Version: 8.0.0
Date: Tue Jan 28 2025
Pka-C1
Drosophila melanogasterFB:FBgn0000273
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pka-C1

Species
Drosophila melanogaster
Symbol
Pka-C1
Name
Protein kinase, cAMP-dependent, catalytic subunit 1
Synonyms
  • 6353
  • C
Biotype
protein coding gene
Automated Description
Enables cAMP-dependent protein kinase activity. Involved in several processes, including oocyte axis specification; regulation of intracellular mRNA localization; and regulation of smoothened signaling pathway. Located in several cellular components, including cytosol; dendrite; and neuronal cell body. Is active in mitochondrial matrix. Is expressed in several structures, including ganglia; gland; gonad; gut section; and synaptic neuropil domain. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha) and PRKACB (protein kinase cAMP-activated catalytic subunit beta).
FB Description
Protein kinase, cAMP-dependent, catalytic subunit 1 (Pka-C1) encodes a serine/threonine kinase that contributes to axis specification, rhythmic behavior and synaptic transmission.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24353
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pka-C1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            Pka-C1 role
            Pka-C1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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