2

(R6)2R:17786136C>A

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786136C>A

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: 5_prime_UTR_variant

Diseases: Not Available

Variant Name: (R6)2R:17786136C>A

Gene Synonyms: CMTr2

(R6)2R:17786277T>G

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786277T>G

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: intron_variant

Diseases: Not Available

Variant Name: (R6)2R:17786277T>G

Gene Synonyms: CMTr2

(R6)2R:17788141C>T

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17788141C>T

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant

Diseases: Not Available

Variant Name: (R6)2R:17788141C>T

Gene Synonyms: CMTr2

(R6)2R:17786283C>T

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786283C>T

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: intron_variant

Diseases: Not Available

Variant Name: (R6)2R:17786283C>T

Gene Synonyms: CMTr2

(R6)2R:17786440G>C

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786440G>C

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant

Diseases: Not Available

Variant Name: (R6)2R:17786440G>C

Gene Synonyms: CMTr2

(R6)2R:17786966G>T

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786966G>T

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant

Diseases: Not Available

Variant Name: (R6)2R:17786966G>T

Gene Synonyms: CMTr2

(R6)2R:17786267T>A

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786267T>A

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: intron_variant

Diseases: Not Available

Variant Name: (R6)2R:17786267T>A

Gene Synonyms: CMTr2

(R6)2R:17786296A>G

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786296A>G

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: splice_region_variant, intron_variant

Diseases: Not Available

Variant Name: (R6)2R:17786296A>G

Gene Synonyms: CMTr2

(R6)2R:17788257G>A

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17788257G>A

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: synonymous_variant

Diseases: Not Available

Variant Name: (R6)2R:17788257G>A

Gene Synonyms: CMTr2

(R6)2R:17788353C>A

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17788353C>A

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: synonymous_variant

Diseases: Not Available

Variant Name: (R6)2R:17788353C>A

Gene Synonyms: CMTr2

(R6)2R:17788368C>T

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17788368C>T

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: synonymous_variant

Diseases: Not Available

Variant Name: (R6)2R:17788368C>T

Gene Synonyms: CMTr2

(R6)2R:17786754T>C

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786754T>C

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: intron_variant

Diseases: Not Available

Variant Name: (R6)2R:17786754T>C

Gene Synonyms: CMTr2

(R6)2R:17786935G>A

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17786935G>A

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant

Diseases: Not Available

Variant Name: (R6)2R:17786935G>A

Gene Synonyms: CMTr2

(R6)2R:17787546G>A

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17787546G>A

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: synonymous_variant

Diseases: Not Available

Variant Name: (R6)2R:17787546G>A

Gene Synonyms: CMTr2

(R6)2R:17787735A>C

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17787735A>C

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: synonymous_variant

Diseases: Not Available

Variant Name: (R6)2R:17787735A>C

Gene Synonyms: CMTr2

(R6)2R:17787737C>A

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17787737C>A

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant

Diseases: Not Available

Variant Name: (R6)2R:17787737C>A

Gene Synonyms: CMTr2

(R6)2R:17788003G>A

(Drosophila melanogaster)

Allele/Variant

Source: NT_033778.4:g.17788003G>A

Genes: aft (Dme)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant

Diseases: Not Available

Variant Name: (R6)2R:17788003G>A

Gene Synonyms: CMTr2

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