Version: 8.0.0Date: Tue Jan 28 2025
Category
Rfwd2em1Mcwi
(Rattus norvegicus)Allele/Variant
Source: RGD:12790718
Genes: Cop1 (Rno)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Rfwd2
Gene Synonyms: Rfwd2...E3 ubiquitin-protein ligase RFWD2
Symbol: Rfwd2em1Mcwi
cop1
(Danio rerio)Gene
Name: COP1 E3 ubiquitin ligase
Synonyms: zgc:163067, rfwd2
Source: ZFIN:ZDB-GENE-070410-134
Biotype: protein coding gene
Synonyms: rfwd2...rfwd2...rfwd2
cop1
(Xenopus tropicalis)Gene
Name: COP1, E3 ubiquitin ligase
Synonyms: cop1, COP1, E3 ubiquitin ligase, rfwd2, rnf200
Source: Xenbase:XB-GENE-1014311
Biotype: gene
Synonyms: rfwd2...rfwd2...rfwd2
cop1.S
(Xenopus laevis)Gene
Name: COP1, E3 ubiquitin ligase
Synonyms: COP1, E3 ubiquitin ligase, rfwd2, rnf200, cop1.S
Source: Xenbase:XB-GENE-17338128
Biotype: gene
Synonyms: rfwd2...rfwd2...rfwd2
cop1.L
(Xenopus laevis)Gene
Name: COP1, E3 ubiquitin ligase
Synonyms: COP1, E3 ubiquitin ligase, cop1.L, rfwd2, rnf200
Source: Xenbase:XB-GENE-1014316
Biotype: gene
Synonyms: rfwd2...rfwd2...rfwd2
COP1
(Homo sapiens)Gene
Name: COP1 E3 ubiquitin ligase
Synonyms: constitutive photomorphogenic protein (COP1), RP11-318C24.3, COP1, E3 ubiquitin ligase, RING-type E3 ubiquitin transferase RFWD2, constitutive photomorphogenesis protein 1 homolog, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, hCOP1, FLJ10416, putative ubiquitin ligase COP1, FAP78, RNF200, ring finger and WD repeat domain 2, E3 ubiquitin-protein ligase COP1, RFWD2, RING finger protein 200, constitutive photomorphogenic protein 1, E3 ubiquitin-protein ligase RFWD2, RING finger and WD repeat domain protein 2, CFAP78
Source: HGNC:17440
Biotype: protein coding gene
Synonyms: RFWD2...RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
Cop1
(Rattus norvegicus)Gene
Name: COP1, E3 ubiquitin ligase
Synonyms: LOC100360800, ring finger and WD repeat domain 2, Rfwd2, E3 ubiquitin-protein ligase COP1, LOC360860, RGD1304773, MGC109175, similar to constitutive photomorphogenic protein 1, E3 ubiquitin-protein ligase RFWD2, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Source: RGD:1304773
Biotype: protein coding gene
Synonyms: Rfwd2...Rfwd2...E3 ubiquitin-protein ligase RFWD2
Alleles: Rfwd2
Cop1
(Mus musculus)Gene
Name: COP1, E3 ubiquitin ligase
Synonyms: ring finger and WD repeat domain 2, Rfwd2, expressed sequence C80879, RGD1304773, AI316802, expressed sequence AI316802, C80879
Source: MGI:1347046
Biotype: protein coding gene
Synonyms: Rfwd2...Rfwd2
SS-Rfwd2em1Mcwi
(Rattus norvegicus)Model
Id: RGD:12790717
Synonyms: SS-Rfwd2em1Mcwi
Alleles: Rfwd2
Name: SS-<Rfwd2>
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE80707
Tags: WT vs. mutant, genotype
Summary: Transcriptome analysis by RNA-seq of lungs from control and Rfwd2 epithelial-specific conditional knockout mice at embryonic 13.5 day age. RFWD2, is an E3 ubiquitin ligase that modifies specific target proteins, priming their degradation via the ubiquitin proteasome system. Rfwd2 deficiency led to a striking halt in branching morphogenesis shortly after secondary branch formation. In the mutant lung, two ETS transcript factors essential for normal lung branching, ETV4 and ETV5, were upregulated at the protein, but not transcript level. Introduction of Etv loss-of-function alleles into the Rfwd2 mutant background attenuated the branching phenotype, suggesting that RFWD2 functions at least in part through degrading ETV proteins. As a number of E3 ligases are known to target factors important for lung development, our findings provides a preview of a protein-level regulatory network essential for lung branching morphogenesis. Total mRNA obtained from three samples per group (control and Rfwd2 conditional knockout)
Symbol: E3 ubiquitin ligase Rfwd2 inactivation effect on embryonic lung development
Name: E3 ubiquitin ligase Rfwd2 inactivation effect on embryonic lung development
Cop1tm2.2Vmd
(Mus musculus)Allele/Variant
Source: MGI:5013595
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1Gt(XR0177)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4331666
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7791661
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7791479
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7791115
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm1.1Vmd
(Mus musculus)Allele/Variant
Source: MGI:5013593
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7786840
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1Gt(XR0653)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4344899
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm3.1Vmd
(Mus musculus)Allele/Variant
Source: MGI:6258676
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm2.1Vmd
(Mus musculus)Allele/Variant
Source: MGI:5013594
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1em1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7289098
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7297309
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7791297
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1Gt(XR0653)1.1Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5301600
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
Cop1tm1a(EUCOMM)Hmgu
(Mus musculus)Allele/Variant
Source: MGI:4436177
Genes: Cop1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Rfwd2
(GRCh38)1:176206878G>A
(Homo sapiens)Allele/Variant
Source: rs765186257
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176206878G>A
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176135067G>C
(Homo sapiens)Allele/Variant
Source: NC_000001.11:g.176135067G>C
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176135067G>C
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176206791C>T
(Homo sapiens)Allele/Variant
Source: NC_000001.11:g.176206791C>T
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176206791C>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176136516A>T
(Homo sapiens)Allele/Variant
Source: NC_000001.11:g.176136516A>T
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, 5_prime_UTR_variant, non_coding_transcript_exon_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176136516A>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176163858A>G
(Homo sapiens)Allele/Variant
Source: rs370091759
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176163858A>G
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176085778G>A
(Homo sapiens)Allele/Variant
Source: NC_000001.11:g.176085778G>A
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, missense_variant, non_coding_transcript_exon_variant, stop_gained
Diseases: Not Available
Variant Name: (GRCh38)1:176085778G>A
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:175987033A>T
(Homo sapiens)Allele/Variant
Source: rs1464569267
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:175987033A>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176046304C>T
(Homo sapiens)Allele/Variant
Source: rs1298887687
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176046304C>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:175989442T>C
(Homo sapiens)Allele/Variant
Source: rs111531372
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)1:175989442T>C
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176136495C>G
(Homo sapiens)Allele/Variant
Source: rs75124417
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, 5_prime_UTR_variant, non_coding_transcript_exon_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176136495C>G
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176206959G>A
(Homo sapiens)Allele/Variant
Source: rs893191628
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176206959G>A
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176206692C>G
(Homo sapiens)Allele/Variant
Source: NC_000001.11:g.176206692C>G
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176206692C>G
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176206777C>T
(Homo sapiens)Allele/Variant
Source: rs769118592
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176206777C>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176206948A>T
(Homo sapiens)Allele/Variant
Source: rs751499796
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176206948A>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176149051C>G
(Homo sapiens)Allele/Variant
Source: rs139373171
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176149051C>G
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:175988404T>A
(Homo sapiens)Allele/Variant
Source: NC_000001.11:g.175988404T>A
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:175988404T>A
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176054453C>T
(Homo sapiens)Allele/Variant
Source: rs207460660
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176054453C>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176162970T>C
(Homo sapiens)Allele/Variant
Source: rs1330861874
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, 5_prime_UTR_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176162970T>C
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176081295A>G
(Homo sapiens)Allele/Variant
Source: rs557168088
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176081295A>G
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176085887T>C
(Homo sapiens)Allele/Variant
Source: NC_000001.11:g.176085887T>C
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176085887T>C
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176206629G>A
(Homo sapiens)Allele/Variant
Source: rs779964540
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176206629G>A
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176116654G>T
(Homo sapiens)Allele/Variant
Source: rs1162820625
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176116654G>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:175986967C>T
(Homo sapiens)Allele/Variant
Source: rs1571414351
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)1:175986967C>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:175988297T>C
(Homo sapiens)Allele/Variant
Source: rs557783032
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)1:175988297T>C
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2
(GRCh38)1:176043256C>T
(Homo sapiens)Allele/Variant
Source: rs1041415266
Genes: COP1 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, synonymous_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)1:176043256C>T
Gene Synonyms: RING-type E3 ubiquitin transferase RFWD2...RFWD2...E3 ubiquitin-protein ligase RFWD2