Version: 8.0.0Date: Tue Jan 28 2025
Category
PPBP
(Homo sapiens)Gene
Name: pro-platelet basic protein
Synonyms: CXCL7, thromboglobulin, beta-1, pro-platelet basic protein (chemokine (C-X-C motif) ligand 7), CTAP3, THBGB1, TGB1, platelet basic protein, small inducible cytokine subfamily B, member 7, NAP-2, CXC chemokine ligand 7, leukocyte-derived growth factor, SCYB7, SCAR10, MDGF, chemokine (C-X-C motif) ligand 7, Beta-TG, connective tissue-activating peptide III, beta-thromboglobulin, neutrophil-activating peptide 2, CTAPIII, CTAP-III, PBP, TC2, TC1, B-TG1, C-X-C motif chemokine 7, low-affinity platelet factor IV, THBGB, thrombocidin 1, small-inducible cytokine B7, neutrophil-activating peptide-2, thrombocidin 2, small inducible cytokine B7, TGB, LDGF, LA-PF4, macrophage-derived growth factor
Source: HGNC:9240
Biotype: protein coding gene
Symbol: PPBP (Hsa)
Strict Orthology Symbols: Ppbp
Symbol: PPBP
Ppb
(Drosophila melanogaster)Gene
Name: Photophobe
Synonyms: Phb
Source: FB:FBgn0003078
Biotype: gene
Symbol: Ppb (Dme)
Symbol: Ppb
Alleles: Ppb<1> (Dme)
Ppbp
(Mus musculus)Gene
Name: pro-platelet basic protein
Synonyms: RIKEN cDNA 2400003M24 gene, AI854500, CTAP3, THBGB1, TGB1, b-TG1, 2400003M24Rik, NAP-2, TGB, expressed sequence AI854500, Cxcl7, MDGF, LDGF, chemokine (C-X-C motif) ligand 7, NAP-2-L1, Nap-2, CTAPIII, beta-TG, Scyb7, LA-PF4
Source: MGI:1888712
Biotype: protein coding gene
Symbol: Ppbp (Mmu)
Strict Orthology Symbols: Ppbp...PPBP
Alleles: Ppbp
Symbol: Ppbp
Ppbp
(Rattus norvegicus)Gene
Name: pro-platelet basic protein
Synonyms: Cxcl7, pro-platelet basic protein (chemokine (C-X-C motif) ligand 7), chemokine (C-X-C motif) ligand 7, platelet basic protein, Nap-2, neutrophil activating peptide-2
Source: RGD:70548
Biotype: protein coding gene
Symbol: Ppbp (Rno)
Strict Orthology Symbols: Ppbp...PPBP
Symbol: Ppbp
Ppbptm1.1(KOMP)Vlcg
(Mus musculus)Allele/Variant
Source: MGI:5692644
Genes: Ppbp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppbp
Genes: Ppbp (Mmu)
Symbol: Ppbptm1.1(KOMP)Vlcg
Ppb1
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0013942
Genes: Ppb (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppb<1> (Dme)
Genes: Ppb (Dme)
Symbol: Ppb1
Ppbpem3Gpt
(Mus musculus)Allele/Variant
Source: MGI:7377065
Genes: Ppbp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppbp
Genes: Ppbp (Mmu)
Symbol: Ppbpem3Gpt
Ppbptm1Tgen
(Mus musculus)Allele/Variant
Source: MGI:6160872
Genes: Ppbp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppbp
Genes: Ppbp (Mmu)
Symbol: Ppbptm1Tgen
Ppbpem1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7290329
Genes: Ppbp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppbp
Genes: Ppbp (Mmu)
Symbol: Ppbpem1Smoc
Ppbptm1(KOMP)Vlcg
(Mus musculus)Allele/Variant
Source: MGI:3797508
Genes: Ppbp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppbp
Genes: Ppbp (Mmu)
Symbol: Ppbptm1(KOMP)Vlcg
PPBPP1
(Homo sapiens)Gene
Name: pro-platelet basic protein pseudogene 1
Synonyms: TGB2, pro-platelet basic protein-like 1 (includes platelet basic protein, beta-thromboglobulin, connective tissue-activating peptide III, neutrophil-activating peptide-2-like 1), Thromboglobulin, beta-2, beta-thromboglobulin, PPBPL1, connective tissue-activating peptide I
Source: HGNC:9241
Biotype: pseudogene
Symbol: PPBPP1 (Hsa)
Symbol: PPBPP1
PPBPP2
(Homo sapiens)Gene
Name: pro-platelet basic protein pseudogene 2
Synonyms: SPBPBP, PPBPL2
Source: HGNC:16981
Biotype: pseudogene
Symbol: PPBPP2 (Hsa)
Symbol: PPBPP2
Ppbptm1.1(KOMP)Vlcg/Ppbptm1.1(KOMP)Vlcg [background:] C57BL/6N-Ppbptm1.1(KOMP)Vlcg/Ucd
(Mus musculus)Model
Id: MGI:5797723
Synonyms: Not Available
Symbol: Ppbp/Ppbp [background:] C57BL/6N-Ppbp/Ucd (Mmu)
Genes: Ppbp (Mmu)
Alleles: Ppbp
Model
Id: MGI:5514233
Synonyms: Not Available
Symbol: Ppbp/Ppbp [background:] involves: C57BL/6NTac (Mmu)
Genes: Ppbp (Mmu)
Alleles: Ppbp
HTN1
(Homo sapiens)Gene
Name: histatin 1
Synonyms: PPB, histatin-1, Hst1, post-PB protein, HIS1, histidine-rich protein 1
Source: HGNC:5283
Biotype: protein coding gene
Synonyms: PPB...PPB
cxcl8a
(Danio rerio)Gene
Name: chemokine (C-X-C motif) ligand 8a
Synonyms: cxcl-chr1a, cxcl-chr1b, cxcl8, il8, CXCL8_L1_chr1, si:dkey-151b16.2, dr-chr1-CXCL8
Source: ZFIN:ZDB-GENE-081104-317
Biotype: protein coding gene
Strict Orthology Symbols: Ppbp...PPBP
cxcl8b.2
(Xenopus tropicalis)Gene
Name: C-X-C motif chemokine ligand 8b gene 2
Synonyms: cxcl8b.2, C-X-C motif chemokine ligand 8b gene 2, LOC100037000, XB5945946, LOC100498234
Source: Xenbase:XB-GENE-5945947
Biotype: gene
Strict Orthology Symbols: PPBP
Gene Ontology
Source: GO:0071624
Synonyms: Not Available
Branch: biological process
Genes: Ppbp (Rno)...Ppbp (Mmu)
Disease
Source: DOID:0080883
Definition: A bone development disease that is characterized by softening and weakening of the bones, hypocalcemia, high levels of parathyroid hormone and hypophosphatemia.
Genes: Ppbp (Mmu)...Ppbp (Rno)...PPBP (Hsa)
Gene Ontology
Source: GO:0031091
Synonyms:
- platelet alpha-granule
Branch: cellular component
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Disease
Source: DOID:10230
Definition: Not Available
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Gene Ontology
Source: GO:0045236
Synonyms:
- C-X-C chemokine receptor ligand
- CXC chemokine receptor ligand
Branch: molecular function
Genes: Ppbp (Mmu)...PPBP (Hsa)
Source: GO:0002523
Synonyms:
- immune cell migration during inflammatory response
- immune cell trafficking during inflammatory response
Branch: biological process
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Disease
Source: DOID:0081063
Definition: A syndrome that is characterized by an increased risk of developing pleuropulmonary blastoma, multinodular goiter, ovarian Sertoli-Leydig cell tumors, and/or other types of tumors, and that has_material_basis_in heterozygous mutation in the DICER1 gene on chromosome 14q32. Mutations of the gene encoding the endoribonuclease, Dicer, disrupts the biogenesis and processing of miRNAs with subsequent disruption in control of gene expression.
Synonyms: PPB familial tumor susceptibility syndrome
Disease
Source: DOID:2988
Definition: An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Disease
Source: DOID:10892
Definition: A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum.
Genes: Ppbp (Rno)...PPBP (Hsa)...Ppbp (Mmu)
Disease
Source: DOID:0050852
Definition: An ischemia that is characterized by low blood supply to tissues in the limb due to interruption in the arterial blood supply.
Genes: Ppbp (Rno)...PPBP (Hsa)...Ppbp (Mmu)
Gene Ontology
Source: GO:0031093
Synonyms:
- platelet alpha-granule lumen
Branch: cellular component
Genes: PPBP (Hsa)
Gene Ontology
Source: GO:1904724
Synonyms:
- gelatinase granule membrane-enclosed lumen
- membrane-enclosed lumen of gelatinase granule
Branch: cellular component
Genes: PPBP (Hsa)
Gene Ontology
Source: GO:0008009
Synonyms: Not Available
Branch: molecular function
Genes: Ppbp (Rno)...PPBP (Hsa)...Ppbp (Mmu)
Gene Ontology
Source: GO:0030593
Synonyms: Not Available
Branch: biological process
Genes: Ppbp (Mmu)...PPBP (Hsa)
Gene Ontology
Source: GO:0030220
Synonyms:
- platelet extrusion
Branch: biological process
Genes: Ppbp (Rno)
Gene Ontology
Source: GO:1904659
Synonyms:
- glucose transmembrane transport
- glucose transport
Branch: biological process
Genes: PPBP (Hsa)
Disease
Source: DOID:9975
Definition: A drug dependence that is a psychological dependency on the regular use of cocaine.
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Source: DOID:4467
Definition: A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Source: GO:0061844
Synonyms:
- antimicrobial peptide-mediated antimicrobial humoral response
- peptide-mediated antimicrobial humoral response
Branch: biological process
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Disease
Source: DOID:9408
Definition: Not Available
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Source: DOID:11394
Definition: A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Gene Ontology
Source: GO:0055056
Synonyms: Not Available
Branch: molecular function
Genes: PPBP (Hsa)
Disease
Source: DOID:0060224
Definition: A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain.
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Disease
Source: DOID:1168
Definition: Not Available
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)
Gene Ontology
Source: GO:0051781
Synonyms:
- activation of cell division
- stimulation of cell division
Branch: biological process
Genes: PPBP (Hsa)
Gene Ontology
Source: GO:0070098
Synonyms:
- chemokine-mediated signalling pathway
Branch: biological process
Genes: PPBP (Hsa)
Gene Ontology
Source: GO:0031640
Synonyms:
- killing of cells of other organism
Branch: biological process
Genes: Ppbp (Mmu)
Wide-scale transcriptome disturbance underlies liver and kidney pathology from chronic ultra low dose Roundup exposure [liver]
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE66058
Tags: unclassified
Summary: Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH residues pose a particular risk to the kidneys and liver. However, the existence of biological effects with negative health implications at low environmentally relevant doses remains unresolved. A previous investigation addressed this issue, by conducting a 2-year feeding study, which included 10 female Sprague Dawley rats administered via drinking water with 0.1 ppb of a major Roundup formulation (50 ng/L glyphosate equivalent dilution). Hepatorenal toxicities, as well as urine and blood biochemistry disturbances at the 15th month of age were observed. In an effort to obtain molecular mechanistic insight into the underlying causes of these pathologies, we have carried out a transcriptome microarray analysis of the liver and kidneys from these same animals. The expression of 4224 and 4447 genes were found to be disturbed respectively in liver and kidney (p<0.01, q<0.08, fold change >1.1). Among the 1319 genes whose expression was altered in both tissues, 3 functional categories were over-represented. First, genes involved in mRNA splicing and small nucleolar RNA were mostly upregulated, suggesting disruption of normal spliceosome activity. Electron microscopic analysis of hepatocytes confirmed nucleolar structural disruption. Second, genes controlling chromatin structure (especially histone-lysine N-methyltransferases) were mostly upregulated. Third, genes related to respiratory chain complex I and the tricarboxylic acid cycle were mostly downregulated. The transcription factor networks that can account for these disruptions were centered on CREB1, ESR1, YY1, c-Myc and Oct3/4 activity, which are known to closely cooperate in the regulation of gene expression after hormonal stimulation. The analysis of pathways and toxicity processes showed that these disturbances in gene expression were representative of fibrosis, necrosis, phospholipidosis, mitochondrial membrane dysfunction and ischemia, which correlate with the pathologies observed at an anatomical and histological level. Our results suggest that new studies incorporating testing principles from endocrinology and developmental epigenetics need to be performed to investigate potential consequences of exposure to low dose, environmental levels of GBH and glyphosate.
Wide-scale transcriptome disturbance underlies liver and kidney pathology from chronic ultra low dose Roundup exposure [kidney]
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE66059
Tags: unclassified
Summary: Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH residues pose a particular risk to the kidneys and liver. However, the existence of biological effects with negative health implications at low environmentally relevant doses remains unresolved. A previous investigation addressed this issue, by conducting a 2-year feeding study, which included 10 female Sprague Dawley rats administered via drinking water with 0.1 ppb of a major Roundup formulation (50 ng/L glyphosate equivalent dilution). Hepatorenal toxicities, as well as urine and blood biochemistry disturbances at the 15th month of age were observed. In an effort to obtain molecular mechanistic insight into the underlying causes of these pathologies, we have carried out a transcriptome microarray analysis of the liver and kidneys from these same animals. The expression of 4224 and 4447 genes were found to be disturbed respectively in liver and kidney (p<0.01, q<0.08, fold change >1.1). Among the 1319 genes whose expression was altered in both tissues, 3 functional categories were over-represented. First, genes involved in mRNA splicing and small nucleolar RNA were mostly upregulated, suggesting disruption of normal spliceosome activity. Electron microscopic analysis of hepatocytes confirmed nucleolar structural disruption. Second, genes controlling chromatin structure (especially histone-lysine N-methyltransferases) were mostly upregulated. Third, genes related to respiratory chain complex I and the tricarboxylic acid cycle were mostly downregulated. The transcription factor networks that can account for these disruptions were centered on CREB1, ESR1, YY1, c-Myc and Oct3/4 activity, which are known to closely cooperate in the regulation of gene expression after hormonal stimulation. The analysis of pathways and toxicity processes showed that these disturbances in gene expression were representative of fibrosis, necrosis, phospholipidosis, mitochondrial membrane dysfunction and ischemia, which correlate with the pathologies observed at an anatomical and histological level. Our results suggest that new studies incorporating testing principles from endocrinology and developmental epigenetics need to be performed to investigate potential consequences of exposure to low dose, environmental levels of GBH and glyphosate.
Gene expression microarray analysis of rat nasal tissue with time and dose following formaldehyde inhalation
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE23179
Tags: unclassified
Summary: Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen. In this study, concentration- and exposure-duration transitions in FA mode of action (MOA) were examined with pharmacokinetic (PK) modeling for tissue formaldehyde acetal (FAcetal) and glutathione (GSH) and with histopathology and gene expression studies for tissue responses in nasal epithelium from rats exposed to 0, 0.7, 2, 6, 10 or 15 ppm FA 6 hr/day for 1, 4 or 13 weeks. The study had two goals. The first goal was to develop a basic PK model to estimate various forms of tissue formaldehyde and tissue glutathione (GSH). The second goal was to compare histopathology and gene expression changes in nasal tissues caused by inhalation of FA with changes in tissue FAcetal and free GSH calculated from the PK model. Patterns of gene expression varied with concentration and with duration. At 0.7 and 2 ppm, sensitive response genes (SRGs) - associated with cellular stress, thiol transport/reduction, inflammation, and cell proliferation - were similarly upregulated at all exposure durations. At 6 ppm and greater, gene expression changes showed enrichment of pathways involved in cell cycle, DNA repair, and apoptosis processes. ERBB, EGFR, WNT, TGF-ß, Hedgehog, and Notch signaling were also enriched in differentially expressed genes. Benchmark doses (BMDs) for genes in significantly enriched pathways were lower at 13 weeks than at 1 or 4-week. The transcriptional and histological changes corresponded to PK model-predicted changes in free GSH at 0.7 and 2 ppm and in FAcetal at 6 ppm. DNA-replication stress, enhanced proliferation, metaplasia, and stem cell-niche activation appear to be associated with FA carcinogenesis at 6 ppm and above. Dose dependencies in MOA, the presence of high physiological FAcetal, and non-linear FAcetal/GSH tissue kinetics indicate that FA concentrations below 150 ppb (and probably any concentrations below irritant levels, i.e., ~ 1 ppm) would not increase cancer risks of inhaled FA in the nose or any other tissue. Closer examination of dose response relationships for endogenous compound toxicity could help guide biologically relevant approaches for chemical risk assessment.
Gene Ontology
Source: GO:0006952
Synonyms:
- antimicrobial peptide activity
- defence response
Branch: biological process
Genes: PPBP (Hsa)
Gene Ontology
Source: GO:0060326
Synonyms: Not Available
Branch: biological process
Genes: PPBP (Hsa)
Disease
Source: DOID:2316
Definition: An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.
Genes: Ppbp (Rno)...Ppbp (Mmu)...PPBP (Hsa)