Version: 8.2.0
Date: Wed Aug 27 2025
2,167 results for ppcdc

Ppcdc

(Rattus norvegicus)
Gene
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: LOC363069, NEWGENE_1306267, RGD1306267, similar to RIKEN cDNA 8430432M10
Source: RGD:1306267
Biotype: protein coding gene
Symbol: Ppcdc (Rno)
Symbol: Ppcdc
Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase); PARTICIPATES IN pantothenic acid
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc

Ppcdc

(Drosophila melanogaster)
Gene
Name: Phosphopantothenoylcysteine decarboxylase
Synonyms: (R)-4'-phospho-N-pantothenoylcysteine decarboxylase, CG30290, BcDNA:LD37882, Dromel_CG30290_FBtr0071672_cx9c_mORF, PPCDC, dPPCDC
Source: FB:FBgn0050290
Biotype: protein coding gene
Symbol: Ppcdc (Dme)
Symbol: Ppcdc
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Synonyms: PPCDC...PPCDC
Strict Orthology Symbols: ppcdc
Alleles: Ppcdc (Dme)

ppcdc

(Danio rerio)
Gene
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: zgc:73297
Source: ZFIN:ZDB-GENE-040426-1749
Biotype: protein coding gene
Symbol: ppcdc (Dre)
Symbol: ppcdc
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc

Ppcdc

(Mus musculus)
Gene
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: RIKEN cDNA 1810057I13 gene, RIKEN cDNA 8430432M10 gene, 1810057I13Rik, RGD1306267, 8430432M10Rik
Source: MGI:1914062
Biotype: protein coding gene
Symbol: Ppcdc (Mmu)
Symbol: Ppcdc
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc
Alleles: Ppcdc (Mmu)...Ppcdc (Mmu)...Ppcdc (Mmu)

PPCDC

(Homo sapiens)
Gene
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: coaC, MDS018, PPC-DC, FLJ14585
Source: HGNC:28107
Biotype: protein coding gene
Symbol: PPCDC (Hsa)
Symbol: PPCDC
Gene Synopsis: PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to
Strict Orthology Symbols: ppcdc

ppcdc

(Xenopus tropicalis)
Gene
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: phosphopantothenoylcysteine decarboxylase, ppcdc
Source: Xenbase:XB-GENE-992268
Biotype: gene
Symbol: ppcdc
Symbol: ppcdc (Xtr)
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Synonyms: ppcdc...ppcdc...ppcdc
Strict Orthology Symbols: ppcdc

ppcdc.S

(Xenopus laevis)
Gene
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: phosphopantothenoylcysteine decarboxylase, ppcdc.S
Source: Xenbase:XB-GENE-992269
Biotype: gene
Symbol: ppcdc.S (Xla)
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc
Symbol: ppcdc.S

ppcdc.L

(Xenopus laevis)
Gene
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: phosphopantothenoylcysteine decarboxylase, ppcdc.L
Source: Xenbase:XB-GENE-17342017
Biotype: gene
Symbol: ppcdc.L (Xla)
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc
Symbol: ppcdc.L

PpcdcKK109377

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0236274
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: neurodegeneration with brain iron accumulation
Variant Name: Not Available
Symbol: Ppcdc (Dme)
Construct Knockdown Component: Ppcdc (Dme)
Symbol: PpcdcKK109377
Constructs: UAS-dPPCDC/ppcdc-RNAi

PpcdcGt(IST10148A1)Tigm

(Mus musculus)
Allele/Variant
Source: MGI:3932228
Genes: Ppcdc (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppcdc (Mmu)
Genes: Ppcdc (Mmu)
Symbol: PpcdcGt(IST10148A1)Tigm

Ppcdcem1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7304550
Genes: Ppcdc (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppcdc (Mmu)
Genes: Ppcdc (Mmu)
Symbol: Ppcdcem1Gpt

PpcdcUAS.ORF.GW.Tag:HA

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0303353
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppcdc (Dme)
Symbol: PpcdcUAS.ORF.GW.Tag:HA
Construct Expressed Component: Ppcdc (Dme)

PpcdcGD8674

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0202542
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppcdc (Dme)
Construct Knockdown Component: Ppcdc (Dme)
Symbol: PpcdcGD8674

Ppcdcem8Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7304551
Genes: Ppcdc (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppcdc (Mmu)
Genes: Ppcdc (Mmu)
Symbol: Ppcdcem8Gpt

PpcdcGD16798

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0202543
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppcdc (Dme)
Construct Knockdown Component: Ppcdc (Dme)
Symbol: PpcdcGD16798

PpcdcHMC05201

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0315012
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppcdc (Dme)
Construct Knockdown Component: Ppcdc (Dme)
Symbol: PpcdcHMC05201
Constructs: Ppcdc RNAi...Ppcdc RNAi

Ppcdcf00839

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0161854
Genes: Ppcdc (Dme)
Synonyms: Not Available
Variant Type: insertion
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Ppcdc (Dme)
Gene Synonyms: PPCDC
Genes: Ppcdc (Dme)
Symbol: Ppcdcf00839

CAB3

(Saccharomyces cerevisiae)
Gene
Name: Coenzyme A Biosynthesis
Synonyms: YKL088W
Source: SGD:S000001571
Biotype: protein coding gene
Gene Synopsis: Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc

VHS3

(Saccharomyces cerevisiae)
Gene
Name: Viable in a Hal3 Sit4 background
Synonyms: YOR29-05, YOR054C
Source: SGD:S000005580
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc

SIS2

(Saccharomyces cerevisiae)
Gene
Name: SIt4 Suppressor
Synonyms: HAL3, YKR072C
Source: SGD:S000001780
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc

F25H9.6

(Caenorhabditis elegans)
Gene
Name: Flavoprotein domain-containing protein
Synonyms: CELE_F25H9.6
Source: WB:WBGene00009138
Biotype: protein coding gene
Gene Synopsis: Is an ortholog of human PPCDC (phosphopantothenoylcysteine decarboxylase).
Automated Gene Synopsis: Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).
Strict Orthology Symbols: ppcdc

phosphopantothenoylcysteine decarboxylase complex

Gene Ontology
Source: GO:0071513
Synonyms: Not Available
Branch: cellular component
Genes: Ppcdc (Rno)...ppcdc (Dre)...Ppcdc (Dme)...PPCDC (Hsa)...Ppcdc (Mmu)

phosphopantothenoylcysteine decarboxylase activity

Gene Ontology
Source: GO:0004633
Synonyms:
  • 4-phosphopantothenoyl-L-cysteine decarboxylase activity
  • 4-phosphopantotheoylcysteine decarboxylase activity
Branch: molecular function
Genes: Ppcdc (Rno)...ppcdc (Dre)...Ppcdc (Dme)...PPCDC (Hsa)...Ppcdc (Mmu)

neurodegeneration with brain iron accumulation

Disease
Source: DOID:0110734
Definition: A neurodegenerative disease characterized by progressive iron accumulation in the basal ganglia and other regions of the brain, resulting in extrapyramidal movements, such as parkinsonism and dystonia.
Genes: Ppcdc (Rno)...PPCDC (Hsa)...Ppcdc (Mmu)...ppcdc (Xtr)...ppcdc (Dre)
Alleles: Ppcdc (Dme)

coenzyme A biosynthetic process

Gene Ontology
Source: GO:0015937
Synonyms:
  • CoA biosynthesis
  • coenzyme A anabolism
Branch: biological process
Genes: Ppcdc (Rno)...PPCDC (Hsa)...Ppcdc (Mmu)...ppcdc (Dre)...Ppcdc (Dme)

FMN binding

Gene Ontology
Source: GO:0010181
Synonyms:
  • flavin mononucleotide binding
Branch: molecular function
Genes: Ppcdc (Rno)...PPCDC (Hsa)...Ppcdc (Mmu)...ppcdc (Dre)...Ppcdc (Dme)

carboxy-lyase activity

Gene Ontology
Source: GO:0016831
Synonyms:
  • decarboxylase activity
Branch: molecular function
Genes: PPCDC (Hsa)...Ppcdc (Mmu)

CG42496HMC05201

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0397934
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Construct Knockdown Component: Ppcdc (Dme)
Constructs: Ppcdc RNAi...Ppcdc RNAi

Sis2 regulates yeast replicative lifespan in a dose-dependent manner

HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by SGD
ID: GEO:GSE205228
Tags: cell aging
Summary: Application of microfluidic platforms facilitated high-precision measurements of yeast replicative lifespan (RLS); however, comparative quantification of lifespan across strain libraries has been missing. Here we microfluidically measured RLS of 307 yeast strains, each deleted for a single gene. Despite previous reports of extended lifespan in these strains, we found that 56% of them did not actually live longer than the wild-type; while the remaining 44% showed extended lifespans, the degree of extension was often different from what was previously reported. Deletion of SIS2 gene led to the largest RLS increase observed. Sis2 regulated yeast lifespan in a dose-dependent manner, implying a role for the coenzyme A biosynthesis pathway in lifespan regulation. Introduction of the human PPCDC gene in the sis2Δ background neutralized the lifespan extension. RNA-seq experiments revealed transcriptional increases in cell-cycle machinery components in sis2Δ background. High-precision lifespan measurement will be essential to elucidate the gene network governing lifespan.

dilated cardiomyopathy

Disease
Source: DOID:12930
Definition: An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.
Genes: Ppcdc (Mmu)...PPCDC (Hsa)...Ppcdc (Dme)...Ppcdc (Rno)...ppcdc (Xtr)

catalytic activity

Gene Ontology
Source: GO:0003824
Synonyms:
  • enzyme activity
Branch: molecular function
Genes: Ppcdc (Mmu)...PPCDC (Hsa)...Ppcdc (Dme)...Ppcdc (Rno)...ppcdc (Dre)

lyase activity

Gene Ontology
Source: GO:0016829
Synonyms: Not Available
Branch: molecular function
Genes: Ppcdc (Mmu)...PPCDC (Hsa)

identical protein binding

Gene Ontology
Source: GO:0042802
Synonyms:
  • isoform-specific homophilic binding
  • protein homopolymerization
Branch: molecular function
Genes: Ppcdc (Mmu)...Ppcdc (Rno)...PPCDC (Hsa)

(R6)2R:21691614T>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21691614T>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant, intron_variant
Diseases: Not Available
Variant Name: (R6)2R:21691614T>A
Gene Synonyms: PPCDC

(R6)2R:21691673G>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21691673G>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:21691673G>A
Gene Synonyms: PPCDC

(R6)2R:21691683G>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21691683G>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:21691683G>A
Gene Synonyms: PPCDC

(R6)2R:21692449C>T

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692449C>T
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21692449C>T
Gene Synonyms: PPCDC

(R6)2R:21692611C>T

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692611C>T
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21692611C>T
Gene Synonyms: PPCDC

(R6)2R:21692314G>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692314G>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21692314G>A
Gene Synonyms: PPCDC

(R6)2R:21691962G>C

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21691962G>C
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21691962G>C
Gene Synonyms: PPCDC

(R6)2R:21691967T>C

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21691967T>C
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:21691967T>C
Gene Synonyms: PPCDC

(R6)2R:21692124C>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692124C>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21692124C>A
Gene Synonyms: PPCDC

(R6)2R:21692491G>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692491G>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21692491G>A
Gene Synonyms: PPCDC

(R6)2R:21692191G>C

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692191G>C
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:21692191G>C
Gene Synonyms: PPCDC

(R6)2R:21692214A>T

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692214A>T
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:21692214A>T
Gene Synonyms: PPCDC

(R6)2R:21692190G>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692190G>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (R6)2R:21692190G>A
Gene Synonyms: PPCDC

(R6)2R:21692332A>G

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692332A>G
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21692332A>G
Gene Synonyms: PPCDC

(R6)2R:21692482G>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692482G>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21692482G>A
Gene Synonyms: PPCDC

(R6)2R:21692641G>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21692641G>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant, synonymous_variant
Diseases: Not Available
Variant Name: (R6)2R:21692641G>A
Gene Synonyms: PPCDC

(R6)2R:21691674G>A

(Drosophila melanogaster)
Allele/Variant
Source: NT_033778.4:g.21691674G>A
Genes: CG42496 (Dme), Ppcdc (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)2R:21691674G>A
Gene Synonyms: PPCDC