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10,214 results for stau2

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Stau2

(Mus musculus)

Gene

Name: staufen double-stranded RNA binding protein 2

Synonyms: Not Available

Source: MGI:1352508

Biotype: protein coding gene

Symbol: Stau2 (Mmu)

Symbol: Stau2

Automated Gene Synopsis: Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2).

Strict Orthology Symbols: stau2

Alleles: Stau2 (Mmu)...Stau2 (Mmu)...Stau2 (Mmu)...Stau2 (Mmu)

STAU2

(Homo sapiens)

Gene

Name: staufen double-stranded RNA binding protein 2

Synonyms: double-stranded RNA-binding protein Staufen homolog 2, 39K2, 39K3, MGC119606, staufen homolog 2, DKFZp781K0371, staufen, RNA binding protein, homolog 2

Source: HGNC:11371

Biotype: protein coding gene

Symbol: STAU2 (Hsa)

Symbol: STAU2

Strict Orthology Symbols: stau2

Stau2

(Rattus norvegicus)

Gene

Name: staufen double-stranded RNA binding protein 2

Synonyms: double-stranded RNA-binding protein Staufen homolog 2, staufen, RNA binding protein, homolog 2 (Drosophila), r-staufen protein, staufen, RNA binding protein, homolog 2, MGC93196

Source: RGD:621479

Biotype: protein coding gene

Symbol: Stau2 (Rno)

Symbol: Stau2

Gene Synopsis: Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2); INTERACTS WITH 1-naphthyl

Automated Gene Synopsis: Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2).

Strict Orthology Symbols: stau2

stau2

(Danio rerio)

Gene

Name: staufen double-stranded RNA binding protein 2

Synonyms: zgc:55287

Source: ZFIN:ZDB-GENE-040426-687

Biotype: protein coding gene

Symbol: stau2 (Dre)

Symbol: stau2

Automated Gene Synopsis: Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2).

Strict Orthology Symbols: stau2

stau2

(Xenopus tropicalis)

Gene

Name: staufen double-stranded RNA binding protein 2

Synonyms: Xstau2, stau2, staufen2, stau2-b, stau2-a, staufen double-stranded RNA binding protein 2

Source: Xenbase:XB-GENE-491508

Biotype: gene

Symbol: stau2

Symbol: stau2 (Xtr)

Automated Gene Synopsis: Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2).

Synonyms: stau2...stau2...stau2

Strict Orthology Symbols: stau2

Disease (1)

STAU2-AS1

(Homo sapiens)

Gene

Name: STAU2 antisense RNA 1

Synonyms: RP11-181D18.2

Source: HGNC:44101

Biotype: ncRNA gene

Symbol: STAU2-AS1 (Hsa)

Symbol: STAU2-AS1

Allele/Variant (5)

stau2.S

(Xenopus laevis)

Gene

Name: staufen double-stranded RNA binding protein 2

Synonyms: Xstau2, staufen2, stau2.S, stau2-b, stau2-a, staufen double-stranded RNA binding protein 2

Source: Xenbase:XB-GENE-6253612

Biotype: gene

Symbol: stau2.S (Xla)

Automated Gene Synopsis: Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2).

Strict Orthology Symbols: stau2

Symbol: stau2.S

stau2.L

(Xenopus laevis)

Gene

Name: staufen double-stranded RNA binding protein 2

Synonyms: stau2.L, Xstau2, staufen2, stau2-b, stau2-a, staufen double-stranded RNA binding protein 2

Source: Xenbase:XB-GENE-866070

Biotype: gene

Symbol: stau2.L (Xla)

Automated Gene Synopsis: Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2).

Strict Orthology Symbols: stau2

Symbol: stau2.L

Stau2^{Gt(RRG396)Byg}

(Mus musculus)

Allele/Variant

Source: MGI:4128933

Genes: Stau2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Stau2 (Mmu)

Genes: Stau2 (Mmu)

Symbol: Stau2^{Gt(RRG396)Byg}

Stau2^{tm1a(EUCOMM)Wtsi}

(Mus musculus)

Allele/Variant

Source: MGI:4431690

Genes: Stau2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Stau2 (Mmu)

Genes: Stau2 (Mmu)

Symbol: Stau2^{tm1a(EUCOMM)Wtsi}

Stau2^em1(IMPC)Mbp

(Mus musculus)

Allele/Variant

Source: MGI:6276995

Genes: Stau2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Stau2 (Mmu)

Genes: Stau2 (Mmu)

Symbol: Stau2^em1(IMPC)Mbp

Stau2^em1Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7377327

Genes: Stau2 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Stau2 (Mmu)

Genes: Stau2 (Mmu)

Symbol: Stau2^em1Gpt

Gene (1)

STAU2P1

(Homo sapiens)

Gene

Name: STAU2 pseudogene 1

Synonyms: Not Available

Source: HGNC:55011

Biotype: pseudogene

Symbol: STAU2P1 (Hsa)

Symbol: STAU2P1

Stau2^{tm1a(EUCOMM)Wtsi}/Stau2^{tm1a(EUCOMM)Wtsi} [background:] C57BL/6N-Stau2^{tm1a(EUCOMM)Wtsi}/Wtsi

(Mus musculus)

Model

Id: MGI:6263584

Synonyms: Not Available

Symbol: Stau2/Stau2 [background:] C57BL/6N-Stau2/Wtsi

Genes: Stau2 (Mmu)

Alleles: Stau2 (Mmu)

Name: Stau2/Stau2 [background:] C57BL/6N-Stau2/Wtsi

Gene (1)

Stau2^em1(IMPC)Mbp/Stau2^em1(IMPC)Mbp [background:] C57BL/6N-Stau2^em1(IMPC)Mbp/MbpMmucd

(Mus musculus)

Model

Id: MGI:6461707

Synonyms: Not Available

Symbol: Stau2/Stau2 [background:] C57BL/6N-Stau2/MbpMmucd (Mmu)

Genes: Stau2 (Mmu)

Alleles: Stau2 (Mmu)

Name: Stau2/Stau2 [background:] C57BL/6N-Stau2/MbpMmucd

Gene (1)

stau2^sa113/sa113 (TL)

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-12332

Synonyms: Not Available

Symbol: stau2 (TL) (Dre)

Genes: stau2 (Dre)

Name: stau2 (TL)

Gene (1)

Stau2^{Gt(RRG396)Byg}/Stau2^{Gt(RRG396)Byg} [background:] B6.129P2-Stau2^{Gt(RRG396)Byg}

(Mus musculus)

Model

Id: MGI:6477565

Synonyms: Not Available

Symbol: Stau2/Stau2 [background:] B6.129P2-Stau2 (Mmu)

Genes: Stau2 (Mmu)

Alleles: Stau2 (Mmu)

Name: Stau2/Stau2 [background:] B6.129P2-Stau2

Gene (1)

stau2^sa113

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-28157

Synonyms: Not Available

Symbol: stau2 (Dre)

Genes: stau2 (Dre)

Name: stau2

Gene (1)

stau

(Drosophila melanogaster)

Gene

Name: staufen

Synonyms: dStau, Dmstau, Stau, CG5753, STAU, Stauffen, staufen, Stauf, Stau1, STAUFEN, Staufen

Source: FB:FBgn0003520

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to several human genes including STAU2 (staufen double-stranded RNA binding protein 2).

Strict Orthology Symbols: stau2

stau-1

(Caenorhabditis elegans)

Gene

Name: STAUfen (dsRNA binding protein) homolog 1

Synonyms: CELE_F55A4.5, F55A4.5

Source: WB:WBGene00018857

Biotype: protein coding gene

Strict Orthology Symbols: stau2

anterograde dendritic transport of messenger ribonucleoprotein complex

Gene Ontology

Source: GO:0098964

Synonyms:

anterograde dendritic transport of mRNA RNP complex

Branch: biological process

Genes: Stau2 (Rno)...STAU2 (Hsa)...stau2 (Dre)...Stau2 (Mmu)

Genes Annotated with this GO Term (13)

positive regulation of long-term synaptic depression

Gene Ontology

Source: GO:1900454

Synonyms:

activation of LTD
activation of long term depression

Branch: biological process

Genes: STAU2 (Hsa)...Stau2 (Mmu)...Stau2 (Rno)

Genes Annotated with this GO Term (28)

eye morphogenesis

Gene Ontology

Source: GO:0048592

Synonyms: Not Available

Branch: biological process

Genes: STAU2 (Hsa)...Stau2 (Mmu)...Stau2 (Rno)

Genes Annotated with this GO Term (1203)

WT + MO1-stau2

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-26350

Synonyms: Not Available

Genes: stau2 (Dre)

Name: WT + MO1-stau2

Gene (1)

la011012Tg

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-120130-585

Genes: stau2 (Dre)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Genes: stau2 (Dre)

Gene (1)

WT + MO2-stau2

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-28231

Synonyms: Not Available

Genes: stau2 (Dre)

Name: WT + MO2-stau2

Gene (1)

la014501Tg

(Danio rerio)

Allele/Variant

Source: ZFIN:ZDB-ALT-120806-8501

Genes: stau2 (Dre)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Genes: stau2 (Dre)

Gene (1)

regulation of filopodium assembly

Gene Ontology

Source: GO:0051489

Synonyms:

regulation of filopodia biosynthesis
regulation of filopodia formation

Branch: biological process

Genes: Stau2 (Mmu)...Stau2 (Rno)...STAU2 (Hsa)

Genes Annotated with this GO Term (221)

intracellular mRNA localization

Gene Ontology

Source: GO:0008298

Synonyms:

establishment and maintenance of intracellular RNA localization
intracellular mRNA localisation

Branch: biological process

Genes: stau2 (Dre)...Stau2 (Mmu)...Stau2 (Rno)...STAU2 (Hsa)

Genes Annotated with this GO Term (139)

microphthalmia

Disease

Source: DOID:10629

Definition: An eye disease where one or both eyeballs are abnormally small.

Genes: stau2 (Xtr)...STAU2 (Hsa)...stau2 (Dre)...Stau2 (Mmu)...Stau2 (Rno)

mitogen-activated protein kinase binding

Gene Ontology

Source: GO:0051019

Synonyms:

MAP kinase binding
MAP-kinase anchoring activity

Branch: molecular function

Genes: STAU2 (Hsa)...Stau2 (Mmu)...Stau2 (Rno)

Genes Annotated with this GO Term (118)

protein localization to synapse

Gene Ontology

Source: GO:0035418

Synonyms:

protein localisation to synapse

Branch: biological process

Genes: stau2 (Dre)...Stau2 (Mmu)...Stau2 (Rno)...STAU2 (Hsa)

Genes Annotated with this GO Term (305)

positive regulation of dendritic spine morphogenesis

Gene Ontology

Source: GO:0061003

Synonyms: Not Available

Branch: biological process

Genes: Stau2 (Mmu)...Stau2 (Rno)...STAU2 (Hsa)

Genes Annotated with this GO Term (89)

stau²

(Drosophila melanogaster)

Allele/Variant

Source: FB:FBal0016165

Genes: stau (Dme)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: stau²

Name: stau²

Gene (1)

dendrite cytoplasm

Gene Ontology

Source: GO:0032839

Synonyms:

dendritic cytoplasm

Branch: cellular component

Genes: STAU2 (Hsa)...Stau2 (Mmu)...Stau2 (Rno)

Genes Annotated with this GO Term (109)

Hsap\STAU2^UAS.Tag:HA

(Drosophila melanogaster)

Allele/Variant

Source: FB:FBal0366530

Genes: Not Available

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Hsap\STAU2

Construct Expressed Component: STAU2 (Hsa)

kinesin binding

Gene Ontology

Source: GO:0019894

Synonyms: Not Available

Branch: molecular function

Genes: STAU2 (Hsa)...Stau2 (Mmu)...Stau2 (Rno)

Genes Annotated with this GO Term (190)

dendritic shaft

Gene Ontology

Source: GO:0043198

Synonyms:

trunk

Branch: cellular component

Genes: STAU2 (Hsa)...Stau2 (Rno)...Stau2 (Mmu)

Genes Annotated with this GO Term (201)

germ cell development

Gene Ontology

Source: GO:0007281

Synonyms:

gametogenesis
germ-cell development

Branch: biological process

Genes: STAU2 (Hsa)...Stau2 (Rno)...stau2 (Dre)...Stau2 (Mmu)

Genes Annotated with this GO Term (2478)

double-stranded RNA binding

Gene Ontology

Source: GO:0003725

Synonyms:

dsRNA binding

Branch: molecular function

Genes: STAU2 (Hsa)...Stau2 (Rno)...stau2 (Dre)...Stau2 (Mmu)

Genes Annotated with this GO Term (339)

Hsp70 protein binding

Gene Ontology

Source: GO:0030544

Synonyms: Not Available

Branch: molecular function

Genes: STAU2 (Hsa)...Stau2 (Rno)...Stau2 (Mmu)

Genes Annotated with this GO Term (242)

positive regulation of synapse assembly

Gene Ontology

Source: GO:0051965

Synonyms:

activation of synapse assembly
positive regulation of synapse biogenesis

Branch: biological process

Genes: STAU2 (Hsa)...Stau2 (Rno)...Stau2 (Mmu)

Genes Annotated with this GO Term (323)

Pumilio2 and Staufen2 selectively balance the synaptic proteome

(Rattus norvegicus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by RGD

ID: GEO:GSE173596

Tags: unclassified

Summary: Cells, in particular neurons, have the capacity to adapt to environmental stimuli, a phenomenon termed cellular plasticity. The underlying processes are controlled by a network of RNA-binding proteins (RBPs). Their impact on cellular plasticity, however, is largely unknown. To address this important question, we chose Pumilio2 (Pum2) and Staufen2 (Stau2) that both regulate synaptic transmission. Surprisingly, even though both RBPs dynamically interact with each other in neurons, their respective impact on the transcriptome and proteome is highly selective. While Pum2 deficiency leads to reduced translation and protein expression, Stau2 depletion preferentially impacts RNA levels and increases protein abundance. Furthermore, we show that Pum2 activates expression of key GABAergic synaptic components, e.g. the GABAA receptor scaffold protein Gephyrin. Consequently, Pum2 depletion selectively reduced the amplitude of miniature inhibitory postsynaptic currents. Together, our data clearly demonstrate that RBPs are needed to maintain proteostasis in order to control distinct signaling pathways which critically balance synaptic transmission.