Version: 8.0.0
Date: Tue Jan 28 2025
1,588 results for mettl16

METTL16

(Homo sapiens)
Gene
Name: methyltransferase 16, RNA N6-adenosine
Synonyms: MGC3329, methyltransferase 10 domain containing, N6-methyladenosine methyltransferase, methyltransferase 16, N6-methyladenosine, N6-adenosine-methyltransferase METTL16, METT10D, U6 snRNA methyltransferase, putative methyltransferase METT10D, RNA N6-adenosine-methyltransferase METTL16, methyltransferase-like protein 16, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase, methyltransferase 10 domain-containing protein, methyltransferase like 16
Source: HGNC:28484
Biotype: protein coding gene
Symbol: METTL16 (Hsa)
Symbol: METTL16
Synonyms: N6-adenosine-methyltransferase METTL16...RNA N6-adenosine-methyltransferase METTL16
Strict Orthology Symbols: mettl16

mettl16

(Danio rerio)
Gene
Name: methyltransferase 16, N6-methyladenosine
Synonyms: wu:fi09d09, mett10d, fi09d09, zgc:100981, zgc:158576, im:7148386
Source: ZFIN:ZDB-GENE-040801-130
Biotype: protein coding gene
Symbol: mettl16 (Dre)
Symbol: mettl16
Automated Gene Synopsis: Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine).
Strict Orthology Symbols: mettl16

Mettl16

(Mus musculus)
Gene
Name: methyltransferase 16, N6-methyladenosine
Synonyms: methyltransferase 10 domain containing, RIKEN cDNA A830095F14 gene, RIKEN cDNA 2610100D03 gene, A830095F14Rik, 2610100D03Rik, AI846133, RIKEN cDNA 2810013M15 gene, expressed sequence AI846133, 2810013M15Rik, Mett10d
Source: MGI:1914743
Biotype: protein coding gene
Symbol: Mettl16 (Mmu)
Symbol: Mettl16
Automated Gene Synopsis: Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine).
Strict Orthology Symbols: mettl16
Alleles: Mettl16 (Mmu)...Mettl16 (Mmu)...Mettl16 (Mmu)...Mettl16 (Mmu)...Mettl16 (Mmu)

Mettl16

(Rattus norvegicus)
Gene
Name: methyltransferase 16, RNA N6-adenosine
Synonyms: methyltransferase 10 domain containing, methyltransferase 16, N6-methyladenosine, similar to Hypothetical UPF0049 protein ZK1128.2 in chromosome III, RNA N6-adenosine-methyltransferase METTL16, LOC360568, Mett10d, methyltransferase like 16
Source: RGD:1593242
Biotype: protein coding gene
Symbol: Mettl16 (Rno)
Symbol: Mettl16
Gene Synopsis: Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine); INTERACTS WITH (+)-schisandrin
Automated Gene Synopsis: Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine).
Synonyms: RNA N6-adenosine-methyltransferase METTL16
Strict Orthology Symbols: mettl16

mettl16

(Xenopus tropicalis)
Gene
Name: methyltransferase 16, RNA N6-adenosine
Synonyms: mettl16, mett10d, methyltransferase 16, RNA N6-adenosine
Source: Xenbase:XB-GENE-952802
Biotype: gene
Symbol: mettl16
Symbol: mettl16 (Xtr)
Automated Gene Synopsis: Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine).
Synonyms: mettl16...mettl16...mettl16
Strict Orthology Symbols: mettl16

mettl16.L

(Xenopus laevis)
Gene
Name: methyltransferase 16, RNA N6-adenosine
Synonyms: mettl16.L, mett10d, methyltransferase 16, RNA N6-adenosine
Source: Xenbase:XB-GENE-952805
Biotype: gene
Symbol: mettl16.L (Xla)
Automated Gene Synopsis: Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine).
Strict Orthology Symbols: mettl16
Symbol: mettl16.L

Mettl16em3Smoc

(Mus musculus)
Allele/Variant
Source: MGI:7766369
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em3Smoc

Mettl16em1Ota

(Mus musculus)
Allele/Variant
Source: MGI:7768094
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em1Ota

Mettl16tm1c(KOMP)Mbp

(Mus musculus)
Allele/Variant
Source: MGI:7514183
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16tm1c(KOMP)Mbp

Mettl16em1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7302176
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em1Gpt

Mettl16em2Rspi

(Mus musculus)
Allele/Variant
Source: MGI:6199132
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em2Rspi

Mettl16tm1a(KOMP)Mbp

(Mus musculus)
Allele/Variant
Source: MGI:4867997
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16tm1a(KOMP)Mbp

Mettl16em2Smoc

(Mus musculus)
Allele/Variant
Source: MGI:7291044
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em2Smoc

Mettl16em1Smoc

(Mus musculus)
Allele/Variant
Source: MGI:7291043
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em1Smoc

Mettl16tm1b(KOMP)Mbp

(Mus musculus)
Allele/Variant
Source: MGI:5583061
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16tm1b(KOMP)Mbp

Mettl16em1Rspi

(Mus musculus)
Allele/Variant
Source: MGI:6199131
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em1Rspi

Mettl16tm1b(KOMP)Mbp/Mettl16+ [background:] C57BL/6N-Mettl16tm1b(KOMP)Mbp/J

(Mus musculus)
Model
Id: MGI:5757359
Synonyms: Not Available
Symbol: Mettl16/Mettl16<+> [background:] C57BL/6N-Mettl16/J (Mmu)
Genes: Mettl16 (Mmu)
Alleles: Mettl16 (Mmu)
Name: Mettl16/Mettl16<+> [background:] C57BL/6N-Mettl16/J

Mettl16em2Rspi/Mettl16em2Rspi [background:] involves: C57BL/6J * C57BL/6JRj * DBA/2J

(Mus musculus)
Model
Id: MGI:6199141
Synonyms: Not Available
Symbol: Mettl16/Mettl16 [background:] involves: C57BL/6J * C57BL/6JRj * DBA/2J (Mmu)
Genes: Mettl16 (Mmu)
Alleles: Mettl16 (Mmu)
Name: Mettl16/Mettl16 [background:] involves: C57BL/6J * C57BL/6JRj * DBA/2J

Mettl16tm1b(KOMP)Mbp/Mettl16tm1b(KOMP)Mbp [background:] C57BL/6N-Mettl16tm1b(KOMP)Mbp/J

(Mus musculus)
Model
Id: MGI:5757360
Synonyms: Not Available
Symbol: Mettl16/Mettl16 [background:] C57BL/6N-Mettl16/J (Mmu)
Genes: Mettl16 (Mmu)
Alleles: Mettl16 (Mmu)
Name: Mettl16/Mettl16 [background:] C57BL/6N-Mettl16/J

Mettl16em1Rspi/Mettl16em1Rspi [background:] involves: C57BL/6J * C57BL/6JRj * DBA/2J

(Mus musculus)
Model
Id: MGI:6199140
Synonyms: Not Available
Symbol: Mettl16/Mettl16 [background:] involves: C57BL/6J * C57BL/6JRj * DBA/2J (Mmu)
Genes: Mettl16 (Mmu)
Alleles: Mettl16 (Mmu)
Name: Mettl16/Mettl16 [background:] involves: C57BL/6J * C57BL/6JRj * DBA/2J

mettl16sa1221/sa1221 (TL)

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-150901-2296
Synonyms: Not Available
Symbol: mettl16 (TL) (Dre)
Genes: mettl16 (Dre)
Name: mettl16 (TL)

Mettl16em4Rspi

(Mus musculus)
Allele/Variant
Source: MGI:7514381
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: MNV
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em4Rspi

Mettl16em3Rspi

(Mus musculus)
Allele/Variant
Source: MGI:7514380
Genes: Mettl16 (Mmu)
Synonyms: Not Available
Variant Type: MNV
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Mettl16 (Mmu)
Genes: Mettl16 (Mmu)
Symbol: Mettl16em3Rspi

CG7544

(Drosophila melanogaster)
Gene
Name: Not Available
Synonyms: METTL16
Source: FB:FBgn0033994
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine).
Synonyms: METTL16...METTL16
Strict Orthology Symbols: mettl16

mett-10

(Caenorhabditis elegans)
Gene
Name: METhylTransferase homolog 10
Synonyms: let-42, stu-18, CELE_ZK1128.2, ZK1128.2
Source: WB:WBGene00014228
Biotype: protein coding gene
Gene Synopsis: Is an ortholog of human METTL16 (methyltransferase 16, RNA N6-adenosine).
Automated Gene Synopsis: Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine).
Strict Orthology Symbols: mettl16

U6 snRNA (adenine-(43)-N(6))-methyltransferase activity

Gene Ontology
Source: GO:0120048
Synonyms: Not Available
Branch: molecular function
Genes: Mettl16 (Rno)...mettl16 (Dre)...Mettl16 (Mmu)...METTL16 (Hsa)

U6 snRNA 3'-end binding

Gene Ontology
Source: GO:0030629
Synonyms:
  • U6 snRNA 3' end binding
Branch: molecular function
Genes: Mettl16 (Rno)...mettl16 (Dre)...Mettl16 (Mmu)...METTL16 (Hsa)

negative regulation of 3'-UTR-mediated mRNA stabilization

Gene Ontology
Source: GO:1905869
Synonyms:
  • down regulation of 3'-UTR-mediated mRNA stabilization
  • down regulation of 3'-untranslated region-mediated mRNA stabilization
Branch: biological process
Genes: Mettl16 (Rno)...Mettl16 (Mmu)...METTL16 (Hsa)

snRNA (adenine-N6)-methylation

Gene Ontology
Source: GO:0120049
Synonyms: Not Available
Branch: biological process
Genes: Mettl16 (Rno)...mettl16 (Dre)...Mettl16 (Mmu)...METTL16 (Hsa)

mRNA m(6)A methyltransferase activity

Gene Ontology
Source: GO:0001734
Synonyms:
  • mRNA (N6-adenosine)-methyltransferase activity
Branch: molecular function
Genes: METTL16 (Hsa)...Mettl16 (Rno)...mettl16 (Dre)...Mettl16 (Mmu)

S-adenosylmethionine biosynthetic process

Gene Ontology
Source: GO:0006556
Synonyms:
  • S-adenosyl methionine biosynthesis
  • S-adenosyl methionine biosynthetic process
Branch: biological process
Genes: mettl16 (Dre)...Mettl16 (Mmu)...METTL16 (Hsa)...Mettl16 (Rno)

rRNA base methylation

Gene Ontology
Source: GO:0070475
Synonyms: Not Available
Branch: biological process
Genes: mettl16 (Dre)...Mettl16 (Mmu)...METTL16 (Hsa)...Mettl16 (Rno)

la019256Tg

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-120806-10365
Genes: mettl16 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: mettl16 (Dre)

RNA stem-loop binding

Gene Ontology
Source: GO:0035613
Synonyms:
  • RNA hairpin binding
  • RNA hairpin loop binding
Branch: molecular function
Genes: mettl16 (Dre)...METTL16 (Hsa)...Mettl16 (Mmu)...Mettl16 (Rno)

mRNA destabilization

Gene Ontology
Source: GO:0061157
Synonyms: Not Available
Branch: biological process
Genes: mettl16 (Dre)...METTL16 (Hsa)...Mettl16 (Mmu)...Mettl16 (Rno)

Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE116329
Tags: WT vs. mutant, developmental stage, genotype
Summary: Internal modification of RNAs with N6-methyladenosine (m6A) is a highly conserved and widely used means of gene expression control. METTL16 is an m6A writer but how it recognizes its RNA targets and its physiological roles remain unknown. Here we describe the crystal structure of human METTL16 to reveal a classical methyltransferase domain but with an extra N-terminal module that is essential for catalysis. Together, they form a deep-cut groove lined by highly conserved positively charged residues that are essential for RNA binding and methylation activity. When given a random pool of RNAs, METTL16 selects structured RNAs for m6A methylation. We demonstrate that mouse Mettl16 is essential for early embryonic development, and acts via regulation of the SAM synthetase Mat2a mRNA. Our results highlight the pivotal role of an m6A RNA methyltransferase in facilitating early developmental decisions via regulation of SAM availability. RNA sequencing was used to identify transcript abundance differences between Mettl16 mutant and control in E2.5 and E3.5 mouse embryos. In vitro RNA methylation assay with METTL16 followed by m6A immunoprecipitation and sequencing was used to identify METTL16 preferred targets.
Symbol: Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development
Name: Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development

regulation of mRNA splicing, via spliceosome

Gene Ontology
Source: GO:0048024
Synonyms:
  • regulation of nuclear mRNA splicing via U2-type spliceosome
  • regulation of nuclear mRNA splicing, via spliceosome
Branch: biological process
Genes: mettl16 (Dre)...METTL16 (Hsa)...Mettl16 (Mmu)...Mettl16 (Rno)

post-transcriptional regulation of gene expression

Gene Ontology
Source: GO:0010608
Synonyms:
  • posttranscriptional regulation of gene expression
Branch: biological process
Genes: mettl16 (Dre)...Mettl16 (Mmu)...Mettl16 (Rno)...METTL16 (Hsa)

RNA methylation

Gene Ontology
Source: GO:0001510
Synonyms: Not Available
Branch: biological process
Genes: METTL16 (Hsa)...Mettl16 (Mmu)...Mettl16 (Rno)

mRNA catabolic process

Gene Ontology
Source: GO:0006402
Synonyms:
  • mRNA breakdown
  • mRNA catabolism
Branch: biological process
Genes: mettl16 (Dre)...Mettl16 (Mmu)...Mettl16 (Rno)...METTL16 (Hsa)

methylation

Gene Ontology
Source: GO:0032259
Synonyms: Not Available
Branch: biological process
Genes: mettl16 (Dre)...METTL16 (Hsa)

methyltransferase activity

Gene Ontology
Source: GO:0008168
Synonyms:
  • methylase
Branch: molecular function
Genes: mettl16 (Dre)...METTL16 (Hsa)

mRNA processing

Gene Ontology
Source: GO:0006397
Synonyms:
  • mRNA maturation
Branch: biological process
Genes: Mettl16 (Mmu)...METTL16 (Hsa)...Mettl16 (Rno)

(GRCh38)17:2419984C>A

(Homo sapiens)
Allele/Variant
Source: rs760960854
Genes: METTL16 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)17:2419984C>A
Gene Synonyms: N6-adenosine-methyltransferase METTL16...RNA N6-adenosine-methyltransferase METTL16

(GRCh38)17:2420170C>T

(Homo sapiens)
Allele/Variant
Source: rs184267301
Genes: METTL16 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)17:2420170C>T
Gene Synonyms: N6-adenosine-methyltransferase METTL16...RNA N6-adenosine-methyltransferase METTL16

(GRCh38)17:2420307T>C

(Homo sapiens)
Allele/Variant
Source: rs201803030
Genes: METTL16 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)17:2420307T>C
Gene Synonyms: N6-adenosine-methyltransferase METTL16...RNA N6-adenosine-methyltransferase METTL16

(GRCh38)17:2420142C>T

(Homo sapiens)
Allele/Variant
Source: rs375545024
Genes: METTL16 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)17:2420142C>T
Gene Synonyms: N6-adenosine-methyltransferase METTL16...RNA N6-adenosine-methyltransferase METTL16

(GRCh38)17:2420799G>A

(Homo sapiens)
Allele/Variant
Source: rs755744679
Genes: METTL16 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)17:2420799G>A
Gene Synonyms: N6-adenosine-methyltransferase METTL16...RNA N6-adenosine-methyltransferase METTL16

(GRCh38)17:2420125C>T

(Homo sapiens)
Allele/Variant
Source: rs370652516
Genes: METTL16 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)17:2420125C>T
Gene Synonyms: N6-adenosine-methyltransferase METTL16...RNA N6-adenosine-methyltransferase METTL16

(GRCh38)17:2420163G>A

(Homo sapiens)
Allele/Variant
Source: rs199713206
Genes: METTL16 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)17:2420163G>A
Gene Synonyms: N6-adenosine-methyltransferase METTL16...RNA N6-adenosine-methyltransferase METTL16