Version: 8.1.0Date: Fri Apr 18 2025
Category
sir-2.2
(Caenorhabditis elegans)Gene
Name: yeast SIR related 2.2
Synonyms: CELE_F46G10.7, F46G10.7
Source: WB:WBGene00004801
Biotype: protein coding gene
Symbol: sir-2.2 (Cel)
Symbol: sir-2.2
Gene Synopsis: sir-2.2 encodes one of four C. elegans proteins with similarity to the Saccharomyces cerevisiae Sir2p...NAD-dependent histone deacetylase; SIR-2.2 may play a role in genomic stability and protecting the genome...against mutations, as loss of SIR-2.2 function via RNA-mediated interference (RNAi) results in an increased
Cross References: sir-2.2...WB:sir-2.2...sir-2.2
SIRT4
(Homo sapiens)Gene
Name: sirtuin 4
Synonyms: MGC130046, MGC130047, MGC57437, SIR2-like protein 4, NAD-dependent ADP-ribosyltransferase sirtuin-4, NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, NAD-dependent protein biotinylase sirtuin-4, sir2-like 4, SIR2L4, regulatory protein SIR2 homolog 4, sirtuin, sirtuin type 4, NAD-dependent protein deacetylase sirtuin-4
Source: HGNC:14932
Biotype: protein coding gene
Strict Orthology Symbols: sir-2.2
Sirt4
(Mus musculus)Gene
Name: sirtuin 4
Synonyms: RIKEN cDNA 4930596O17 gene, 4930596O17Rik
Source: MGI:1922637
Biotype: protein coding gene
Strict Orthology Symbols: sir-2.2
Sirt4
(Rattus norvegicus)Gene
Name: sirtuin 4
Synonyms: sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae), NAD-dependent ADP-ribosyltransferase sirtuin-4, LOC304539, sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae), NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, NAD-dependent protein deacetylase sirtuin-4
Source: RGD:1310413
Biotype: protein coding gene
Strict Orthology Symbols: sir-2.2
Sirt4
(Drosophila melanogaster)Gene
Name: Sirtuin 4
Synonyms: dSIRT4, CG3187, dmSRT407, SIRT4, D.mel3, Sirt4, dSirt4
Source: FB:FBgn0029783
Biotype: protein coding gene
Strict Orthology Symbols: sir-2.2
sirt4
(Danio rerio)Gene
Name: sirtuin 4
Synonyms: im:7139453, zgc:103539
Source: ZFIN:ZDB-GENE-041010-65
Biotype: protein coding gene
Strict Orthology Symbols: sir-2.2
sirt4
(Xenopus tropicalis)Gene
Name: sirtuin 4
Synonyms: sirtuin 4, sirt4
Source: Xenbase:XB-GENE-948981
Biotype: gene
Strict Orthology Symbols: sir-2.2
Gene Ontology
Source: GO:0017136
Synonyms:
- NAD-dependent histone deacetylase activity
- NAD-dependent histone lysine deacetylase activity
Branch: molecular function
Genes: sir-2.2 (Cel)
Gene Ontology
Source: GO:0034979
Synonyms:
- NAD(+)-dependent protein deacetylase
- NAD(+)-dependent protein deacylase
Branch: molecular function
Genes: sir-2.2 (Cel)
Gene Ontology
Source: GO:0006476
Synonyms:
- protein amino acid deacetylation
Branch: biological process
Genes: sir-2.2 (Cel)
Gene Ontology
Source: GO:0070403
Synonyms:
- NAD (oxidized) binding
- NAD binding
Branch: molecular function
Genes: sir-2.2 (Cel)
Source: DOID:0080208
Definition: A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.
Genes: sir-2.2 (Cel)
Gene Ontology
Source: GO:0005759
Synonyms:
- mitochondrial lumen
- mitochondrial stroma
Branch: cellular component
Genes: sir-2.2 (Cel)
Gene Ontology
Source: GO:0045087
Synonyms:
- innate immunity
- nonspecific immune response
Branch: biological process
Genes: sir-2.2 (Cel)
(WBcel235)X:13330196C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330196C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330196C>T
Gene Cross References: sir-2.2
(WBcel235)X:13329673T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329673T>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329673T>A
Gene Cross References: sir-2.2
(WBcel235)X:13330850G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330850G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330850G>A
Gene Cross References: sir-2.2
(WBcel235)X:13331208G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13331208G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13331208G>A
Gene Cross References: sir-2.2
(WBcel235)X:13329062C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329062C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329062C>T
Gene Cross References: sir-2.2
(WBcel235)X:13329241T>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329241T>C
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329241T>C
Gene Cross References: sir-2.2
(WBcel235)X:13328068T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13328068T>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13328068T>A
Gene Cross References: sir-2.2
(WBcel235)X:13329570A>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329570A>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329570A>T
Gene Cross References: sir-2.2
(WBcel235)X:13331031C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13331031C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13331031C>T
Gene Cross References: sir-2.2
(WBcel235)X:13330678G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330678G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330678G>A
Gene Cross References: sir-2.2
Gene Ontology
Source: GO:0006338
Synonyms:
- ATP-dependent chromatin remodeling
- ATP-dependent chromatin remodelling
Branch: biological process
Genes: sir-2.2 (Cel)
(WBcel235)X:13329828C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329828C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329828C>T
Gene Cross References: sir-2.2
(WBcel235)X:13329845G>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329845G>C
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329845G>C
Gene Cross References: sir-2.2
(WBcel235)X:13328932C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13328932C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13328932C>T
Gene Cross References: sir-2.2
(WBcel235)X:13329672T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329672T>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329672T>A
Gene Cross References: sir-2.2
(WBcel235)X:13330177A>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330177A>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330177A>T
Gene Cross References: sir-2.2
(WBcel235)X:13329445C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329445C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329445C>T
Gene Cross References: sir-2.2
(WBcel235)X:13329744A>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329744A>C
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329744A>C
Gene Cross References: sir-2.2
(WBcel235)X:13329909G>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329909G>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329909G>T
Gene Cross References: sir-2.2
(WBcel235)X:13330425G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330425G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330425G>A
Gene Cross References: sir-2.2
(WBcel235)X:13330449A>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330449A>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330449A>T
Gene Cross References: sir-2.2
(WBcel235)X:13329344G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329344G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329344G>A
Gene Cross References: sir-2.2
(WBcel235)X:13328717C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13328717C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13328717C>T
Gene Cross References: sir-2.2
(WBcel235)X:13329567G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329567G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329567G>A
Gene Cross References: sir-2.2
(WBcel235)X:13329674T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329674T>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329674T>A
Gene Cross References: sir-2.2
(WBcel235)X:13330249A>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330249A>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330249A>T
Gene Cross References: sir-2.2
(WBcel235)X:13330662G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330662G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330662G>A
Gene Cross References: sir-2.2
(WBcel235)X:13329827G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329827G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329827G>A
Gene Cross References: sir-2.2
(WBcel235)X:13329946C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329946C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329946C>T
Gene Cross References: sir-2.2
(WBcel235)X:13329855G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329855G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329855G>A
Gene Cross References: sir-2.2
(WBcel235)X:13330588G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330588G>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330588G>A
Gene Cross References: sir-2.2
(WBcel235)X:13328149T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13328149T>A
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13328149T>A
Gene Cross References: sir-2.2
(WBcel235)X:13328981C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13328981C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13328981C>T
Gene Cross References: sir-2.2
(WBcel235)X:13329834C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13329834C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13329834C>T
Gene Cross References: sir-2.2
(WBcel235)X:13330007T>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330007T>C
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330007T>C
Gene Cross References: sir-2.2
(WBcel235)X:13330659C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.13330659C>T
Genes: sir-2.2 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)X:13330659C>T
Gene Cross References: sir-2.2