Version: 8.0.0Date: Tue Jan 28 2025
Category
NEK8
(Homo sapiens)Gene
Name: NIMA related kinase 8
Synonyms: serine/threonine-protein kinase Nek8, NEK12A, NIMA-related kinase 8, NIMA-related kinase 12a, PKD8, nima-related protein kinase 12a, RHPD2, nimA-related protein kinase 8, NIMA-family kinase NEK8, JCK, serine/thrionine-protein kinase NEK8, nephrocystin 9, MGC138445, NIMA (never in mitosis gene a)- related kinase 8, never in mitosis A-related kinase 8, NPHP9
Source: HGNC:13387
Biotype: protein coding gene
Symbol: NEK8 (Hsa)
Symbol: NEK8
Synonyms: serine/threonine-protein kinase Nek8...NIMA-family kinase NEK8...serine/thrionine-protein kinase NEK8
Strict Orthology Symbols: nek8
nek8
(Danio rerio)Gene
Name: NIMA-related kinase 8
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-020509-1
Biotype: protein coding gene
Symbol: nek8 (Dre)
Symbol: nek8
Automated Gene Synopsis: Orthologous to human NEK8 (NIMA related kinase 8).
Strict Orthology Symbols: nek8
Nek8
(Rattus norvegicus)Gene
Name: NIMA-related kinase 8
Synonyms: serine/threonine-protein kinase Nek8, NIMA (never in mitosis gene a)-related expressed kinase 8, NIMA (never in mitosis gene a)- related kinase 8, never in mitosis A-related kinase 8, nimA-related protein kinase 8, LOC287473
Source: RGD:1306897
Biotype: protein coding gene
Symbol: Nek8 (Rno)
Symbol: Nek8
Gene Synopsis: Orthologous to human NEK8 (NIMA related kinase 8); INTERACTS WITH 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene
Automated Gene Synopsis: Orthologous to human NEK8 (NIMA related kinase 8).
Synonyms: serine/threonine-protein kinase Nek8
Strict Orthology Symbols: nek8
Alleles: Nek8
Nek8
(Mus musculus)Gene
Name: NIMA (never in mitosis gene a)-related expressed kinase 8
Synonyms: juvenile cystic kidney, RIKEN cDNA 4632401F23 gene, jck, Mutant line 1449, 4632401F23Rik, b2b1449Clo
Source: MGI:1890646
Biotype: protein coding gene
Symbol: Nek8 (Mmu)
Symbol: Nek8
Automated Gene Synopsis: Orthologous to human NEK8 (NIMA related kinase 8).
Strict Orthology Symbols: nek8
Alleles: Nek8
nek8
(Xenopus tropicalis)Gene
Name: NIMA-related kinase 8
Synonyms: jck, NIMA-related kinase 8, nek8, nek12a, nphp9
Source: Xenbase:XB-GENE-990378
Biotype: gene
Symbol: nek8
Symbol: nek8 (Xtr)
Automated Gene Synopsis: Orthologous to human NEK8 (NIMA related kinase 8).
Synonyms: nek8...nek8...nek8
Strict Orthology Symbols: nek8
nek8.S
(Xenopus laevis)Gene
Name: NIMA-related kinase 8
Synonyms: jck, NIMA-related kinase 8, nek12a, nek8.S, nphp9
Source: Xenbase:XB-GENE-990383
Biotype: gene
Symbol: nek8.S (Xla)
Automated Gene Synopsis: Orthologous to human NEK8 (NIMA related kinase 8).
Strict Orthology Symbols: nek8
Symbol: nek8.S
Nek8jck
(Mus musculus)Allele/Variant
Source: MGI:1856919
Genes: Nek8 (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant, synonymous_variant
Diseases: autosomal recessive polycystic kidney disease
Variant Name: Not Available
Symbol: Nek8
Genes: Nek8 (Mmu)
Symbol: Nek8jck
Nek8em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7576449
Genes: Nek8 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Nek8
Genes: Nek8 (Mmu)
Symbol: Nek8em1Gpt
Nek8lpkArc
(Rattus norvegicus)Allele/Variant
Source: RGD:42721975
Genes: Nek8 (Rno)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: nephronophthisis 9
Variant Name: Not Available
Symbol: Nek8
Gene Synonyms: serine/threonine-protein kinase Nek8
Genes: Nek8 (Rno)
Symbol: Nek8lpkArc
Nek8tm1Bei
(Mus musculus)Allele/Variant
Source: MGI:5503122
Genes: Nek8 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Nek8
Genes: Nek8 (Mmu)
Symbol: Nek8tm1Bei
Model
Id: MGI:5317611
Synonyms: Not Available
Symbol: Nek8/Nek8 [background:] C57BL/6J-Nek8 (Mmu)
Genes: Nek8 (Mmu)
Alleles: Nek8
Name: Nek8/Nek8 [background:] C57BL/6J-Nek8
Nek8jck/Nek8jck [background:] involves: C57BL/6J
(Mus musculus)Model
Id: MGI:2429561
Synonyms: Not Available
Symbol: Nek8/Nek8 [background:] involves: C57BL/6J (Mmu)
Genes: Nek8 (Mmu)
Alleles: Nek8
Name: Nek8/Nek8 [background:] involves: C57BL/6J
Model
Id: MGI:5503225
Synonyms: Not Available
Symbol: Nek8/Nek8 [background:] involves: 129S6/SvEvTac * C57BL/6NCr (Mmu)
Genes: Nek8 (Mmu)
Alleles: Nek8
Name: Nek8/Nek8 [background:] involves: 129S6/SvEvTac * C57BL/6NCr
Id: MGI:5503226
Synonyms: Not Available
Symbol: Nek8/Nek8 [background:] involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr (Mmu)
Genes: Nek8 (Mmu)
Alleles: Nek8
Name: Nek8/Nek8 [background:] involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr
Nek8jck/Nek8+ Pkd1tm1Bdgz/Pkd1+ [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
(Mus musculus)Model
Id: MGI:3776501
Synonyms: Not Available
Symbol: Nek8/Nek8<+> Pkd1/Pkd1<+> [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6J (Mmu
Genes: Nek8 (Mmu)
Alleles: Nek8
Name: Nek8/Nek8<+> Pkd1/Pkd1<+> [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Nek8m1Btlr/Nek8m1Btlr [background:] C57BL/6J-Nek8m1Btlr
(Mus musculus)Model
Id: MGI:6268752
Synonyms: Not Available
Symbol: Nek8/Nek8 [background:] C57BL/6J-Nek8 (Mmu)
Genes: Nek8 (Mmu)
Alleles: Nek8
Name: Nek8/Nek8 [background:] C57BL/6J-Nek8
Nek8m1Btlr
(Mus musculus)Allele/Variant
Source: MGI:6268750
Genes: Nek8 (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Nek8
Genes: Nek8 (Mmu)
Symbol: Nek8m1Btlr
Nek8b2b1449Clo
(Mus musculus)Allele/Variant
Source: MGI:5317588
Genes: Nek8 (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Nek8
Genes: Nek8 (Mmu)
Symbol: Nek8b2b1449Clo
NEK9
(Homo sapiens)Gene
Name: NIMA related kinase 9
Synonyms: nimA-related kinase 8, Nek8, NIMA-related kinase Nek8, serine/threonine-protein kinase Nek9, LCCS10, nercc1 kinase, NIMA-related kinase 9, nimA-related protein kinase 9, NERCC, NC, MGC16714, NERCC1, NIMA (never in mitosis gene a)- related kinase 9, MGC138306, never in mitosis A-related kinase 9, DKFZp434D0935, APUG
Source: HGNC:18591
Biotype: protein coding gene
Synonyms: Nek8...Nek8...NIMA-related kinase Nek8
nekl-1
(Caenorhabditis elegans)Gene
Name: NEK (NEver in mitosis Kinase) Like 1
Synonyms: CELE_Y39G10AR.3, Y39G10AR.3
Source: WB:WBGene00021461
Biotype: protein coding gene
Strict Orthology Symbols: nek8
niki
(Drosophila melanogaster)Gene
Name: nimA-like kinase
Synonyms: CG10951, NEK1, Niki
Source: FB:FBgn0045980
Biotype: protein coding gene
Strict Orthology Symbols: nek8
nekl-2
(Caenorhabditis elegans)Gene
Name: NEK (NEver in mitosis Kinase) Like 2
Synonyms: ZC581.1, phi-35, CELE_ZC581.1
Source: WB:WBGene00022631
Biotype: protein coding gene
Gene Synopsis: encodes a putative serine/threonine protein kinase orthologousto Aspergillus nidulans nimA and human NEK8
Strict Orthology Symbols: Nek8
Disease
Source: DOID:0111120
Definition: A nephronophthisis that has_material_basis_in homozygous mutation in the NEK8 gene on chromosome 17q11.
Genes: nek8.S (Xla)...Nek8 (Rno)...nek8 (Dre)...NEK8 (Hsa)...nek8 (Xtr)
Alleles: Nek8
Source: DOID:0060259
Definition: A physical disorder characterized by pancreatic fibrosis, renal dysplasia and hepatic dysgenesis; it is usual fatal soon after birth.
Genes: nek8.S (Xla)...nek8 (Dre)...NEK8 (Hsa)...Nek8 (Mmu)...Nek8 (Rno)
Source: DOID:0081378
Definition: An amyotrophic lateral sclerosis that is characterized by adult-onset loss of motor neurons and that has_material_basis_in heterozygous mutation in the NEK1 gene on chromosome 4q33.
Genes: nek8 (Dre)...NEK8 (Hsa)...Nek8 (Mmu)...Nek8 (Rno)
LEW-Nek8lpk/Arc
(Rattus norvegicus)Model
Id: RGD:42721974
Synonyms: Not Available
Genes: Nek8 (Rno)
Alleles: Nek8
Name: LEW-<Nek8>/Arc
Gene Ontology
Source: GO:0097543
Synonyms:
- Inv compartment of the cilium
- cilial inversin compartment
Branch: cellular component
Genes: NEK8 (Hsa)...Nek8 (Mmu)...Nek8 (Rno)
Gene Ontology
Source: GO:0035330
Synonyms:
- regulation of hippo signaling cascade
- regulation of hippo signaling pathway
Branch: biological process
Genes: NEK8 (Hsa)...Nek8 (Rno)...Nek8 (Mmu)
WT + MO2-invs + MO3-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-5569
Synonyms: Not Available
Genes: nek8 (Dre)
Name: WT + MO2-invs + MO3-nek8
nk20aEt; nkuasgfp1aTg + MO3-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-11225
Synonyms: Not Available
Genes: nek8 (Dre)
Name: nk20aEt; nkuasgfp1aTg + MO3-nek8
TL + MO2-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-26997
Synonyms: Tübingen long fin, Tup, Tuebingen long fin, TLF
Genes: nek8 (Dre)
Name: TL + MO2-nek8
WT + MO2-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-25552
Synonyms: Not Available
Genes: nek8 (Dre)
Name: WT + MO2-nek8
nk20aEt; nkuasgfp1aTg + MO2-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-12131
Synonyms: Not Available
Genes: nek8 (Dre)
Name: nk20aEt; nkuasgfp1aTg + MO2-nek8
li1Tg + MO3-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-170228-2
Synonyms: Not Available
Genes: nek8 (Dre)
Name: li1Tg + MO3-nek8
Gene Ontology
Source: GO:0072116
Synonyms:
- pronephric kidney formation
Branch: biological process
Genes: nek8 (Dre)
TL + MO1-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-5223
Synonyms: Tübingen long fin, Tup, Tuebingen long fin, TLF
Genes: nek8 (Dre)
Name: TL + MO1-nek8
WT + MO3-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-10116
Synonyms: Not Available
Genes: nek8 (Dre)
Name: WT + MO3-nek8
AB/TU + MO1-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-23637
Synonyms: Not Available
Genes: nek8 (Dre)
Name: AB/TU + MO1-nek8
li1Tg + MO1-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-20384
Synonyms: Not Available
Genes: nek8 (Dre)
Name: li1Tg + MO1-nek8
f1Tg + MO3-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-170228-1
Synonyms: Not Available
Genes: nek8 (Dre)
Name: f1Tg + MO3-nek8
li1Tg + MO1-anks6 + MO1-nek8
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-18558
Synonyms: Not Available
Genes: nek8 (Dre)
Name: li1Tg + MO1-anks6 + MO1-nek8
Gene Ontology
Source: GO:0061326
Synonyms: Not Available
Branch: biological process
Genes: nek8 (Dre)
Source: DOID:0110861
Definition: A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal recessive fashion.
Genes: nek8 (Xtr)...nek8 (Dre)...NEK8 (Hsa)...Nek8 (Rno)...Nek8 (Mmu)
Alleles: Nek8
Gene Ontology
Source: GO:0097546
Synonyms:
- cilial base
- cilium base
Branch: cellular component
Genes: NEK8 (Hsa)...Nek8 (Rno)...Nek8 (Mmu)
Gene Ontology
Source: GO:0009887
Synonyms:
- histogenesis and organogenesis
Branch: biological process
Genes: Nek8 (Rno)...Nek8 (Mmu)...nek8 (Dre)...NEK8 (Hsa)
Gene Ontology
Source: GO:0048793
Synonyms:
- pronephric kidney development
Branch: biological process
Genes: nek8 (Dre)
Gene Ontology
Source: GO:0007368
Synonyms:
- determination of left/right asymmetry
Branch: biological process
Genes: Nek8 (Rno)...Nek8 (Mmu)...NEK8 (Hsa)
Gene Ontology
Source: GO:0061371
Synonyms:
- determination of cardiac left/right asymmetry
Branch: biological process
Genes: nek8 (Dre)
Gene Ontology
Source: GO:0140823
Synonyms:
- histone H2B-S36 kinase activity
- histone kinase activity (H2B-S36 specific)
Branch: molecular function
Genes: Nek8 (Rno)...Nek8 (Mmu)...nek8 (Dre)...NEK8 (Hsa)
Gene Ontology
Source: GO:0035175
Synonyms:
- histone kinase activity (H3-S10 specific)
- histone serine kinase activity (H3-S10 specific)
Branch: molecular function
Genes: Nek8 (Rno)...Nek8 (Mmu)...nek8 (Dre)...NEK8 (Hsa)