Enables several functions, including enzyme binding activity; microtubule binding activity; and smoothened binding activity. Involved in several processes, including cytoplasmic sequestering of protein; intraciliary transport; and negative regulation of smoothened signaling pathway. Located in cytosol. Part of Hedgehog signaling complex and microtubule associated complex. Colocalizes with extrinsic component of cytoplasmic side of plasma membrane. Is expressed in organism; segment; wing disc; wing disc anterior compartment; and wing disc posterior compartment. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF27 (kinesin family member 27) and KIF7 (kinesin family member 7).
FB Description
costa (cos) encodes a kinesin-like protein and a key component in the Hedgehog (Hh) pathway that is involved in pattern formation and growth control. It forms a complex with the product of fu to restrict the activity of the Hh pathway transcription factor encoded by ci.