Version: 8.0.0Date: Tue Jan 28 2025
Category
coch
(Danio rerio)Gene
Name: coagulation factor C homolog, cochlin (Limulus polyphemus)
Synonyms: si:dz234g15.4
Source: ZFIN:ZDB-GENE-030616-403
Biotype: protein coding gene
Symbol: coch (Dre)
Symbol: coch
Automated Gene Synopsis: Orthologous to human COCH (cochlin).
Strict Orthology Symbols: coch
COCH
(Homo sapiens)Gene
Name: cochlin
Synonyms: COCH-5B2, COCH5B2, coagulation factor C homolog, cochlin (Limulus polyphemus), DFNA9, DFNB110
Source: HGNC:2180
Biotype: protein coding gene
Symbol: COCH (Hsa)
Symbol: COCH
Strict Orthology Symbols: coch
Coch
(Rattus norvegicus)Gene
Name: cochlin
Synonyms: coagulation factor C homolog (Limulus polyphemus), coagulation factor C homolog, cochlin (Limulus polyphemus), LOC362735
Source: RGD:1308536
Biotype: protein coding gene
Symbol: Coch (Rno)
Symbol: Coch
Gene Synopsis: Orthologous to human COCH (cochlin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene
Automated Gene Synopsis: Orthologous to human COCH (cochlin).
Strict Orthology Symbols: coch
Coch
(Mus musculus)Gene
Name: cochlin
Synonyms: AW122937, DNA segment, Chr 12, human D14S564E, D12H14S564E, Coch-5B2, expressed sequence AW122937
Source: MGI:1278313
Biotype: protein coding gene
Symbol: Coch (Mmu)
Symbol: Coch
Automated Gene Synopsis: Orthologous to human COCH (cochlin).
Strict Orthology Symbols: coch
Alleles: Coch
coch
(Xenopus tropicalis)Gene
Name: cochlin
Synonyms: coch5b2, dfna9, cochlin, coch-5b2, coch
Source: Xenbase:XB-GENE-982366
Biotype: gene
Symbol: coch
Symbol: coch (Xtr)
Automated Gene Synopsis: Orthologous to human COCH (cochlin).
Synonyms: coch...coch...coch
Strict Orthology Symbols: coch
coch.L
(Xenopus laevis)Gene
Name: cochlin
Synonyms: coch5b2, dfna9, coch.L, cochlin, coch-5b2
Source: Xenbase:XB-GENE-17340589
Biotype: gene
Symbol: coch.L (Xla)
Automated Gene Synopsis: Orthologous to human COCH (cochlin).
Strict Orthology Symbols: coch
Symbol: coch.L
coch.S
(Xenopus laevis)Gene
Name: cochlin
Synonyms: coch5b2, dfna9, cochlin, coch.S, coch-5b2
Source: Xenbase:XB-GENE-6489029
Biotype: gene
Symbol: coch.S (Xla)
Automated Gene Synopsis: Orthologous to human COCH (cochlin).
Strict Orthology Symbols: coch
Symbol: coch.S
Cochem1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7462082
Genes: Coch (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Coch
Genes: Coch (Mmu)
Symbol: Cochem1Gpt
Cochtm1.1Stw
(Mus musculus)Allele/Variant
Source: MGI:3624560
Genes: Coch (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Coch
Genes: Coch (Mmu)
Symbol: Cochtm1.1Stw
Cochem1(cre)Bcgen
(Mus musculus)Allele/Variant
Source: MGI:7461129
Genes: Coch (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Coch
Genes: Coch (Mmu)
Symbol: Cochem1(cre)Bcgen
Construct Regulatory Region: Coch (Mmu)
Constructs: Coch< construct
Cochem7Gpt
(Mus musculus)Allele/Variant
Source: MGI:7297245
Genes: Coch (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Coch
Genes: Coch (Mmu)
Symbol: Cochem7Gpt
Cochtm1Wtsi
(Mus musculus)Allele/Variant
Source: MGI:6336160
Genes: Coch (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Coch
Genes: Coch (Mmu)
Symbol: Cochtm1Wtsi
Cochtm1Stw
(Mus musculus)Allele/Variant
Source: MGI:3624559
Genes: Coch (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Coch
Genes: Coch (Mmu)
Symbol: Cochtm1Stw
Cochem1(IMPC)Ccpcz
(Mus musculus)Allele/Variant
Source: MGI:6388368
Genes: Coch (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Coch
Genes: Coch (Mmu)
Symbol: Cochem1(IMPC)Ccpcz
cochsh536/sh536
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-240215-5
Synonyms: Not Available
Symbol: coch
Genes: coch (Dre)
Name: coch
Gene Ontology
Source: GO:0090102
Synonyms: Not Available
Branch: biological process
Symbol: cochlea development
Model
Id: MGI:4880751
Synonyms: Not Available
Symbol: Coch/Coch<+> [background:] CBACa.129S1-Coch (Mmu)
Genes: Coch (Mmu)
Alleles: Coch
Name: Coch/Coch<+> [background:] CBACa.129S1-Coch
Model
Id: MGI:3630341
Synonyms: Not Available
Symbol: Coch/Coch [background:] involves: 129S1/Sv (Mmu)
Genes: Coch (Mmu)
Alleles: Coch
Name: Coch/Coch [background:] involves: 129S1/Sv
Gene Ontology
Source: GO:0099129
Synonyms: Not Available
Branch: biological process
Symbol: cochlear outer hair cell electromotile response
Gene Ontology
Source: GO:0021747
Synonyms: Not Available
Branch: biological process
Symbol: cochlear nucleus development
Cochtm1Stw/Cochtm1Stw Tmem163Tg(ACTB-cre)2Mrt/? [background:] involves: 129S1/Sv * FVB/N
(Mus musculus)Model
Id: MGI:3714194
Synonyms: Not Available
Symbol: Coch/Coch Tmem163/?
Genes: Coch (Mmu)
Alleles: Coch
Name: Coch/Coch Tmem163/? [background:] involves: 129S1/Sv * FVB/N
Cochtm1Mrtn/Coch+ [background:] CBACa.129S4-Cochtm1Mrtn
(Mus musculus)Model
Id: MGI:4880748
Synonyms: Not Available
Symbol: Coch/Coch<+> [background:] CBACa.129S4-Coch (Mmu)
Genes: Coch (Mmu)
Alleles: Coch
Name: Coch/Coch<+> [background:] CBACa.129S4-Coch
Gene Ontology
Source: GO:0098683
Synonyms: Not Available
Branch: cellular component
Symbol: cochlear hair cell ribbon synapse
Gene Ontology
Source: GO:0090103
Synonyms: Not Available
Branch: biological process
Symbol: cochlea morphogenesis
Model
Id: MGI:3814540
Synonyms: Not Available
Symbol: Coch/Coch [background:] CBACa.129S4-Coch (Mmu)
Genes: Coch (Mmu)
Alleles: Coch
Name: Coch/Coch [background:] CBACa.129S4-Coch
Model
Id: MGI:3700754
Synonyms: Not Available
Symbol: Coch/Coch [background:] involves: 129S1/Sv * C57BL/6 * CD-1 (Mmu)
Genes: Coch (Mmu)
Alleles: Coch
Name: Coch/Coch [background:] involves: 129S1/Sv * C57BL/6 * CD-1
Model
Id: MGI:4880749
Synonyms: Not Available
Symbol: Coch/Coch [background:] CBACa.129S1-Coch (Mmu)
Genes: Coch (Mmu)
Alleles: Coch
Name: Coch/Coch [background:] CBACa.129S1-Coch
Cochtm1Mrtn
(Mus musculus)Allele/Variant
Source: MGI:3814536
Genes: Coch (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: autosomal dominant nonsyndromic deafness 9
Variant Name: Not Available
Symbol: Coch
Genes: Coch (Mmu)
Symbol: Cochtm1Mrtn
C16E9.1
(Caenorhabditis elegans)Gene
Name: VWFA domain-containing protein
Synonyms: CELE_C16E9.1
Source: WB:WBGene00015865
Biotype: protein coding gene
Strict Orthology Symbols: Coch
Source: DOID:0111644
Definition: An autosomal recessive nonsyndromic deafness characterized by prelingual, bilateral hearing loss that has_material_basis_in homozygous or compound heterozygous mutation in the COCH gene on chromosome 14q12.
Genes: coch (Dre)...Coch (Rno)...Coch (Mmu)...coch (Xtr)...COCH (Hsa)
Source: DOID:0110593
Definition: An autosomal dominant nonsyndromic deafness that is characterized by postlingual onset in the second decade with high frequency progressive hearing loss and has_material_basis_in mutation in the COCH gene on chromosome 14q12.
Genes: coch (Dre)...Coch (Rno)...Coch (Mmu)...coch (Xtr)...COCH (Hsa)
Alleles: Coch
sh536
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-231113-2
Genes: coch (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: coch (Dre)
WT + MO1-coch
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-240215-6
Synonyms: Not Available
Genes: coch (Dre)
Name: WT + MO1-coch
sh535
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-231113-1
Genes: coch (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: coch (Dre)
sh556
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-231113-4
Genes: coch (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: coch (Dre)
sh555
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-231113-3
Genes: coch (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: coch (Dre)
Gene Ontology
Source: GO:0045299
Synonyms: Not Available
Branch: biological process
Genes: coch (Dre)
Source: DOID:13490
Definition: Not Available
Symbol: active cochleovestibular Meniere's disease
Source: DOID:13492
Definition: Not Available
Symbol: active cochlear Meniere's disease
Rat Normal Cochlear Nucleus
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE3628
Tags: unclassified
Summary: Keywords: normal, comparative
Symbol: Rat Normal Cochlear Nucleus
Ikzf2/helios mutant cochlear RNA-seq analysis
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE116702
Tags: WT vs. mutant, genotype
Summary: Given the potential role of the helios transcription factor in postnatal outer hair cell gene regulation indicated by our RiboTag translatome analyses, our next goal was to identify and validate genes that are regulated by helios in outer hair cells by performing RNA-seq on P8 cello mutant animals compared to wild-type littermates. Difference in cochlear gene expression between wild-type Ikzf2+/+ animals and mutant Ikzf2cello/cello littermates was analyzed by RNA-seq in biological duplicates.
Symbol: Ikzf2/helios mutant cochlear RNA-seq analysis
Gene Ontology
Source: GO:0021748
Synonyms: Not Available
Branch: biological process
Symbol: dorsal cochlear nucleus development
Gene Ontology
Source: GO:0021749
Synonyms: Not Available
Branch: biological process
Symbol: ventral cochlear nucleus development
Gene Ontology
Source: GO:0110078
Synonyms:
- TELO2-TTI1-TTI2
- TTT complex
Branch: cellular component
Symbol: TTT Hsp90 cochaperone complex
Transcriptional profiling of cochlear neurons
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE114759
Tags: baseline
Summary: In order to characterize the various subpopulations of neurons present in the inner ear, we dissected out the cochleas from wild-type mice, removing non-neuronal populations as possible, then dissociated the tissue to obtain a single cell suspension and profiled these by single cell RNA-Seq. This study's goal was to characterize the native populations of murine cochlear neurons. To ensure reproducibility of our findings, neurons from 4 separate mice were profiled.
Symbol: Transcriptional profiling of cochlear neurons
scRNA-seq of P2 mouse cochlea
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE135737
Tags: baseline
Summary: Age-related hearing impairment (ARHI), one of the most common medical conditions, is strongly heritable, yet its genetic causes remain largely unknown. We conducted a meta-analysis of GWAS summary statistics from multiple hearing-related traits in the UK Biobank (n = up to 323,978) and identified 31 genome-wide significant risk loci for self-reported hearing difficulty (p < 5e-8), of which 30 have not been reported previously at genome-wide significance. We interpreted these loci in the context of newly generated ATAC-seq and single-cell RNA-seq from cells in the mouse cochlea. Risk-associated genes were enriched for expression in cochlear epithelial and non-epithelial cells, as well as for genes related to sensory perception and known Mendelian deafness genes, supporting their relevance to auditory function. Regions of the human genome homologous to open chromatin in sensory epithelial cells from the mouse were strongly enriched for heritable risk for hearing difficulty, even after adjusting for baseline effects of evolutionary conservation and cell-type non-specific regulatory regions. Epigenomic and statistical fine-mapping most strongly supported 50 putative risk genes. Of these, at least 45 were expressed in mouse cochlea and 15 were enriched specifically in sensory hair cells. These results reveal new risk loci and risk genes for hearing difficulty and suggest an important role for altered gene regulation in the cochlear sensory epithelium. Examination of expression patterns of genes expressed in day 2 mouse cochlea.
Symbol: scRNA-seq of P2 mouse cochlea
scRNA-seq of P20 mouse cochlea
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE181454
Tags: baseline
Summary: ARHL has been thought to result from disordered hair cell function and their loss. ARHL has a significant genetic component. We sought to determine the expression in the cochlea of genes associated with single nucleotide polymorphisms linked to ARHL. We find widespread and varying expression of genes associated with these SNPs in subtypes of cells in the cochlea identified by single-cell RNA sequencing. Genes associated with SNPs with the highest significance were preferentially expressed highly in hair cells while genes associated with SNPs with a lower significance were expressed more universally. Examination of expression patterns of genes expressed in day 20 mouse cochlea.
Symbol: scRNA-seq of P20 mouse cochlea
Postnatal Development of Mouse Cochlear Nucleus
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE2390
Tags: baseline, age
Summary: Developmental differences in gene expression in the postnatal mouse cochlear nucleus was analyzed at two or three ages using two different array platforms, the Affymetrix Mouse 430A GeneChip or the NIA 15K mouse cDNA microarray. These ages, P7, P14, and P21 parallel a critical period of neuron survival dependent on input from the auditory nerve. Keywords: parallel sample Comparison of baseline gene expression in the CN at P7, P14, and P21 using Affymetrix 430A chips or NIA 15K cDNA mouse array. For Affy chips, 3 replicates were done at P7 and P21, 2 replicates at P14. For NIA arrays, 5 replicates were done comparing P7 and P21. There was one dye flip included.
Symbol: Postnatal Development of Mouse Cochlear Nucleus
Bl6 Ndp-KO systemic gene therapy whole cochlea samples
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-MTAB-12703
Tags: WT vs. mutant, genotype
Summary: We aimed to identify the effect of an AAV-based NDP gene therapy for Norrie disease. This therapy was tested on an Ndp-KO mouse model previously shown to recapitulate Norrie cochlear phenotype (Bryant et al 2022, PMID 35132964). We used transcriptomic analysis of whole cochlea lysates to determine the effect of this therapy on pathology related genes and downstream targets of Norrin signalling. Mice were treated at postnatal day 2 and cochleas collected for analysis at 2 months old.
Symbol: Bl6 Ndp-KO systemic gene therapy whole cochlea samples