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666 results for map3k10

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Map3k10

(Mus musculus)

Gene

Name: mitogen-activated protein kinase kinase kinase 10

Synonyms: BC028668, Mlk2, MKN28 derived nonreceptor_type, MKN28 kinase, mixed lineage kinase 2, serine/threonine kinase, BC046514, cDNA sequence BC046514, cDNA sequence BC028668, mixed lineage kinase 2 (tyrosine and serine/threonine specificity)

Source: MGI:1346879

Biotype: protein coding gene

Symbol: Map3k10 (Mmu)

Symbol: Map3k10

Automated Gene Synopsis: Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10).

Strict Orthology Symbols: map3k10

Alleles: Map3k10 (Mmu)...Map3k10 (Mmu)...Map3k10 (Mmu)...Map3k10 (Mmu)...Map3k10 (Mmu)

MAP3K10

(Homo sapiens)

Gene

Name: mitogen-activated protein kinase kinase kinase 10

Synonyms: MLK2, MEKK10, protein kinase MST, MKN28 kinase, MKN28 derived nonreceptor_type serine/threonine kinase, mixed lineage kinase 2, MST

Source: HGNC:6849

Biotype: protein coding gene

Symbol: MAP3K10 (Hsa)

Symbol: MAP3K10

Strict Orthology Symbols: map3k10

Allele/Variant (69)

Map3k10

(Rattus norvegicus)

Gene

Name: mitogen activated protein kinase kinase kinase 10

Synonyms: mitogen-activated protein kinase kinase kinase 10-like, LOC102552215, Mlk2, LOC308463, mixed-lineage kinase 2, mitogen-activated protein kinase kinase kinase 10

Source: RGD:1308381

Biotype: protein coding gene

Symbol: Map3k10 (Rno)

Symbol: Map3k10

Gene Synopsis: Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10); PARTICIPATES IN c-Jun

Automated Gene Synopsis: Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10).

Strict Orthology Symbols: map3k10

Allele/Variant (44)

map3k10

(Danio rerio)

Gene

Name: mitogen-activated protein kinase kinase kinase 10

Synonyms: si:ch211-238g23.2

Source: ZFIN:ZDB-GENE-050419-112

Biotype: protein coding gene

Symbol: map3k10 (Dre)

Symbol: map3k10

Automated Gene Synopsis: Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10).

Strict Orthology Symbols: map3k10

Allele/Variant (4)

map3k10

(Xenopus tropicalis)

Gene

Name: mitogen-activated protein kinase kinase kinase 10

Synonyms: xmlk2, map3k10, mitogen-activated protein kinase kinase kinase 10, mlk2

Source: Xenbase:XB-GENE-920944

Biotype: gene

Symbol: map3k10

Symbol: map3k10 (Xtr)

Automated Gene Synopsis: Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10).

Synonyms: map3k10...map3k10...map3k10

Strict Orthology Symbols: map3k10

map3k10.L

(Xenopus laevis)

Gene

Name: mitogen-activated protein kinase kinase kinase 10

Synonyms: map3k10.L, xmlk2, mitogen-activated protein kinase kinase kinase 10, mlk2

Source: Xenbase:XB-GENE-920952

Biotype: gene

Symbol: map3k10.L (Xla)

Automated Gene Synopsis: Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10).

Strict Orthology Symbols: map3k10

Symbol: map3k10.L

Map3k10^em1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7290957

Genes: Map3k10 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Map3k10 (Mmu)

Genes: Map3k10 (Mmu)

Symbol: Map3k10^em1Smoc

Gene (1)

Map3k10^{tm1a(EUCOMM)Hmgu}

(Mus musculus)

Allele/Variant

Source: MGI:4435860

Genes: Map3k10 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Map3k10 (Mmu)

Genes: Map3k10 (Mmu)

Symbol: Map3k10^{tm1a(EUCOMM)Hmgu}

Gene (1)

Map3k10^{tm1b(EUCOMM)Hmgu}

(Mus musculus)

Allele/Variant

Source: MGI:5548463

Genes: Map3k10 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Map3k10 (Mmu)

Genes: Map3k10 (Mmu)

Symbol: Map3k10^{tm1b(EUCOMM)Hmgu}

Map3k10^em46Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7301970

Genes: Map3k10 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Map3k10 (Mmu)

Genes: Map3k10 (Mmu)

Symbol: Map3k10^em46Gpt

Gene (1)

Map3k10^tm1Dsd

(Mus musculus)

Allele/Variant

Source: MGI:5296039

Genes: Map3k10 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Map3k10 (Mmu)

Genes: Map3k10 (Mmu)

Symbol: Map3k10^tm1Dsd

Map3k10^tm1Lex

(Mus musculus)

Allele/Variant

Source: MGI:3800582

Genes: Map3k10 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Map3k10 (Mmu)

Genes: Map3k10 (Mmu)

Symbol: Map3k10^tm1Lex

Map3k10^tm1Dsd/Map3k10^tm1Dsd Map3k11^tm1Rjd/Map3k11^tm1Rjd [background:] involves: 129 * 129S6/SvEvTac * C57BL/6J

(Mus musculus)

Model

Id: MGI:5296041

Synonyms: Not Available

Symbol: Map3k10/Map3k10 Map3k11/Map3k11 [background:] involves: 129 * 129S6/

Genes: Map3k10 (Mmu)

Alleles: Map3k10 (Mmu)

Name: Map3k10/Map3k10 Map3k11/Map3k11 [background:] involves: 129 * 129S6/

Gene (2)

Map3k10^{tm1b(EUCOMM)Hmgu}/Map3k10^{tm1b(EUCOMM)Hmgu} [background:] C57BL/6N-Map3k10^{tm1b(EUCOMM)Hmgu}/Cnrm

(Mus musculus)

Model

Id: MGI:5757333

Synonyms: Not Available

Symbol: Map3k10/Map3k10 [background:] C57BL/6N-Map3k10

Genes: Map3k10 (Mmu)

Alleles: Map3k10 (Mmu)

Name: Map3k10/Map3k10 [background:] C57BL/6N-Map3k10

Gene (1)

Map3k10^tm1Lex/Map3k10^tm1Lex [background:] 129S-Map3k10^tm1Lex

(Mus musculus)

Model

Id: MGI:3801185

Synonyms: Not Available

Symbol: Map3k10/Map3k10 [background:] 129S-Map3k10 (Mmu)

Genes: Map3k10 (Mmu)

Alleles: Map3k10 (Mmu)

Name: Map3k10/Map3k10 [background:] 129S-Map3k10

Gene (1)

Map3k10^tm1Lex/Map3k10^tm1Lex Map3k9^tm1Lex/Map3k9^tm1Lex [background:] either: 129S-Map3k10^tm1Lex Map3k9^tm1Lex or B6.129S-Map3k10^tm1Lex Map3k9^tm1Lex

(Mus musculus)

Model

Id: MGI:3801188

Synonyms: Not Available

Symbol: Map3k10/Map3k10 Map3k9/Map3k9 [background:] either: 129S-Map3k10

Genes: Map3k10 (Mmu)

Alleles: Map3k10 (Mmu)

Name: Map3k10/Map3k10 Map3k9/Map3k9 [background:] either: 129S-Map3k10 Map3k9 or B6.129S-Map3k10 Map3k9

Gene (2)

Map3k10^tm1Dsd/Map3k10^tm1Dsd Map3k11^tm2.1Rjd/Map3k11^tm2.1Rjd [background:] involves: 129 * C57BL/6J

(Mus musculus)

Model

Id: MGI:5296040

Synonyms: Not Available

Symbol: Map3k10/Map3k10 Map3k11/Map3k11 [background:] involves: 129 * C57BL

Genes: Map3k10 (Mmu)

Alleles: Map3k10 (Mmu)

Name: Map3k10/Map3k10 Map3k11/Map3k11 [background:] involves: 129 * C57BL

Gene (2)

slpr

(Drosophila melanogaster)

Gene

Name: slipper

Synonyms: Jnkkk, Mlk2, MLK2, Mixed lineage protein kinase 2, dMLK, CG2272, Mlk, MLK, dMLK2, JNKKK, D-MLK, Slipper, Slpr

Source: FB:FBgn0030018

Biotype: protein coding gene

Strict Orthology Symbols: map3k10

Allele/Variant (160)

mlk-1

(Caenorhabditis elegans)

Gene

Name: human MLK (Mixed Lineage Kinase) homolog 1

Synonyms: CELE_K11D12.10, Y58A7A.f, K11D12.10

Source: WB:WBGene00003374

Biotype: protein coding gene

Strict Orthology Symbols: map3k10

JUN kinase kinase kinase activity

Gene Ontology

Source: GO:0004706

Synonyms:

JNK kinase kinase activity
JNKKK

Branch: molecular function

Genes: Map3k10 (Rno)...MAP3K10 (Hsa)...Map3k10 (Mmu)...map3k10 (Dre)

Genes Annotated with this GO Term (78)

bHLH transcription factor binding

Gene Ontology

Source: GO:0043425

Synonyms: Not Available

Branch: molecular function

Genes: MAP3K10 (Hsa)...Map3k10 (Rno)...Map3k10 (Mmu)

Genes Annotated with this GO Term (114)

positive regulation of JUN kinase activity

Gene Ontology

Source: GO:0043507

Synonyms:

positive regulation of JUNK activity
stimulation of JNK activity

Branch: biological process

Genes: MAP3K10 (Hsa)...Map3k10 (Rno)...Map3k10 (Mmu)

Genes Annotated with this GO Term (146)

MAP kinase kinase kinase activity

Gene Ontology

Source: GO:0004709

Synonyms:

ATP:protein phosphotransferase (MAPKKKK-activated) activity
MAP3K

Branch: molecular function

Genes: MAP3K10 (Hsa)...map3k10 (Dre)

Genes Annotated with this GO Term (122)

peptidyl-threonine phosphorylation

Gene Ontology

Source: GO:0018107

Synonyms: Not Available

Branch: biological process

Genes: MAP3K10 (Hsa)...Map3k10 (Rno)...Map3k10 (Mmu)

Genes Annotated with this GO Term (159)

Hsap\MAP3K10^UAS.Tag:HA

(Drosophila melanogaster)

Allele/Variant

Source: FB:FBal0393122

Genes: Not Available

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Hsap\MAP3K10

Construct Expressed Component: MAP3K10 (Hsa)

negative regulation of DNA-binding transcription factor activity

Gene Ontology

Source: GO:0043433

Synonyms:

down regulation of transcription factor activity
down-regulation of transcription factor activity

Branch: biological process

Genes: MAP3K10 (Hsa)...Map3k10 (Mmu)...Map3k10 (Rno)

Genes Annotated with this GO Term (504)

peptidyl-serine phosphorylation

Gene Ontology

Source: GO:0018105

Synonyms: Not Available

Branch: biological process

Genes: MAP3K10 (Hsa)...Map3k10 (Mmu)...Map3k10 (Rno)

Genes Annotated with this GO Term (370)

smoothened signaling pathway

Gene Ontology

Source: GO:0007224

Synonyms:

Shh signaling pathway
Sonic hedgehog signaling pathway

Branch: biological process

Genes: MAP3K10 (Hsa)...Map3k10 (Mmu)...Map3k10 (Rno)

Genes Annotated with this GO Term (385)

positive regulation of JNK cascade

Gene Ontology

Source: GO:0046330

Synonyms:

activation of JNK cascade
stimulation of JNK cascade

Branch: biological process

Genes: MAP3K10 (Hsa)...Map3k10 (Mmu)...Map3k10 (Rno)

Genes Annotated with this GO Term (375)

MAPK cascade

Gene Ontology

Source: GO:0000165

Synonyms:

ERK/MAPK cascade
MAP kinase cascade

Branch: biological process

Genes: Map3k10 (Rno)...Map3k10 (Mmu)

Genes Annotated with this GO Term (840)

transcription corepressor activity

Gene Ontology

Source: GO:0003714

Synonyms:

RNA polymerase II transcription co-repressor activity
RNA polymerase II transcription corepressor activity

Branch: molecular function

Genes: Map3k10 (Rno)...MAP3K10 (Hsa)...Map3k10 (Mmu)

Genes Annotated with this GO Term (825)

positive regulation of apoptotic process

Gene Ontology

Source: GO:0043065

Synonyms:

activation of apoptosis
positive regulation of apoptosis

Branch: biological process

Genes: map3k10 (Dre)...Map3k10 (Rno)...MAP3K10 (Hsa)...Map3k10 (Mmu)

Genes Annotated with this GO Term (2239)

JNK cascade

Gene Ontology

Source: GO:0007254

Synonyms:

JNK1 cascade
JNK2 cascade

Branch: biological process

Genes: MAP3K10 (Hsa)

Genes Annotated with this GO Term (293)

protein tyrosine kinase activity

Gene Ontology

Source: GO:0004713

Synonyms:

protein-tyrosine kinase activity

Branch: molecular function

Genes: MAP3K10 (Hsa)

Genes Annotated with this GO Term (714)

protein kinase activity

Gene Ontology

Source: GO:0004672

Synonyms:

protamine kinase activity

Branch: molecular function

Genes: map3k10 (Dre)...Map3k10 (Rno)...MAP3K10 (Hsa)...Map3k10 (Mmu)

Genes Annotated with this GO Term (3352)

protein serine/threonine kinase activity

Gene Ontology

Source: GO:0004674

Synonyms:

protein serine kinase activity
protein serine-threonine kinase activity

Branch: molecular function

Genes: map3k10 (Dre)...Map3k10 (Rno)...MAP3K10 (Hsa)...Map3k10 (Mmu)

Genes Annotated with this GO Term (2534)

protein serine kinase activity

Gene Ontology

Source: GO:0106310

Synonyms:

protein-serine kinase activity

Branch: molecular function

Genes: Map3k10 (Rno)...MAP3K10 (Hsa)...Map3k10 (Mmu)

Genes Annotated with this GO Term (1225)

negative regulation of DNA-templated transcription

Gene Ontology

Source: GO:0045892

Synonyms:

down regulation of gene-specific transcription
down regulation of transcription, DNA-dependent

Branch: biological process

Genes: Map3k10 (Rno)...MAP3K10 (Hsa)...Map3k10 (Mmu)

Genes Annotated with this GO Term (4986)

protein autophosphorylation

Gene Ontology

Source: GO:0046777

Synonyms:

protein amino acid autophosphorylation

Branch: biological process

Genes: MAP3K10 (Hsa)

Genes Annotated with this GO Term (561)

protein phosphorylation

Gene Ontology

Source: GO:0006468

Synonyms:

protein amino acid phosphorylation

Branch: biological process

Genes: map3k10 (Dre)...Map3k10 (Rno)...MAP3K10 (Hsa)...Map3k10 (Mmu)

Genes Annotated with this GO Term (2934)

sa2969

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-161003-13846

Genes: map3k10 (Dre)

Synonyms: Not Available

Variant Type: point_mutation

Molecular Consequence: splice_donor_variant

Diseases: Not Available

Variant Name: Not Available

Genes: map3k10 (Dre)

sa9813

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-130411-5401

Genes: map3k10 (Dre)

Synonyms: Not Available

Variant Type: point_mutation

Molecular Consequence: stop_gained

Diseases: Not Available

Variant Name: Not Available

Genes: map3k10 (Dre)

sa14946

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-130411-3567

Genes: map3k10 (Dre)

Synonyms: Not Available

Variant Type: point_mutation

Molecular Consequence: splice_donor_variant

Diseases: Not Available

Variant Name: Not Available

Genes: map3k10 (Dre)

sa5640

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-161003-17705

Genes: map3k10 (Dre)

Synonyms: Not Available

Variant Type: point_mutation

Molecular Consequence: splice_donor_variant

Diseases: Not Available

Variant Name: Not Available

Genes: map3k10 (Dre)

phosphorylation

Gene Ontology

Source: GO:0016310

Synonyms: Not Available

Branch: biological process

Genes: map3k10 (Dre)

Genes Annotated with this GO Term (3423)

signal transduction

Gene Ontology

Source: GO:0007165

Synonyms:

signaling cascade
signaling pathway

Branch: biological process

Genes: map3k10 (Dre)...Map3k10 (Mmu)...Map3k10 (Rno)...MAP3K10 (Hsa)

Genes Annotated with this GO Term (10000)

(GRCh38)19:40213681C>T

(Homo sapiens)

Allele/Variant

Source: rs1238082876

Genes: MAP3K10 (Hsa)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant

Diseases: Not Available

Variant Name: (GRCh38)19:40213681C>T

(GRCh38)19:40215173C>A

(Homo sapiens)

Allele/Variant

Source: rs776846148

Genes: MAP3K10 (Hsa)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant, non_coding_transcript_exon_variant

Diseases: Not Available

Variant Name: (GRCh38)19:40215173C>A

(GRCh38)19:40213996G>A

(Homo sapiens)

Allele/Variant

Source: rs1226010589

Genes: MAP3K10 (Hsa)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant, non_coding_transcript_exon_variant

Diseases: Not Available

Variant Name: (GRCh38)19:40213996G>A

(GRCh38)19:40192316C>A

(Homo sapiens)

Allele/Variant

Source: rs1341869847

Genes: MAP3K10 (Hsa)

Synonyms: Not Available

Variant Type: SNP

Molecular Consequence: missense_variant, non_coding_transcript_exon_variant

Diseases: Not Available

Variant Name: (GRCh38)19:40192316C>A

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