Version: 8.0.0Date: Tue Jan 28 2025
Category
timp2a
(Danio rerio)Gene
Name: TIMP metallopeptidase inhibitor 2a
Synonyms: wu:fa96h09, zgc:136726, fa96h09, TIMP2a, etID32613.12, timp2
Source: ZFIN:ZDB-GENE-030612-1
Biotype: protein coding gene
Symbol: timp2a (Dre)
Symbol: timp2a
Synonyms: TIMP2a...TIMP2a
TIMP2
(Homo sapiens)Gene
Name: TIMP metallopeptidase inhibitor 2
Synonyms: metalloproteinase inhibitor 2, TIMP-2, tissue inhibitor of metalloproteinases 2, KIAA1731NL, testicular secretory protein Li 57, tissue inhibitor of metalloproteinase 2, DDC8, CSC-21K
Source: HGNC:11821
Biotype: protein coding gene
Strict Orthology Symbols: timp2a
Timp2
(Rattus norvegicus)Gene
Name: TIMP metallopeptidase inhibitor 2
Synonyms: metalloproteinase inhibitor 2, TIMP-2, tissue inhibitor of metalloproteinases 2, tissue inhibitor of metalloproteinase 2, MGC105282
Source: RGD:61312
Biotype: protein coding gene
Strict Orthology Symbols: timp2a
Timp2
(Mus musculus)Gene
Name: tissue inhibitor of metalloproteinase 2
Synonyms: DNA segment, Chr 11, Brigham & Women's Genetics 1104 expressed, TIMP-2, D11Bwg1104e, Timp-2
Source: MGI:98753
Biotype: protein coding gene
Strict Orthology Symbols: timp2a
cri-2
(Caenorhabditis elegans)Gene
Name: Conserved Regulator of Innate immunity 2
Synonyms: 5I683, CELE_K07C11.5, tag-225, K07C11.5
Source: WB:WBGene00019478
Biotype: protein coding gene
Strict Orthology Symbols: timp2a
Timp
(Drosophila melanogaster)Gene
Name: Tissue inhibitor of metalloproteases
Synonyms: dTIMP, tissue inhibitor of metalloproteinases, Dtimp, DTIMP, tissue inhibitor of metalloproteases, TIMP1, timp, TIMP, CG6281
Source: FB:FBgn0025879
Biotype: protein coding gene
Strict Orthology Symbols: timp2a
AB + MO2-timp2a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-181031-6
Synonyms: Not Available
Genes: timp2a (Dre)
Name: AB + MO2-timp2a
timp2
(Xenopus tropicalis)Gene
Name: TIMP metallopeptidase inhibitor 2
Synonyms: timp-2, TIMP metallopeptidase inhibitor 2, timp2
Source: Xenbase:XB-GENE-949671
Biotype: gene
Strict Orthology Symbols: timp2a
WT + MO1-timp2a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-7415
Synonyms: Not Available
Genes: timp2a (Dre)
Name: WT + MO1-timp2a
zf148Tg + CRISPR2-timp2b + CRISPR4-timp2a (WIK)
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-240409-21
Synonyms: Not Available
Genes: timp2a (Dre)
Name: zf148Tg + CRISPR2-timp2b + CRISPR4-timp2a (WIK)
Source: GO:0051045
Synonyms:
- down regulation of membrane protein ectodomain proteolysis
- down-regulation of membrane protein ectodomain proteolysis
Branch: biological process
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0008191
Synonyms:
- metalloprotease inhibitor
- metalloproteinase inhibitor
Branch: molecular function
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0010466
Synonyms: Not Available
Branch: biological process
Genes: timp2a (Dre)
Disease
Source: DOID:13099
Definition: A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.
Genes: timp2a (Dre)
Disease
Source: DOID:14323
Definition: A connective tissue disease that is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens.
Genes: timp2a (Dre)
Source: DOID:3744
Definition: A cervix carcinoma that has_material_basis_in squamous cells of the cervix.
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0004857
Synonyms:
- metalloenzyme inhibitor activity
Branch: molecular function
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0030414
Synonyms:
- protease inhibitor activity
Branch: molecular function
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0009725
Synonyms:
- growth regulator
- response to hormone stimulus
Branch: biological process
Genes: timp2a (Dre)
Disease
Source: DOID:11723
Definition: A muscular dystrophy that has_material_basis_in X-linked mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.
Genes: timp2a (Dre)
Disease
Source: DOID:14004
Definition: An aortic aneurysm that is located_in the thoracic aorta.
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0034097
Synonyms:
- response to cytokine stimulus
Branch: biological process
Genes: timp2a (Dre)
Disease
Source: DOID:2871
Definition: A endometrial cancer that is located_in the tissue lining the uterus.
Genes: timp2a (Dre)
Disease
Source: DOID:0060074
Definition: A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells.
Genes: timp2a (Dre)
Disease
Source: DOID:11984
Definition: An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.
Genes: timp2a (Dre)
Disease
Source: DOID:2671
Definition: A carcinoma that derives_from transitional epithelial cells.
Genes: timp2a (Dre)
Disease
Source: DOID:12858
Definition: A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.
Genes: timp2a (Dre)
Disease
Source: DOID:0050700
Definition: A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.
Genes: timp2a (Dre)
Disease
Source: DOID:9744
Definition: A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.
Genes: timp2a (Dre)
Disease
Source: DOID:11054
Definition: An urinary system cancer that results_in malignant growth located_in the urinary bladder.
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0005615
Synonyms:
- intercellular space
Branch: cellular component
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0031012
Synonyms:
- matrisome
- proteinaceous extracellular matrix
Branch: cellular component
Genes: timp2a (Dre)
Gene Ontology
Source: GO:0046872
Synonyms:
- heavy metal binding
- metal binding
Branch: molecular function
Genes: timp2a (Dre)
Disease
Source: DOID:6000
Definition: A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.
Genes: timp2a (Dre)
Disease
Source: DOID:4450
Definition: A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.
Genes: timp2a (Dre)
Disease
Source: DOID:10283
Definition: A male reproductive organ cancer that is located_in the prostate.
Genes: timp2a (Dre)
Disease
Source: DOID:10652
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Genes: timp2a (Dre)