Version: 8.0.0
Date: Tue Jan 28 2025
7,281 results for greb1l

GREB1L

(Homo sapiens)
Gene
Name: GREB1 like retinoic acid receptor coactivator
Synonyms: DFNA80, C18orf6, RHDA3, growth regulation by estrogen in breast cancer-like, GREB1-like protein, growth regulation by estrogen in breast cancer 1 like, KIAA1772
Source: HGNC:31042
Biotype: protein coding gene
Symbol: GREB1L (Hsa)
Symbol: GREB1L
Strict Orthology Symbols: greb1l

greb1l

(Danio rerio)
Gene
Name: GREB1 like retinoic acid receptor coactivator
Synonyms: wu:fc55e03, si:dkey-203o21.1, wu:fc65f09, si:dkey-264l15.1, fc65f09
Source: ZFIN:ZDB-GENE-030131-4022
Biotype: protein coding gene
Symbol: greb1l (Dre)
Symbol: greb1l
Automated Gene Synopsis: Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator).
Strict Orthology Symbols: greb1l

Greb1l

(Rattus norvegicus)
Gene
Name: GREB1 like retinoic acid receptor coactivator
Synonyms: similar to GREB1 protein isoform a, LOC498819, growth regulation by estrogen in breast cancer-like, growth regulation by estrogen in breast cancer 1 like, RGD1562371
Source: RGD:1562371
Biotype: protein coding gene
Symbol: Greb1l (Rno)
Symbol: Greb1l
Gene Synopsis: Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator); INTERACTS WITH 1,1,1-trichloro
Automated Gene Synopsis: Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator).
Strict Orthology Symbols: greb1l

Greb1l

(Mus musculus)
Gene
Name: growth regulation by estrogen in breast cancer-like
Synonyms: AK220484, mKIAA4095, cDNA sequence AK220484, RGD1562371
Source: MGI:3576497
Biotype: protein coding gene
Symbol: Greb1l (Mmu)
Symbol: Greb1l
Automated Gene Synopsis: Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator).
Strict Orthology Symbols: greb1l
Alleles: Greb1l (Mmu)...Greb1l (Mmu)...Greb1l (Mmu)...Greb1l (Mmu)

greb1l

(Xenopus tropicalis)
Gene
Name: GREB1 like retinoic acid receptor coactivator
Synonyms: GREB1 like retinoic acid receptor coactivator, greb1l, LOC108719216, LOC108695263
Source: Xenbase:XB-GENE-5965356
Biotype: gene
Symbol: greb1l
Symbol: greb1l (Xtr)
Automated Gene Synopsis: Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator).
Synonyms: greb1l...greb1l...greb1l
Strict Orthology Symbols: greb1l

GREB1L-DT

(Homo sapiens)
Gene
Name: GREB1L divergent transcript
Synonyms: uncharacterized LOC101927496, LOC101927496
Source: HGNC:55323
Biotype: ncRNA gene
Symbol: GREB1L-DT (Hsa)
Symbol: GREB1L-DT

Greb1lem1Cjea

(Mus musculus)
Allele/Variant
Source: MGI:6117871
Genes: Greb1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Greb1l (Mmu)
Genes: Greb1l (Mmu)
Symbol: Greb1lem1Cjea

Greb1lem6Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7299870
Genes: Greb1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Greb1l (Mmu)
Genes: Greb1l (Mmu)
Symbol: Greb1lem6Gpt

Greb1lem2Cjea

(Mus musculus)
Allele/Variant
Source: MGI:7544906
Genes: Greb1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Greb1l (Mmu)
Genes: Greb1l (Mmu)
Symbol: Greb1lem2Cjea

Greb1lem1(IMPC)J

(Mus musculus)
Allele/Variant
Source: MGI:5812878
Genes: Greb1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Greb1l (Mmu)
Genes: Greb1l (Mmu)
Symbol: Greb1lem1(IMPC)J

greb1lrdu1000/rdu1000

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-180605-18
Synonyms: Not Available
Symbol: greb1l (Dre)
Genes: greb1l (Dre)
Name: greb1l

greb1lsa1657/sa1657 (TL)

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-150901-8629
Synonyms: Not Available
Symbol: greb1l (TL) (Dre)
Genes: greb1l (Dre)
Name: greb1l (TL)

greb1lsa1260/sa1260

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-171025-7
Synonyms: Not Available
Symbol: greb1l (Dre)
Genes: greb1l (Dre)
Name: greb1l

Greb1lem1(IMPC)J/Greb1lem1(IMPC)J [background:] C57BL/6NJ-Greb1lem1(IMPC)J/Mmjax

(Mus musculus)
Model
Id: MGI:6262577
Synonyms: Not Available
Symbol: Greb1l/Greb1l [background:] C57BL/6NJ-Greb1l/Mmjax (Mmu)
Genes: Greb1l (Mmu)
Alleles: Greb1l (Mmu)
Name: Greb1l/Greb1l [background:] C57BL/6NJ-Greb1l/Mmjax

Greb1lem1Cjea/Greb1l+ [background:] involves: C57BL/6J

(Mus musculus)
Model
Id: MGI:6163484
Synonyms: Not Available
Symbol: Greb1l/Greb1l<+> [background:] involves: C57BL/6J (Mmu)
Genes: Greb1l (Mmu)
Alleles: Greb1l (Mmu)
Name: Greb1l/Greb1l<+> [background:] involves: C57BL/6J

greb1lsa16374/sa16374

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-190114-1
Synonyms: Not Available
Symbol: greb1l (Dre)
Genes: greb1l (Dre)
Name: greb1l

greb1lsa1260/sa1260 (TL)

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-150901-26787
Synonyms: Not Available
Symbol: greb1l (TL) (Dre)
Genes: greb1l (Dre)
Name: greb1l (TL)

greb1lsa17608/sa17608

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-190319-7
Synonyms: Not Available
Symbol: greb1l (Dre)
Genes: greb1l (Dre)
Name: greb1l

Greb1lem1Cjea/Greb1lem1Cjea [background:] involves: C57BL/6J

(Mus musculus)
Model
Id: MGI:6163481
Synonyms: Not Available
Symbol: Greb1l/Greb1l [background:] involves: C57BL/6J (Mmu)
Genes: Greb1l (Mmu)
Alleles: Greb1l (Mmu)
Name: Greb1l/Greb1l [background:] involves: C57BL/6J

Greb1lem1(IMPC)J/Greb1l+ [background:] C57BL/6NJ-Greb1lem1(IMPC)J/Mmjax

(Mus musculus)
Model
Id: MGI:6262576
Synonyms: Not Available
Symbol: Greb1l/Greb1l<+> [background:] C57BL/6NJ-Greb1l/Mmjax (Mmu)
Genes: Greb1l (Mmu)
Alleles: Greb1l (Mmu)
Name: Greb1l/Greb1l<+> [background:] C57BL/6NJ-Greb1l/Mmjax

autosomal dominant nonsyndromic deafness 80

Disease
Source: DOID:0070602
Definition: An autosomal dominant nonsyndromic deafness characterized by congenital deafness associated with absent or malformed cochleae and eighth cranial nerves that has_material_basis_in heterozygous mutation in the GREB1L gene on chromosome 18q11.
Genes: GREB1L (Hsa)...Greb1l (Rno)...Greb1l (Mmu)...greb1l (Dre)...greb1l (Xtr)

renal agenesis

Disease
Source: DOID:14766
Definition: A renal disease that is characterized by the failure of one or both kidneys to develop.
Genes: GREB1L (Hsa)...greb1l (Xtr)...greb1l (Dre)...Greb1l (Mmu)...Greb1l (Rno)

paramesonephric duct development

Gene Ontology
Source: GO:0061205
Synonyms:
  • Mullerian duct development
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)

epithelial tube morphogenesis

Gene Ontology
Source: GO:0060562
Synonyms: Not Available
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)

mesonephric duct development

Gene Ontology
Source: GO:0072177
Synonyms:
  • Wolffian duct development
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)

WT + MO1-greb1l

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-171025-10
Synonyms: Not Available
Genes: greb1l (Dre)
Name: WT + MO1-greb1l

EKW + MO2-greb1l

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-180605-19
Synonyms: Not Available
Genes: greb1l (Dre)
Name: EKW + MO2-greb1l

cardiac ventricle development

Gene Ontology
Source: GO:0003231
Synonyms: Not Available
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)

WT + CRISPR1-greb1l

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-171025-9
Synonyms: Not Available
Genes: greb1l (Dre)
Name: WT + CRISPR1-greb1l

uterus development

Gene Ontology
Source: GO:0060065
Synonyms:
  • Mullerian tract development
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)

male genitalia development

Gene Ontology
Source: GO:0030539
Synonyms:
  • male genital development
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)

Torsion of the heart tube by shortage of progenitor cells: identification of Greb1l as a genetic determinant of criss-cross hearts in mice

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE199647
Tags: WT vs. mutant, genotype
Summary: Despite their burden and impact, most congenital defects remain poorly understood by lack of knowledge of the embryological mechanisms. Here, we identify Greb1l mutants as the first mouse model of criss-cross heart. Based on 3D quantifications of shape changes, we demonstrate that torsion of the atrioventricular canal occurs together with supero-inferior ventricles at E10.5, after heart looping. Mutants phenocopy specific features of partial deficiency in retinoic acid signalling, suggesting that GREB1L is a novel modulator of this signalling. Spatio-temporal gene mapping and cross-correlated transcriptomic analyses further reveal the role of Greb1l in maintaining a pool of precursor cells during heart tube elongation, by controlling ribosome biogenesis and cell differentiation. Growth arrest and malposition of the outflow tract are predictive of abnormal tube remodelling in mutants. Our work on a rare cardiac malformation opens novel perspectives on the origin of a broader spectrum of congenital defects associated with GREB1L in humans. Transcriptomic analysis of the microdissected cardiac region at E8.5 of two Greb1l mutant mouse lines (G3 and G17), 4 mutants and 4 control littermates each.
Symbol: Torsion of the heart tube by shortage of progenitor cells: identification of Greb1l as a genetic determinant
Name: Torsion of the heart tube by shortage of progenitor cells: identification of Greb1l as a genetic determinant

metanephros development

Gene Ontology
Source: GO:0001656
Synonyms: Not Available
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)

morphogenesis of an epithelium

Gene Ontology
Source: GO:0002009
Synonyms:
  • epithelium morphogenesis
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)...greb1l (Dre)

branching involved in ureteric bud morphogenesis

Gene Ontology
Source: GO:0001658
Synonyms:
  • ureteric bud branching
Branch: biological process
Genes: GREB1L (Hsa)...Greb1l (Mmu)...Greb1l (Rno)

pronephros development

Gene Ontology
Source: GO:0048793
Synonyms:
  • pronephric kidney development
Branch: biological process
Genes: greb1l (Dre)

kidney development

Gene Ontology
Source: GO:0001822
Synonyms:
  • nephrogenesis
Branch: biological process
Genes: Greb1l (Rno)...Greb1l (Mmu)...GREB1L (Hsa)...greb1l (Dre)

sa1657

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-120411-233
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

sa19691

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-131217-14854
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

rdu1000

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-180605-6
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: deletion
Molecular Consequence: frameshift_variant
Diseases: renal agenesis
Variant Name: Not Available
Genes: greb1l (Dre)

sa32856

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-161003-14708
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

sa5124

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-161003-17640
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

sa17608

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-131217-13709
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

sa1260

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-120411-60
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

sa14368

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-131217-12731
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: splice_donor_variant
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

sa25771

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-161003-12637
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

sa16374

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-130411-4849
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

sa16854

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-131217-13029
Genes: greb1l (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: greb1l (Dre)

molecular_function

Gene Ontology
Source: GO:0003674
Synonyms:
  • molecular function
Branch: molecular function
Genes: Greb1l (Mmu)

(GRCh38)18:21395403A>G

(Homo sapiens)
Allele/Variant
Source: rs1479687090
Genes: GREB1L (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)18:21395403A>G