Version: 8.0.0Date: Tue Jan 28 2025
Category
SEL1L
(Homo sapiens)Gene
Name: SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Synonyms: sel-1 suppressor of lin-12-like 1, IBD2, suppressor of lin-12-like protein 1, sel-1 (suppressor of lin-12, C.elegans)-like, SEL1L1, sel-1L, protein sel-1 homolog 1, SEL1L adaptor subunit of ERAD E3 ubiquitin ligase, SEL1-LIKE, Suppressor of lin 12 (sel-1), C. elegans, homolog of, SEL1L ERAD E3 ligase adaptor subunit, PRO1063, SEL1L, ERAD E3 ligase adaptor subunit, Hrd3
Source: HGNC:10717
Biotype: protein coding gene
Symbol: SEL1L (Hsa)
Symbol: SEL1L
Synonyms: SEL1L adaptor subunit of ERAD E3 ubiquitin ligase...SEL1L ERAD E3 ligase adaptor subunit
Strict Orthology Symbols: sel1l
Sel1l
(Mus musculus)Gene
Name: sel-1 suppressor of lin-12-like (C. elegans)
Synonyms: Sel1h, expressed sequence AW493766, AW493766, Sel1 (suppressor of lin-12) 1 homolog (C. elegans)
Source: MGI:1329016
Biotype: protein coding gene
Symbol: Sel1l (Mmu)
Symbol: Sel1l
Automated Gene Synopsis: Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Strict Orthology Symbols: sel1l
Alleles: Sel1l
sel1l
(Danio rerio)Gene
Name: SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Synonyms: fj60e07, si:dkey-177p2.3, wu:fj60e07
Source: ZFIN:ZDB-GENE-041001-122
Biotype: protein coding gene
Symbol: sel1l (Dre)
Symbol: sel1l
Automated Gene Synopsis: Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Strict Orthology Symbols: sel1l
Sel1l
(Rattus norvegicus)Gene
Name: SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Synonyms: Sel1h, sel-1L, protein sel-1 homolog 1, SEL1L adaptor subunit of ERAD E3 ubiquitin ligase, suppressor of lin-12-like protein 1, SEL1L ERAD E3 ligase adaptor subunit, sel-1 suppressor of lin-12-like, Sel1 (suppressor of lin-12) 1 homolog, Sel1 (suppressor of lin-12) 1 homolog (C. elegans), sel-1 suppressor of lin-12-like (C. elegans)
Source: RGD:620147
Biotype: protein coding gene
Symbol: Sel1l (Rno)
Symbol: Sel1l
Gene Synopsis: Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase); PARTICIPATES IN Endoplasmic
Automated Gene Synopsis: Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Synonyms: SEL1L adaptor subunit of ERAD E3 ubiquitin ligase...SEL1L ERAD E3 ligase adaptor subunit
Strict Orthology Symbols: sel1l
sel1l
(Xenopus tropicalis)Gene
Name: SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Synonyms: sel1l, SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Source: Xenbase:XB-GENE-973992
Biotype: gene
Symbol: sel1l
Symbol: sel1l (Xtr)
Automated Gene Synopsis: Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Synonyms: sel1l...sel1l...SEL1L adaptor subunit of SYVN1 ubiquitin ligase...sel1l
Strict Orthology Symbols: sel1l
SEL1L2
(Homo sapiens)Gene
Name: SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase
Synonyms: sel-1 suppressor of lin-12-like 2, dJ631M13.1, suppressor of lin-12-like protein 2, sel-1L2, DKFZp434C1826, protein sel-1 homolog 2, SEL1L2 adaptor subunit of ERAD E3 ubiquitin ligase, SEL1L2, ERAD E3 ligase adaptor subunit, SEL1L2 adaptor subunit of ERAD E3 ligase, chromosome 20 open reading frame 50, FLJ22324, DJ842G6.2, C20orf50, SEL1L2 ERAD E3 ligase adaptor subunit
Source: HGNC:15897
Biotype: protein coding gene
Symbol: SEL1L2 (Hsa)
Strict Orthology Symbols: Sel1l2
Symbol: SEL1L2
SEL1L3
(Homo sapiens)Gene
Name: SEL1L family member 3
Synonyms: suppressor of lin-12-like protein 3, Sel-1L3, sel-1 suppressor of lin-12-like 3, FLJ21629, KIAA0746, protein sel-1 homolog 3, FLJ41299, DKFZp781J1697
Source: HGNC:29108
Biotype: protein coding gene
Symbol: SEL1L3 (Hsa)
Strict Orthology Symbols: sel1l3...sel1l3.L...Sel1l3...sel1l3.S
Symbol: SEL1L3
sel1l.S
(Xenopus laevis)Gene
Name: SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Synonyms: sel1l.S, SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Source: Xenbase:XB-GENE-17335826
Biotype: gene
Symbol: sel1l.S (Xla)
Automated Gene Synopsis: Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Synonyms: SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Strict Orthology Symbols: sel1l
Symbol: sel1l.S
sel1l.L
(Xenopus laevis)Gene
Name: SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Synonyms: sel1l.L, SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Source: Xenbase:XB-GENE-973996
Biotype: gene
Symbol: sel1l.L (Xla)
Automated Gene Synopsis: Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Synonyms: SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Strict Orthology Symbols: sel1l
Symbol: sel1l.L
sel1l3
(Danio rerio)Gene
Name: SEL1L family member 3
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-131002-1
Biotype: protein coding gene
Symbol: sel1l3 (Dre)
Symbol: sel1l3
Sel1l3
(Rattus norvegicus)Gene
Name: SEL1L family member 3
Synonyms: sel-1 suppressor of lin-12-like 3, RGD1562860, RGD1310366, protein sel-1 homolog 3, similar to RIKEN cDNA 2310045A20, LOC360945, sel-1 suppressor of lin-12-like 3 (C. elegans)
Source: RGD:1562860
Biotype: protein coding gene
Symbol: Sel1l3 (Rno)
Strict Orthology Symbols: sel1l3...Sel1l3...SEL1L3
Symbol: Sel1l3
Sel1l2
(Rattus norvegicus)Gene
Name: SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase
Synonyms: RGD1311278, sel-1 suppressor of lin-12-like 2 (C. elegans), sel-1 suppressor of lin-12-like 2, protein sel-1 homolog 2, SEL1L2 adaptor subunit of ERAD E3 ubiquitin ligase, similar to dJ842G6.2 (novel protein imilar to SEL1L (sel-1 (suppressor of lin-12, C.elegans)-like)), suppressor of lin-12-like protein 2, SEL1L2 adaptor subunit of ERAD E3 ligase, sel-1L2, LOC311470, SEL1L2 ERAD E3 ligase adaptor subunit
Source: RGD:1311278
Biotype: protein coding gene
Symbol: Sel1l2 (Rno)
Synonyms: similar to dJ842G6.2 (novel protein imilar to SEL1L (sel-1 (suppressor of lin-12, C.elegans)-like))
Strict Orthology Symbols: SEL1L2...Sel1l2
Symbol: Sel1l2
Sel1l3
(Mus musculus)Gene
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: RGD1562860, RGD1310366, RIKEN cDNA 2310045A20 gene, 2310045A20Rik, mKIAA0746, AI429585, expressed sequence AI429585
Source: MGI:1916941
Biotype: protein coding gene
Symbol: Sel1l3 (Mmu)
Strict Orthology Symbols: sel1l3...Sel1l3...SEL1L3
Alleles: Sel1l3
Symbol: Sel1l3
Sel1l2
(Mus musculus)Gene
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: RGD1311278, gene model 118, (NCBI), LOC228684, Gm118
Source: MGI:2684964
Biotype: protein coding gene
Symbol: Sel1l2 (Mmu)
Strict Orthology Symbols: SEL1L2...Sel1l2
Alleles: Sel1l2
Symbol: Sel1l2
sel1l3.S
(Xenopus laevis)Gene
Name: sel-1 suppressor of lin-12-like 3
Synonyms: sel-1 suppressor of lin-12-like 3, sel1l3.S
Source: Xenbase:XB-GENE-5891033
Biotype: gene
Symbol: sel1l3.S (Xla)
Strict Orthology Symbols: sel1l3...SEL1L3
Symbol: sel1l3.S
sel1l3
(Xenopus tropicalis)Gene
Name: sel-1 suppressor of lin-12-like 3
Synonyms: sel-1 suppressor of lin-12-like 3, sel1l3
Source: Xenbase:XB-GENE-5891026
Biotype: gene
Symbol: sel1l3 (Xtr)
Strict Orthology Symbols: sel1l3.L...Sel1l3...sel1l3.S...SEL1L3
Symbol: sel1l3
sel1l3.L
(Xenopus laevis)Gene
Name: sel-1 suppressor of lin-12-like 3
Synonyms: sel-1 suppressor of lin-12-like 3, sel1l3.L
Source: Xenbase:XB-GENE-17337789
Biotype: gene
Symbol: sel1l3.L (Xla)
Strict Orthology Symbols: sel1l3...SEL1L3
Symbol: sel1l3.L
Sel1l3em1(IMPC)J
(Mus musculus)Allele/Variant
Source: MGI:5829466
Genes: Sel1l3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l3
Genes: Sel1l3 (Mmu)
Symbol: Sel1l3em1(IMPC)J
Sel1lGt(CA0017)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:3864670
Genes: Sel1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l
Genes: Sel1l (Mmu)
Symbol: Sel1lGt(CA0017)Wtsi
Sel1ltm1c(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5576558
Genes: Sel1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l
Genes: Sel1l (Mmu)
Symbol: Sel1ltm1c(KOMP)Wtsi
Sel1l2Gt(OST396024)Lex
(Mus musculus)Allele/Variant
Source: MGI:4304959
Genes: Sel1l2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l2
Genes: Sel1l2 (Mmu)
Symbol: Sel1l2Gt(OST396024)Lex
Sel1l2tm1e(EUCOMM)Hmgu
(Mus musculus)Allele/Variant
Source: MGI:4842097
Genes: Sel1l2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l2
Genes: Sel1l2 (Mmu)
Symbol: Sel1l2tm1e(EUCOMM)Hmgu
Sel1lem2Cya
(Mus musculus)Allele/Variant
Source: MGI:7586405
Genes: Sel1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l
Genes: Sel1l (Mmu)
Symbol: Sel1lem2Cya
Sel1lem1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7305874
Genes: Sel1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l
Genes: Sel1l (Mmu)
Symbol: Sel1lem1Gpt
Sel1ltm1Lex
(Mus musculus)Allele/Variant
Source: MGI:5007317
Genes: Sel1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l
Genes: Sel1l (Mmu)
Symbol: Sel1ltm1Lex
Sel1l3em6Gpt
(Mus musculus)Allele/Variant
Source: MGI:7305876
Genes: Sel1l3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l3
Genes: Sel1l3 (Mmu)
Symbol: Sel1l3em6Gpt
Sel1l3em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7305875
Genes: Sel1l3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l3
Genes: Sel1l3 (Mmu)
Symbol: Sel1l3em1Gpt
Sel1ltm1e(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4364219
Genes: Sel1l (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sel1l
Genes: Sel1l (Mmu)
Symbol: Sel1ltm1e(KOMP)Wtsi
Model
Id: MGI:4440852
Synonyms: Not Available
Symbol: Sel1l/Sel1l [background:] involves: 129P2/OlaHsd (Mmu)
Genes: Sel1l (Mmu)
Alleles: Sel1l
Name: Sel1l/Sel1l [background:] involves: 129P2/OlaHsd
Sel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi Tg(CAG-cre/Esr1*)5Amc/0 [background:] involves: C57BL/6 * C57BL/6N * CBA * SJL
(Mus musculus)Model
Id: MGI:5581523
Synonyms: Not Available
Symbol: Sel1l/Sel1l Tg(CAG-cre/Esr1*)5Amc/0 [background:] involves: C57BL/6
Genes: Sel1l (Mmu)
Alleles: Sel1l
Name: Sel1l/Sel1l Tg(CAG-cre/Esr1*)5Amc/0 [background:] involves: C57BL/6
Model
Id: MGI:5797798
Synonyms: Not Available
Symbol: Sel1l/Sel1l<+> [background:] C57BL/6N-Sel1l/Wtsi (Mmu)
Genes: Sel1l (Mmu)
Alleles: Sel1l
Name: Sel1l/Sel1l<+> [background:] C57BL/6N-Sel1l/Wtsi
Id: MGI:6493084
Synonyms: Not Available
Symbol: Sel1l3/Sel1l3 [background:] C57BL/6NJ-Sel1l3/Mmjax (Mmu)
Genes: Sel1l3 (Mmu)
Alleles: Sel1l3
Sel1ltm1e(KOMP)Wtsi/Sel1ltm1e(KOMP)Wtsi [background:] C57BL/6N-Sel1ltm1e(KOMP)Wtsi/Wtsi
(Mus musculus)Model
Id: MGI:5757689
Synonyms: Not Available
Symbol: Sel1l/Sel1l [background:] C57BL/6N-Sel1l/Wtsi (Mmu)
Genes: Sel1l (Mmu)
Alleles: Sel1l
Name: Sel1l/Sel1l [background:] C57BL/6N-Sel1l/Wtsi
sel-1
(Caenorhabditis elegans)Gene
Name: Suppressor/Enhancer of Lin-12 1
Synonyms: sup-25, CELE_F45D3.5, F45D3.5
Source: WB:WBGene00004759
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Strict Orthology Symbols: sel1l
HRD3
(Saccharomyces cerevisiae)Gene
Name: HMG-coA Reductase Degradation
Synonyms: YLR207W
Source: SGD:S000004197
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Strict Orthology Symbols: sel1l
Hrd3
(Drosophila melanogaster)Gene
Name: HMG-coA reductase degradation 3
Synonyms: HRD3, hrd3, Hrd3, CG10221, BcDNA:LD23587
Source: FB:FBgn0028475
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
Strict Orthology Symbols: sel1l
si:dkey-24p1.6
(Danio rerio)Gene
Name: si:dkey-24p1.6
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-060503-67
Biotype: protein coding gene
Strict Orthology Symbols: Sel1l3...SEL1L3
Gene Ontology
Source: GO:0000839
Synonyms: Not Available
Branch: cellular component
Genes: SEL1L (Hsa)...Sel1l (Rno)...Sel1l (Mmu)
Gene Ontology
Source: GO:0036513
Synonyms:
- Derlin-1 complex
- Derlin-1 protein dislocation complex
Branch: cellular component
Genes: Sel1l (Mmu)...SEL1L (Hsa)...Sel1l (Rno)
AB + MO1-sel1l + MO4-tp53
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-180824-25
Synonyms: Not Available
Genes: sel1l (Dre)
Name: AB + MO1-sel1l + MO4-tp53
s843Tg; sd2Tg + MO2-sel1l
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-180824-22
Synonyms: Not Available
Genes: sel1l (Dre)
Name: s843Tg; sd2Tg + MO2-sel1l
AB + MO2-sel1l
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-180824-24
Synonyms: Not Available
Genes: sel1l (Dre)
Name: AB + MO2-sel1l
Gene Ontology
Source: GO:0000836
Synonyms:
- HRD1 ubiquitin ligase complex
Branch: cellular component
Genes: SEL1L (Hsa)
The ER-Associated Degradation Adapter Protein Sel1L Regulates Triglyceride Metabolism via Lipoprotein Lipase
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-56918, GEO:GSE56918
Tags: WT vs. mutant, genotype
Summary: Sel1L is an adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum-associated degradation (ERAD), but its physiological role in a cell-type-specific manner remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-induced obesity and exhibit postprandial hypertriglyceridemia. Mechanistically, our data demonstrate a critical requirement of Sel1L for the secretion of lipoprotein lipase (LPL), independently of its role in Hrd1-mediated ERAD and ER homeostasis. Further biochemical analyses revealed that Sel1L physically interacts and stabilizes the LPL maturation complex consisted of LPL and lipase-maturation factor 1 (LMF1). In the absence of Sel1L, LPL is retained in the ER and prone to the formation of protein aggregates, which are degraded by autophagy-mediated degradation. The Sel1L-mediated control of LPL secretion is seen in other LPL-expressing cell types as well such as cardiac muscle and macrophages. Thus, our study reports a novel role of Sel1L in LPL secretion and systemic lipid metabolism. Sel1Lflox/flox mice were crossed with adiponectin promoter driven Cre mice to create adipose tissue-specific Sel1L-/- mice. Male wildtype C57Bl/6 mice and adipose tissue-specific Sel1l-/- mice were fed a high fat diet (Research Diets D12492) for 5 weeks. Adipose tissue was excised and used for microarray analysis.
Symbol: The ER-Associated Degradation Adapter Protein Sel1L Regulates Triglyceride Metabolism via Lipoprotein
Name: The ER-Associated Degradation Adapter Protein Sel1L Regulates Triglyceride Metabolism via Lipoprotein
Gene Ontology
Source: GO:0030970
Synonyms:
- protein dislocation from ER
- protein retrotranslocation, ER to cytosol
Branch: biological process
Genes: SEL1L (Hsa)...Sel1l (Mmu)...Sel1l (Rno)
Gene Ontology
Source: GO:0006641
Synonyms:
- triacylglycerol metabolic process
- triacylglycerol metabolism
Branch: biological process
Genes: SEL1L (Hsa)...Sel1l (Mmu)...Sel1l (Rno)
Mmus\Sel1lC141Y.UAS
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0400541
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mmus\Sel1l
Construct Expressed Component: Sel1l (Mmu)
Mmus\Sel1lG585D.UAS
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0400539
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mmus\Sel1l
Construct Expressed Component: Sel1l (Mmu)
Mmus\Sel1lS658P.UAS
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0400542
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mmus\Sel1l
Construct Expressed Component: Sel1l (Mmu)
Mmus\Sel1lM528R.UAS
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0400540
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mmus\Sel1l
Construct Expressed Component: Sel1l (Mmu)