Version: 8.1.0
Date: Fri Apr 18 2025
1,499 results for relb

Relb

(Mus musculus)
Gene
Name: avian reticuloendotheliosis viral (v-rel) oncogene related B
Synonyms: spontaneous hepatitis, shep
Source: MGI:103289
Biotype: protein coding gene
Symbol: Relb (Mmu)
Symbol: Relb
Automated Gene Synopsis: Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).
Strict Orthology Symbols: relb
Alleles: Relb (Mmu)...Relb (Mmu)...Relb (Mmu)...Relb (Mmu)...Relb (Mmu)

RELB

(Homo sapiens)
Gene
Name: RELB proto-oncogene, NF-kB subunit
Synonyms: v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, IREL, IMD53, REL-B, v-rel avian reticuloendotheliosis viral oncogene homolog B, v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3), transcription factor RelB, I-REL
Source: HGNC:9956
Biotype: protein coding gene
Symbol: RELB (Hsa)
Symbol: RELB
Synonyms: transcription factor RelB
Strict Orthology Symbols: relb

relb

(Danio rerio)
Gene
Name: v-rel avian reticuloendotheliosis viral oncogene homolog B
Synonyms: fj85b02, wu:fj85b02
Source: ZFIN:ZDB-GENE-030131-9531
Biotype: protein coding gene
Symbol: relb (Dre)
Symbol: relb
Automated Gene Synopsis: Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).
Strict Orthology Symbols: relb

Relb

(Rattus norvegicus)
Gene
Name: RELB proto-oncogene, NF-kB subunit
Synonyms: v-rel reticuloendotheliosis viral oncogene homolog B, LOC100360982, v-rel avian reticuloendotheliosis viral oncogene homolog B, avian reticuloendotheliosis viral (v-rel) oncogene related B, transcription factor RelB
Source: RGD:2321078
Biotype: protein coding gene
Symbol: Relb (Rno)
Symbol: Relb
Gene Synopsis: Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit); PARTICIPATES IN interleukin-12 signaling
Automated Gene Synopsis: Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).
Synonyms: transcription factor RelB
Strict Orthology Symbols: relb

relb

(Xenopus tropicalis)
Gene
Name: v-rel avian reticuloendotheliosis viral oncogene homolog B
Synonyms: xrelb, v-rel avian reticuloendotheliosis viral oncogene homolog B, relb
Source: Xenbase:XB-GENE-964072
Biotype: gene
Symbol: relb
Symbol: relb (Xtr)
Automated Gene Synopsis: Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).
Synonyms: relb...relb...relb
Strict Orthology Symbols: relb

relb.L

(Xenopus laevis)
Gene
Name: v-rel avian reticuloendotheliosis viral oncogene homolog B
Synonyms: xrelb, v-rel avian reticuloendotheliosis viral oncogene homolog B, relb.L
Source: Xenbase:XB-GENE-17330719
Biotype: gene
Symbol: relb.L (Xla)
Automated Gene Synopsis: Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).
Strict Orthology Symbols: relb
Symbol: relb.L

relb.S

(Xenopus laevis)
Gene
Name: v-rel avian reticuloendotheliosis viral oncogene homolog B
Synonyms: xrelb, relb.S, v-rel avian reticuloendotheliosis viral oncogene homolog B
Source: Xenbase:XB-GENE-6068550
Biotype: gene
Symbol: relb.S (Xla)
Automated Gene Synopsis: Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).
Strict Orthology Symbols: relb
Symbol: relb.S

Relbtm1.1Jino

(Mus musculus)
Allele/Variant
Source: MGI:6474232
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbtm1.1Jino

RelbTg(H2-K1/GH1)106Bri

(Mus musculus)
Allele/Variant
Source: MGI:2179544
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: RelbTg(H2-K1/GH1)106Bri

Relbtm1Sbn

(Mus musculus)
Allele/Variant
Source: MGI:6509303
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbtm1Sbn

Relbem1Smoc

(Mus musculus)
Allele/Variant
Source: MGI:7292011
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbem1Smoc

Relbtm1Brv

(Mus musculus)
Allele/Variant
Source: MGI:2179545
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: atopic dermatitis
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbtm1Brv

Relbem1(IMPC)Ccpcz

(Mus musculus)
Allele/Variant
Source: MGI:7425942
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbem1(IMPC)Ccpcz

Relbtm1.1Alex

(Mus musculus)
Allele/Variant
Source: MGI:7561998
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbtm1.1Alex

Relbtm1.1Fwei

(Mus musculus)
Allele/Variant
Source: MGI:5441212
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbtm1.1Fwei

Relbtm1Ukl

(Mus musculus)
Allele/Variant
Source: MGI:5788155
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbtm1Ukl

Relbem1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7305338
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbem1Gpt

Relbtm1Brv/Relbtm1Brv [background:] involves: 129S2/SvPas * C57BL/6

(Mus musculus)
Model
Id: MGI:2179553
Synonyms: Not Available
Symbol: Relb/Relb [background:] involves: 129S2/SvPas * C57BL/6 (Mmu)
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb [background:] involves: 129S2/SvPas * C57BL/6

RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri [background:] involves: C57BL/6

(Mus musculus)
Model
Id: MGI:4361565
Synonyms: Not Available
Symbol: Relb/Relb [background:] involves: C57BL/6 (Mmu)
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb [background:] involves: C57BL/6

Relbtm1Brv/Relbtm1Brv [background:] involves: 129S2/SvPas

(Mus musculus)
Model
Id: MGI:4457004
Synonyms: Not Available
Symbol: Relb/Relb [background:] involves: 129S2/SvPas (Mmu)
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb [background:] involves: 129S2/SvPas

Relbshep/Relbshep [background:] A;C-Relbshep/GrsrJ

(Mus musculus)
Model
Id: MGI:5003486
Synonyms: Not Available
Symbol: Relb/Relb [background:] A;C-Relb/GrsrJ (Mmu)
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb [background:] A;C-Relb/GrsrJ

Relbtm1.1Fwei/Relbtm1.1Fwei Tg(Cd4-cre)1Cwi/0 [background:] involves: C57BL/6 * DBA/2

(Mus musculus)
Model
Id: MGI:5441217
Synonyms: Not Available
Symbol: Relb/Relb Tg(Cd4-cre)1Cwi/0 [background:] involves: C57BL/6 * DBA/2 (Mmu)
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb Tg(Cd4-cre)1Cwi/0 [background:] involves: C57BL/6 * DBA/2

RelbTg(H2-K1/GH1)106Bri/Relb+ [background:] involves: C57BL/6

(Mus musculus)
Model
Id: MGI:4361566
Synonyms: Not Available
Symbol: Relb/Relb<+> [background:] involves: C57BL/6 (Mmu)
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb<+> [background:] involves: C57BL/6

RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri [background:] C57BL/6-RelbTg(H2-K1/GH1)106Bri

(Mus musculus)
Model
Id: MGI:2179614
Synonyms: Not Available
Symbol: Relb/Relb [background:] C57BL/6-Relb
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb [background:] C57BL/6-Relb

Relbtm1.1Fwei/Relbtm1.1Fwei Tg(Lck-cre)I57Jxm/0 [background:] involves: ICR

(Mus musculus)
Model
Id: MGI:5441216
Synonyms: Not Available
Symbol: Relb/Relb Tg(Lck-cre)I57Jxm/0 [background:] involves: ICR (Mmu)
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb Tg(Lck-cre)I57Jxm/0 [background:] involves: ICR

Relbtm1Brv/Relbtm1Brv [background:] either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

(Mus musculus)
Model
Id: MGI:3588865
Synonyms: Not Available
Symbol: Relb/Relb [background:] either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Relb/Relb [background:] either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves

Relbshep

(Mus musculus)
Allele/Variant
Source: MGI:5002714
Genes: Relb (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Relb (Mmu)
Genes: Relb (Mmu)
Symbol: Relbshep

Dif

(Drosophila melanogaster)
Gene
Name: Dorsal-related immunity factor
Synonyms: Dif, dif, DIF, dorsal-related immunity factor, 6794, NF-KB, Dorsal related immunity factor, NF-kappaB, Dif2, Dorsal-related transcription factor, CG6794, Dorsal-like immunity factor, NFkappaB
Source: FB:FBgn0011274
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including RELA (RELA proto-oncogene, NF-kB subunit) and RELB (RELB
Strict Orthology Symbols: relb

dl

(Drosophila melanogaster)
Gene
Name: dorsal
Synonyms: dorsal, mat(2)dorsal, Dor, NF-KB, dL, DL, Dl, Embryonic polarity protein dorsal, anon-EST:GressD7, NF-kappaB, Dorsal, fs(2)k10816, NFkappabeta, p65, CG6667, GSd447, Dorsal/NF-kappaB, DORSAL, NFkappaB
Source: FB:FBgn0260632
Biotype: protein coding gene
Strict Orthology Symbols: RELB

Comparison of RelB-/- and RelB+/- thymi

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-43154, GEO:GSE43154
Tags: WT vs. mutant, genotype
Summary: Thymic medullary epithelial cell (mTEC) expression of the autoimmune regulator AIRE, and of tissue-specific antigens, is controlled by members of the non-canonical NF-kB signalling pathway, including RelB and NF-kB2. Of the genes in this pathway, RelB-/- mice develop a particularly severe multi-organ autoimmune syndrome, resembling Foxp3-deficiency. RelB-/- mice have medullary atrophy and few mTECs but the mechanism is unknown. We show that RelB is required for expression of medullary chemokines and mTEC AIRE, selection of a diverse peripheral T cell repertoire, and for peripheral Foxp3+ Treg function. Vbeta families of T cells infiltrating diseased peripheral organs and thymic Treg were similarly skewed. Surprisingly, medullary atrophy results from intra-thymic granulocyte infiltration, consequent upon the Th2-mediated autoimmune disease. Dominant tolerance corrects thymic inflammatory disease and loss of thymic function. We demonstrate a reversible RelB-dependent inflammatory mechanism for loss of central tolerance associated with medullary atrophy. Thymi from 4 RelB+/- mice and 3 RelB-/- mice were profiled by microarrays
Symbol: Comparison of RelB-/- and RelB+/- thymi

immunodeficiency 53

Disease
Source: DOID:0111992
Definition: A combined T cell and B cell immunodeficiency characterized by recurrent upper and lower respiratory infections, increase in the CD4+ T cell to CD8+ T cell ratio, impaired T-cell proliferative responses to multiple antigens, and impaired ability to produce specific immunoglobulins that has_material_basis_in homozygous or compound heterozygous mutation in the RELB gene on chromosome 19q13.32.
Genes: relb (Dre)...relb.L (Xla)...RELB (Hsa)...Relb (Rno)...relb (Xtr)

Map3k14aly/Map3k14+ RelbTg(H2-K1/GH1)106Bri/Relb+ [background:] involves: C57BL/6 * C57BL/6J

(Mus musculus)
Model
Id: MGI:4361564
Synonyms: Not Available
Genes: Relb (Mmu)
Alleles: Relb (Mmu)
Name: Map3k14/Map3k14<+> Relb/Relb<+> [background:] involves: C57BL/6 * C57BL/6J
Symbol: Map3k14/Map3k14<+> Relb/Relb<+> [background:] involves: C57BL/6 * C57BL/6J

zf148Tg + CRISPR1-relb + CRISPR2-relb + CRISPR3-relb + CRISPR4-relb (WIK/AB)

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-240409-16
Synonyms: Not Available
Genes: relb (Dre)
Name: zf148Tg + CRISPR1-relb + CRISPR2-relb + CRISPR3-relb + CRISPR4-relb (WIK/AB)

T-helper 1 cell differentiation

Gene Ontology
Source: GO:0045063
Synonyms:
  • T-helper 1 cell development
Branch: biological process
Genes: RELB (Hsa)...Relb (Rno)...Relb (Mmu)

non-canonical NF-kappaB signal transduction

Gene Ontology
Source: GO:0038061
Synonyms:
  • NF-kappaB cascade
  • NIK-IKK kinase cascade
Branch: biological process
Genes: relb (Dre)...RELB (Hsa)...Relb (Rno)...Relb (Mmu)

T-helper 1 type immune response

Gene Ontology
Source: GO:0042088
Synonyms:
  • Th1 immune response
Branch: biological process
Genes: RELB (Hsa)...Relb (Rno)...Relb (Mmu)

lymphocyte differentiation

Gene Ontology
Source: GO:0030098
Synonyms:
  • lymphocyte cell differentiation
  • lymphocyte development
Branch: biological process
Genes: RELB (Hsa)...Relb (Rno)...Relb (Mmu)

NF-kappaB complex

Gene Ontology
Source: GO:0071159
Synonyms: Not Available
Branch: cellular component
Genes: RELB (Hsa)

myeloid dendritic cell differentiation

Gene Ontology
Source: GO:0043011
Synonyms: Not Available
Branch: biological process
Genes: RELB (Hsa)...Relb (Rno)...Relb (Mmu)

prediabetes syndrome

Disease
Source: DOID:11716
Definition: A glucose metabolism disease that is characterized by blood glucose levels are high, but not high enough to be classified as type 2 diabetes.
Genes: relb (Dre)...relb (Xtr)...RELB (Hsa)...Relb (Rno)...Relb (Mmu)

la027597Tg

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-130129-2310
Genes: relb (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: relb (Dre)

negative regulation of interferon-beta production

Gene Ontology
Source: GO:0032688
Synonyms:
  • down regulation of interferon-beta production
  • down-regulation of interferon-beta production
Branch: biological process
Genes: RELB (Hsa)...Relb (Rno)...Relb (Mmu)

bacterial infectious disease

Disease
Source: DOID:104
Definition: A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.
Genes: relb (Dre)...relb (Xtr)...RELB (Hsa)...Relb (Rno)...Relb (Mmu)

canonical NF-kappaB signal transduction

Gene Ontology
Source: GO:0007249
Synonyms:
  • I-kappaB kinase/NF-kappaB cascade
  • I-kappaB kinase/NF-kappaB signal transduction
Branch: biological process
Genes: relb (Dre)...RELB (Hsa)...Relb (Rno)...Relb (Mmu)

cellular response to osmotic stress

Gene Ontology
Source: GO:0071470
Synonyms:
  • cellular osmotic response
  • cellular osmotic stress response
Branch: biological process
Genes: RELB (Hsa)...Relb (Rno)...Relb (Mmu)

RNA-seq data from murine eGFP+ relbfl/flnfkb2fl/flCg1-Cre and Cg1-Cre splenic germinal center B cells purified by fluorescent activated cell sorting.

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE77374
Tags: WT vs. mutant, genotype
Summary: RNA-seq analysis of murine eGFP+ relbfl/flnfkb2fl/flCg1-Cre and Cg1-Cre splenic germinal center B cells identifies genes regulated by the transcription factors RELB and p52 (NF-kB2) in germinal center B cells. Germinal center B cells from 12-week old relbfl/flnfkb2fl/flCg1-Cre and Cg1-Cre littermate mice immunized with sheep red blood cells (SRBC) were isolated at day 7 after immunization by flow cytometric sorting from splenic mononuclear cells. RNA was isolated, amplified and submitted for RNA-sequencing on an Illumina HiSeq2500 instrument for 35-40 million 2x50 paired-ended reads.
Symbol: RNA-seq data from murine eGFP+ relbfl/flnfkb2fl/flCg1-Cre and Cg1-Cre splenic germinal center B cells

muscular atrophy

Disease
Source: DOID:767
Definition: Not Available
Genes: relb (Dre)...Relb (Mmu)...relb (Xtr)...RELB (Hsa)...Relb (Rno)

antigen processing and presentation

Gene Ontology
Source: GO:0019882
Synonyms:
  • antigen presentation
  • antigen processing
Branch: biological process
Genes: RELB (Hsa)...Relb (Rno)...Relb (Mmu)

Tg(Relb-cre)53Rie

(Mus musculus)
Allele/Variant
Source: MGI:6729308
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tg(Relb-cre)53Rie
Construct Regulatory Region: Relb (Mmu)
Constructs: Tg(Relb-cre)53Rie construct

Hsap\RELBUAS.Tag:HA

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0366381
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hsap\RELB
Construct Expressed Component: RELB (Hsa)