8,800 results for dchs2

DCHS2

(Homo sapiens)
Gene
Name: dachsous cadherin-related 2
Synonyms: dachsous-like, protocadherin protein PCDHJ, cadherin-like protein CDHJ, dachsous 2, cadherin-like protein VR8, cadherin-like 27, PCDH23, cadherin-27, protocadherin 23, protein dachsous homolog 2, cadherin-related family member 7, protocadherin protein CDHJ, PCDHJ, protocadherin PCDHJ, FLJ20047, protocadherin J, protocadherin-23, CDHJ, CDHR7, CDH27, cadherin J
Source: HGNC:23111
Biotype: protein coding gene
Symbol: DCHS2 (Hsa)
Symbol: DCHS2
Strict Orthology Symbols: dchs2

dchs2

(Danio rerio)
Gene
Name: dachsous cadherin-related 2
Synonyms: si:dkey-30k22.7
Source: ZFIN:ZDB-GENE-150311-2
Biotype: protein coding gene
Symbol: dchs2 (Dre)
Symbol: dchs2
Automated Gene Synopsis: Orthologous to human DCHS2 (dachsous cadherin-related 2).
Strict Orthology Symbols: dchs2

Dchs2

(Rattus norvegicus)
Gene
Name: dachsous cadherin-related 2
Synonyms: similar to dachsous 2 isoform 1, dachsous 2 (Drosophila), LOC310550, dachsous 2, protocadherin-23, RGD1563329, protocadherin-23-like
Source: RGD:1563329
Biotype: protein coding gene
Symbol: Dchs2 (Rno)
Symbol: Dchs2
Gene Synopsis: Orthologous to human DCHS2 (dachsous cadherin-related 2); INTERACTS WITH bisphenol A; glyphosate; (+)
Automated Gene Synopsis: Orthologous to human DCHS2 (dachsous cadherin-related 2).
Strict Orthology Symbols: dchs2

Dchs2

(Mus musculus)
Gene
Name: dachsous cadherin related 2
Synonyms: LOC229459, gene model 417, (NCBI), Gm417, RGD1563329
Source: MGI:2685263
Biotype: protein coding gene
Symbol: Dchs2 (Mmu)
Symbol: Dchs2
Automated Gene Synopsis: Orthologous to human DCHS2 (dachsous cadherin-related 2).
Strict Orthology Symbols: dchs2
Alleles: Dchs2 (Mmu)...Dchs2 (Mmu)...Dchs2 (Mmu)...Dchs2 (Mmu)...Dchs2 (Mmu)

dchs2

(Xenopus tropicalis)
Gene
Name: dachsous cadherin-related 2
Synonyms: dchs2, dachsous cadherin-related 2, pcdh23, LOC108704336, pcdhj, protocadherin-23, cadherin-27, cdhj, cdh27, cdhr7
Source: Xenbase:XB-GENE-6048959
Biotype: gene
Symbol: dchs2
Symbol: dchs2 (Xtr)
Automated Gene Synopsis: Orthologous to human DCHS2 (dachsous cadherin-related 2).
Synonyms: dchs2...dchs2...dchs2
Strict Orthology Symbols: dchs2

dchs2.L

(Xenopus laevis)
Gene
Name: dachsous cadherin-related 2
Synonyms: pcdh23, dachsous cadherin-related 2, LOC108704336, protocadherin-23, pcdhj, dchs2.L, cadherin-27, cdhj, cdhr7, cdh27
Source: Xenbase:XB-GENE-17333160
Biotype: gene
Symbol: dchs2.L (Xla)
Automated Gene Synopsis: Orthologous to human DCHS2 (dachsous cadherin-related 2).
Strict Orthology Symbols: dchs2
Symbol: dchs2.L

dchs2.S

(Xenopus laevis)
Gene
Name: dachsous cadherin-related 2
Synonyms: dchs2.S, pcdh23, dachsous cadherin-related 2, LOC108704336, protocadherin-23, pcdhj, cadherin-27, cdhj, cdh27, cdhr7
Source: Xenbase:XB-GENE-17333161
Biotype: gene
Symbol: dchs2.S (Xla)
Automated Gene Synopsis: Orthologous to human DCHS2 (dachsous cadherin-related 2).
Strict Orthology Symbols: dchs2
Symbol: dchs2.S

Dchs2tm1.1Hmd

(Mus musculus)
Allele/Variant
Source: MGI:7367199
Genes: Dchs2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Dchs2 (Mmu)
Genes: Dchs2 (Mmu)
Symbol: Dchs2tm1.1Hmd

Dchs2em2Hmd

(Mus musculus)
Allele/Variant
Source: MGI:7314315
Genes: Dchs2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Dchs2 (Mmu)
Genes: Dchs2 (Mmu)
Symbol: Dchs2em2Hmd

Dchs2tm1.2Fhel

(Mus musculus)
Allele/Variant
Source: MGI:5700381
Genes: Dchs2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Dchs2 (Mmu)
Genes: Dchs2 (Mmu)
Symbol: Dchs2tm1.2Fhel

Dchs2em2Cya

(Mus musculus)
Allele/Variant
Source: MGI:7792989
Genes: Dchs2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Dchs2 (Mmu)
Genes: Dchs2 (Mmu)
Symbol: Dchs2em2Cya

Dchs2tm1.2Hmd

(Mus musculus)
Allele/Variant
Source: MGI:7314314
Genes: Dchs2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Dchs2 (Mmu)
Genes: Dchs2 (Mmu)
Symbol: Dchs2tm1.2Hmd

Dchs2em1Cya

(Mus musculus)
Allele/Variant
Source: MGI:7792988
Genes: Dchs2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Dchs2 (Mmu)
Genes: Dchs2 (Mmu)
Symbol: Dchs2em1Cya

dchs2stl1/+ (AB)

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-160809-5
Synonyms: Not Available
Symbol: dchs2 (AB) (Dre)
Genes: dchs2 (Dre)
Name: dchs2 (AB)

dchs2stl1/stl1

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-151228-3
Synonyms: Not Available
Symbol: dchs2 (Dre)
Genes: dchs2 (Dre)
Name: dchs2

cdh-1

(Caenorhabditis elegans)
Gene
Name: CaDHerin family 1
Synonyms: R10F2.1, CELE_R10F2.1
Source: WB:WBGene00019994
Biotype: protein coding gene
Strict Orthology Symbols: dchs2

ds

(Drosophila melanogaster)
Gene
Name: dachsous
Synonyms: lethal (2) 01855, cad2, l(2)01855, Dachsous, CG17941, cadherin-2, EP-822, CT39575, l(2)05142, Daschous, Ds, DS
Source: FB:FBgn0284247
Biotype: protein coding gene
Strict Orthology Symbols: dchs2

cdh-3

(Caenorhabditis elegans)
Gene
Name: CaDHerin family 3
Synonyms: CELE_ZK112.7, ZK112.7
Source: WB:WBGene00000395
Biotype: protein coding gene
Strict Orthology Symbols: dchs2

Source: GO:0072137
Synonyms: Not Available
Branch: biological process
Genes: Dchs2 (Mmu)...Dchs2 (Rno)...DCHS2 (Hsa)

Id: ZFIN:ZDB-FISH-151228-2
Synonyms: Not Available
Genes: dchs2 (Dre)
Name: dchs1b; dchs2
Symbol: dchs1b; dchs2 (Dre)

Gene Ontology
Source: GO:0072006
Synonyms:
  • nephrogenesis
Branch: biological process
Genes: Dchs2 (Rno)...Dchs2 (Mmu)...DCHS2 (Hsa)

WT + MO1-dchs2

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-150901-2926
Synonyms: Not Available
Genes: dchs2 (Dre)
Name: WT + MO1-dchs2

Model
Id: ZFIN:ZDB-FISH-150901-4243
Synonyms: Not Available
Genes: dchs2 (Dre)
Name: ir1040Tg + MO2-dchs2 (AB)

Model
Id: ZFIN:ZDB-FISH-150901-7842
Synonyms: Not Available
Genes: dchs2 (Dre)
Name: rerea + MO1-dchs2

Model
Id: ZFIN:ZDB-FISH-150901-17829
Synonyms: Not Available
Genes: dchs2 (Dre)
Name: ir1040Tg + MO1-dchs2 (AB)

Id: ZFIN:ZDB-FISH-150901-9729
Synonyms: Not Available
Genes: dchs2 (Dre)
Name: rerea + MO1-dchs2

Source: GO:0060536
Synonyms: Not Available
Branch: biological process
Genes: dchs2 (Dre)

High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-70452, GEO:GSE70452
Tags: WT vs. mutant, genotype
Summary: Regulation of the balance between progenitor self-renewal and differentiation is critical to development. In the mammalian kidney, reciprocal signaling between three lineages (stromal, mesenchymal and ureteric) ensures correct nephron progenitor self-renewal and differentiation. Loss of either the atypical cadherin Fat4 or its ligand Dachsous1 (Dchs1) results in expansion of the mesenchymal nephron progenitor pool, called the condensing mesenchyme (CM). This has been proposed to be due to misregulation of the Hippo kinase pathway transcriptional co-activator YAP. Here, we use tissue-specific deletions to prove that Fat4 acts non-autonomously in the renal stroma to control nephron progenitors. We show that loss of Yap from the CM in a Fat4-null background does not reduce the expanded CM, indicating Fat4 regulates the CM independent of YAP. Analysis of Six2-/-;Fat4-/- double mutants demonstrates that excess progenitors in Fat4 mutants are dependent on Six2, a critical regulator of nephron progenitor self-renewal. Electron microscopy reveals that cell organization is disrupted in Fat4 mutants. Gene expression analysis demonstrates that the expression of Notch and FGF pathway components are altered in Fat4 mutants. Finally, we show that Dchs1, and its paralog Dchs2 function in a partially redundant fashion to regulate the number of nephron progenitors. Our data supports a model in which FAT4 in the stroma binds to DCHS1/2 in the CM to restrict progenitor self-renewal. A total of 3 Fat4-/- mutant embryos and 3 wildtype (Fat4+/+) control embryos were examined. Two kidneys from each embryo was used thereby yielding a total of 6 Fat4-/- mutant kidneys and 6 Fat4+/+ wildype kidneys. All kidneys examined were at E13.5.

Source: GO:0007156
Synonyms: Not Available
Branch: biological process
Genes: dchs2 (Dre)...DCHS2 (Hsa)...Dchs2 (Rno)

Gene Ontology
Source: GO:0098609
Synonyms:
  • single organismal cell-cell adhesion
Branch: biological process
Genes: dchs2 (Dre)...Dchs2 (Mmu)

Gene Ontology
Source: GO:0007155
Synonyms:
  • cell adhesion molecule activity
  • single organism cell adhesion
Branch: biological process
Genes: dchs2 (Dre)...Dchs2 (Rno)...DCHS2 (Hsa)

Disease
Source: DOID:9970
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Genes: Dchs2 (Rno)...Dchs2 (Mmu)...DCHS2 (Hsa)...dchs2 (Xtr)...dchs2 (Dre)

Gene Ontology
Source: GO:0005911
Synonyms:
  • cell-cell contact region
  • cell-cell contact zone
Branch: cellular component
Genes: Dchs2 (Mmu)

sa39615

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-160601-6018
Genes: dchs2 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: dchs2 (Dre)

Gene Ontology
Source: GO:0005509
Synonyms:
  • calcium ion storage activity
Branch: molecular function
Genes: Dchs2 (Rno)...Dchs2 (Mmu)...DCHS2 (Hsa)...dchs2 (Dre)

sa19502

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-131217-14741
Genes: dchs2 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: dchs2 (Dre)

sa19501

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-161003-20132
Genes: dchs2 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: dchs2 (Dre)

sa9493

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-130411-5113
Genes: dchs2 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: dchs2 (Dre)

stl1

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-151228-4
Genes: dchs2 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: dchs2 (Dre)

Gene Ontology
Source: GO:0005886
Synonyms:
  • bacterial inner membrane
  • cell membrane
Branch: cellular component
Genes: Dchs2 (Rno)...DCHS2 (Hsa)...dchs2 (Dre)

Allele/Variant
Source: rs201027235
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154490082C>A

Allele/Variant
Source: rs199621086
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154490569G>A

Allele/Variant
Source: rs17373874
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154490787A>C

Allele/Variant
Source: rs780799959
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154491175C>T

Allele/Variant
Source: rs13149269
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154491312C>T

Allele/Variant
Source: rs72731016
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154489579G>C

Allele/Variant
Source: rs562496396
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154490422C>T

Allele/Variant
Source: rs114469698
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154298636C>A

Allele/Variant
Source: rs28622098
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154304869C>T

Allele/Variant
Source: rs111557030
Genes: DCHS2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:154328137G>A