Version: 8.0.0Date: Tue Jan 28 2025
Category
Tprkb
(Rattus norvegicus)Gene
Name: Tp53rk binding protein
Synonyms: LOC100910911, RGD1309786, TP53RK-binding protein, TP53RK-binding protein-like, Prpk (p53-related protein kinase)-binding protein, Cgi-121, LOC297411, EKC/KEOPS complex subunit Tprkb, similar to CGI-121 protein, LOC103690067
Source: RGD:1309786
Biotype: protein coding gene
Symbol: Tprkb (Rno)
Symbol: Tprkb
Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine
Automated Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein).
Synonyms: EKC/KEOPS complex subunit Tprkb
Strict Orthology Symbols: tprkb
Tprkb
(Mus musculus)Gene
Name: Tp53rk binding protein
Synonyms: RIKEN cDNA 1810034M08 gene, RGD1309786, DRWMS1, Cgi-121, RIKEN cDNA 0610033G21 gene, 0610033G21Rik, 1810034M08Rik
Source: MGI:1917036
Biotype: protein coding gene
Symbol: Tprkb (Mmu)
Symbol: Tprkb
Automated Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein).
Strict Orthology Symbols: tprkb
Alleles: Tprkb
tprkb
(Danio rerio)Gene
Name: Tp53rk binding protein
Synonyms: zgc:101896
Source: ZFIN:ZDB-GENE-041114-68
Biotype: protein coding gene
Symbol: tprkb (Dre)
Symbol: tprkb
Automated Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein).
Strict Orthology Symbols: tprkb
TPRKB
(Homo sapiens)Gene
Name: TP53RK binding protein
Synonyms: PRPK-binding protein, PRPK (p53-related protein kinase)-binding protein, CGI121, TP53RK-binding protein, CGI-121, EKC/KEOPS complex subunit TPRKB, GAMOS5
Source: HGNC:24259
Biotype: protein coding gene
Symbol: TPRKB (Hsa)
Symbol: TPRKB
Synonyms: EKC/KEOPS complex subunit TPRKB
Strict Orthology Symbols: tprkb
tprkb
(Xenopus tropicalis)Gene
Name: TP53RK binding protein
Synonyms: cgi-121, tprkb, TP53RK binding protein, Cgi121
Source: Xenbase:XB-GENE-5749722
Biotype: gene
Symbol: tprkb
Symbol: tprkb (Xtr)
Automated Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein).
Synonyms: tprkb...tprkb...tprkb
Strict Orthology Symbols: tprkb
tprkb.L
(Xenopus laevis)Gene
Name: TP53RK binding protein
Synonyms: cgi-121, tprkb.L, TP53RK binding protein, Cgi121
Source: Xenbase:XB-GENE-6255942
Biotype: gene
Symbol: tprkb.L (Xla)
Automated Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein).
Strict Orthology Symbols: tprkb
Symbol: tprkb.L
tprkb.S
(Xenopus laevis)Gene
Name: TP53RK binding protein
Synonyms: cgi-121, tprkb.S, TP53RK binding protein, Cgi121
Source: Xenbase:XB-GENE-17331529
Biotype: gene
Symbol: tprkb.S (Xla)
Automated Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein).
Strict Orthology Symbols: tprkb
Symbol: tprkb.S
Tprkbem24Gpt
(Mus musculus)Allele/Variant
Source: MGI:7307781
Genes: Tprkb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tprkb
Genes: Tprkb (Mmu)
Symbol: Tprkbem24Gpt
Tprkbem1Chuan
(Mus musculus)Allele/Variant
Source: MGI:7382804
Genes: Tprkb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tprkb
Genes: Tprkb (Mmu)
Symbol: Tprkbem1Chuan
Tprkbem1(IMPC)Bay
(Mus musculus)Allele/Variant
Source: MGI:6414546
Genes: Tprkb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tprkb
Genes: Tprkb (Mmu)
Symbol: Tprkbem1(IMPC)Bay
TPRKBP1
(Homo sapiens)Gene
Name: TP53RK binding protein pseudogene 1
Synonyms: Not Available
Source: HGNC:44943
Biotype: pseudogene
Symbol: TPRKBP1 (Hsa)
Symbol: TPRKBP1
TPRKBP2
(Homo sapiens)Gene
Name: TP53RK binding protein pseudogene 2
Synonyms: Not Available
Source: HGNC:44944
Biotype: pseudogene
Symbol: TPRKBP2 (Hsa)
Symbol: TPRKBP2
Model
Id: MGI:7267116
Synonyms: Not Available
Symbol: Tprkb/Tprkb [background:] C57BL/6N-Tprkb/BayMmucd (Mmu)
Genes: Tprkb (Mmu)
Alleles: Tprkb
Name: Tprkb/Tprkb [background:] C57BL/6N-Tprkb/BayMmucd
tprkbcl601/cl601
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-180412-15
Synonyms: Not Available
Symbol: tprkb
Genes: tprkb (Dre)
Name: tprkb
tprkbcl603/cl603
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-181025-5
Synonyms: Not Available
Symbol: tprkb
Genes: tprkb (Dre)
Name: tprkb
CGI121
(Saccharomyces cerevisiae)Gene
Name: homolog of human CGI-121
Synonyms: YML036W
Source: SGD:S000004500
Biotype: protein coding gene
Gene Synopsis: for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p; ortholog of human TPRKB
Automated Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein).
Strict Orthology Symbols: tprkb
W03F8.4
(Caenorhabditis elegans)Gene
Name: EKC/KEOPS complex subunit TPRKB
Synonyms: CELE_W03F8.4
Source: WB:WBGene00020994
Biotype: protein coding gene
Gene Synopsis: Is an ortholog of human TPRKB (TP53RK binding protein).
Automated Gene Synopsis: Orthologous to human TPRKB (TP53RK binding protein).
Strict Orthology Symbols: tprkb
TP53RK
(Homo sapiens)Gene
Name: TP53 regulating kinase
Synonyms: C20orf64, TP53-regulating kinase, atypical serine/threonine protein kinase TP53RK, dJ101A2, Nori-2p, EKC/KEOPS complex subunit TP53RK, Nori-2, TPRKB, PRPK, p53-related protein kinase, BUD32, GAMOS4
Source: HGNC:16197
Biotype: protein coding gene
Synonyms: TPRKB...TPRKB
Gene Ontology
Source: GO:0000408
Synonyms:
- KEOPS/EKC complex
- TCTC
Branch: cellular component
Genes: tprkb (Dre)...Tprkb (Mmu)...TPRKB (Hsa)...Tprkb (Rno)
Disease
Source: DOID:0080247
Definition: A Galloway-Mowat syndrome that has_material_basis_in homozygous mutation in the TPRKB gene on chromosome 2p13.
Genes: Tprkb (Mmu)...Tprkb (Rno)...tprkb.S (Xla)...TPRKB (Hsa)...tprkb (Xtr)
Gene Ontology
Source: GO:0002949
Synonyms:
- t6A biosynthesis
- t6A biosynthetic process
Branch: biological process
Genes: tprkb (Dre)...Tprkb (Mmu)...TPRKB (Hsa)...Tprkb (Rno)
In(6)1J/In(6)1J Mitfem1Chuan/Mitfem1Chuan Tprkbem1Chuan/Tprkbem1Chuan [background:] B6N.Cg-In(6)1J Tprkbem1Chuan Mitfem1Chuan
(Mus musculus)Model
Id: MGI:7382808
Synonyms: Not Available
Genes: Tprkb (Mmu)
Alleles: Tprkb
Name: In(6)1J/In(6)1J Mitf/Mitf Tprkb/Tprkb [background:] B6N.Cg-In...(6)1J Tprkb Mitf
Symbol: In(6)1J/In(6)1J Mitf/Mitf Tprkb/Tprkb [background:] B6N.Cg-In...(6)1J Tprkb (Mmu)
cl603
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-180625-6
Genes: tprkb (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: tprkb (Dre)
Mitfem1Chuan/Mitfem1Chuan Tprkbem1Chuan/Tprkbem1Chuan [background:] B6N.Cg-Tprkbem1Chuan Mitfem1Chuan
(Mus musculus)Model
Id: MGI:7382810
Synonyms: Not Available
Genes: Tprkb (Mmu)
Alleles: Tprkb
Name: Mitf/Mitf Tprkb/Tprkb [background:] B6N.Cg-Tprkb Mitf
Symbol: Mitf/Mitf Tprkb/Tprkb [background:] B6N.Cg-Tprkb Mitf
Gene Ontology
Source: GO:0008033
Synonyms:
- tRNA maturation
Branch: biological process
Genes: Tprkb (Rno)...TPRKB (Hsa)...tprkb (Dre)
Dysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-54418, GEO:GSE54418
Tags: WT vs. mutant, anatomical structure, age, genotype
Summary: During cell stress, the transcription and translation of immediate early genes are prioritized, while most other mRNAs are stored away in stress granules or degraded in P-bodies. TIA-1 is an mRNA binding protein that needs to translocate from the nucleus to seed the formation of stress granules in the cytoplasm. Since other stress granule components such as TDP-43, FUS, ATXN2, SMN, MAPT, HNRNPA2B1 and HNRNPA1 are crucial for the motor neuron diseases ALS / SMA and for the frontotemporal dementia FTD, here we studied mouse nervous tissue to identify mRNAs with selective dependence on Tia1 deletion. Transcriptome profiling with oligonucleotide microarrays in comparison of spinal cord and cerebellum, together with independent validation in quantitative reverse transcriptase PCR and immunoblots demonstrated several strong and consistent dysregulations. In agreement with previously reported TIA1 knock-down effects, cell cycle and apoptosis regulators were affected markedly with expression changes up to 2-fold, exhibiting increased levels for Cdkn1a, Ccnf, and Tprkb versus decreased levels for Bid and Inca1 transcripts. Novel and surprisingly strong expression alterations were detected for fat storage and membrane trafficking factors, with prominent above 3-fold upregulations of Plin4, Wdfy1, Tbc1d24, and Pnpla2, versus a 0.5 -fold?? downregulation of Cntn4 transcript, encoding an axonal membrane adhesion factor with established haploinsufficiency. In comparison subtle effects on the RNA processing machinery included up to 1.2-fold upregulations of Dcp1b and Tial1. The effect on lipid dynamics factors is noteworthy, since also the gene deletion of Tardbp (encoding TDP-43) and Atxn2 led to fat metabolism phenotypes in mouse. In conclusion, genetic ablation of the stress granule nucleator TIA-1 has a novel major effect on mRNAs encoding lipid homeostasis factors in the brain. Factorial design comparing Tia1 knock-out mice with wild type littermates in four different tissues (midbrain, cerebellum, liver, spinal cord) and 2 different ages.
Gene Ontology
Source: GO:0019901
Synonyms: Not Available
Branch: molecular function
Genes: Tprkb (Rno)...TPRKB (Hsa)...Tprkb (Mmu)
(GRCh38)2:73732245G>C
(Homo sapiens)Allele/Variant
Source: NC_000002.12:g.73732245G>C
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73732245G>C
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73734529C>G
(Homo sapiens)Allele/Variant
Source: rs996672742
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73734529C>G
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73732224C>T
(Homo sapiens)Allele/Variant
Source: rs138861686
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73732224C>T
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730611C>T
(Homo sapiens)Allele/Variant
Source: rs144417465
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730611C>T
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730008C>T
(Homo sapiens)Allele/Variant
Source: NC_000002.12:g.73730008C>T
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730008C>T
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730595G>C
(Homo sapiens)Allele/Variant
Source: rs1180522719
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730595G>C
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730632T>C
(Homo sapiens)Allele/Variant
Source: rs371941818
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730632T>C
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730679C>G
(Homo sapiens)Allele/Variant
Source: rs377749247
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730679C>G
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730026A>T
(Homo sapiens)Allele/Variant
Source: NC_000002.12:g.73730026A>T
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730026A>T
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73734564C>G
(Homo sapiens)Allele/Variant
Source: rs1438811085
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73734564C>G
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730025T>C
(Homo sapiens)Allele/Variant
Source: rs1233885358
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730025T>C
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730715A>T
(Homo sapiens)Allele/Variant
Source: rs769029364
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730715A>T
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730019A>G
(Homo sapiens)Allele/Variant
Source: NC_000002.12:g.73730019A>G
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730019A>G
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73734555A>C
(Homo sapiens)Allele/Variant
Source: rs1181710439
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73734555A>C
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73734434T>C
(Homo sapiens)Allele/Variant
Source: rs780348427
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73734434T>C
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730100T>A
(Homo sapiens)Allele/Variant
Source: rs13003035
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730100T>A
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730674G>A
(Homo sapiens)Allele/Variant
Source: rs149388000
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730674G>A
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730727C>T
(Homo sapiens)Allele/Variant
Source: rs148515124
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730727C>T
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73732267T>C
(Homo sapiens)Allele/Variant
Source: rs749359016
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73732267T>C
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73732282C>T
(Homo sapiens)Allele/Variant
Source: rs145872059
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73732282C>T
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73732182T>C
(Homo sapiens)Allele/Variant
Source: rs147434102
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73732182T>C
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73729997A>G
(Homo sapiens)Allele/Variant
Source: rs7210
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, non_coding_transcript_variant, synonymous_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73729997A>G
Gene Synonyms: EKC/KEOPS complex subunit TPRKB
(GRCh38)2:73730724A>G
(Homo sapiens)Allele/Variant
Source: rs202183143
Genes: TPRKB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)2:73730724A>G
Gene Synonyms: EKC/KEOPS complex subunit TPRKB