Gene

ac

Species
Drosophila melanogaster
Symbol
ac
Name
achaete
Synonyms
  • 990 E5 F1
  • Ac
Biotype
protein coding gene
Automated Description
Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule development; chaeta morphogenesis; and positive regulation of antibacterial peptide biosynthetic process. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including adult thoracic mechanosensory chaeta; imaginal disc; neurogenic region; procephalic segment; and somatic precursor cell. Orthologous to several human genes including ASCL2 (achaete-scute family bHLH transcription factor 2).
FB Description
achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13935
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions