Version: 8.1.0Date: Fri Apr 18 2025
Category
HECW2
(Homo sapiens)Gene
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: DKFZp686M17164, NEDD4-related E3 ubiquitin ligase NEDL2, NDHSAL, E3 ubiquitin-protein ligase HECW2, NEDL2, NEDD4-like E3 ubiquitin-protein ligase 2, HECT-type E3 ubiquitin transferase HECW2, HECT, C2 and WW domain-containing protein 2
Source: HGNC:29853
Biotype: protein coding gene
Symbol: HECW2 (Hsa)
Symbol: HECW2
Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
Strict Orthology Symbols: hecw2a...hecw2b...Hecw2
Hecw2
(Rattus norvegicus)Gene
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: LOC316395, E3 ubiquitin-protein ligase HECW2, similar to HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 isoform 1
Source: RGD:1593244
Biotype: protein coding gene
Symbol: Hecw2 (Rno)
Symbol: Hecw2
Gene Synopsis: Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2); INTERACTS
Automated Gene Synopsis: Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2).
Synonyms: E3 ubiquitin-protein ligase HECW2
Strict Orthology Symbols: hecw2a...HECW2...hecw2b...Hecw2
Hecw2
(Mus musculus)Gene
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: RIKEN cDNA D030049F17 gene, D030049F17Rik, gene model 971, (NCBI), mKIAA1301, Gm971, Nedl2, RIKEN cDNA A730039N16 gene, A730039N16Rik
Source: MGI:2685817
Biotype: protein coding gene
Symbol: Hecw2 (Mmu)
Symbol: Hecw2
Automated Gene Synopsis: Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2).
Strict Orthology Symbols: hecw2a...HECW2...hecw2b...Hecw2
Alleles: Hecw2
hecw2a
(Danio rerio)Gene
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
Synonyms: si:dkey-191g15.6, hecw2, nedl2a
Source: ZFIN:ZDB-GENE-090311-22
Biotype: protein coding gene
Symbol: hecw2a (Dre)
Automated Gene Synopsis: Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2).
Synonyms: hecw2...hecw2...hecw2
Strict Orthology Symbols: HECW2...Hecw2
Symbol: hecw2a
hecw2b
(Danio rerio)Gene
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b
Synonyms: nedl2b
Source: ZFIN:ZDB-GENE-101001-3
Biotype: protein coding gene
Symbol: hecw2b (Dre)
Automated Gene Synopsis: Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2).
Strict Orthology Symbols: HECW2...Hecw2
Symbol: hecw2b
HECW2-AS1
(Homo sapiens)Gene
Name: HECW2 antisense RNA 1
Synonyms: Not Available
Source: HGNC:54062
Biotype: ncRNA gene
Symbol: HECW2-AS1 (Hsa)
Symbol: HECW2-AS1
Hecw2em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7300206
Genes: Hecw2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hecw2
Genes: Hecw2 (Mmu)
Symbol: Hecw2em1Gpt
Hecw2tm1.1Fhe
(Mus musculus)Allele/Variant
Source: MGI:6720293
Genes: Hecw2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hecw2
Genes: Hecw2 (Mmu)
Symbol: Hecw2tm1.1Fhe
Hecw2Gt(IST12103C8)Tigm
(Mus musculus)Allele/Variant
Source: MGI:4041575
Genes: Hecw2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hecw2
Genes: Hecw2 (Mmu)
Symbol: Hecw2Gt(IST12103C8)Tigm
Hecw2em1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7290195
Genes: Hecw2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hecw2
Genes: Hecw2 (Mmu)
Symbol: Hecw2em1Smoc
Hecw2tm1a(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4441860
Genes: Hecw2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hecw2
Genes: Hecw2 (Mmu)
Symbol: Hecw2tm1a(EUCOMM)Wtsi
Hecw2tm1.2Fhe
(Mus musculus)Allele/Variant
Source: MGI:6720295
Genes: Hecw2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hecw2
Genes: Hecw2 (Mmu)
Symbol: Hecw2tm1.2Fhe
Model
Id: MGI:6720335
Synonyms: Not Available
Symbol: Hecw2/Hecw2 [background:] involves: C57BL/6J (Mmu)
Genes: Hecw2 (Mmu)
Alleles: Hecw2
Name: Hecw2/Hecw2 [background:] involves: C57BL/6J
Hecw2tm1a(EUCOMM)Wtsi/Hecw2tm1a(EUCOMM)Wtsi [background:] C57BL/6N-Hecw2tm1a(EUCOMM)Wtsi/Wtsi
(Mus musculus)Model
Id: MGI:5700914
Synonyms: Not Available
Symbol: Hecw2/Hecw2 [background:] C57BL/6N-Hecw2/Wtsi
Genes: Hecw2 (Mmu)
Alleles: Hecw2
Name: Hecw2/Hecw2 [background:] C57BL/6N-Hecw2/Wtsi
hecw-1
(Caenorhabditis elegans)Gene
Name: HECT, C2 and WW domain-containing ubiquitin ligase 1
Synonyms: F45H7.6, CELE_F45H7.6
Source: WB:WBGene00009738
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) and HECW2
Strict Orthology Symbols: hecw2a...HECW2...hecw2b...Hecw2
Hecw
(Drosophila melanogaster)Gene
Name: Hecw ubiquitin protein ligase
Synonyms: CG3003, CG3099, BT058014.1, CG42797
Source: FB:FBgn0261931
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) and HECW2
Strict Orthology Symbols: hecw2a...HECW2...hecw2b...Hecw2
rw0Tg + MO2-hecw2a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-220616-4
Synonyms: Not Available
Genes: hecw2a (Dre)
AB + MO2-hecw2a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-220616-2
Synonyms: Not Available
Genes: hecw2a (Dre)
AB + MO1-hecw2a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-220616-1
Synonyms: Not Available
Genes: hecw2a (Dre)
AB + MO1-hecw2a + MO4-tp53
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-220616-3
Synonyms: Not Available
Genes: hecw2a (Dre)
RSP5
(Saccharomyces cerevisiae)Gene
Name: Reverses Spt- Phenotype
Synonyms: UBY1, MUT2, HPG1, SMM1, YER125W, MDP1, NPI1
Source: SGD:S000000927
Biotype: protein coding gene
Strict Orthology Symbols: HECW2
Gene Ontology
Source: GO:0048814
Synonyms: Not Available
Branch: biological process
Genes: Hecw2 (Mmu)...hecw2a (Dre)...Hecw2 (Rno)...hecw2b (Dre)...HECW2 (Hsa)
Gene Ontology
Source: GO:0030071
Synonyms: Not Available
Branch: biological process
Genes: Hecw2 (Mmu)...HECW2 (Hsa)...Hecw2 (Rno)
Disease
Source: DOID:0050477
Definition: A renal tubular transport disease that is characterized by hypertension and hypokalemia caused by dysregulation of epithelial sodium channels causing over expression of the channel.
Genes: HECW2 (Hsa)
Gene Ontology
Source: GO:0072686
Synonyms: Not Available
Branch: cellular component
Genes: Hecw2 (Mmu)...HECW2 (Hsa)...Hecw2 (Rno)
Gene Ontology
Source: GO:0006511
Synonyms:
- myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown
- myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process
Branch: biological process
Genes: HECW2 (Hsa)...Hecw2 (Rno)...Hecw2 (Mmu)...hecw2b (Dre)...hecw2a (Dre)
Gene Ontology
Source: GO:0004842
Synonyms:
- E2
- E3
Branch: molecular function
Genes: HECW2 (Hsa)...Hecw2 (Mmu)...hecw2b (Dre)...hecw2a (Dre)
Gene Ontology
Source: GO:0061630
Synonyms:
- E3
- ER-associated E3 ligase
Branch: molecular function
Genes: Hecw2 (Mmu)...hecw2b (Dre)...hecw2a (Dre)...HECW2 (Hsa)...Hecw2 (Rno)
Gene Ontology
Source: GO:0016567
Synonyms:
- protein ubiquitinylation
- protein ubiquitylation
Branch: biological process
Genes: Hecw2 (Mmu)...hecw2b (Dre)...HECW2 (Hsa)...Hecw2 (Rno)
Gene Ontology
Source: GO:0005819
Synonyms: Not Available
Branch: cellular component
Genes: HECW2 (Hsa)
(GRCh38)2:196319135G>A
(Homo sapiens)Allele/Variant
Source: rs142030437
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196319135G>A
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196319235C>T
(Homo sapiens)Allele/Variant
Source: NC_000002.12:g.196319235C>T
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196319235C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196319322G>A
(Homo sapiens)Allele/Variant
Source: rs958764823
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196319322G>A
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196242163G>A
(Homo sapiens)Allele/Variant
Source: rs1575279293
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196242163G>A
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196254005C>T
(Homo sapiens)Allele/Variant
Source: rs4850690
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196254005C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196215918G>A
(Homo sapiens)Allele/Variant
Source: rs17310196
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196215918G>A
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196292575T>C
(Homo sapiens)Allele/Variant
Source: NC_000002.12:g.196292575T>C
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196292575T>C
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196292624C>T
(Homo sapiens)Allele/Variant
Source: rs771405901
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196292624C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196292687C>A
(Homo sapiens)Allele/Variant
Source: NC_000002.12:g.196292687C>A
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196292687C>A
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196306451C>T
(Homo sapiens)Allele/Variant
Source: rs4241189
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196306451C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196242155G>A
(Homo sapiens)Allele/Variant
Source: rs146564746
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, stop_gained, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196242155G>A
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196308010C>T
(Homo sapiens)Allele/Variant
Source: rs1220232756
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196308010C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196318561C>T
(Homo sapiens)Allele/Variant
Source: rs144966097
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196318561C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196318661C>A
(Homo sapiens)Allele/Variant
Source: rs138073304
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: stop_gained, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196318661C>A
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196240483T>G
(Homo sapiens)Allele/Variant
Source: rs760965096
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196240483T>G
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196220808C>T
(Homo sapiens)Allele/Variant
Source: rs760300569
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196220808C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196220828C>T
(Homo sapiens)Allele/Variant
Source: rs61748259
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196220828C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196278534C>T
(Homo sapiens)Allele/Variant
Source: rs1212609807
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196278534C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196319650C>T
(Homo sapiens)Allele/Variant
Source: rs764436402
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196319650C>T
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2
(GRCh38)2:196318629G>A
(Homo sapiens)Allele/Variant
Source: rs1691794356
Genes: HECW2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:196318629G>A
Gene Synonyms: E3 ubiquitin-protein ligase HECW2...HECT-type E3 ubiquitin transferase HECW2