Version: 8.0.0Date: Tue Jan 28 2025
Category
Pde4b
(Mus musculus)Gene
Name: phosphodiesterase 4B, cAMP specific
Synonyms: Pde4B2, Pde4B1, Pde4b5, Pde4B4, dunce, Pde4B3, R74983, Pde4b_v1, Pde4b_v3, Pde4b_v2, Pde4b_v4, expressed sequence R74983, Dpde4, PDE4/IVb
Source: MGI:99557
Biotype: protein coding gene
Symbol: Pde4b (Mmu)
Symbol: Pde4b
Automated Gene Synopsis: Orthologous to human PDE4B (phosphodiesterase 4B).
Strict Orthology Symbols: pde4b
Alleles: Pde4b
PDE4B
(Homo sapiens)Gene
Name: phosphodiesterase 4B
Synonyms: phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila), phosphodiesterase 4B cAMP-specific, cAMP-specific phosphodiesterase-4 B isoform, phosphodiesterase E4 dunce homolog, DPDE4, PDEIVB, 3',5'-cyclic-AMP phosphodiesterase 4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, MGC126529, PDE4B5, cAMP-specific phosphodiesterase 4B, phosphodiesterase 4B, cAMP-specific (dunce, PDE32, DKFZp686F2182, dunce-like phosphodiesterase E4
Source: HGNC:8781
Biotype: protein coding gene
Symbol: PDE4B (Hsa)
Symbol: PDE4B
Strict Orthology Symbols: pde4b
Pde4b
(Rattus norvegicus)Gene
Name: phosphodiesterase 4B
Synonyms: Phosphodiesterase 4B cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4), Pde4B2, Pde4B1, Pde4B4, Pde4B3, Pde4b_v1, 3',5'-cyclic-AMP phosphodiesterase 4B, MGC93193, Pde4b_v3, Pde4b_v2, Pde4b_v4, Phosphodiesterase 4B cAMP-specific (dunce, DPDE4, Pde4b5, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, phosphodiesterase 4B, variant 3, phosphodiesterase 4B, variant 4, phosphodiesterase 4B, variant 1, phosphodiesterase 4B, variant 2, cAMP-specific phosphodiesterase 4B, phosphodiesterase type 4B5, phosphodiesterase 4B, cAMP specific, 3',5'-cyclic AMP phosphodiesterase, Phosphodiesterase 4B, cAMP-specific (dunce, PDE4/IVb
Source: RGD:3280
Biotype: protein coding gene
Symbol: Pde4b (Rno)
Symbol: Pde4b
Gene Synopsis: Orthologous to human PDE4B (phosphodiesterase 4B); PARTICIPATES IN protein kinase A (PKA) signaling pathway
Automated Gene Synopsis: Orthologous to human PDE4B (phosphodiesterase 4B).
Strict Orthology Symbols: pde4b
Alleles: Pde4b
pde4b
(Xenopus tropicalis)Gene
Name: phosphodiesterase 4B
Synonyms: dpde4, pde4b, pde4b5, pdeivb, phosphodiesterase 4B
Source: Xenbase:XB-GENE-963512
Biotype: gene
Symbol: pde4b (Xtr)
Symbol: pde4b
Automated Gene Synopsis: Orthologous to human PDE4B (phosphodiesterase 4B).
Synonyms: pde4b...pde4b...pde4b
Strict Orthology Symbols: pde4b.S...PDE4B...Pde4b...pde4ba...pde4bb
pde4bb
(Danio rerio)Gene
Name: phosphodiesterase 4B, cAMP-specific b
Synonyms: si:dkey-228i19.35
Source: ZFIN:ZDB-GENE-070912-454
Biotype: protein coding gene
Symbol: pde4bb (Dre)
Automated Gene Synopsis: Orthologous to human PDE4B (phosphodiesterase 4B).
Strict Orthology Symbols: pde4b
Symbol: pde4bb
pde4ba
(Danio rerio)Gene
Name: phosphodiesterase 4B, cAMP-specific a
Synonyms: fj87g04, pde4b, wu:fj87g04
Source: ZFIN:ZDB-GENE-030131-9570
Biotype: protein coding gene
Symbol: pde4ba (Dre)
Automated Gene Synopsis: Orthologous to human PDE4B (phosphodiesterase 4B).
Synonyms: pde4b...pde4b...pde4b
Strict Orthology Symbols: pde4b
Symbol: pde4ba
PDE4B-AS1
(Homo sapiens)Gene
Name: PDE4B antisense RNA 1
Synonyms: Not Available
Source: HGNC:40437
Biotype: ncRNA gene
Symbol: PDE4B-AS1 (Hsa)
Symbol: PDE4B-AS1
pde4b.S
(Xenopus laevis)Gene
Name: phosphodiesterase 4B
Synonyms: pde4b.S, dpde4, pde4b5, pdeivb, phosphodiesterase 4B
Source: Xenbase:XB-GENE-963517
Biotype: gene
Symbol: pde4b.S (Xla)
Automated Gene Synopsis: Orthologous to human PDE4B (phosphodiesterase 4B).
Strict Orthology Symbols: pde4b
Symbol: pde4b.S
pde4b.L
(Xenopus laevis)Gene
Name: phosphodiesterase 4B
Synonyms: dpde4, pde4b5, pdeivb, pde4b.L, phosphodiesterase 4B
Source: Xenbase:XB-GENE-17337118
Biotype: gene
Symbol: pde4b.L (Xla)
Automated Gene Synopsis: Orthologous to human PDE4B (phosphodiesterase 4B).
Strict Orthology Symbols: pde4b
Symbol: pde4b.L
Pde4bem1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7304014
Genes: Pde4b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pde4b
Genes: Pde4b (Mmu)
Symbol: Pde4bem1Gpt
Pde4bem1Cya
(Mus musculus)Allele/Variant
Source: MGI:7585656
Genes: Pde4b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pde4b
Genes: Pde4b (Mmu)
Symbol: Pde4bem1Cya
Pde4btm1Dgen
(Mus musculus)Allele/Variant
Source: MGI:5427687
Genes: Pde4b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pde4b
Genes: Pde4b (Mmu)
Symbol: Pde4btm1Dgen
Pde4brgsc02383
(Mus musculus)Allele/Variant
Source: MGI:7716870
Genes: Pde4b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pde4b
Genes: Pde4b (Mmu)
Symbol: Pde4brgsc02383
Pde4btm1Mct
(Mus musculus)Allele/Variant
Source: MGI:2181444
Genes: Pde4b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pde4b
Genes: Pde4b (Mmu)
Symbol: Pde4btm1Mct
Pde4benu1H
(Mus musculus)Allele/Variant
Source: MGI:5648042
Genes: Pde4b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pde4b
Genes: Pde4b (Mmu)
Symbol: Pde4benu1H
Pde4bem1Sage
(Rattus norvegicus)Allele/Variant
Source: RGD:13782129
Genes: Pde4b (Rno)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pde4b
Genes: Pde4b (Rno)
Symbol: Pde4bem1Sage
Model
Id: MGI:3717679
Synonyms: Not Available
Symbol: Pde4b/Pde4b [background:] involves: 129P2/OlaHsd (Mmu)
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b [background:] involves: 129P2/OlaHsd
Model
Id: MGI:6695904
Synonyms: Not Available
Symbol: Pde4b/Pde4b [background:] B6N.129P2-Pde4b/Mmucd (Mmu)
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b [background:] B6N.129P2-Pde4b/Mmucd
Pde4btm1Mct/Pde4btm1Mct Pde4dtm1Mct/Pde4d+ [background:] involves: 129P2/OlaHsd * C57BL/6
(Mus musculus)Model
Id: MGI:3525454
Synonyms: Not Available
Symbol: Pde4b/Pde4b Pde4d/Pde4d<+> [background:] involves: 129P2/OlaHsd * C57BL/6 (Mmu
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b Pde4d/Pde4d<+> [background:] involves: 129P2/OlaHsd * C57BL/6
Model
Id: MGI:5427850
Synonyms: Not Available
Symbol: Pde4b/Pde4b [background:] involves: 129P2/OlaHsd * C57BL/6J (Mmu)
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b [background:] involves: 129P2/OlaHsd * C57BL/6J
Pde4benu1H/Pde4benu1H Tg(Thy1-EGFP)#Jrs/0 [background:] involves: BALB/cAnN * C3H/HeH * C57BL/6 * CBA
(Mus musculus)Model
Id: MGI:5648931
Synonyms: Not Available
Symbol: Pde4b/Pde4b Tg(Thy1-EGFP)#Jrs/0 [background:] involves: BALB/cAnN * C3H/HeH * C57BL/6
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b Tg(Thy1-EGFP)#Jrs/0 [background:] involves: BALB/cAnN * C3H/HeH * C57BL/6
Model
Id: MGI:3054237
Synonyms: Not Available
Symbol: Pde4b/Pde4b [background:] involves: 129X1/SvJ * C57BL/6 (Mmu)
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b [background:] involves: 129X1/SvJ * C57BL/6
Model
Id: MGI:3525449
Synonyms: Not Available
Symbol: Pde4b/Pde4b [background:] involves: 129P2/OlaHsd * C57BL/6 (Mmu)
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b [background:] involves: 129P2/OlaHsd * C57BL/6
Pde4btm1Mct/Pde4btm1Mct Pde4dtm1Mct/Pde4dtm1Mct [background:] involves: 129P2/OlaHsd * C57BL/6
(Mus musculus)Model
Id: MGI:3525453
Synonyms: Not Available
Symbol: Pde4b/Pde4b Pde4d/Pde4d [background:] involves: 129P2/OlaHsd * C57BL
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b Pde4d/Pde4d [background:] involves: 129P2/OlaHsd * C57BL
Pde4btm1Mct/Pde4b+ Pde4dtm1Mct/Pde4dtm1Mct [background:] involves: 129P2/OlaHsd * C57BL/6
(Mus musculus)Model
Id: MGI:3525456
Synonyms: Not Available
Symbol: Pde4b/Pde4b<+> Pde4d/Pde4d [background:] involves: 129P2/OlaHsd * C57BL/6 (Mmu
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b<+> Pde4d/Pde4d [background:] involves: 129P2/OlaHsd * C57BL/6
Pde4benu1H/Pde4benu1H [background:] B6.C(C3H)-Pde4benu1H
(Mus musculus)Model
Id: MGI:5648933
Synonyms: Not Available
Symbol: Pde4b/Pde4b [background:] B6.C(C3H)-Pde4b (Mmu)
Genes: Pde4b (Mmu)
Alleles: Pde4b
Name: Pde4b/Pde4b [background:] B6.C(C3H)-Pde4b
Pde4
(Drosophila melanogaster)Gene
Name: Phosphodiesterase 4
Synonyms: CG10797, Dunce PDE, EG:BACN05I09.3, PDE4, dunce, EG:96G10.7, Dunce, EG:BACN5I9.2, PDE, EG:140G11.4, fs(1)M42, Dunce phosphodiesterase, PDEII, DNC, dnc, CG14267, Dnc, CG14268, phosphodiesterase, CG10791, CG32498, CG10792
Source: FB:FBgn0000479
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including PDE4B (phosphodiesterase 4B).
Strict Orthology Symbols: pde4b
pde-4
(Caenorhabditis elegans)Gene
Name: PhosphoDiEsterase 4
Synonyms: CELE_R153.1, R153.1
Source: WB:WBGene00020114
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including PDE4B (phosphodiesterase 4B).
Strict Orthology Symbols: pde4b
SD-Pde4bem1Sage
(Rattus norvegicus)Model
Id: RGD:13782128
Synonyms: Pde4b Knockout Rat, TGRA7210
Genes: Pde4b (Rno)
Synonyms: Pde4b Knockout Rat
Alleles: Pde4b
Name: SD-<Pde4b>
PDE2
(Saccharomyces cerevisiae)Gene
Name: PhosphoDiEsterase
Synonyms: SRA5, YOR360C
Source: SGD:S000005887
Biotype: protein coding gene
Strict Orthology Symbols: pde4b
Gene Ontology
Source: GO:1901898
Synonyms:
- down regulation of relaxation of cardiac muscle
- down-regulation of relaxation of cardiac muscle
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)
sa44638
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-190123-286
Genes: pde4ba (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: pde4b
Genes: pde4ba (Dre)
la023456Tg
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-120806-9292
Genes: pde4bb (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: pde4bb (Dre)
Gene Ontology
Source: GO:0004114
Synonyms:
- 3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity
- 3',5' cyclic-nucleotide phosphodiesterase activity
Branch: molecular function
Genes: Pde4b (Rno)...pde4bb (Dre)...pde4ba (Dre)...PDE4B (Hsa)
Gene Ontology
Source: GO:0006198
Synonyms:
- 3',5' cAMP catabolic process
- 3',5' cAMP catabolism
Branch: biological process
Genes: Pde4b (Rno)...pde4bb (Dre)...PDE4B (Hsa)...pde4ba (Dre)
Gene Ontology
Source: GO:0047555
Synonyms:
- 3',5' cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-GMP 5'-nucleotidohydrolase activity
Branch: molecular function
Genes: Pde4b (Rno)...pde4bb (Dre)...PDE4B (Hsa)...pde4ba (Dre)...Pde4b (Mmu)
Gene Ontology
Source: GO:0004115
Synonyms:
- 3',5' cAMP-specific phosphodiesterase activity
- 3',5'-cAMP-specific phosphodiesterase activity
Branch: molecular function
Genes: Pde4b (Rno)...pde4bb (Dre)...PDE4B (Hsa)...pde4ba (Dre)...Pde4b (Mmu)
Gene Ontology
Source: GO:0071878
Synonyms:
- negative regulation of adrenergic receptor signaling pathway
- negative regulation of adrenergic receptor signalling pathway
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)
la014826Tg
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-120806-9985
Genes: pde4bb (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: pde4bb (Dre)
Gene Ontology
Source: GO:0000930
Synonyms: Not Available
Branch: cellular component
Genes: Pde4b (Rno)...PDE4B (Hsa)...Pde4b (Mmu)
Gene Ontology
Source: GO:0086004
Synonyms: Not Available
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)
Gene Ontology
Source: GO:1902514
Synonyms:
- regulation of generation of L-type calcium current
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)
Gene Ontology
Source: GO:0001780
Synonyms: Not Available
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)...Pde4b (Mmu)
Expression profiling PDE4B inhibitor BI 1015550 treatment in a therapeutic Rat Lung Bleomycin Model
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE248263
Tags: unclassified
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressing chronic and fibrotic lung response with poor prognosis. To study the underlying molecular mechanisms of IPF, the rat bleomycin model is commonly used. Intratracheal application of bleomycin is known to induce inflammatory and fibrotic processes in the lung, e.g. infiltratin of inflammatory cells and collagen deposition. Recently, the PDE4B inhibitor BI 1015550 has been reported to prevent a decrease in lung function in patients with IPF. Here we examined the effect of PDE4 inhibitor BI 1015550 in the rat bleomycin model on transcriptional level by RNASeq.
Symbol: Expression profiling PDE4B inhibitor BI 1015550 treatment in a therapeutic Rat Lung Bleomycin Model
Name: Expression profiling PDE4B inhibitor BI 1015550 treatment in a therapeutic Rat Lung Bleomycin Model
Gene Ontology
Source: GO:0019933
Synonyms:
- 3',5' cAMP-mediated signaling
- 3',5' cAMP-mediated signalling
Branch: biological process
Genes: Pde4b (Rno)...pde4bb (Dre)...PDE4B (Hsa)...pde4ba (Dre)...Pde4b (Mmu)
Gene Ontology
Source: GO:0071872
Synonyms:
- cellular response to adrenaline stimulus
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)
Gene Ontology
Source: GO:0006939
Synonyms:
- visceral muscle contraction
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)...Pde4b (Mmu)
Gene Ontology
Source: GO:0030552
Synonyms:
- 3',5' cAMP binding
- 3',5'-cAMP binding
Branch: molecular function
Genes: Pde4b (Rno)...PDE4B (Hsa)...Pde4b (Mmu)
Gene Ontology
Source: GO:0050900
Synonyms:
- immune cell migration
- immune cell trafficking
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)...Pde4b (Mmu)
Gene Ontology
Source: GO:0032743
Synonyms:
- activation of interleukin-2 production
- positive regulation of IL-2 production
Branch: biological process
Genes: Pde4b (Rno)...PDE4B (Hsa)...Pde4b (Mmu)