Version: 8.0.0Date: Tue Jan 28 2025
Category
sfrp5
(Danio rerio)Gene
Name: secreted frizzled-related protein 5
Synonyms: zgc:101849, sfrp1
Source: ZFIN:ZDB-GENE-011108-2
Biotype: protein coding gene
Symbol: sfrp5 (Dre)
Symbol: sfrp5
Automated Gene Synopsis: Orthologous to human SFRP5 (secreted frizzled related protein 5).
Strict Orthology Symbols: sfrp5
Sfrp5
(Rattus norvegicus)Gene
Name: secreted frizzled-related protein 5
Synonyms: LOC309377, secreted frizzled-related sequence protein 5
Source: RGD:1310369
Biotype: protein coding gene
Symbol: Sfrp5 (Rno)
Symbol: Sfrp5
Gene Synopsis: Orthologous to human SFRP5 (secreted frizzled related protein 5); PARTICIPATES IN Wnt signaling, canonical
Automated Gene Synopsis: Orthologous to human SFRP5 (secreted frizzled related protein 5).
Strict Orthology Symbols: sfrp5
SFRP5
(Homo sapiens)Gene
Name: secreted frizzled related protein 5
Synonyms: FRP-1b, secreted frizzled-related protein 5, secreted apoptosis-related protein 3, sFRP-5, SARP3, frizzled-related protein 1b, secreted apoptosis related protein 3, SARP-3
Source: HGNC:10779
Biotype: protein coding gene
Symbol: SFRP5 (Hsa)
Symbol: SFRP5
Gene Synopsis: SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina....SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas
Strict Orthology Symbols: sfrp5
Sfrp5
(Mus musculus)Gene
Name: secreted frizzled-related sequence protein 5
Synonyms: AI605071, expressed sequence AI605071, SARP3
Source: MGI:1860298
Biotype: protein coding gene
Symbol: Sfrp5 (Mmu)
Symbol: Sfrp5
Automated Gene Synopsis: Orthologous to human SFRP5 (secreted frizzled related protein 5).
Strict Orthology Symbols: sfrp5
Alleles: Sfrp5
sfrp5
(Xenopus tropicalis)Gene
Name: secreted frizzled-related protein 5
Synonyms: sfrp5, frp5, secreted frizzled-related protein 5, sFRP-5, XsFRP5, sfrp5-b, sfrp5-a
Source: Xenbase:XB-GENE-482920
Biotype: gene
Symbol: sfrp5
Symbol: sfrp5 (Xtr)
Automated Gene Synopsis: Orthologous to human SFRP5 (secreted frizzled related protein 5).
Synonyms: sfrp5...sfrp5...sfrp5
Strict Orthology Symbols: sfrp5
sfrp5.L
(Xenopus laevis)Gene
Name: secreted frizzled-related protein 5
Synonyms: secreted frizzled-related protein 5, frp5, sfrp5.L, sFRP-5, XsFRP5, sfrp5-b, sfrp5-a
Source: Xenbase:XB-GENE-6254210
Biotype: gene
Symbol: sfrp5.L (Xla)
Automated Gene Synopsis: Orthologous to human SFRP5 (secreted frizzled related protein 5).
Strict Orthology Symbols: sfrp5
Symbol: sfrp5.L
sfrp5.S
(Xenopus laevis)Gene
Name: secreted frizzled-related protein 5
Synonyms: frp5, secreted frizzled-related protein 5, sFRP-5, sfrp5-b, XsFRP5, sfrp5.S, sfrp5-a
Source: Xenbase:XB-GENE-864922
Biotype: gene
Symbol: sfrp5.S (Xla)
Automated Gene Synopsis: Orthologous to human SFRP5 (secreted frizzled related protein 5).
Strict Orthology Symbols: sfrp5
Symbol: sfrp5.S
Sfrp5em1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7626820
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5em1Smoc
Sfrp5tm1Shwl
(Mus musculus)Allele/Variant
Source: MGI:3696766
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5tm1Shwl
Sfrp5tm1Aksh
(Mus musculus)Allele/Variant
Source: MGI:3793862
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5tm1Aksh
Sfrp5em2.1(dre)Kkb
(Mus musculus)Allele/Variant
Source: MGI:7610639
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5em2.1(dre)Kkb
Construct Regulatory Region: Sfrp5 (Mmu)
Constructs: Sfrp5< construct
Sfrp5em1Cya
(Mus musculus)Allele/Variant
Source: MGI:7586466
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5em1Cya
Sfrp5em5Gpt
(Mus musculus)Allele/Variant
Source: MGI:7306003
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5em5Gpt
Sfrp5em1.1(ERT2/cre)Kkb
(Mus musculus)Allele/Variant
Source: MGI:7437538
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5em1.1(ERT2/cre)Kkb
Construct Regulatory Region: Sfrp5 (Mmu)
Constructs: Sfrp5< construct
Sfrp5tm1.1(cre)Kkb
(Mus musculus)Allele/Variant
Source: MGI:7437537
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5tm1.1(cre)Kkb
Construct Regulatory Region: Sfrp5 (Mmu)
Constructs: Sfrp5< construct
Sfrp5Q27stop
(Mus musculus)Allele/Variant
Source: MGI:3056483
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5Q27stop
Sfrp5em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7306002
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5em1Gpt
Sfrp5Gt(OST392953)Lex
(Mus musculus)Allele/Variant
Source: MGI:4304107
Genes: Sfrp5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sfrp5
Genes: Sfrp5 (Mmu)
Symbol: Sfrp5Gt(OST392953)Lex
Model
Id: MGI:3717758
Synonyms: Not Available
Symbol: Sfrp5/Sfrp5 [background:] involves: BALB/c * C3H/HeH (Mmu)
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp5/Sfrp5 [background:] involves: BALB/c * C3H/HeH
Sfrp5tm1Shwl/Sfrp5tm1Shwl [background:] either: 129S-Sfrp5tm1Shwl or B6.129S7-Sfrp5tm1Shwl
(Mus musculus)Model
Id: MGI:3697479
Synonyms: Not Available
Symbol: Sfrp5/Sfrp5 [background:] either: 129S-Sfrp5 or B6.129S7-Sfrp5 (
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp5/Sfrp5 [background:] either: 129S-Sfrp5 or B6.129S7-Sfrp5
Model
Id: MGI:3697478
Synonyms: Not Available
Symbol: Sfrp5/Sfrp5 [background:] involves: 129S7/SvEvBrd * CD-1 (Mmu)
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp5/Sfrp5 [background:] involves: 129S7/SvEvBrd * CD-1
sfrp-1
(Caenorhabditis elegans)Gene
Name: Secreted Frizzled-Related Protein 1
Synonyms: Y73B6BL.21, CELE_Y73B6BL.21
Source: WB:WBGene00022242
Biotype: protein coding gene
Strict Orthology Symbols: sfrp5
Source: GO:2000051
Synonyms:
- negative regulation of beta-catenin-independent Wnt receptor signaling pathway
- negative regulation of non-canonical Wnt receptor signaling pathway
Branch: biological process
Genes: SFRP5 (Hsa)...Sfrp5 (Mmu)...Sfrp5 (Rno)
Model
Id: MGI:3697480
Synonyms: Not Available
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Dkk1/Dkk1 Sfrp5/Sfrp5 [background:] involves: 129 * CD-1
Symbol: Dkk1/Dkk1 Sfrp5/Sfrp5 [background:] involves: 129 * CD-1 (Mmu)
wz08
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-171113-4
Genes: sfrp5 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: sfrp5 (Dre)
s854Tg + MO1-sfrp5
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-25607
Synonyms: Not Available
Genes: sfrp5 (Dre)
Name: s854Tg + MO1-sfrp5
WT + MO1-sfrp5
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-8333
Synonyms: Not Available
Genes: sfrp5 (Dre)
Name: WT + MO1-sfrp5
Gene Ontology
Source: GO:0090175
Synonyms: Not Available
Branch: biological process
Genes: SFRP5 (Hsa)...Sfrp5 (Mmu)...Sfrp5 (Rno)
w25Tg + MO2-sfrp5 + MO3-sfrp1a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-17284
Synonyms: Not Available
Genes: sfrp5 (Dre)
Name: w25Tg + MO2-sfrp5 + MO3-sfrp1a
cq95
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-240118-14
Genes: sfrp5 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: sfrp5 (Dre)
Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp2tm1Aksh/Sfrp2tm1Aksh Sfrp5tm1Aksh/Sfrp5tm1Aksh [background:] involves: 129 * C57BL/6
(Mus musculus)Model
Id: MGI:3795557
Synonyms: Not Available
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp1/Sfrp1 Sfrp2/Sfrp2 Sfrp5/Sfrp5 [background
Symbol: Sfrp1/Sfrp1 Sfrp2/Sfrp2 Sfrp5/Sfrp5 [background
Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp2tm1Aksh/Sfrp2tm1Aksh Sfrp5tm1Aksh/Sfrp5+ [background:] involves: 129 * C57BL/6
(Mus musculus)Model
Id: MGI:3795554
Synonyms: Not Available
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp1/Sfrp1 Sfrp2/Sfrp2 Sfrp5/Sfrp5<+> [background:] involves
Symbol: Sfrp1/Sfrp1 Sfrp2/Sfrp2 Sfrp5/Sfrp5<+> [background:] involves
mw29Tg + MO2-sfrp5 + MO3-sfrp1a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-21311
Synonyms: Not Available
Genes: sfrp5 (Dre)
Name: mw29Tg + MO2-sfrp5 + MO3-sfrp1a
Sfrp2C50F/Sfrp2C50F Sfrp5Q27stop/Sfrp5Q27stop [background:] involves: BALB/c * C3H/HeH
(Mus musculus)Model
Id: MGI:3717759
Synonyms: Not Available
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp2/Sfrp2 Sfrp5/Sfrp5 [background:] involves: BALB/c * C3H/HeH
Symbol: Sfrp2/Sfrp2 Sfrp5/Sfrp5 [background:] involves: BALB/c * C3H/HeH (Mmu)
WT + MO2-sfrp5 + MO3-sfrp1a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-5617
Synonyms: Not Available
Genes: sfrp5 (Dre)
Name: WT + MO2-sfrp5 + MO3-sfrp1a
Gene Ontology
Source: GO:0043508
Synonyms:
- down regulation of JNK activity
- down-regulation of JNK activity
Branch: biological process
Genes: Sfrp5 (Mmu)...SFRP5 (Hsa)...Sfrp5 (Rno)
Gene Ontology
Source: GO:0060028
Synonyms: Not Available
Branch: biological process
Genes: Sfrp5 (Mmu)...SFRP5 (Hsa)...Sfrp5 (Rno)
Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp5tm1Aksh/Sfrp5tm1Aksh Vangl2Lp/Vangl2+ [background:] involves: 129 * A * C57BL/6 * LPT/LeJ
(Mus musculus)Model
Id: MGI:3795556
Synonyms: Not Available
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp1/Sfrp1 Sfrp5/Sfrp5 Vangl2/Vangl2<+> [background:] involves
Symbol: Sfrp1/Sfrp1 Sfrp5/Sfrp5 Vangl2/Vangl2<+> [background:] involves
Model
Id: MGI:3795553
Synonyms: Not Available
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp1/Sfrp1 Sfrp2/Sfrp2 Sfrp5/Sfrp5<+> Vangl2/Vangl2
Symbol: Sfrp1/Sfrp1 Sfrp2/Sfrp2 Sfrp5/Sfrp5<+> Vangl2/Vangl2
Model
Id: MGI:3795555
Synonyms: Not Available
Genes: Sfrp5 (Mmu)
Alleles: Sfrp5
Name: Sfrp1/Sfrp1 Sfrp2/Sfrp2<+> Sfrp5/Sfrp5 Vangl2/Vangl2
Symbol: Sfrp1/Sfrp1 Sfrp2/Sfrp2<+> Sfrp5/Sfrp5 Vangl2/Vangl2
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-37514, GEO:GSE37514
Tags: WT vs. mutant, genotype
Summary: We identified secreted frizzled-related protein-5 (Sfrp5) as a transcript that is upregulated during adipocyte differentiation and that is increased in white adipose tissue (WAT) of obese mice, compared to lean mice. To investigate the function of sFRP5 in adipose tissue biology, we studied sFRP5Q27stop mice, in which ENU mutagenesis was used to create a premature stop codon at Gln27, thereby creating a likely null allele. Male wild-type or Sfrp5 KO (Q27Stop) mice were fed a high-fat diet from the ages of four weeks to twelve weeks. At twelve weeks of age, mice were euthanized. Total RNA was then isolated from gonadal WAT and RNA was analyzed by Affymetrix microarrays. Seven wild-type and eight Sfrp5 KO mice were used.
Symbol: Effect of ablation of Sfrp5 on gene expression in gonadal white adipose tissue
Name: Effect of ablation of Sfrp5 on gene expression in gonadal white adipose tissue
Gene Ontology
Source: GO:0061031
Synonyms: Not Available
Branch: biological process
Genes: sfrp5 (Dre)
Gene Ontology
Source: GO:0035567
Synonyms:
- beta-catenin-independent Wnt receptor signaling pathway
- non-canonical Wnt receptor signaling pathway
Branch: biological process
Genes: Sfrp5 (Rno)...Sfrp5 (Mmu)...sfrp5 (Dre)...SFRP5 (Hsa)
Gene Ontology
Source: GO:0048546
Synonyms:
- alimentary canal morphogenesis
- digestive tube morphogenesis
Branch: biological process
Genes: Sfrp5 (Mmu)...SFRP5 (Hsa)...Sfrp5 (Rno)
Gene Ontology
Source: GO:0072576
Synonyms: Not Available
Branch: biological process
Genes: sfrp5 (Dre)
Gene Ontology
Source: GO:0061386
Synonyms:
- closure or choriod fissure
Branch: biological process
Genes: sfrp5 (Dre)
Gene Ontology
Source: GO:0036342
Synonyms: Not Available
Branch: biological process
Genes: Sfrp5 (Rno)...Sfrp5 (Mmu)...SFRP5 (Hsa)
Gene Ontology
Source: GO:0017147
Synonyms: Not Available
Branch: molecular function
Genes: Sfrp5 (Rno)...Sfrp5 (Mmu)...sfrp5 (Dre)...SFRP5 (Hsa)
Secreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ß-Cell Proliferation [30 days]
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE44046
Tags: unclassified
Summary: Obesity is associated with an increase in ß-cell mass in response tothe rising demand for insulin. ß-cell plasticity is essential to maintaining glucose homeostasis, however,the cellular and molecular mechanisms by which ß-cell mass is regulated remain poorly understood.Recently, we described the existence of a crosstalk between the peripancreatic adipose tissue and ß-cells as a novel mechanism that participates in the regulation of ß-cell plasticity. Here, we identify the secreted frizzled-related protein (Sfrp) 5 as down-regulated in the pancreatic islets of obese rats as well as in the pancreatic islets of human obese patients. Our results demonstrate that the silencing of Sfrp5 induces an increase in ß-cell proliferation, which we correlate with the activation of Wnt signaling and of the MAPK and PI3 kinase pathways. Together, these findings expand our understanding of the mechanisms underlying ß-cell proliferation under conditions of obesity. Furthermore, this study opens new insights into the specific targeting of Sfrp5 as a novel therapeutic strategy for balancing ß-cell mass.
Secreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ß-Cell Proliferation [10 days]
(Rattus norvegicus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE44045
Tags: unclassified
Summary: Obesity is associated with an increase in ß-cell mass in response tothe rising demand for insulin. ß-cell plasticity is essential to maintaining glucose homeostasis, however,the cellular and molecular mechanisms by which ß-cell mass is regulated remain poorly understood.Recently, we described the existence of a crosstalk between the peripancreatic adipose tissue and ß-cells as a novel mechanism that participates in the regulation of ß-cell plasticity. Here, we identify the secreted frizzled-related protein (Sfrp) 5 as down-regulated in the pancreatic islets of obese rats as well as in the pancreatic islets of human obese patients. Our results demonstrate that the silencing of Sfrp5 induces an increase in ß-cell proliferation, which we correlate with the activation of Wnt signaling and of the MAPK and PI3 kinase pathways. Together, these findings expand our understanding of the mechanisms underlying ß-cell proliferation under conditions of obesity. Furthermore, this study opens new insights into the specific targeting of Sfrp5 as a novel therapeutic strategy for balancing ß-cell mass.