Version: 8.0.0Date: Tue Jan 28 2025
Category
MYSM1
(Homo sapiens)Gene
Name: Myb like, SWIRM and MPN domains 1
Synonyms: DKFZp779J1554, DKFZp779J1721, RP4-592A1.1, 2A-DUB, myb-like, SWIRM and MPN domain-containing protein 1, Myb-like, SWIRM and MPN domains 1, BMFS4, histone H2A deubiquitinase MYSM1, deubiquitinase MYSM1, 2ADUB, KIAA1915
Source: HGNC:29401
Biotype: protein coding gene
Symbol: MYSM1 (Hsa)
Symbol: MYSM1
Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
Strict Orthology Symbols: mysm1
Mysm1
(Rattus norvegicus)Gene
Name: myb-like, SWIRM and MPN domains 1
Synonyms: RGD1311787, histone H2A deubiquitinase MYSM1, LOC298247, similar to KIAA1915 protein, deubiquitinase MYSM1
Source: RGD:1311787
Biotype: protein coding gene
Symbol: Mysm1 (Rno)
Symbol: Mysm1
Gene Synopsis: Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1); PARTICIPATES IN histone modification
Automated Gene Synopsis: Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1).
Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
Strict Orthology Symbols: mysm1
Mysm1
(Mus musculus)Gene
Name: myb-like, SWIRM and MPN domains 1
Synonyms: C530050H10Rik, RIKEN cDNA C130067A03 gene, C130067A03Rik, RGD1311787, RIKEN cDNA C530050H10 gene
Source: MGI:2444584
Biotype: protein coding gene
Symbol: Mysm1 (Mmu)
Symbol: Mysm1
Automated Gene Synopsis: Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1).
Strict Orthology Symbols: mysm1
Alleles: Mysm1
mysm1
(Danio rerio)Gene
Name: Myb-like, SWIRM and MPN domains 1
Synonyms: si:ch211-59d15.8, im:7153144
Source: ZFIN:ZDB-GENE-041014-28
Biotype: protein coding gene
Symbol: mysm1 (Dre)
Symbol: mysm1
Automated Gene Synopsis: Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1).
Strict Orthology Symbols: mysm1
mysm1
(Xenopus tropicalis)Gene
Name: Myb like, SWIRM and MPN domains 1
Synonyms: mysm1, 2adub, 2a-dub, Myb like, SWIRM and MPN domains 1
Source: Xenbase:XB-GENE-1032957
Biotype: gene
Symbol: mysm1
Symbol: mysm1 (Xtr)
Automated Gene Synopsis: Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1).
Synonyms: mysm1...mysm1...mysm1
Strict Orthology Symbols: mysm1
mysm1.L
(Xenopus laevis)Gene
Name: Myb like, SWIRM and MPN domains 1
Synonyms: mysm1.L, 2a-dub, 2adub, Myb like, SWIRM and MPN domains 1
Source: Xenbase:XB-GENE-1032962
Biotype: gene
Symbol: mysm1.L (Xla)
Automated Gene Synopsis: Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1).
Strict Orthology Symbols: mysm1
Symbol: mysm1.L
Mysm1em3Cya
(Mus musculus)Allele/Variant
Source: MGI:7585219
Genes: Mysm1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mysm1
Genes: Mysm1 (Mmu)
Symbol: Mysm1em3Cya
Mysm1tm1c(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5896988
Genes: Mysm1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mysm1
Genes: Mysm1 (Mmu)
Symbol: Mysm1tm1c(KOMP)Wtsi
Mysm1tm1a(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4362924
Genes: Mysm1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mysm1
Genes: Mysm1 (Mmu)
Symbol: Mysm1tm1a(KOMP)Wtsi
Mysm1tm1b(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5896989
Genes: Mysm1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mysm1
Genes: Mysm1 (Mmu)
Symbol: Mysm1tm1b(KOMP)Wtsi
Mysm1em1Cya
(Mus musculus)Allele/Variant
Source: MGI:7585218
Genes: Mysm1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mysm1
Genes: Mysm1 (Mmu)
Symbol: Mysm1em1Cya
Mysm1em2Cya
(Mus musculus)Allele/Variant
Source: MGI:7585220
Genes: Mysm1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mysm1
Genes: Mysm1 (Mmu)
Symbol: Mysm1em2Cya
Mysm1em1Nki
(Mus musculus)Allele/Variant
Source: MGI:6363967
Genes: Mysm1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mysm1
Genes: Mysm1 (Mmu)
Symbol: Mysm1em1Nki
Mysm1em29Gpt
(Mus musculus)Allele/Variant
Source: MGI:7302736
Genes: Mysm1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mysm1
Genes: Mysm1 (Mmu)
Symbol: Mysm1em29Gpt
Mysm1tm1a(KOMP)Wtsi/Mysm1+ [background:] Not Specified
(Mus musculus)Model
Id: MGI:5449985
Synonyms: Not Available
Symbol: Mysm1/Mysm1<+> [background:] Not Specified (Mmu)
Genes: Mysm1 (Mmu)
Alleles: Mysm1
Name: Mysm1/Mysm1<+> [background:] Not Specified
Mysm1tm1b(KOMP)Wtsi/Mysm1tm1b(KOMP)Wtsi Tg(MMTV-cre)4Mam/0 [background:] involves: 129 * C57BL/6N * FVB/N
(Mus musculus)Model
Id: MGI:5311943
Synonyms: Not Available
Symbol: Mysm1/Mysm1 Tg(MMTV-cre)4Mam/0 [background:] involves: 129 * C57BL/6N
Genes: Mysm1 (Mmu)
Alleles: Mysm1
Name: Mysm1/Mysm1 Tg(MMTV-cre)4Mam/0 [background:] involves: 129 * C57BL/6N
Model
Id: MGI:5641692
Synonyms: Not Available
Symbol: Mysm1/Mysm1 [background:] C57BL/6-Mysm1 (Mmu)
Genes: Mysm1 (Mmu)
Alleles: Mysm1
Name: Mysm1/Mysm1 [background:] C57BL/6-Mysm1
Model
Id: MGI:5449983
Synonyms: Not Available
Symbol: Mysm1/Mysm1 [background:] Not Specified (Mmu)
Genes: Mysm1 (Mmu)
Alleles: Mysm1
Name: Mysm1/Mysm1 [background:] Not Specified
Gene Ontology
Source: GO:0140950
Synonyms:
- histone H2A deubiquitination
Branch: molecular function
Genes: Mysm1 (Mmu)...Mysm1 (Rno)...mysm1 (Dre)...MYSM1 (Hsa)
Gene Ontology
Source: GO:0051797
Synonyms: Not Available
Branch: biological process
Genes: Mysm1 (Mmu)...MYSM1 (Hsa)...Mysm1 (Rno)
Gene Ontology
Source: GO:0140492
Synonyms:
- metal-dependent ubiquitin-like hydrolase activity
- metal-dependent ubiquitinyl-like hydrolase activity
Branch: molecular function
Genes: Mysm1 (Mmu)...Mysm1 (Rno)...mysm1 (Dre)...MYSM1 (Hsa)
Gene Ontology
Source: GO:1903706
Synonyms:
- regulation of blood cell biosynthesis
- regulation of blood cell formation
Branch: biological process
Genes: Mysm1 (Mmu)...Mysm1 (Rno)...MYSM1 (Hsa)
AB + MO1-mysm1
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-17866
Synonyms: Not Available
Genes: mysm1 (Dre)
Name: AB + MO1-mysm1
Gene Ontology
Source: GO:0008242
Synonyms:
- peptidase activity, acting on peptides containing modified amino acids
Branch: molecular function
Genes: mysm1 (Dre)
Effects of Mysm1 deficiency on gene expression across a range of mouse tissues and cell types (tissue data)
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-34282, GEO:GSE34282
Tags: WT vs. mutant, anatomical structure, genotype
Summary: Stem cell differentiation and lineage specification depend on coordinated programs of gene expression, but our knowledge of the chromatin modifying factors regulating these events remains incomplete. Ubiquitination of histone H2A (H2A-K119u) is a common chromatin modification associated with gene silencing, and controlled by the ubiquitin-ligase polycomb repressor complex 1 (PRC1) and H2A-deubiquitinating enzymes (H2A-DUBs). The roles of H2A-DUBs in mammalian development, stem cells, and haematopoiesis have not been addressed. Here we characterized an H2A-DUB targeted mouse line Mysm1-tm1a/tm1a and demonstrated defects in bone marrow haematopoiesis, resulting in lymphopenia, anemia, and thrombocytosis. Development of lymphocytes was impaired from the earliest stages of their differentiation; and there was also a depletion of erythroid cells and a defect in erythroid progenitor function. These phenotypes were due to a cell-intrinsic requirement for Mysm1 in the bone marrow. Importantly, Mysm1-tm1a/tm1a haematopoietic stem cells were functionally impaired, and this was associated with elevated levels of reactive oxygen species, γH2AX DNA damage marker, and p53 protein in the haematopoietic progenitors. Overall these data establish a role for Mysm1 in the maintenance of bone marrow stem cell function, in the control of oxidative stress and genetic stability in haematopoietic progenitors, and in the development of lymphoid and erythroid lineages. Total RNA from different mouse tissues (liver, bone marrow, brain) and cell types (embryonic fibroblasts - MEFs, and embryonic stem cells - ESCs) from wild type, Mysm1+/tm1a (heterozygous), and Mysm1tma1/tm1a (homozygous) mice was analyzed. Tissue and MEFs comparisons are between 3-4 animals per group; ESC comparisons are between three independently passaged samples of wild type, Mysm1+/tm1a, and Mysm1tma1/tm1aES-cells, all on C57BL/6 background. Full allele name: Mysm1tm1a(KOMP)WTSI . This Series includes the data from the tissues.
Symbol: Effects of Mysm1 deficiency on gene expression across a range of mouse tissues and cell types (tissue
Name: Effects of Mysm1 deficiency on gene expression across a range of mouse tissues and cell types (tissue
Gene Ontology
Source: GO:0043473
Synonyms: Not Available
Branch: biological process
Genes: MYSM1 (Hsa)...Mysm1 (Mmu)...Mysm1 (Rno)
Disease
Source: DOID:8947
Definition: Not Available
Genes: mysm1.L (Xla)...MYSM1 (Hsa)...Mysm1 (Rno)...Mysm1 (Mmu)...mysm1 (Xtr)
Gene Ontology
Source: GO:0030334
Synonyms: Not Available
Branch: biological process
Genes: Mysm1 (Mmu)...MYSM1 (Hsa)...Mysm1 (Rno)
Gene Ontology
Source: GO:1904888
Synonyms:
- cranial skeleton development
- craniofacial development
Branch: biological process
Genes: mysm1 (Dre)
Gene Ontology
Source: GO:0002376
Synonyms: Not Available
Branch: biological process
Genes: Mysm1 (Mmu)...MYSM1 (Hsa)
Gene Ontology
Source: GO:0003713
Synonyms:
- RNA polymerase II transcription co-activator activity
- RNA polymerase II transcription coactivator activity
Branch: molecular function
Genes: MYSM1 (Hsa)...Mysm1 (Rno)...Mysm1 (Mmu)...mysm1 (Dre)
Gene Ontology
Source: GO:0042393
Synonyms:
- histone-specific chaperone activity
Branch: molecular function
Genes: Mysm1 (Mmu)...MYSM1 (Hsa)...Mysm1 (Rno)...mysm1 (Dre)
Gene Ontology
Source: GO:0008237
Synonyms:
- metalloprotease activity
- metalloproteinase activity
Branch: molecular function
Genes: MYSM1 (Hsa)...mysm1 (Dre)
Gene Ontology
Source: GO:0005730
Synonyms: Not Available
Branch: cellular component
Genes: MYSM1 (Hsa)...Mysm1 (Rno)...Mysm1 (Mmu)
(GRCh38)1:58661472T>G
(Homo sapiens)Allele/Variant
Source: rs369239315
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58661472T>G
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58667135G>A
(Homo sapiens)Allele/Variant
Source: rs2100602470
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58667135G>A
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58669036G>A
(Homo sapiens)Allele/Variant
Source: rs186559420
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58669036G>A
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58685231C>T
(Homo sapiens)Allele/Variant
Source: rs2100658801
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant, non_coding_transcript_exon_variant, stop_gained
Diseases: Not Available
Variant Name: (GRCh38)1:58685231C>T
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58685239G>A
(Homo sapiens)Allele/Variant
Source: rs866468317
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant, non_coding_transcript_exon_variant, stop_gained
Diseases: Not Available
Variant Name: (GRCh38)1:58685239G>A
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58675466T>C
(Homo sapiens)Allele/Variant
Source: rs759547905
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58675466T>C
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58682119T>C
(Homo sapiens)Allele/Variant
Source: rs770840414
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58682119T>C
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58699985C>T
(Homo sapiens)Allele/Variant
Source: rs1227003630
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58699985C>T
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58677041T>C
(Homo sapiens)Allele/Variant
Source: rs579110
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58677041T>C
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58681847C>T
(Homo sapiens)Allele/Variant
Source: rs1644747746
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58681847C>T
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58661163A>G
(Homo sapiens)Allele/Variant
Source: rs372535103
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58661163A>G
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58665500A>G
(Homo sapiens)Allele/Variant
Source: rs754483165
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, synonymous_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58665500A>G
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58667839G>A
(Homo sapiens)Allele/Variant
Source: rs756657675
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58667839G>A
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58668618T>C
(Homo sapiens)Allele/Variant
Source: rs375572305
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58668618T>C
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58685238C>T
(Homo sapiens)Allele/Variant
Source: rs770341254
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, 5_prime_UTR_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58685238C>T
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1
(GRCh38)1:58677009C>A
(Homo sapiens)Allele/Variant
Source: rs1644663803
Genes: MYSM1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:58677009C>A
Gene Synonyms: histone H2A deubiquitinase MYSM1...deubiquitinase MYSM1